Article
Immunology
Ming Wu, Hongfei Yu, Yueqian Gao, Huanrong Li, Chen Wang, Huiyang Li, Xiaotong Ma, Mengting Dong, Bijun Li, Junyi Bai, Yalan Dong, Xiangqin Fan, Jintian Zhang, Ye Yan, Wenhui Qi, Cha Han, Aiping Fan, Fengxia Xue
Summary: This study analyzed 171 vaginal samples and identified microbial signatures associated with cervical cancer. By clustering and multivariate analysis, 14 significantly changed microbial taxa were identified and predicted metabolic pathways relevant to cervical cancer were revealed.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Cell Biology
Matthias Laesche, Horst Urban, Julia Gallwas, Carsten Gruendker
Summary: Cervical cancer is mainly caused by long-term infection of HPV virus, with weakened immune system and damaged cervical mucosa being crucial factors for carcinogenesis. Aberrant microbial microenvironment, immune and metabolic signalling are pathological mechanisms of cervical cancer.
Review
Biochemistry & Molecular Biology
Barbara Gardella, Marianna Francesca Pasquali, Marco La Verde, Stefano Cianci, Marco Torella, Mattia Dominoni
Summary: This study reviewed the interaction between vaginal microbiota, cervical intraepithelial neoplasia (CIN), and the immune response. While some studies struggle to demonstrate the correlation between vaginal microbiota and HPV-related lesions, there is significant evidence suggesting changes in vaginal microbiota in HPV-positive women. The presence of new bacteria, pathway deregulation, and cytokine overexpression are strongly associated with the progression of cervical dysplasia and chronic inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Flavia M. Correa, Arn Migowski, Liz M. De Almeida, Marcelo A. Soares
Summary: This review discusses the current strategies in Brazil for screening, treatment, and prevention (HPV vaccination) against cervical cancer, highlighting the country's large public health system and the disparities in access to healthcare. It also explores the potential integration of newer technologies to eliminate cervical cancer.
FRONTIERS IN MEDICINE
(2022)
Review
Microbiology
Ciro Gargiulo Isacco, Mario G. Balzanelli, Stefania Garzone, Mara Lorusso, Francesco Inchingolo, Kieu C. D. Nguyen, Luigi Santacroce, Adriana Mosca, Raffaele Del Prete
Summary: This study emphasizes the complexity and fragility of the vaginal microenvironment and the fundamental role of all elements and systems involved in preserving it, including the immune-endocrine system and Lactobacillus strains. Age, diet, genetic predisposition, and persistent low-grade inflammation were found to be implicated in a high frequency and severity of disease, potentially leading to pre-cancerous and cancerous cervical lesions.
Article
Oncology
Shreya Desai, Michelle J. Zhu, Ilana Lapidos-Salaiz
Summary: Low- and middle-income countries bear a high burden of preventable cervical cancer cases and deaths, with human papillomavirus DNA-based testing increasingly being the preferred screening method. This commentary discusses next steps and key considerations for the expansion of this screening approach.
Review
Medicine, Research & Experimental
Yan Wang, Hui Li
Summary: The gut microbiota plays a crucial role in the development of colorectal cancer, and various strategies have been developed to modify the microbiota. However, the potential implications and long-term effects of these strategies in clinical settings need to be evaluated.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Yi Liu, Hejing Liu, Bo Sheng, Shuya Pan, Zhi-wei Wang, Xueqiong Zhu
Summary: This review describes the incidence and development of HPV-negative cervical cancer, pointing out the differences in diagnosis, age, stage, and prognosis between HPV-negative and HPV-positive cervical cancer. Furthermore, the significant role and functions of lncRNAs in HPV-negative cervical cancer are clarified.
Review
Pharmacology & Pharmacy
Xiumiao Zhao, Zhaoxia Liu, Tingtao Chen
Summary: Ovarian cancer is a challenging gynecologic cancer with unknown pathogenesis. Vaginal microbiota has been identified as a potential factor in ovarian cancer, with studies showing microbial dysbiosis in cancer cases. The correlation between vaginal microbes and ovarian cancer carcinogenesis, progression, and treatment is increasingly recognized. However, research on the role of vaginal microbiota in ovarian cancer remains limited. This review aims to summarize the potential mechanisms and applications of vaginal microbiota in ovarian cancer and shed light on its involvement in gynecologic cancer treatment.
Article
Microbiology
Brhanu Teka, Kyoko Yoshida-Court, Ededia Firdawoke, Zewditu Chanyalew, Muluken Gizaw, Adamu Addissie, Adane Mihret, Lauren E. E. Colbert, Tatiana Cisneros Napravnik, Molly B. B. El Alam, Erica J. J. Lynn, Melissa Mezzari, Jhingran Anuja, Eva Johanna Kantelhardt, Andreas M. M. Kaufmann, Ann H. H. Klopp, Tamrat Abebe
Summary: This study aimed to compare the cervicovaginal microbiota in women with cervical cancer, premalignant dysplasia, and healthy women. The results showed differences in microbiota diversity, composition, and relative abundance among the three groups.
Review
Immunology
Hanghang Yuan, Ruirui Gui, Zhicheng Wang, Fang Fang, Hongguang Zhao
Summary: Colorectal cancer (CRC) is a common and deadly cancer that poses a major burden on human health. Gut microbiota regulate human immunity and metabolism through producing numerous metabolites, but the specific mechanisms by which gut microbiota interact with immunotherapy and radiotherapy remain incongruent. This review discusses recent advances and the potential of targeting gut microbiota to enhance the efficacy of radioimmunotherapy in CRC, providing references and fresh ideas for the clinical application of this novel strategy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Bartosz Kamil Sobocki, Karolina Kazmierczak-Siedlecka, Marcin Folwarski, Viktoria Hawrylkowicz, Wojciech Makarewicz, Ewa Stachowska
Summary: Dysbiosis of gut microbiota may influence tumorigenic pathways, trigger pancreatic cancer development, and modulate tumor aggressiveness and microenvironment. Strategies such as prebiotics, probiotics, and next-generation probiotics can potentially enhance pancreatic cancer treatment outcomes and improve patients' quality of life.
Article
Oncology
Maria Hortlund, Tine van Mol, Frederik Van de Pol, Johannes Bogers, Joakim Dillner
Summary: HPV-based cervical screening is a globally recommended health policy, with sensitivity and specificity varying for different HPV types at different viral loads. Testing for HPV16 and 18 at low viral load significantly increases sensitivity for cervical cancer, while testing for HPV types 31, 33, 45, and 52 also improves prediction sensitivity. However, for some HPV types, detection of low viral load does not further increase sensitivity.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Maria Kyrgiou, Anna-Barbara Moscicki
Summary: The microbiome in the female reproductive tract plays a crucial role in maintaining health and homeostasis. Imbalances in the genital tract microbiome and specific bacteria and cytokines may contribute to the development of HPV infection and cervical intra-epithelial neoplasia, leading to cervical cancer.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Cell Biology
Xiaoqiang Qi, Yajun Liu, Samira Hussein, Grace Choi, Eric T. Kimchi, Kevin F. Staveley-O'Carroll, Guangfu Li
Summary: Modulation of gut microbiota is a promising strategy for enhancing antitumor immune responses and reducing resistance to immunotherapy in cancer. However, identifying gut bacteria species that are favorable or unfavorable for cancer therapy remains a major challenge.