Letter
Gastroenterology & Hepatology
Qun-Ying Yang, Jian-Wen Hu
Summary: This article reviews a study on the development and validation of a prediction model for moderately severe and severe acute pancreatitis in pregnancy. Some statistical deficiencies were identified and it is suggested that the role of cholesterol as a predictor be described in more detail.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Cell Biology
Fumin Xu, Xiao Chen, Chenwenya Li, Jing Liu, Qiu Qiu, Mi He, Jingjing Xiao, Zhihui Liu, Bingjun Ji, Dongfeng Chen, Kaijun Liu
Summary: The study successfully developed a predictive model of multiple organ failure complicating moderately severe or severe acute pancreatitis using machine learning. The adaptive boosting algorithm showed the best predictive performance among the six models tested.
MEDIATORS OF INFLAMMATION
(2021)
Article
Gastroenterology & Hepatology
Du-Jiang Yang, Hui-Min Lu, Yong Liu, Mao Li, Wei-Ming Hu, Zong-Guang Zhou
Summary: The study developed a nomogram for predicting moderately severe and severe acute pancreatitis in pregnancy (MSIP) using characteristic parameters and laboratory results. The nomogram performed well in both the training and validation sets, with good predictive performance for MSIP.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Elif Tutku Durmus, Ibrahim Akdag, Mehmet Yildiz
Summary: This study aimed to investigate the impact of diabetes mellitus on the severity of acute pancreatitis and its predictive value for severe acute pancreatitis. The results showed that diabetes was associated with a higher severity of acute pancreatitis and an increased risk of developing severe acute pancreatitis. The presence of diabetes, high Ranson score, and high maximum C-reactive protein level were identified as independent risk factors for severe acute pancreatitis.
POSTGRADUATE MEDICINE
(2022)
Review
Medicine, General & Internal
Hongxin Kang, Yue Yang, Lv Zhu, Xianlin Zhao, Juan Li, Wenfu Tang, Meihua Wan
Summary: Severe acute pancreatitis (SAP) is a life-threatening abdominal disease. Neutrophil extracellular traps (NETs) play an important role in the occurrence and development of SAP, as well as its fatal complications. This review provides insights into the involvement of NETs in SAP and suggests targeting NETs as a promising strategy in SAP treatment.
CHINESE MEDICAL JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Shan-Shan He, Dan Li, Qi-Yong He, Xiao-Ping Chen, Yong-Xu Lin, Yun-Wen Yu, Feng-Lin Chen, Jian Ding
Summary: This study aimed to establish two early multi-indicator prediction models for moderately SAP and SAP. By retrospectively analyzing clinical data, researchers selected seven prognostic indicators and found that unwScore and wScore had better predictive value for moderately SAP and SAP compared to other systems.
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2022)
Article
Gastroenterology & Hepatology
Nina Gliem, Christoph Ammer-Herrmenau, Volker Ellenrieder, Albrecht Neesse
Summary: Severe acute pancreatitis is a serious gastrointestinal disease with high morbidity and mortality. Successful clinical management requires close interdisciplinary cooperation and coordination. Early targeted fluid therapy, thoracic epidural analgesia, and early enteral feeding are important for improving outcomes in severe AP patients. Persistent organ failure is a strong predictor of poor prognosis, and infected walled-off necrosis should be primarily treated by minimally invasive endoscopic step-up approaches.
Article
Surgery
Jie Huang, Lei Li, Ying Chen, Enqiang Mao, Hongping Qu
Summary: This study evaluated the effect of early short-term abdominal paracentesis drainage on patients with moderately severe and severe acute pancreatitis with pelvic ascites, and found that early short-term APD can improve symptoms, reduce intra-abdominal infection, and shorten hospital stay.
