Article
Microbiology
Valeria Mateo-Estrada, Jose Luis Fernandez-Vazquez, Julia Moreno-Manjon, Ismael L. Hernandez-Gonzalez, Eduardo Rodriguez-Noriega, Rayo Morfin-Otero, Maria Dolores Alcantar-Curiel, Santiago Castillo-Ramirez
Summary: This study used whole-genome sequencing to uncover the transmission dynamics of extensive and multidrug-resistant A. baumannii in a tertiary hospital over a decade, showing that accessory genome variation can be a powerful tool for conducting genomic epidemiology.
Editorial Material
Microbiology
Santiago Castillo-Ramirez
Summary: A recent study published in mBio sequenced the genomes of 313 carbapenem-resistant A. baumannii isolates from over 100 hospitals in almost 50 countries, providing an updated view of the global distribution of major international clones and their carbapenemase genes. Future global genomic epidemiology studies can be enhanced by considering both human and non-human isolates and their antibiotic resistance profiles.
Article
Microbiology
Carina Mueller, Sandra Reuter, Julia Wille, Kyriaki Xanthopoulou, Danuta Stefanik, Hajo Grundmann, Paul G. Higgins, Harald Seifert
Summary: This study conducted molecular epidemiology and global distribution research on 313 carbapenem-resistant Acinetobacter baumannii isolated from 114 study centers in 47 countries. The results revealed a wide variation in the distribution of carbapenemase encoding genes among different geographical regions.
Article
Microbiology
Alina Iovleva, Mustapha M. Mustapha, Marissa P. Griffith, Lauren Komarow, Courtney Luterbach, Daniel R. Evans, Eric Cober, Sandra S. Richter, Kirsten Rydell, Cesar A. Arias, Jesse T. Jacob, Robert A. Salata, Michael J. Satlin, Darren Wong, Robert A. Bonomo, David van Duin, Vaughn S. Cooper, Daria Van Tyne, Yohei Doi
Summary: Carbapenem-resistant Acinetobacter baumannii (CRAb) is a significant threat to public health, particularly for hospitalized patients. The Study Network of Acinetobacter as a Carbapenem-Resistant Pathogen (SNAP) conducted whole-genome sequencing (WGS) analysis of 120 CRAb patients from four U.S. centers, revealing the dominance of the ST2(Pas) lineage within clonal complex 2 (CC2), as well as the emergence of sublineages with different antibiotic resistance phenotypes. The study emphasizes the need for real-time surveillance and molecular epidemiology to understand CRAb dissemination and clinical impact.
Article
Infectious Diseases
Frieder Fuchs, Federico Becerra-Aparicio, Kyriaki Xanthopoulou, Harald Seifert, Paul G. Higgins
Summary: This study investigated the in vitro activity of nitroxoline against carbapenem-resistant Acinetobacter baumannii. The results showed that nitroxoline exhibited excellent activity against a collection of carbapenem-resistant Acinetobacter baumannii isolates. This suggests that nitroxoline could be a promising drug for the treatment of lower urinary tract infections caused by this bacterium.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Immunology
Mariana Castanheira, Rodrigo E. Mendes, Ana C. Gales
Summary: The Acinetobacter baumannii-calcoaceticus complex (ABC) is a significant group of organisms causing human infections worldwide, with a small number of clones responsible for increased infections and resistance to antimicrobial agents. This article discusses the current epidemiology and resistance mechanisms in ABC. A. baumannii-calcoaceticus is the most common species in the Acinetobacter genus and is responsible for a large percentage of nosocomial infections, including bacteremia, pneumonia, and skin and urinary tract infections. Key clones of A. baumannii-calcoaceticus play a major role in the global dissemination of these organisms, and multidrug resistance is a common trait among these clones due to their remarkable adaptability. A. baumannii-calcoaceticus isolates can develop resistance through various mechanisms, such as horizontal gene transfer, natural transformation, acquisition of mutations, and mobilization of genetic elements.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Meijie Jiang, Xia Chen, Shuang Liu, Zhijun Zhang, Ning Li, Chao Dong, Ling Zhang, Haiyan Wu, Shuping Zhao
Summary: The study found that there was no significant change in the antibiotic-resistant and carbapenemase-resistant genes of 295 MDR A. baumannii isolates in the hospital over the past 12 years, and most isolates had a relatively close genetic relationship. The detection rates of carbapenemase-resistant genes bla(OXA-23), bla(TEM-1), and bla(OXA-66) were high, and the most common sequence types were ST208 and ST369.
