Article
Nutrition & Dietetics
Liesbeth V. V. Maggiotto, Shubhamoy Ghosh, Bo-Chul Shin, Amit Ganguly, Venu Lagishetty, Jonathan P. P. Jacobs, Sherin U. U. Devaskar
Summary: Intra-Uterine Growth Restriction (IUGR) is a risk factor for adult-onset chronic diseases and is associated with dysbiosis of the intestinal microbiome. A hypercaloric diet can worsen dysbiosis and contribute to childhood obesity. This study compared different diets in rats with IUGR and found that a high-fat-high-fructose diet exacerbated dysbiosis, increasing the risk of detrimental health problems in IUGR offspring.
Article
Biochemistry & Molecular Biology
Thiago da Rosa Lima, Fabricio Azevedo Voltarelli, Lorena Silva Freire, Franciely Alves da Silva, Paula Caroline de Almeida, Eudes Thiago Pereira Avila, Suelem Aparecida de Franca, Mayara Peron Pereira, Amilcar Sabino Damazo, James Wilfred Navalta, Carlos Alexandre Fett, Nair Honda Kawashita
Summary: This study found that combining a high-fat diet with a fructose drink resulted in metabolic and hormonal changes more similar to human obesity. The high-fat diet group showed higher body weight and other related indicators compared to the control group.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Tianle He, Qingyun Chen, Zhidong Yuan, Yulian Yang, Kai Cao, Ju Luo, Guozhong Dong, Xie Peng, Zhenguo Yang
Summary: There is a strong correlation between maternal high-fat diet and fetal-placental development. Maternal high-fat diet can affect fetal growth and placental nutrient transporters through differentially expressed circRNAs.
Article
Nutrition & Dietetics
Chun-Wai Chan, Bi-Fong Lin
Summary: The prevalence of obesity and chronic kidney disease (CKD) is increasing rapidly worldwide. Folate deficiency was found to increase lipid accumulation and leptin production in adipocytes. In this study, it was discovered that folate deficiency might aggravate inflammatory status and enhance renal fibrosis in diet-induced obese mice with CKD.
Review
Cell Biology
Xuehan Li, Chunyu Liang, Yi Yan
Summary: The Kiss1/GPR54 system plays a crucial role in regulating energy balance and metabolic homeostasis by controlling energy intake and expenditure balance, affecting insulin secretion, and influencing skeletal muscle function.
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Endocrinology & Metabolism
Eulalia A. Coutinho, Lourdes A. Esparza, Alexandra D. Hudson, Nathanael Rizo, Paige Steffen, Alexander S. Kauffman
Summary: Classic pharmacological studies have shown the importance of endogenous dynorphin-KOR signaling in reproductive neuroendocrine regulation. However, the necessity of KOR signaling in kisspeptin neurons for LH secretion has not been directly tested until now. This study knocked out KOR selectively from kisspeptin neurons and found no significant effect on puberty, LH pulse parameters, LH surges, FSH levels, estrous cycles, or fertility. These findings suggest that besides KNDy neurons, other mechanisms may regulate GnRH and LH pulses, necessitating the expansion of current models.
Article
Pharmacology & Pharmacy
Mobeen Ghulam Ahmed, Malik Hassan Mehmood, Shumaila Mehdi, Maryam Farrukh
Summary: This study aims to investigate the potential efficacy of C. odorata and coumarin in treating cardiometabolic syndrome (CMS). The results showed that C. odorata and coumarin can improve the characteristic features of CMS, such as obesity, insulin resistance, hypertension, and dyslipidemia. These effects may be achieved through improved adipokines, glucose tolerance, and insulin sensitivity, inhibition of HMG-CoA reductase and inflammatory biomarkers, and modulation of oxidative stress biomarkers. This study provides a rationale for the therapeutic potential of C. odorata and coumarin in CMS.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Cho-Won Kim, Hong Kyu Lee, Min-Woo Nam, Gabsang Lee, Kyung-Chul Choi
Summary: This study found that KiSS1 overexpression increases the growth and migration of metastatic prostate cancer cells, as well as promoting tumor metastasis and angiogenesis. These findings highlight the critical role of KiSS1 in prostate cancer progression.
Article
Obstetrics & Gynecology
Fanting Meng, Aiqin Zhao, Haiying Lu, Dan Zou, Bei Dong, Xiaoqing Wang, Li Liu, Sufang Zhou
Summary: The study examines the association between three missense SNPs (rs12998, rs35431622, and rs4889) in the KISS1 gene and idiopathic recurrent pregnancy loss (iRPL). The results suggest that rs12998 and rs4889 variants are associated with unexplained recurrent pregnancy loss.
