4.7 Article

Neuroprotective Effects of Lycium chinense Miller Against Rotenone-Induced Neurotoxicity in PC12 Cells

Journal

AMERICAN JOURNAL OF CHINESE MEDICINE
Volume 41, Issue 6, Pages 1343-1359

Publisher

WORLD SCIENTIFIC PUBL CO PTE LTD
DOI: 10.1142/S0192415X13500900

Keywords

Lycium chinense Miller; Neuroprotection; Rotenone; PC12 Cell; Mitochondrial Dysfunction

Funding

  1. Study of aging-control by energy metabolism based on oriental medicine [K12101]
  2. Korea Institute of Oriental Medicine

Ask authors/readers for more resources

Rotenone, an inhibitor of mitochondrial complex I, has been widely regarded as a neurotoxin because it induces a Parkinson's disease-like syndrome. The fruit and root bark of Lycium chinense Miller have been used as traditional medicines in Asia to treat neuro-degenerative diseases. In this study, we examined the neuroprotective effects of Lycium chinense Miller extracts in rotenone-treated PC12 cells. Treatment with rotenone reduced PC12 cell viability and cellular ATP levels. Conversely, caspase 3/7 activity, the ratio of Bax: Bcl-2 expression levels, mitochondrial superoxide level, and intracellular calcium (Ca2+) concentration were elevated. Pretreatment with Lycium chinense Miller extracts significantly increased cell viability and ATP levels. Additionally, they attenuated caspase activation, mitochondrial membrane depolarization and mitochondrial superoxide production. Moreover, confocal microscopy showed that the mitochondrial staining pattern was restored from that of extracts treated cells and that the increase in intracellular Ca2+ level was blunted by treatment with the extracts. Our results suggest that Lycium chinense Miller extracts may have the possible beneficial effects in Parkinson's disease by attenuating rotenone induced toxicity.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Biochemistry & Molecular Biology

Letrozole Accelerates Metabolic Remodeling through Activation of Glycolysis in Cardiomyocytes: A Role beyond Hormone Regulation

Jun H. Heo, Sang R. Lee, Seong Lae Jo, Hyun Yang, Hye Won Lee, Eui-Ju Hong

Summary: Letrozole, an aromatase inhibitor used in breast cancer treatment, has been reported to cause metabolic changes and structural remodeling in the heart. Our study found that letrozole exposure in female rats resulted in decreased fatty acid oxidation, increased glycolysis, and left ventricular hypertrophy. This shift in cardiac metabolism may lead to reduced energy supply and increased risk of heart failure.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Green & Sustainable Science & Technology

Exploring Farmers' Insight on Cropping Pattern for Sustainable Crop Production in Char Area of Bangladesh

Uttam Kumer Sarker, Md. Salahuddin Kaysar, Md. Romij Uddin, Md. Alamgir Hossain, Sabry Hassan, Mohamed M. Hassan

Summary: Bangladesh is primarily an agricultural country where agriculture in the char areas faces challenges such as climate risks, lack of resources, and underdeveloped markets. By studying cropping patterns and proposing adjustment strategies, solutions can be provided to improve production conditions for local farmers.

SUSTAINABILITY (2022)

Article Nutrition & Dietetics

Curcumae Radix Decreases Neurodegenerative Markers through Glycolysis Decrease and TCA Cycle Activation

Seong-Lae Jo, Hyun Yang, Sang R. Lee, Jun H. Heo, Hye-Won Lee, Eui-Ju Hong

Summary: This study focuses on the relationship between neurodegenerative diseases and energy metabolism, using Curcumae radix extract in cells and animal models. The results show that Curcumae radix can reduce neurodegenerative markers and influence cellular glycolysis and mitochondrial function.

NUTRIENTS (2022)

Article Plant Sciences

Assessing Silicon-Mediated Growth Performances in Contrasting Rice Cultivars under Salt Stress

Uzzal Somaddar, Hridoy Chandra Dey, Sarah Khanam Mim, Uttam Kumer Sarker, Md Romij Uddin, Nasar Uddin Ahmed, Mohammad Golam Mostofa, Gopal Saha

Summary: Silicon application can improve salt tolerance in rice, especially in salt-sensitive cultivars.

