Review
Cardiac & Cardiovascular Systems
Stefano Masi, Damiano Rizzoni, Stefano Taddei, Robert Jay Widmer, Augusto C. Montezano, Thomas F. Luscher, Ernesto L. Schiffrin, Rhian M. Touyz, Francesco Paneni, Amir Lerman, Gaetano A. Lanza, Agostino Virdis
Summary: The development of novel, non-invasive techniques and standardization of protocols to assess microvascular dysfunction has highlighted the key role of microvascular changes in cardiovascular damage evolution and their predictive ability for increased risk of adverse events. These advancements complement the identification of pathways promoting microvascular dysfunction ex vivo, providing potential treatment targets for preventing cerebral-CV disease. Understanding the pathophysiology of microvascular dysfunction and the regulation of oxidative stress by epigenetic mechanisms may offer potential targets for novel interventions beyond conventional approaches in reducing cardiovascular disease.
EUROPEAN HEART JOURNAL
(2021)
Editorial Material
Hematology
Laurent A. Messonnier
Summary: Although sickle cell disease (SCD) is related to a single point mutation, there is extreme variability in the clinical presentation among patients. Genetic variants may contribute to this variability. In this study, Dosunmu-Ogunbi et al. highlighted the importance of a genetic variant affecting mitochondrial function in the cardiovascular pathophysiology of SCD. Their findings provide important insights and perspectives for patient management.
Review
Biochemistry & Molecular Biology
Rani Ashouri, Madison Fangman, Alicia Burris, Miriam O. Ezenwa, Diana J. Wilkie, Sylvain Dore
Summary: Circulating hemopexin plays a critical role in combating deleterious inflammation and oxidative stress induced by free heme, particularly in hemolytic pathophysiology. Research suggests that rectifying depleted hemopexin in patients with sickle cell disease may improve or prevent symptoms, indicating its potential clinical function as a biomarker and therapy. Further preclinical and clinical research is needed to uncover pathways of hemopexin in pathological states and evaluate its clinical potential for sickle cell disease and related hemoglobinopathies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Endre Sulyok, Balint Farkas, Bernadett Nagy, Akos Varnagy, Kalman Kovacs, Jozsef Bodis
Summary: This article discusses the risks of excessive sodium intake on the development of cardiovascular and renal diseases, as well as the storage and dissociation of sodium in the skin interstitium. It also explores the cellular response to increased tissue sodium concentration and the protective role of endothelial glycocalyx in sodium retention. Furthermore, it highlights the involvement of oxygen free radicals in sodium-induced tissue damage and mentions some clinical entities associated with sodium/volume retention and oxidative stress.
Review
Biochemistry & Molecular Biology
Rosa Vona, Nadia Maria Sposi, Lorenza Mattia, Lucrezia Gambardella, Elisabetta Straface, Donatella Pietraforte
Summary: Sickle cell disease is a hereditary disorder of hemoglobin characterized by abnormal sickle hemoglobin production, leading to oxidative stress and organ damage. Antioxidant agents have been shown to reduce disease consequences and delay organ complications. Understanding oxidative stress may lead to targeted antioxidant therapies to prevent organ complications in sickle cell patients.
Review
Biochemistry & Molecular Biology
Abdelrahman AlAshqar, Bethlehem Lulseged, Akailah Mason-Otey, Jinxiao Liang, Umme Aoufa Mafruha Begum, Sadia Afrin, Mostafa A. Borahay
Summary: In recent decades, our understanding of the complex pathobiology of uterine fibroid development has expanded. It is now known that uterine fibroids have different aspects of their genesis and oxidative stress plays an important role in their development. The influence of oxidative stress on fibroid development is mediated through genetic, epigenetic, and profibrotic mechanisms. This knowledge has led to clinical implications for diagnosis and treatment using biomarkers and antioxidants.
Article
Biochemistry & Molecular Biology
Marika Cordaro, Angela Trovato Salinaro, Rosalba Siracusa, Ramona D'Amico, Daniela Impellizzeri, Maria Scuto, Maria Laura Ontario, Salvatore Cuzzocrea, Rosanna Di Paola, Roberta Fusco, Vittorio Calabrese
Summary: Alzheimer's disease is the principal cause of dementia and is associated with neurodegenerative disorders. Hericium erinaceus, a nutritional mushroom with important antioxidant effects, has shown significant therapeutic effects in a rat model of AD, reducing behavioral changes and hippocampal neuronal degeneration.
Review
Medicine, General & Internal
Elie Nader, Yohann Garnier, Philippe Connes, Marc Romana
Summary: Sickle cell disease is a monogenic disorder caused by a single mutation in the beta-globin gene, leading to the production of abnormal hemoglobin S. Studies have shown that extracellular vesicles (EVs) are both biomarkers and bio-effectors in the pathophysiology of SCD, originating mainly from red blood cells and platelets, and playing a role in inflammation and endothelial damage.