REPRODUCTIVE SCIENCES
(2023)
Article
Endocrinology & Metabolism
Noelia P. Di Giorgio, Marianne Bizzozzero-Hiriart, Pablo N. Surkin, Esteban Repetto, Maria M. Bonaventura, Florencia N. Tabares, Nadia S. Bourguignon, Ayelen Converti, Juan M. Riano Gomez, Bernhard Bettler, Victoria Lux-Lantos
Summary: GABA and Kisspeptin play critical roles in reproduction and metabolic control. A unique mouse lacking GABAB receptors in Kiss1 cells showed severe impairment in glucose homeostasis, which worsened with aging. These results reinforce the involvement of Kisspeptin in metabolic regulation and highlight the importance of GABA through GABAB receptors in the regulation of the peripheral pancreas Kisspeptin system.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Review
Neurosciences
Alexander S. Kauffman
Summary: Sex steroid feedback is a fundamental principle in reproductive neuroendocrinology, which regulates the neural circuits governing the reproductive neuroendocrine axis through the feedback loops. In females, the rise of estradiol during the menstrual cycle switches the effect on GnRH secretion from negative to positive, resulting in ovulation. However, the underlying mechanisms and the interaction between the circadian clock and endocrine signals are still poorly understood.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Kaori Cho, Takashi Ushiki, Hajime Ishiguro, Suguru Tamura, Masaya Araki, Tatsuya Suwabe, Takayuki Katagiri, Mari Watanabe, Yoko Fujimoto, Riuko Ohashi, Yoichi Ajioka, Ippei Shimizu, Shujiro Okuda, Masayoshi Masuko, Yoshimi Nakagawa, Hideyo Hirai, Warren S. Alexander, Hitoshi Shimano, Hirohito Sone
Summary: SOCS3 protein plays a critical role in regulating obesity and diabetes, but the mechanism of action and the relationship with gut microbiota remain to be clarified.
Article
Endocrinology & Metabolism
Lanlan Fang, Yang Yan, Yibo Gao, Ze Wu, Zhen Wang, Sizhu Yang, Jung-Chien Cheng, Ying-Pu Sun
Summary: This study found that TGF-beta 1 can upregulate the expression of kisspeptin in human EVT cells through the ALK5 receptor. TGF-beta 1 activates both the SMAD2/3 and the ERK1/2 and PI3K/AKT signaling pathways, with inhibition of ERK1/2 attenuating the stimulatory effect of TGF-beta 1 on kisspeptin expression. Knockdown of kisspeptin attenuates the inhibitory effect of TGF-beta 1 on EVT cell invasion. Serum levels of TGF-beta 1 and kisspeptin are also significantly elevated in patients with PE.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lin Song, Jiaqi Cui, Rui Wang, Ning Wang, Jianqun Yan, Bo Sun
Summary: This study investigates the impact of maternal high-fat diet and exercise during gestation and lactation on the development of hypothalamic neural projections in offspring. The results show that maternal high-fat diet increases offspring's body weight, fat deposits, and hormone levels, with long-term effects on male offspring. Maternal exercise, on the other hand, reduces offspring's body weight. Furthermore, both maternal high-fat diet and exercise have different effects on the development of hypothalamic neural projections.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Behavioral Sciences
Takeshi Iwasa, Toshiya Matsuzaki, Altankhuu Tungalagsuvd, Munkhsaikhan Munkhzaya, Mayila Yiliyasi, Takeshi Kato, Akira Kuwahara, Minoru Irahara
BEHAVIOURAL BRAIN RESEARCH
(2016)
Article
Endocrinology & Metabolism