PLANTS-BASEL (2022)

Article Biology

Dissecting the Relationship between Root Morphological Traits and Yield Attributes in Diverse Rice Cultivars under Subtropical Condition

Md Salahuddin Kaysar, Uttam Kumer Sarker, Sirajam Monira, Md Alamgir Hossain, Md Sabibul Haque, Uzzal Somaddar, Gopal Saha, Apurbo Kumar Chaki, Md Romij Uddin

Summary: Understanding the link between root morphological traits and yields is crucial for improving crop management. In this study, a pot experiment was conducted to evaluate root traits and grain yield performance of 13 rice cultivars. Considerable variations were observed among cultivars in root traits, total dry matter, and grain yield. Cluster analysis and principal component analysis identified promising cultivars with favorable root traits, total dry matter, and yield performance.

LIFE-BASEL (2022)

Review Integrative & Complementary Medicine

Complementary and alternative medicine (CAM) interventions for COVID-19: An overview of systematic reviews

Sae-Rom Jeon, Jung Won Kang, Lin Ang, Hye Won Lee, Myeong Soo Lee, Tae-Hun Kim

Summary: This article provides an overview of the evidence for complementary and alternative medicines (CAMs) interventions in the treatment of COVID-19 patients. The study found that Traditional Chinese Medicine (TCM) herbal medications showed positive results in reducing disease progression, shortening fever resolution time, and decreasing the risk of severe COVID-19 cases. However, the effectiveness of other interventions still needs further evaluation. Gastric disturbance was a main adverse event of TCM medications.

INTEGRATIVE MEDICINE RESEARCH (2022)

Article Environmental Sciences

Water Stress Induced Changes in Root Traits and Yield of Irrigated Rice under Subtropical Condition

Md. Salahuddin Kaysar, Uttam Kumer Sarker, Sirajam Monira, Md. Alamgir Hossain, Nadira Mokarroma, Uzzal Somaddar, Gopal Saha, S. S. Farhana Hossain, Apurbo Kumar Chaki, Md. Romij Uddin

Summary: The presence of water or the degree of soil saturation directly affects the root development and function in rice. A pot investigation was conducted to test the response of root traits and yield components of boro rice varieties under different irrigation regimes. The study revealed a decline in root attributes at lower soil saturation levels and observed an increase in root number, length, volume, dry matter, and grain yield under saturated condition.

WATER (2023)

Article Chemistry, Medicinal

Pharmacological Properties of Jaeumgeonbi-Tang on Redox System and Stress-Related Hormones in Chronic Subjective Dizziness: A Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Trial

Chan-young Kim, Hyeong-Geug Kim, Hye Won Lee, In-Chan Seol, Yoon-Sik Kim, Hyung Il Choi, Miso S. Park, Ho-Ryong Yoo

Summary: This study evaluated the pharmacological properties of Jaeumgeonbi-Tang (JGT) in chronic subjective dizziness (CSD) patients. The results showed that JGT can improve redox status and balance psycho-emotional stress hormones, which is beneficial for CSD patients.

PHARMACEUTICALS (2022)

Article Nutrition & Dietetics

Neuroprotective Effects of Ecklonia cava in a Chronic Neuroinflammatory Disease Model

Seong-Lae Jo, Hyun Yang, Kang-Joo Jeong, Hye-Won Lee, Eui-Ju Hong

Summary: Inflammation is a natural defense mechanism, but chronic inflammation can lead to various chronic diseases. Neuroinflammation in the central nervous system is important in the development of neurodegenerative diseases. Polyphenol-rich natural products, such as Ecklonia cava, have anti-inflammatory and antioxidant properties and can be used to control neuroinflammation in the treatment of neurodegenerative diseases. In this study, we found that Ecklonia cava extract can reduce the levels of pro-inflammatory cytokines and markers of inflammation and neurodegeneration in mice with chronic inflammation induced by lipopolysaccharide.

NUTRIENTS (2023)

Article Green & Sustainable Science & Technology

Variations in Root Morphology and Yield among Rice Varieties in Response to Potassium under Subtropical Conditions

Md. Salahuddin Kaysar, Uttam Kumer Sarker, Sirajam Monira, Md. Alamgir Hossain, Uzzal Somaddar, Gopal Saha, Apurbo Kumar Chaki, Abeer Hashem, Elsayed Fathi Abd Allah, Md Romij Uddin

Summary: The relationship between rice root morphology and potassium (K) has a significant impact on the growth and development of rice as well as its yield. In this study conducted at the net house of the Department of Agronomy at the Bangladesh Agricultural University, different rice varieties (Binadhan-10, Hira-2, and BRRI dhan29) were treated with different doses of K fertilizers. The results showed that the dose of 65 kg K ha(-1) significantly improved root traits and yield. However, further increase in K dosage did not lead to an increase in root traits and yield. A positive correlation was observed between yield and all root traits except root porosity. Therefore, a dose of 65 kg K ha(-1) can be recommended for satisfactory yield when cultivating Binadhan-10 at the field level.

