Review
Immunology
Dermot Cox
Summary: Sepsis is accompanied by thrombocytopenia, which is associated with mortality. This thrombocytopenia is characteristic of disseminated intravascular coagulation (DIC), the sepsis-associated coagulopathy. Pathogens that cause sepsis directly activate platelets, leading to systemic thrombosis and multi-organ failure of DIC. This paper reviews the mechanisms of platelet activation by pathogens and the evidence for the use of anti-platelet agents in the management of sepsis.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Hematology
Nelson J. Chao
Summary: In this article, the impact of chronic graft-versus-host disease on the formation of germinal centers is described. Using different small molecules, the study demonstrates the improvement of related disease models.
Review
Physiology
Amaloha Casanova, Anne Wevers, Santiago Navarro-Ledesma, Leo Pruimboom
Summary: Mitochondria play a crucial role in various biological mechanisms and can influence overall health and disease. They are involved in energy production as well as maintaining iron and calcium balance and producing hormones and neurotransmitters. Mitochondria interact with other organelles, the nucleus, and the external environment, facilitating communication at all levels. Dysfunctional mitochondria have been linked to metabolic syndrome, neurological disorders, cancer, cardiovascular diseases, inflammatory disorders, and infections. This review focuses on understanding the mechanisms of mitochondrial function and dysregulation and proposes strategies to recover mitochondrial health and treat chronic diseases.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Chemistry, Analytical
David Morgenstern, Hila Wolf-Levy, Nili Tickotsky-Moskovitz, Itzik Cooper, Aron S. Buchman, David A. Bennett, Michal Schnaider Beeri, Yishai Levin
Summary: Protein glycosylation plays a crucial role in many biological pathways and diseases. This study found that the choice of buffer is just as important as the affinity of boronic acids for successful enrichment of glycopeptides. The elimination of amines significantly improves the method.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
David Morgenstern, Hila Wolf-Levy, Nili Tickotsky-Moskovitz, Itzik Cooper, Aron S. Buchman, David A. Bennett, Michal Schnaider Beeri, Yishai Levin
Summary: Protein glycosylation plays a crucial role in biological pathways and diseases. Enrichment and analysis of glycosylation modifications are challenging due to the diversity of glycan-peptide combinations. In this study, we found that buffer choice is equally important as improving the affinity of boronic acids to sugars for successful enrichment. The elimination of amines significantly improved the method, resulting in a 10-fold increase in quantified glycopeptides.
ANALYTICAL CHEMISTRY
(2022)
Article
Health Care Sciences & Services
Steffen Hackbarth, Rayhanul Islam, Vladimir Subr, Tomas Etrych, Jun Fang
Summary: This study investigates the impact of illumination intensity on singlet oxygen generation in tumor tissue. The results reveal that excessive illumination hinders singlet oxygen production, while lower intensity illumination can generate singlet oxygen in areas beyond blood vessels and walls. This finding has significant implications for tumor diagnosis using photosensitizers.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Fisheries
Gosta F. M. Baganz, Ranka Junge, Maria C. Portella, Simon Goddek, Karel J. Keesman, Daniela Baganz, Georg Staaks, Christopher Shaw, Frank Lohrberg, Werner Kloas
Summary: The study developed new or revised definitions for aquaponics and introduced a system analysis approach to explore different aquaponic setups. The new terms 'coupling type' and 'coupling degree' were introduced to better describe water-mediated connections of aquaponic subsystems. This new framework provides a basis for improved communication, uniform metric for comparing aquaponic facilities, and criteria for facility optimization.
REVIEWS IN AQUACULTURE
(2022)
Editorial Material
Oncology
Vivek Subbiah, Boyi Gan
Summary: Understanding metabolic dependencies and therapeutic vulnerabilities is crucial for precision oncology. Overexpression of ME1 is common in cancers with protumori-genic effects, while consistent loss of ME1 expression in synovial sarcoma suggests a specific susceptibility to ferroptosis and potential for precision therapy.