Article
Gastroenterology & Hepatology
Jiajia Lin, Cheng Lv, Cuili Wu, He Zhang, Zirui Liu, Lu Ke, Gang Li, Zhihui Tong, Jianfeng Tu, Weiqin Li
Summary: This study investigated the incidence and risk factors of gastric feeding intolerance in moderately-severe to severe acute pancreatitis patients. The findings showed that respiratory failure was an independent risk factor for gastric feeding intolerance. The energy intake significantly increased after switching to nasojejunal feeding.
BMC GASTROENTEROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lina Wirestam, Pernilla Benjaminsson Nyberg, Todor Dzhendov, Thomas Gasslander, Per Sandstrom, Christopher Sjowall, Bergthor Bjornsson
Summary: The study found a relationship between plasma levels of Osteopontin (OPN) and the severity of acute pancreatitis (AP). OPN levels can reflect tissue injury and changes in OPN over time can help assess the disease progression and identify at-risk patients.
Article
Gastroenterology & Hepatology
Phil J. Greer, Peter J. Lee, Pedram Paragomi, Kim Stello, Anna Phillips, Phil Hart, Cate Speake, Adam Lacy-Hulbert, David C. Whitcomb, Georgios I. Papachristou
Summary: In this study, the early trajectories of cytokines in severe acute pancreatitis (SAP) were characterized, showing an early upregulation and subsequent downregulation of proinflammatory cytokines starting from day 1 of symptom onset. These findings highlight the importance of enrolling patients early in the disease course when studying early immune events in SAP, and provide valuable information for future biomarker studies and therapeutic trials.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Dong Wook Lee, Ho Gak Kim, Chang Min Cho, Min Kyu Jung, Jun Heo, Kwang Bum Cho, Sung Bum Kim, Kook Hyun Kim, Tae Nyeun Kim, Jimin Han, Hyunsoo Kim
Summary: In patients with acute pancreatitis, the natural course of APFC can vary greatly, including spontaneous resolution, transformation into pseudocyst or walled-off necrosis. High BISAP score, elevated CRP level after 48 hours of admission, and non-improved abdominal pain are risk factors for developing late complications.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, Research & Experimental
Xin-Xin Hong, Hong-Yan Wang, Jiong-Ming Yang, Bao-Fu Lin, Qin-Qin Min, Yi-Zhong Liang, Pei-Di Huang, Zi-You Zhong, Shao-Ju Guo, Bin Huang, Yi-Fei Xu
Summary: NaT-induced SAP rats have characteristics of necrotizing hemorrhagic pancreatitis with multiple organ injuries, including inflammatory lung injury, ischemic intestinal injury, and slight liver and kidney injuries.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Surgery
Basavaraj Patil, Laxmi Narayan Meena, Dinesh Chandra Sharma, Garima Agarwal, Yogendra Dadhich, Gaurav Gupta
Summary: The study aimed to investigate the effect of low-molecular-weight heparin on the outcome of moderately severe and severe acute pancreatitis. The results of the randomized controlled trial showed that early use of low-molecular-weight heparin significantly reduced the chance of disease progression and pancreatic necrosis in patients with moderately severe and severe acute pancreatitis.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Gastroenterology & Hepatology
Elise Vannier, Claire Dupont-Lucas, Benoit Lagarde, Benjamin Menahem, Thomas Chaigneau, Marie-Astrid Piquet, Benoit Dupont
Summary: The study aimed to identify parameters at admission associated with severe pancreatitis and develop a predictive score. The results showed that hypothermia, low oxygen saturation or albumin levels, and high creatinine levels were significantly associated with severe pancreatitis. The ASAP score demonstrated remarkable predictive accuracy in distinguishing severe forms of acute pancreatitis.
