Article
Medicine, General & Internal
M. Olszowka, C. Held, N. Hadziosmanovic, S. Denchev, A. Manolis, L. Wallentin, H. D. White, R. A. H. Stewart, E. Hagstrom
Summary: In patients with chronic coronary syndrome (CCS), increasing levels of excessive daytime sleepiness (EDS) and morning tiredness (MT) were independently associated with an increased risk of major adverse cardiovascular events (MACE), including mortality. Other sleep-related breathing disorder (SRBD) symptoms were not consistently associated with worse outcomes.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Raffaele Bugiardini, Jinsung Yoon, Guiomar Mendieta, Sasko Kedev, Marija Zdravkovic, Zorana Vasiljevic, Davor Milicic, Olivia Manfrini, Mihaela van der Schaar, Chris P. Gale, Maria Bergami, Lina Badimon, Edina Cenko
Summary: This study found that previous statin therapy is associated with a reduced risk of AHF and improved survival from AHF in ACS patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Peripheral Vascular Disease
Thomas G. Riemer, Linda E. Villagomez Fuentes, Engi A. E. Algharably, Marie S. Schafer, Eva Mangelsen, Marc-Alexander Furtig, Nadine Bittner, Annalena Bar, Laila Zaidi Touis, Kristian Wachtell, Tomislav Majic, Martin J. Dinges, Reinhold Kreutz
Summary: Analysis of large-scale data from double-blind, randomized controlled trials did not find an association between beta-blocker therapy and depression. Similarly, beta-blockers showed no effect on other psychiatric adverse events, except for a possible link with sleep-related disorders. Therefore, concerns about the impact of beta-blockers on mental health should not affect their clinical use.
Article
Cardiac & Cardiovascular Systems
Ben-Hui Yu, Yen-Chun Chen, Yi-Da Li, Wen-Yen Chiou, Yi-Chun Chen
Summary: This study found that clarithromycin use was associated with increased risk for short-term cardiovascular morbidity (especially, heart events) and mortality in patients with stable CHD, without a dose-response relationship and without confounding by indications.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Teng Ma, Jian Zhao, Yechao Yan, Junying Liu, Jie Zang, Yaqi Zhang, Kun Ruan, Hong Xu, Wan He
Summary: This study observed 3,766 patients with stable coronary artery disease and found that higher plasma OPG levels were associated with an increased incidence of all-cause death, cardiovascular death, and heart failure. This suggests that elevated plasma OPG levels are associated with poor prognosis in patients with stable coronary artery disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Takeo Horikoshi, Takamitsu Nakamura, Toru Yoshizaki, Jun Nakamura, Yosuke Watanabe, Manabu Uematsu, Aritaka Makino, Yukio Saito, Jun-ei Obata, Takao Sawanobori, Hajime Takano, Ken Umetani, Akinori Watanabe, Tetsuya Asakawa, Akira Sato, Kiyotaka Kugiyama
Summary: In an extremely elderly population with coronary artery disease who underwent successful percutaneous coronary intervention, statin therapy was found to be effective in reducing major adverse cardiac events such as all-cause death and non-fatal myocardial infarction. Long-term follow-up showed consistent effectiveness of statin therapy in preventing MACEs, particularly in patients without symptomatic heart failure.
Article
Cardiac & Cardiovascular Systems
Ke Qian, Xin Yan, Cheng Xu, Yijia Fang, Moshuang Ma
Summary: This study found a significant association between higher circulating RBP4 levels and increased risk of major adverse cardiovascular events in patients with stable CAD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Immunology
Christopher Gupta, Anjali Sachdeva, Jigish Khamar, Cecilia Bu, Jessica Bartoszko, Mark Loeb
Summary: Influenza vaccination appears to reduce adverse cardiovascular events in heart failure patients, although the certainty of the evidence is low or very low. Rigorous randomized controlled trial evidence is needed to further examine the protective effect of the influenza vaccine.