CLINICAL CANCER RESEARCH
(2022)
Article
Surgery
Elisa Bannone, Giovanni Marchegiani, Giampaolo Perri, Giuseppa Procida, Pier Giuseppe Vacca, Alice Cattelani, Roberto Salvia, Claudio Bassi
Summary: Postoperative serum hyperamylasaemia (POH) may lead to higher postoperative burden, especially when occurring simultaneously with postoperative pancreatic fistula (POPF). Risk factors for additional POPF, once POH has occurred, include body mass index, male sex, increased amylase in drain fluid postoperatively, and elevated C-reactive protein levels.
Article
Endocrinology & Metabolism
Zi-yi Chen, Lei Liu, Xu-xiu Zhuang, Yi-cong Zhang, Ya-nan Ma, Yang Liu, De-liang Wen
Summary: This study aimed to confirm and compare the associations of non-traditional lipid profiles with metabolic syndrome (MetS) in Chinese adolescents, determine the lipid parameter with better predictive potential, and investigate its discriminatory power on MetS. Medical measurements and blood tests were conducted on 1112 adolescents aged 13-18. Univariate and multivariate logistic regression analyses were used to assess the relationships between lipid profiles and MetS. The lipid accumulation product (LAP) index was found to have the closest association with MetS and showed sufficient capabilities to identify adolescents with MetS and its components.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Sumel Ashique, Abdul Faruk, Farhan Jalees Ahmad, Tasneem Khan, Neeraj Mishra
Summary: Cervical cancer is a common malignancy in females, with HPV infection being a leading cause. In India, the death rate of cervical cancer is high, necessitating the search for more effective treatments. Probiotics have been shown to play an important role in the diagnosis, prevention, and treatment of cervical cancer.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Frank Schwarz, Ausra Ramanauskaite
Summary: Healthy peri-implant tissues are crucial for the success of dental implants. This article discusses the prevention and management of various complications in implant dentistry, including the influence of multiple factors on implant outcomes and the challenges associated with bone augmentation and prosthesis failure. It also highlights the importance of patient-reported outcomes in assessing the success of implant dentistry.
PERIODONTOLOGY 2000
(2022)
Review
Biochemistry & Molecular Biology
Elena Ortiz-Zapater, Jaime Signes-Costa, Paula Montero, Ines Roger
Summary: Fibrosis in the lungs is a growing clinical problem that leads to shortness of breath and respiratory failure. It can be caused by various diseases such as idiopathic pulmonary fibrosis, asthma, COPD, allergies, and infection clearance. This review discusses the different types of fibrosis, the main cells involved, and the mechanisms of fibrosis. It also highlights current treatments and potential targets for anti-fibrotic therapies.
Article
Health Care Sciences & Services
Steffen Hackbarth, Shanghui Gao, Vladimir Subr, Lisheng Lin, Jakob Pohl, Tomas Etrych, Jun Fang
Summary: Recently, we discovered induced anoxia as a limiting factor for photodynamic tumor therapy. The amount of generated singlet oxygen depends on photosensitizer accumulation, efficiency, and illumination intensity. Our experimental results provide proof for the described model and demonstrate characteristic changes in signal kinetics of singlet oxygen and photosensitizer phosphorescence in vivo, allowing for better optimization and coordination of PDT drugs and treatment.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Bianca-Eugenia Osz, George Jitca, Ruxandra-Emilia Stefanescu, Amalia Puscas, Amelia Tero-Vescan, Camil-Eugen Vari
Summary: Caffeine is a commonly used central nervous system stimulant that can bring various benefits and is safe for human consumption within a certain dosage range. The intake of caffeine can prevent certain neurodegenerative diseases and other medical conditions associated with reactive oxygen or nitrogen species. However, most studies on the beneficial effects of caffeine have focused on pure caffeine, and whether the intake of caffeine from food or drink has similar benefits remains unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