Takeshi Iwasa, Toshiya Matsuzaki, Altankhuu Tungalagsuvd, Munkhsaikhan Munkhzaya, Mayila Yiliyasi, Takeshi Kato, Akira Kuwahara, Minoru Irahara
GYNECOLOGICAL ENDOCRINOLOGY
(2016)
Article
Immunology
Takeshi Iwasa, Toshiya Matsuzaki, Sumika Matsui, Altankhuu Tungalagsuvd, Munkhsaikhan Munkhzaya, Eri Takiguchi, Takako Kawakita, Akira Kuwahara, Toshiyuki Yasui, Minoru Irahara
INTERNATIONAL IMMUNOPHARMACOLOGY
(2016)
Article
Developmental Biology
Takeshi Iwasa, Toshiya Matsuzaki, Altankhuu Tungalagsuvd, Munkhsaikhan Munkhzaya, Maira Yiliyasi, Takeshi Kato, Akira Kuwahara, Minoru Irahara
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2016)
Article
Behavioral Sciences
Takeshi Iwasa, Toshiya Matsuzaki, Kiyohito Yano, Rie Yanagihara, Altankhuu Tungalagsuvd, Munkhsaikhan Munkhzaya, Yiliyasi Mayila, Akira Kuwahara, Minoru Irahara
HORMONES AND BEHAVIOR
(2017)
Article
Endocrinology & Metabolism
Toshiya Matsuzaki, Altankhuu Tungalagsuvd, Munkhsaikhan Munkhzaya, Takeshi Iwasa, Kiyohito Yano, Yiliyasi Mayila, Takako Tokui, Rie Yanagihara, Sumika Matsui, Takeshi Kato, Akira Kuwahara, Minoru Irahara
Article
Endocrinology & Metabolism
Toshiya Matsuzaki, Munkhsaikhan Munkhzaya, Takeshi Iwasaa, Altankhuu Tungalagsuvd, Kiyohito Yano, Yiliyasi Mayila, Rie Yanagihara, Takako Tokui, Takeshi Kato, Akira Kuwahara, Sumika Matsui, Minoru Irahara
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2018)
Article
Developmental Biology
Yiliyasi Mayila, Toshiya Matsuzaki, Takeshi Iwasa, Altankhuu Tungalagsuvd, Munksaihan Munkhzaya, Kiyohito Yano, Rie Yanagihara, Takako Tokui, Takeshi Kato, Akira Kuwahara, Minoru Irahara
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2018)
Article
Endocrinology & Metabolism
Yiliyasi Mayila, Toshiya Matsuzaki, Takeshi Iwasa, Altankhuu Tungalagsuvd, Munkhsaikhan Munkhzaya, Kiyohito Yano, Rie Yanagihara, Takako Tokui, Saki Minato, Asuka Takeda, Sachiko Endo, Takaaki Maeda, Minoru Irahara
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2020)
Article
Obstetrics & Gynecology
Kiyohito Yano, Toshiya Matsuzaki, Takeshi Iwasa, Yiliyasi Mayila, Rie Yanagihara, Altankhuu Tungalagsuvd, Munkhsaihan Munkhzaya, Takako Tokui, Shuhei Kamada, Aki Hayashi, Rie Masaki, Hidenori Aoki, Kou Tamura, Minoru Irahara
REPRODUCTIVE MEDICINE AND BIOLOGY
(2020)
Article
Obstetrics & Gynecology
Toshiya Matsuzaki, Munkhsaikhan Munkhzaya, Altankhuu Tungalagsuvd, Yiliyasi Mayila, Takeshi Iwasa, Kiyohito Yano, Rie Yanagihara, Takako Tokui, Takeshi Kato, Akira Kuwahara, Sumika Matsui, Minoru Irahara
REPRODUCTIVE MEDICINE AND BIOLOGY
(2017)
Article
Endocrinology & Metabolism
Takeshi Iwasa, Toshiya Matsuzaki, Kiyohito Yano, Altankhuu Tungalagsuvd, Munkhsaikhan Munkhzaya, Yiliyasi Mayila, Akira Kuwahara, Minoru Irahara
Article
Endocrinology & Metabolism
Toshiya Matsuzaki, Munkhsaikhan Munkhzaya, Takeshi Iwasa, Altankhuu Tungalagsuvd, Kiyohito Yano, Yiliyasi Mayila, Rie Yanagihara, Takako Tokui, Takeshi Kato, Akira Kuwahara, Sumika Matsui, Minoru Irahara
Article
Obstetrics & Gynecology
Toshiya Matsuzaki, Altankhuu Tungalagsuvd, Takeshi Iwasa, Munkhsaikhan Munkhzaya, Kiyohito Yano, Yiliyasi Mayila, Takako Tokui, Rie Yanagihara, Sumika Matsui, Takeshi Kato, Akira Kuwahara, Minoru Irahara
REPRODUCTIVE MEDICINE AND BIOLOGY
(2017)
Article
Endocrinology & Metabolism
Toshiya Matsuzaki, Altankhuu Tungalagsuvd, Takeshi Iwasa, Munkhsaikhan Munkhzaya, Rie Yanagihara, Takako Tokui, Kiyohito Yano, Yiliyasi Mayila, Takeshi Kato, Akira Kuwahara, Sumika Matsui, Minoru Irahara