Article
Multidisciplinary Sciences
Kyari Sumayin Ngamdu, Dhairyasheel S. Ghosalkar, Hojune E. Chung, Jared L. Christensen, Cadence Lee, Celia A. Butler, Tiffany Ho, Alice Chu, Jacob R. Heath, Muhammad Baig, Wen-Chih Wu, Gaurav Choudhary, Alan R. Morrison
Summary: This study found that long-term use of statins is associated with an increased likelihood of severe coronary artery calcium score (CACS) in patients with significant smoking history.
Article
Gastroenterology & Hepatology
Yen-Chun Chen, Yi-Da Li, Ben-Hui Yu, Yi-Chun Chen
Summary: This study investigated the use of clarithromycin and its potential risks in patients with stable coronary heart disease and subsequent peptic ulcer disease. The results suggest that clarithromycin-based therapy for Helicobacter pylori eradication may be safe in these patients.
BMC GASTROENTEROLOGY
(2022)
Article
Geriatrics & Gerontology
Shasha Yu, Hongmei Yang, Bo Wang, Xiaofan Guo, Guangxiao Li, Yingxian Sun
Summary: This study aimed to examine the potential impact of consuming soybean and its products on cardiovascular events, cardiovascular mortality, and all-cause mortality among the elderly population in rural China. The results showed that high-frequency consumption of soybean was associated with a significant reduction in the risk of cardiovascular events and all-cause mortality. These findings provide new insights into the impact of soybean consumption on cardiovascular well-being in the elderly rural population.
Article
Cardiac & Cardiovascular Systems
Jessica Schubert, Bertil Lindahl, Hakan Melhus, Henrik Renlund, Margret Leosdottir, Ali Yari, Peter Ueda, Stefan James, Stephanie R. Reading, Paul J. Dluzniewski, Andrew W. Hamer, Tomas Jernberg, Emil Hagstrom
Summary: Clinical trials have shown that reducing LDL-C can decrease cardiovascular events, and a study found that larger reductions in LDL-C and more intensive statin therapy after myocardial infarction were associated with lower risks of cardiovascular outcomes and all-cause mortality.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Takeo Horikoshi, Takamitsu Nakamura, Toru Yoshizaki, Jun Nakamura, Aritaka Makino, Yukio Saito, Jun-ei Obata, Takao Sawanobori, Hajime Takano, Ken Umetani, Akinori Watanabe, Tetsuya Asakawa, Kiyotaka Kugiyama
Summary: This study examined the relationship between clinical factors and the secondary prevention of adverse cardiovascular events with statin use in patients on hemodialysis. The results showed that statin therapy significantly reduced the occurrence of major adverse cardiac events in these patients. Specific clinical factors were identified to affect the effectiveness of statin therapy for secondary prevention.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Emaad Siddiqui, Darcy Banco, Jeffrey S. Berger, Nathaniel R. Smilowitz
Summary: This study aims to estimate the prevalence of frailty and the association with major adverse cardiovascular events (MACE) among adults hospitalized for noncardiac surgery. The results showed that patients with higher frailty risk had a higher incidence of MACE, especially among younger individuals aged 45-64.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Widya N. Insani, Cate Whittlesea, Chengsheng Ju, Kenneth K. C. Man, Hassan Alwafi, Alaa Alsharif, Sarah Chapman, Li Wei
Summary: This study investigated the risk of cardiovascular disease (CVD) events and all-cause mortality in patients with statin-related adverse drug reactions (ADRs) and examined the impact of different treatments on subsequent outcomes. The results showed that statin-related ADRs were associated with an increased risk of CVD events, and continued use of lipid-lowering medication was important in preventing CVD events and mortality.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Review
Multidisciplinary Sciences
Steven Kwasi Korang, Elena Von Rohden, Areti Angeliki Veroniki, Giok Ong, Owen Ngalamika, Faiza Siddiqui, Sophie Juul, Emil Eik Nielsen, Joshua Buron Feinberg, Johanne Juul Petersen, Christian Legart, Afoke Kokogho, Mathias Maagaard, Sarah Klingenberg, Lehana Thabane, Ariel Bardach, Agustin Ciapponi, Allan Randrup Thomsen, Janus C. Jakobsen, Christian Gluud
Summary: This study assessed the effectiveness and safety of COVID-19 vaccines through analyses of randomized clinical trials. The findings suggest that all included vaccines are effective in preventing COVID-19, with mRNA vaccines being most effective in prevention and viral vector vaccines being most effective in reducing mortality. However, further trials and longer follow-up are needed to better understand the safety profile of these vaccines.