Article
Gastroenterology & Hepatology
Wansu Chen, Rebecca K. Butler, Eva Lustigova, Suresh T. Chari, Bechien U. Wu
Summary: The END-PAC model was validated in a cohort of NOD patients, with a higher risk of developing PDAC in high-risk patients, particularly among white individuals. At the 3+ threshold, the model showed sensitivity, specificity, PPV, and NPV values of 62.6%, 78.5%, 2.0%, and 99.7%, respectively. Efforts are needed to develop appropriate screening strategies for patients with NOD in real-world settings.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Lillian Wang, Sherif Elhanafi, Andrew C. Storm, Mark D. Topazian, Shounak Majumder, Barham K. Abu Dayyeh, Michael J. Levy, Bret T. Petersen, John A. Martin, Suresh T. Chari, Santhi S. Vege, Vinay Chandrasekhara
Summary: DPDS is frequently seen in patients with PFCs, but does not impact successful resolution. Patients with DPDS have an increased risk of PFC recurrence after stent removal.
Article
Gastroenterology & Hepatology
Ahmad Hassan Ali, Yan Bi, Jorge D. Machicado, Sushil Garg, Ryan J. Lennon, Lizhi Zhang, Naoki Takahashi, Elizabeth J. Carey, Keith D. Lindor, J. Gage Buness, James H. Tabibian, Suresh T. Chari
JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Gastroenterology & Hepatology
Dhruv Pratap Singh, Shannon Sheedy, Ajit H. Goenka, Michael Wells, Nam Ju Lee, John Barlow, Ayush Sharma, Harika Kandlakunta, Shruti Chandra, Sushil Kumar Garg, Shounak Majumder, Michael J. Levy, Naoki Takahashi, Suresh T. Chari
Correction
Pharmacology & Pharmacy
Hongxue Shi, Jian Jin, Josiah E. Hardesty, K. Cameron Falkner, Russell A. Prough, Appakalai N. Balamurugan, Sri Prakash Mokshagundam, Suresh T. Chari, Matthew C. Cave
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2020)
Article
Gastroenterology & Hepatology
Neil B. Marya, Patrick D. Powers, Suresh T. Chari, Ferga C. Gleeson, Cadman L. Leggett, Barham K. Abu Dayyeh, Vinay Chandrasekhara, Prasad G. Iyer, Shounak Majumder, Randall K. Pearson, Bret T. Petersen, Elizabeth Rajan, Tarek Sawas, Andrew C. Storm, Santhi S. Vege, Shigao Chen, Zaiyang Long, David M. Hough, Kristin Mara, Michael J. Levy
Summary: The study developed an endoscopic ultrasound-based convolutional neural network model that can differentiate autoimmune pancreatitis from other pancreatic diseases in real time with high accuracy. The use of this model can help in early diagnosis and improve patient outcomes.
Biographical-Item
Gastroenterology & Hepatology
Pramod K. Garg, Suresh T. Chari, Ashok K. Saluja
Editorial Material
Gastroenterology & Hepatology
Frederico G. S. Toledo, Suresh Chari, Dhiraj Yadav
Summary: The study demonstrates that insulin resistance can independently increase pancreatic cancer mortality, even in individuals without diabetes and hyperglycemia. This finding has significant implications for our understanding of pancreatic cancer risk.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Oncology
Shounak Majumder, William R. Taylor, Patrick H. Foote, Calise K. Berger, Chung Wah Wu, Douglas W. Mahoney, William R. Bamlet, Kelli N. Burger, Neil Postier, Jaime de la Fuente, Karen A. Doering, Graham P. Lidgard, Hatim T. Allawi, Gloria M. Petersen, Suresh T. Chari, David A. Ahlquist, John B. Kisiel
Summary: This study aimed to evaluate the diagnostic performance of plasma MDMs for PDAC, and the results showed that the combination of plasma MDMs with CA19-9 detects PDAC with significantly higher accuracy compared with either biomarker individually, especially for early-stage PDAC patients.
CLINICAL CANCER RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ananya Panda, Panagiotis Korfiatis, Garima Suman, Sushil K. Garg, Eric C. Polley, Dhruv P. Singh, Suresh T. Chari, Ajit H. Goenka
Summary: The study developed a two-stage 3D convolutional neural network for fully automated volumetric pancreas segmentation on CT images, and evaluated its performance across different CT slice thicknesses, radiation doses, and patient gender. The model showed high accuracy and reliability in pancreas segmentation, making it a scalable tool for leveraging biomarkers in pancreatic diseases, including early detection of pancreatic cancer.