FRONTIERS IN PUBLIC HEALTH
(2021)
Review
Immunology
Ning Yang, Xiao Jin, Chenghua Zhu, Fenglin Gao, Zheqi Weng, Xingran Du, Ganzhu Feng
Summary: Acinetobacter baumannii is a gram-negative bacterium and an important opportunistic pathogen in hospitals. Its increasing multidrug-resistant strains and global prevalence have made A. baumannii infection a challenging problem in clinical practice. Vaccines, specifically subunit vaccines, are being researched as effective tools to prevent and control A. baumannii infection. However, the lack of clinical trials may be due to the degradation and weak immunogenicity of subunit vaccines. Using adjuvants or delivery vehicles to prepare subunit vaccines can improve their stability and efficacy. Selecting the appropriate adjuvant and immunization method is essential for subunit vaccine research. This review aims to guide current and future research on A. baumannii subunit vaccines.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Infectious Diseases
Katarina Novovic, Branko Jovcic
Summary: A. baumannii is a clinically significant pathogen causing various nosocomial infections. Colistin, as a last-resort antibiotic, is used to treat multidrug-resistant A. baumannii infections. However, several mechanisms of colistin resistance in A. baumannii have been reported, including loss of LPS, modifications of target LPS, and efflux of colistin. In addition, widespread heteroresistance in A. baumannii contributes to colistin treatment failure. This review critically assesses the molecular mechanisms and global distribution of colistin-resistant strains in A. baumannii based on more than 50 experimental papers.
Article
Microbiology
Valeria Mateo-Estrada, Leila Vali, Ahmed Hamouda, Benjamin A. Evans, Santiago Castillo-Ramirez
Summary: This study compares the genomic identity of Scottish cattle and pig isolates with human clinical international clones of Acinetobacter baumannii. The results show that the animal isolates represent novel clones distinct from the major international clones, and they possess fewer antibiotic resistance and virulence genes compared to the human clinical isolates.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Congcong Liu, Kaichao Chen, Yuchen Wu, Ling Huang, Yinfei Fang, Jiayue Lu, Yu Zeng, Miaomiao Xie, Edward Wai Chi Chan, Sheng Chen, Rong Zhang
Summary: Acinetobacter baumannii is a significant Gram-negative pathogen causing nosocomial infections. In China, a large portion of clinical A. baumannii strains are multidrug resistant, particularly towards carbapenems. Nationwide surveillance revealed a prevalence of carbapenem-resistant A. baumannii (CRAB) strains in intensive care units (ICUs), with clonal spread observed in some ICUs. Carbapenem-hydrolysing class D beta-lactamases (CHDL) were primarily responsible for carbapenem resistance, and the ST2 global clone was the predominant type of CRAB in China. Notably, CRAB isolates exhibited low resistance to colistin and tigecycline, but high resistance to ceftazidime-avibactam.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Immunology
Sandra Sanchez-Urtaza, Alain Ocampo-Sosa, Ainhoa Molins-Bengoetxea, Mohammed A. A. El-Kholy, Marta Hernandez, David Abad, Sherine M. M. Shawky, Itziar Alkorta, Lucia Gallego
Summary: This study investigated the genetic characteristics and antimicrobial susceptibility profile of multidrug resistant Acinetobacter baumannii clinical isolates obtained from hospitals in Alexandria, Egypt. The results showed resistance to multiple antibiotics and the presence of various antibiotic resistance genes and virulence factors. The study highlights the importance of investigating molecular epidemiology to control the spread of these multidrug resistant isolates.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Immunology
Sean Jeffreys, James P. Chambers, Jieh-Juen Yu, Chiung-Yu Hung, Thomas Forsthuber, Bernard P. Arulanandam
Summary: Acinetobacter baumannii is a drug-resistant bacteria that causes hospital-acquired infections, which have contributed to increased costs and mortality during the COVID-19 pandemic. Immune-based therapy, including vaccines and monoclonal antibodies, is a promising strategy to combat this pathogen.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Qaqamba Mapipa, Tennison Onoriode Digban, Nonso Emmanuel Nnolim, Nolonwabo Nontongana, Anthony Ifeanyi Okoh, Uchechukwu U. Nwodo
Summary: This study analyzed the antibiotic profile and antibiotic resistance genes of A. baumannii isolated from hospital wastewater, and found that these isolates exhibited high levels of antibiotic resistance, with some carrying virulence and resistance traits.