Article
Medicine, General & Internal
Johanne Pereira Ribeiro, Charlotte Lunde, Christian Gluud, Erik Simonsen, Ole Jakob Storebo
BMJ EVIDENCE-BASED MEDICINE
(2023)
Article
Psychiatry
Anne Katrine Pagsberg, Camilla Uhre, Valdemar Uhre, Linea Pretzmann, Sofie Heidenheim Christensen, Christine Thoustrup, Iben Clemmesen, Amanda Aaen Gudmandsen, Nicoline Locke Jepsen Korsbjerg, Anna-Rosa Cecilie Mora-Jensen, Melanie Ritter, Emilie D. Thorsen, Klara Sofie Vangstrup Halberg, Birgitte Bugge, Nina Staal, Helga Kristensen Ingstrup, Birgitte Borgbjerg Moltke, Anne Murphy Kloster, Pernille Juul Zoega, Marie Sommer Mikkelsen, Gitte Sommer Harboe, Katrin Frimann Larsen, Line Katrine Harder Clemmesen, Jane Lindschou, Janus Christian Jakobsen, Janus Engstrom, Christian Gluud, Hartwig Roman Siebner, Per Hove Thomsen, Katja Hybel, Frank Verhulst, Pia Jeppesen, Jens Richardt Mollegaard Jepsen, Signe Vangkilde, Markus Harboe Olsen, Julie Hagstrom, Nicole Nadine Lonfeldt, Kerstin Jessica Plessen
Summary: This study aims to compare the benefits and harms of family-based cognitive behavioural therapy (CBT) and family-based psychoeducation and relaxation training (FPRT) in youth with obsessive-compulsive disorder (OCD). The trial is designed to reduce bias and includes follow-up assessments to evaluate the outcomes of the participants. The study is a randomized clinical trial with approximately 128 participants, with equal numbers assigned to the experimental intervention (FCBT) and the control intervention (FPRT).
Article
Critical Care Medicine
Anders Granholm, Maj-Brit Norregaard Kjaer, Marie Warrer Munch, Sheila Nainan Myatra, Bharath Kumar Tirupakuzhi Vijayaraghavan, Maria Cronhjort, Rebecka Rubenson Wahlin, Stephan M. Jakob, Luca Cioccari, Gitte Kingo Vesterlund, Tine Sylvest Meyhoff, Marie Helleberg, Morten Hylander Moller, Thomas Benfield, Balasubramanian Venkatesh, Naomi E. Hammond, Sharon Micallef, Abhinav Bassi, Oommen John, Vivekanand Jha, Klaus Tjelle Kristiansen, Charlotte Suppli Ulrik, Vibeke Lind Jorgensen, Margit Smitt, Morten H. Bestle, Anne Sofie Andreasen, Lone Musaeus Poulsen, Bodil Steen Rasmussen, Anne Craveiro Brochner, Thomas Strom, Anders Moller, Mohd Saif Khan, Ajay Padmanaban, Jigeeshu Vasishtha Divatia, Sanjith Saseedharan, Kapil Borawake, Farhad Kapadia, Subhal Dixit, Rajesh Chawla, Urvi Shukla, Pravin Amin, Michelle S. Chew, Christian Aage Wamberg, Neeta Bose, Mehul S. Shah, Iben S. Darfelt, Christian Gluud, Theis Lange, Anders Perner
Summary: Among patients with COVID-19 and severe hypoxaemia, the use of dexamethasone 12 mg compared to 6 mg did not result in statistically significant improvements in mortality or health-related quality of life at 180 days, but the results suggest potential benefit from the higher dose.