Article
Gastroenterology & Hepatology
Barbara Kenner, Suresh T. Chari, David Kelsen, David S. Klimstra, Stephen J. Pandol, Michael Rosenthal, Anil K. Rustgi, James A. Taylor, Adam Yala, Noura Abul-Husn, Dana K. Andersen, David Bernstein, Soren Brunak, Marcia Irene Canto, Yonina C. Eldar, Elliot K. Fishman, Julie Fleshman, Vay Liang W. Go, Jane M. Holt, Bruce Field, Ann Goldberg, William Hoos, Christine Iacobuzio-Donahue, Debiao Li, Graham Lidgard, Anirban Maitra, Lynn M. Matrisian, Sung Poblete, Laura Rothschild, Chris Sander, Lawrence H. Schwartz, Uri Shalit, Sudhir Srivastava, Brian Wolpin
Summary: Despite the challenging prognosis of pancreatic cancer, AI methodology has shown promise in risk stratification and identification, potentially improving early detection efforts for the disease. Collaborative efforts among investigators and institutions from multidisciplinary backgrounds, supported by committed funders, are crucial for significant progress in this area.
Review
Gastroenterology & Hepatology
Peter Macinga, Lukas Bajer, Marco Del Chiaro, Suresh T. Chari, Petr Dite, Luca Frulloni, Tsukasa Ikeura, Terumi Kamisawa, Kensuke Kubota, Itaru Naitoh, Kazuichi Okazaki, Raffaele Pezzilli, Miroslav Vujasinovic, Julius Spicak, Tomas Hucl, Matthias Lohr
Summary: Numerous cases of PDAC in AIP patients have been reported in the literature. PDAC is more frequent in AIP type 1 patients, typically metachronous in character, and generally found in the part of the pancreas affected by AIP.
Article
Gastroenterology & Hepatology
Garima Suman, Anurima Patra, Panagiotis Korfiatis, Shounak Majumder, Suresh T. Chari, Mark J. Truty, Joel G. Fletcher, Ajit H. Goenka
Summary: This study aims to evaluate the quality gaps in public pancreas imaging datasets, revealing substantial quality gaps, sources of bias, and a significant proportion of CTs unsuitable for AI. The published studies using these datasets do not take these quality gaps into consideration.
Review
Oncology
Chamini J. Perera, Marco Falasca, Suresh T. Chari, Jerry R. Greenfield, Zhihong Xu, Romano C. Pirola, Jeremy S. Wilson, Minoti V. Apte
Summary: PDAC is a rapidly fatal disease with a major association with new onset diabetes, which could serve as an early sign of the disease. PCRD may be the result of exosomal cargo released by PDAC cells and pancreatic stellate cells working together.
Article
Gastroenterology & Hepatology
Seifeldin Hakim, Emmanuel Coronel, Graciela M. Nogueras Gonzalez, Philip S. Ge, Suresh T. Chari, Nirav Thosani, Srinivas Ramireddy, Ricardo Badillo, Tomas DaVee, Marc F. Catalano, Robert J. Sealock, Sreeram Parupudi, Lyndon Hernandez, Virendra Joshi, Atsushi Irisawa, Surinder Rana, Sundeep Lakhtakia, Peter Vilmann, Adrian Saftoiu, Siyu Sun, Marc Giovannini, Matthew H. Katz, Michael P. Kim, Manoop S. Bhutani
Summary: The string sign test shows good interobserver agreement in distinguishing mucinous from nonmucinous pancreatic cysts among 14 observers. However, there is significant variability among observers in the length of the string and the cutoff length for a positive string sign.
ENDOSCOPIC ULTRASOUND
(2021)