CURRENT MICROBIOLOGY
(2022)
Article
Infectious Diseases
Bin Liu, Lei Liu
Summary: CRAB isolates from the ICU showed higher resistance to tigecycline and cefoperazone/sulbactam compared to RD. PCR detection revealed different ratios of resistance-associated genes in ICU and RD, while PFGE and MLST results also indicated variations in molecular epidemiology and resistance mechanisms between the two departments.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Immunology
Subhra Chakraborty, Arlo Randall, Tim J. Vickers, Doug Molina, Clayton D. Harm, Barbara DeNearing, Ljessica Brubaker, David A. Sack, A. Louis Bourgeois, Philip L. Felgner, Xiaowu Liang, Sachin Mani, Heather Wenzel, R. Reid Townsend, Petra E. Gilmore, Michael J. Darsley, David A. Rasko, James M. Fleckenstein
JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Microbiology
Courtney E. Chandler, Alexander M. Horspool, Preston J. Hill, Daniel J. Wozniak, Jeffrey W. Schertzer, David A. Rasko, Robert K. Ernst
JOURNAL OF BACTERIOLOGY
(2019)
Article
Infectious Diseases
Roberto M. Vidal, Khitam Muhsen, Sharon M. Tennant, Ann-Mari Svennerholm, Samba O. Sow, Dipika Sur, Anita K. M. Zaidi, Abu S. G. Faruque, Debasish Saha, Richard Adegbola, M. Jahangir Hossain, Pedro L. Alonso, Robert F. Breiman, Quique Bassat, Boubou Tamboura, Doh Sanogo, Uma Onwuchekwa, Byomkesh Manna, Thandavarayan Ramamurthy, Suman Kanungo, Shahnawaz Ahmed, Shahida Qureshi, Farheen Quadri, Anowar Hossain, Sumon K. Das, Martin Antonio, Inacio Mandomando, Tacilta Nhampossa, Sozinho Acacio, Richard Omore, John B. Ochieng, Joseph O. Oundo, Eric D. Mintz, Ciara E. O'Reilly, Lynette Y. Berkeley, Sofie Livio, Sandra Panchalingam, Dilruba Nasrin, Tamer H. Farag, Yukun Wu, Halvor Sommerfelt, Roy M. Robins-Browne, Felipe Del Canto, Tracy H. Hazen, David A. Rasko, Karen L. Kotloff, James P. Nataro, Myron M. Levine
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Microbiology
Tracy H. Hazen, Sushma Nagaraj, Sunil Sen, Jasnehta Permala-Booth, Felipe Del Canto, Roberto Vidal, Eileen M. Barry, Jacob P. Bitoun, Wilbur H. Chen, Sharon M. Tennant, David A. Rasko
Article
Immunology
David Arturo Montero, Felipe Del Canto, Juliana Velasco, Rocio Colell, Nora Lia Padola, Juan Carlos Salazar, Carla San Martin, Angel Onate, Jorge Blanco, David A. Rasko, Carmen Contreras, Jose Luis Puente, Flemming Scheutz, Eelco Franz, Roberto M. Vidal
EMERGING MICROBES & INFECTIONS
(2019)
Article
Immunology
Tracy H. Hazen, David A. Rasko
INFECTION AND IMMUNITY
(2019)
Article
Infectious Diseases
Kristin Bornstein, Sharon M. Tennant, Tracy H. Hazen, John D. Sorkin, Milagritos D. Tapia, Samba O. Sow, Uma Onwuchekwa, Myron M. Levine, David A. Rasko
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Immunology
Subhra Chakraborty, Arlo Randall, Tim J. Vickers, Doug Molina, Clayton D. Harro, Barbara DeNearing, Jessica Brubaker, David A. Sack, A. Louis Bourgeois, Philip L. Feigner, Xiaowu Liang, Sachin Mani, Heather Wenzel, R. Reid Townsend, Petra E. Gilmore, Michael J. Darsley, David A. Rasko, James M. Fleckenstein
Article
Infectious Diseases
F. Matthew Kuhlmann, John Martin, Tracy H. Hazen, Tim J. Vickers, Madeline Pashos, Pablo C. Okhuysen, Oscar G. Gomez-Duarte, Elizabeth Cebelinski, Dave Boxrud, Felipe del Canto, Roberto Vidal, Firdausi Qadri, Makedonka Mitreva, David A. Rasko, James M. Fleckenstein
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Infectious Diseases
David A. Rasko, Felipe Del Canto, Qingwei Luo, James M. Fleckenstein, Roberto Vidal, Tracy H. Hazen
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Microbiology
Rachael B. Chanin, Kourtney P. Nickerson, Alejandro Llanos-Chea, Jeticia R. Sistrunk, David A. Rasko, Deepak Kumar Vijaya Kumar, John de la Parra, Jared R. Auclair, Jessica Ding, Kelvin Li, Snaha Krishna Dogiparthi, Benjamin J. D. Kusber, Christina S. Faherty
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Genetics & Heredity
Amol C. Shetty, John Mattick, Matthew Chung, Carrie McCracken, Anup Mahurkar, Scott G. Filler, Claire M. Fraser, David A. Rasko, Vincent M. Bruno, Julie C. Dunning Hotopp
MICROBIAL GENOMICS
(2020)
Article
Infectious Diseases
Rodrigo T. Hernandes, Tracy H. Hazen, Luis F. dos Santos, Taylor K. S. Richter, Jane M. Michalski, David A. Rasko
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Microbiology
Timileyin Adedrian, Stephanie Hitchcock, Lyndsay M. O'Hara, Jane M. Michalski, J. Kristie Johnson, David P. Calfee, Loren G. Miller, Tracy H. Hazen, David A. Rasko, Anthony D. Harris
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2019)
Article
Tracy H. Hazen, Roberta T. Mettus, Christi L. McElheny, Sarah L. Bowler, Yohei Doi, David A. Rasko
GENOME ANNOUNCEMENTS
(2018)