FRONTIERS IN MEDICINE
(2021)
Review
Immunology
Pan Shen, Weiji Lin, Xuan Deng, Xin Ba, Liang Han, Zhe Chen, Kai Qin, Ying Huang, Shenghao Tu
Summary: Autoimmune diseases are a global health problem characterized by immune system breakdown and dysregulation. Quercetin, a natural flavonoid found in fruits, herbs, and vegetables, has beneficial effects such as anti-inflammation, anti-oxidation, and neuroprotection. Studies have indicated that quercetin may have potential preventive and therapeutic effects on autoimmune diseases like rheumatoid arthritis and inflammatory bowel disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Maria Carolina Jurcau, Felicia Liana Andronie-Cioara, Anamaria Jurcau, Florin Marcu, Delia Mirela Tit, Nicoleta Pascalau, Delia Carmen Nistor-Cseppento
Summary: Alzheimer's disease is a common form of dementia with increasing incidence and mortality rates. Current approved drugs for treatment have little effect on disease progression. Research has identified oxidative stress, mitochondrial dysfunction, and chronic neuroinflammation as key factors, pointing to potential therapeutic targets. Novel molecules and cell-based therapies have shown efficacy in vitro and animal models, but further research is needed for clinical translation.
Article
Multidisciplinary Sciences
Hai-Jian Sun, Zhi-Yuan Wu, Xiao-Wei Nie, Xin-Yu Wang, Jin-Song Bian
Summary: Hydrogen sulfide (H2S) plays multiple physiological functions in mammal systems, with a significant role in regulating liver functions. Targeting H2S-producing enzymes may offer a promising strategy for managing hepatic disorders.
JOURNAL OF ADVANCED RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Dina Alramadhani, Anfal S. Aljahdali, Osheiza Abdulmalik, B. Daniel Pierce, Martin K. Safo
Summary: Sickle cell disease is a genetic disorder that affects millions of individuals worldwide and is associated with chronic anemia, hemolysis, and vasculopathy. The understanding of altered metabolism in sickle red blood cells highlights potential targets for the development of novel therapeutics for the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Sundeep Khosla, Joshua N. Farr, David G. Monroe
Summary: Cellular senescence is a key mechanism in aging, especially in the skeletal system, and targeting senescent cells shows promise in preventing age-related bone loss and fragility. Efforts are underway to develop senolytic drugs that specifically kill senescent cells while sparing normal cells, offering a potential treatment for multiple age-related comorbidities.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Biochemistry & Molecular Biology
Rayan Bou-Fakhredin, Lucia De Franceschi, Irene Motta, Assaad A. Eid, Ali T. Taher, Maria Domenica Cappellini
Summary: Beta-thalassemia and sickle cell disease lead to variations in hemoglobin, which affect the oxidative environment. Oxidative stress plays a significant role in these diseases, causing cellular damage. This review summarizes the mechanisms and therapeutic strategies of oxidative stress in these diseases, and discusses the role of targeted therapy.
Review
Cell Biology
Nyshadham S. N. Chaitanya, Prasad Tammineni, Ganji Purnachandra Nagaraju, Aramati B. M. Reddy
Summary: The cytosolic adaptor protein ECSIT is involved in the toll-like receptor pathway and regulates various biological processes. It interacts with multiple signaling intermediates and its molecular functions in pathophysiology remain unclear.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Letter
Hematology
Jose Archuleta, Marcella van der Graaf, Fleur H. J. Kaptein, Lars Althaus, Nina Kooij, John-John Schnog
AMERICAN JOURNAL OF HEMATOLOGY
(2021)
Article
Oncology
Emmy Boerrigter, Thomas Havenith, Nielka P. van Erp, John-John B. Schnog
Summary: Low doses of enzalutamide may be effective in treating chemotherapy-naive metastatic castration-resistant prostate cancer, providing long-term response without significant side effects. Further studies on the efficacy of lower enzalutamide doses are needed to reduce healthcare costs and increase patient access.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2021)
Article
Hematology
Jorn Gerritsma, Vera Bongaerts, Corien Eckhardt, Harriet Heijboer, Erfan Nur, Bart Biemond, Ellen van der Schoot, Karin Fijnvandraat
Summary: Delayed haemolytic transfusion reaction (DHTR) is a potentially life-threatening complication of red blood cell (RBC) transfusions in sickle cell disease (SCD), with a high incidence rate despite extended donor RBC matching. Early diagnosis is crucial for improving outcomes.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Letter
