Article
Pharmacology & Pharmacy
Narimane Lammari, Tanguy Demautis, Ouahida Louaer, Abdeslam Hassen Meniai, Herve Casabianca, Chawki Bensouici, Gilles Devouassoux, Hatem Fessi, Abderrazzak Bentaher, Abdelhamid Elaissari
Summary: A new polymethyl methacrylate based nanocapsules were developed as carriers of Saussurea lappa essential oil, showing promising biological functions such as anti-inflammatory, anti-Alzheimer, and antidiabetic effects. Further studies, including in vivo studies, pharmacokinetic properties, bioavailability, and metabolic pathways, are needed for a comprehensive understanding.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Plant Sciences
Pawan Kumar Ojha, Darbin Kumar Poudel, Anil Rokaya, Rakesh Satyal, William N. Setzer, Prabodh Satyal
Summary: This study compared the chemical constituents of commercial frankincense essential oils and lab-distilled frankincense oil using GC-MS and CGC-MS. It was found that several commercial samples were adulterated or contaminated, while lab-distilled frankincense oil had specific chiral compounds that can be used for authentication.
Article
Biochemistry & Molecular Biology
Wenxia Wang, Yalan Zhang, Zhao Yang, Qi He
Summary: This research focused on improving the performance of chitosan-based functional materials by introducing an active additive, specifically clove essential oil (CEO), which significantly enhanced the physical, chemical, and antimicrobial properties of chitosan. The chitosan-CEO film showed improvements in color parameters, mechanical strength, and water vapor permeability, and demonstrated potential as an antioxidant and antimicrobial material for fresh-cutting foods during storage. The coatings effectively slowed down the quality deterioration process of preserved apple samples and reduced microbial counts, highlighting their potential for food preservation applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Materials Science, Paper & Wood
Hanoch Julianus Sohilait, Healthy Kainama, Martha Kaihena
Summary: The essential oils of clove species Eugenia caryophyllata (COs) from northern Buru Island were analyzed and found to contain high levels of eugenol, beta-caryophyllene, and eugenyl acetate. COsI of bud exhibited superior antioxidant activity.
Review
Biochemistry & Molecular Biology
Filippa Lo Cascio, Paola Marzullo, Rakez Kayed, Antonio Palumbo Piccionello
Summary: This review highlights recent research on modifying the structure of curcumin to search for new effective therapeutic agents against neurodegenerative diseases, with a particular focus on Alzheimer's disease.
Article
Multidisciplinary Sciences
Romany Abskharon, Michael R. Sawaya, David R. Boyer, Qin Cao, Binh A. Nguyen, Duilio Cascio, David S. Eisenberg
Summary: In this study, the structure of RNA-bound tau protein fibrils was determined using cryo-EM. The findings demonstrate that RNA is necessary for the integrity of the fibrils and reveal a potential mechanism for the nucleating effects of RNA in neurodegenerative diseases. This research provides insight into the formation of protein aggregates in these diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Joseph R. Winer, Allison Morehouse, Laura Fenton, Theresa M. Harrison, Lylian Ayangma, Mark Reed, Samika Kumar, Suzanne L. Baker, William J. Jagust, Matthew P. Walker
Summary: This study found that early-stage tau and Aβ deposition in Alzheimer's disease can impact sleep, with tau burden leading to worse objective sleep and Aβ burden associated with decreased self-reported sleep quality. Aβ deposition also predicts a mismatch between objective and subjective sleep evaluation, with individuals underestimating their sleep, which is further linked to worse executive function.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Amelia Strom, Leonardo Iaccarino, Lauren Edwards, Orit H. Lesman-Segev, David N. Soleimani-Meigooni, Julie Pham, Suzanne L. Baker, Susan M. Landau, William J. Jagust, Bruce L. Miller, Howard J. Rosen, Maria Luisa Gorno-Tempini, Gil D. Rabinovici, Renaud La Joie
Summary: Posterior cortical hypometabolism measured with F-18-fluorodeoxyglucose (FDG)-PET is a marker of neurodegeneration in Alzheimer's disease, and it is mainly associated with structural neurodegeneration and tau pathology, rather than amyloid pathology.
Review
Biochemistry & Molecular Biology
Yuanxin Zhao, Buhan Liu, Jian Wang, Long Xu, Sihang Yu, Jiaying Fu, Xiaoyu Yan, Jing Su
Summary: Neuroinflammation mediated by microglia is a common feature in neurodegenerative diseases. The accumulation of Aβ and tau proteins can disrupt the metabolism of microglia, leading to neuroinflammation.
Article
Clinical Neurology
Ashvini Keshavan, Josef Pannee, Thomas K. Karikari, Juan Lantero Rodriguez, Nicholas J. Ashton, Jennifer M. Nicholas, David M. Cash, William Coath, Christopher A. Lane, Thomas D. Parker, Kirsty Lu, Sarah M. Buchanan, Sarah E. Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C. Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C. Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M. Schott
Summary: The study compared three different blood-based techniques for identifying early stage Alzheimer's disease, with mass spectrometry plasma measures performing significantly better than other measures.
Article
Clinical Neurology
Ashvini Keshavan, Josef Pannee, Thomas K. Karikari, Juan Lantero Rodriguez, Nicholas J. Ashton, Jennifer M. Nicholas, David M. Cash, William Coath, Christopher A. Lane, Thomas D. Parker, Kirsty Lu, Sarah M. Buchanan, Sarah E. Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C. Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C. Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M. Schott
Summary: The study compared three different blood-based techniques to detect amyloid PET positivity in dementia-free individuals, finding that mass spectrometry plasma measures performed significantly better than other measures, with higher sensitivity and specificity for detecting amyloid PET positivity.
Article
Medicine, General & Internal
Giulia Bivona, Matilda Iemmolo, Tommaso Piccoli, Luisa Agnello, Bruna Lo Sasso, Marcello Ciaccio, Giulio Ghersi
Summary: Alzheimer's disease (AD) is the most common form of cognitive decline, characterized by aggregates of A beta and tau protein. In addition to A beta deposition, inflammation and microglia activation in the brain may also play a role in the pathogenesis of AD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Huiqin Zhang, Wei Wei, Ming Zhao, Lina Ma, Xuefan Jiang, Hui Pei, Yu Cao, Hao Li
Summary: Extracellular neuritic plaques and intracellular neurofibrillary tangles, composed of amyloid-beta and phosphorylated tau protein respectively, are hallmark proteins of Alzheimer's disease. The interactions between these proteins have been extensively studied, with A beta accelerating tau phosphorylation, tau mediating A beta toxicity, and potential synergistic effects on microglial cells and astrocytes. Understanding these interactions may lead to new interventions against Alzheimer's disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Neurosciences
Philip S. Insel, Michael C. Donohue, David Berron, Oskar Hansson, Niklas Mattsson-Carlgren
Summary: The study revealed that changes in key pathological markers A beta and tau in Alzheimer's disease may occur several decades or years before A beta-positivity, while cognitive dysfunction may appear 4-6 years before A beta-positivity, providing potential windows for specific treatments.
Article
Public, Environmental & Occupational Health
Chris Ho Ching Yeung, Kathleen Wen Din Lau, Shiu Lun Au Yeung, C. Mary Schooling
Summary: Genetic associations with plasma amyloid species, CSF total tau, and phosphorylated tau(181) were not found to be associated with Alzheimer's disease, while the effects of CSF Aβ(42) showed inconsistencies between different studies.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)