SUSTAINABILITY (2023)

Article Agronomy

Root System Response and Yield of Irrigated Rice in Relation to Irrigation, Potassium and Nitrogen under Subtropical Conditions

Md. Salahuddin Kaysar, Uttam Kumer Sarker, Sinthia Afsana Kheya, Ahmed Khairul Hasan, Md. Alamgir Hossain, Uzzal Somaddar, Gopal Saha, Apurbo Kumar Chaki, Abeer Hashem, Elsayed Fathi Abd-Allah, Md. Romij Uddin

Summary: Irrigation and fertilizer have significant effects on rice root traits and yield. A pot experiment was conducted in the boro season of 2021-2022 to investigate the effects of different irrigation, potassium, and nitrogen conditions on root parameters and yield of the rice variety Binadhan-10. The results showed that the saturation condition with K-65 and N-140 had the best performance in terms of root parameters, and grain yield was highest under this combination. Therefore, Binadhan-10 can be successfully cultivated with K-65 and N-140 under saturation conditions.

AGRONOMY-BASEL (2023)

Article Green & Sustainable Science & Technology

Introducing New Cropping Pattern to Increase Cropping Intensity in Hill Tract Area in Bangladesh

Rigyan Gupta, Mohammad Joyel Sarkar, Md. Shafiqul Islam, Md. Romij Uddin, Israt Jahan Riza, Sirajam Monira, Farhana Zaman, Ahmed Khairul Hasan, A. K. M. Mominul Islam, Abeer Hashem, Graciela Dolores Avila-Quezada, Javid A. Parray, Elsayed Fathi Abd Allah, Uttam Kumer Sarker

Summary: In the hill regions of Bangladesh, where cultivable land is limited, efficient land use is necessary to increase crop output. Through a field experiment, incorporating mustard and mungbean into a rice-based cropping pattern was found to significantly improve yield and farmer income. The modified cropping pattern resulted in a higher rice equivalent yield compared to the existing cropping patterns, and the gross margin was significantly higher as well. Mustard and mungbean cultivation in hilly areas can bring quick economic returns and may be introduced on a large scale in Khagrachhari district.

SUSTAINABILITY (2023)

Article Biochemistry & Molecular Biology

Curcumae radix Reduces Endoplasmic Reticulum Stress in Mice with Chronic Neuroinflammation

Seong-Lae Jo, Hyun Yang, Hye Won Lee, Eui-Ju Hong

Summary: Endoplasmic reticulum (ER) stress is caused by impaired protein-folding machinery, leading to accumulation of misfolded proteins and triggering unfolded-protein response. Excessive ER stress leads to cell death and chronic disease development. Curcumin regulates ER stress and inflammation, exerting neuroprotective effects. Investigating the effects of curcumin on ER stress, inflammation, and neurodegeneration is therefore important.

BIOMEDICINES (2023)

Review Medicine, General & Internal

Aromatherapy for Symptom Relief in Patients with Burn: A Systematic Review and Meta-Analysis

Hye Won Lee, Lin Ang, Jung Tae Kim, Myeong Soo Lee

Summary: This updated review provides a detailed understanding of the potential application of aromatherapy for relieving pain and anxiety in burn patients. The meta-analyses show that inhaled aromatherapy plus routine care has beneficial effects in relieving pain after dressing and calming anxiety.

MEDICINA-LITHUANIA (2022)

Review Andrology

Ginseng for Erectile Dysfunction: A Cochrane Systematic Review

Hye Won Lee, Myeong Soo Lee, Tae-Hun Kim, Terje Alraek, Chris Zaslawski, Jong Wook Kim, Du Geon Moon

Summary: Ginseng has minimal impact on erectile dysfunction, adverse events, and satisfaction, but may improve self-reported sexual performance in men.

WORLD JOURNAL OF MENS HEALTH (2022)

No Data Available