Hematology
Mesire Aydin, Man Wai Tang, Marielle J. Wondergem, David C. de Leeuw, Jurgen J. Wegman, Bart J. Biemond, Niels W. C. J. van de Donk, Sonja Zweegman, Ellen Meijer, Erfan Nur
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Letter
Hematology
Kadere Konte, Erfan Nur, Man Wai Tang, Jarom Heijmans, Charlotte F. J. van Tuijn, Bart J. Biemond
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2022)
Article
Medicine, General & Internal
R. Peffault de Latour, A. Kulasekararaj, S. Iacobelli, S. R. Terwel, R. Cook, M. Griffin, C. J. M. Halkes, C. Recher, F. Barraco, E. Forcade, J-C Vallejo, B. Drexler, J-B Mear, A. E. Smith, E. Angelucci, R. A. P. Raymakers, M. R. de Groot, E. Daguindau, E. Nur, W. Barcellini, N. H. Russell, L. Terriou, A-P Iori, U. La Rocca, A. Sureda, I Sanchez-Ortega, B. Xicoy, I Jarque, J. Cavenagh, F. Sicre de Fontbrune, S. Marotta, T. Munir, J. M. L. Tjon, S. Tavitian, A. Praire, L. Clement, F. Rabian, L. Marano, A. Hill, E. Palmisani, P. Muus, F. Cacace, C. Frieri, M-T Van Lint, J. R. Passweg, J. C. W. Marsh, G. Socie, G. J. Mufti, C. Dufour, A. M. Risitano
Summary: Eltrombopag improves the efficacy of standard immunosuppressive therapy for severe aplastic anemia, leading to higher complete response rates within 3 months.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Hematology
Annelies van Vuren, Jean Louis Kerkhoffs, Saskia Schols, Anita Rijneveld, Erfan Nur, Dore Peereboom, Yves Gandon, Paco Welsing, Richard van Wijk, Roger Schutgens, Wouter van Solinge, Joannes Marx, Tim Leiner, Bart Biemond, Eduard van Beers
Summary: In patients with non-transfusion-dependent hereditary anemias, treatment with esomeprazole significantly reduces liver iron content compared to placebo. This finding is significant internationally as proton pump inhibitors can serve as an alternative therapy for patients without access to or tolerance of iron chelators.
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Letter
Hematology
Myrthe J. van Dijk, Minke A. E. Rab, Brigitte A. van Oirschot, Jennifer Bos, Cleo Derichs, Anita W. Rijneveld, Marjon H. Cnossen, Erfan Nur, Bart J. Biemond, Marije Bartels, Judith J. M. Jans, Wouter W. van Solinge, Roger E. G. Schutgens, Richard van Wijk, Eduard J. van Beers
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Letter
Hematology
Aafke E. Gaartman, Anniek Strijdhorst, Nick van Es, Man Wai Tang, Jarom Heijmans, Bart J. Biemond, Erfan Nur
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Letter
Hematology
Aafke E. Gaartman, Charlotte F. J. van Tuijn, Erfan Nur, Liffert Vogt, Bart J. Biemond
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Letter
Hematology
John-John B. Schnog, Michael J. Samson, Ashley J. Duits
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Hematology
Charlotte C. M. Schaap, Floor C. J. I. Heubel-Moenen, Erfan Nur, Marije Bartels, Olivier W. H. van Der Heijden, Emiel de Jonge, Frank W. M. B. Preijers, Nicole M. A. Blijlevens, Saskia M. C. Langemeijer, Dutch PNH Working Grp
Summary: A retrospective cohort study in the Netherlands showed that most PNH patients benefit from eculizumab when adhering to the indications as formulated in the Dutch PNH guideline. However, novel therapies are needed to improve hematological responses and quality of life.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2023)
Article
Hematology
Rajani P. Brandsen, Roselie M. H. Diederen, Siham Bakhlakh, Erfan Nur, Reinier O. Schlingemann, Bart J. Biemond
Summary: This study retrospectively analyzed the disease progression in 129 patients with SCD and found that approximately 28.7% of patients had progression of SCR. The study also identified age, genotype, and HbF levels as risk factors for the development of PSCR. Differentiated strategies for screening and follow-up could be considered based on the risk level of patients.
Article
Medicine, General & Internal
Eline Houben, Pieter F. de Groot, Yosta Vegting, Josephine M. I. Vos, Erfan Nur, Marc L. Hilhorst, A. E. (Liesbeth) Hak, Arjan J. Kwakernaak
Summary: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare disease that requires early treatment to prevent irreversible organ damage and death. However, there are several diseases that can mimic AAV, even with positive ANCA serology and/or histological evidence of vasculitis. This article reflects on the diagnostic approach for AAV and provides an overview of AAV-mimicking diseases to consider when patients present with atypical symptoms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Health Care Sciences & Services
John-John B. Schnog, Michael J. Samson, Ashley J. Duits
LANCET REGIONAL HEALTH-AMERICAS
(2022)