INTENSIVE CARE MEDICINE
(2022)
Editorial Material
Clinical Neurology
Mathias Maagaard, William K. Karlsson, Christian Ovesen, Christian Gluud, Janus C. Jakobsen
Article
Anesthesiology
Sine Wichmann, Theis S. Itenov, Rasmus E. Berthelsen, Theis Lange, Anders Perner, Christian Gluud, Pia Lawson-Smith, Lars Nebrich, Jorgen Wiis, Anne C. Brochner, Thomas Hildebrandt, Meike T. Behzadi, Kristian Strand, Finn H. Andersen, Thomas Strom, Mikko Jarvisalo, Kjeld A. J. Damgaard, Marianne L. Vang, Rebecka R. Wahlin, Martin Sigurdsson, Katrin M. Thormar, Marlies Ostermann, Frederik Keus, Morten H. Bestle
Summary: The GODIF trial aims to evaluate the benefits and harms of fluid removal with furosemide in ICU patients with fluid overload. The trial will use a randomised, blinded, stratified, parallel-group design and aims to achieve a neutral fluid balance. The primary outcome is the number of days alive and out of hospital within 90 days after randomisation.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2022)
Correction
Psychiatry
Anne Katrine Pagsberg, Camilla Uhre, Valdemar Uhre, Linea Pretzmann, Sofie Heidenheim Christensen, Christine Thoustrup, Iben Clemmesen, Amanda Aaen Gudmandsen, Nicoline Locke Jepsen Korsbjerg, Anna-Rosa Cecilie Mora-Jensen, Melanie Ritter, Emilie D. Thorsen, Klara Sofie Vangstrup Halberg, Birgitte Bugge, Nina Staal, Helga Kristensen Ingstrup, Birgitte Borgbjerg Moltke, Anne Murphy Kloster, Pernille Juul Zoega, Marie Sommer Mikkelsen, Gitte Sommer Harboe, Katrin Frimann Larsen, Line Katrine Harder Clemmensen, Jane Lindschou, Janus Christian Jakobsen, Janus Engstrom, Christian Gluud, Hartwig Roman Siebner, Per Hove Thomsen, Katja Hybel, Frank Verhulst, Pia Jeppesen, Jens Richardt Mollegaard Jepsen, Signe Vangkilde, Markus Harboe Olsen, Julie Hagstrom, Nicole Nadine Lonfeldt, Kerstin Jessica Plessen
Review
Medicine, General & Internal
Sara Russo Krauss, Marija Barbateskovic, Sarah Louise Klingenberg, Snezana Djurisic, Sesilje Bondo Petersen, Mette Kenfelt, De Zhao Kong, Janus C. Jakobsen, Christian Gluud
Summary: Aluminium adjuvants may not have significant benefits compared to placebo or no intervention in human vaccine development, and may increase the risk of adverse events, based on evidence of very low certainty. More high-quality studies are needed to determine the efficacy of aluminium adjuvants.
Review
Medicine, General & Internal
Ruben J. Eck, Tessa Elling, Alex J. Sutton, Jorn Wetterslev, Christian Gluud, Iwan C. C. van der Horst, Reinold O. B. Gans, Karina Meijer, Frederik Keus
Summary: This study assessed the benefits and harms of different types and doses of anticoagulant drugs for preventing venous thromboembolism in acutely ill patients admitted to the hospital. The results suggest that intermediate dose low-molecular-weight heparin appears to provide the best balance of benefits and harms, while unfractionated heparin and direct oral anticoagulants have the least favorable profile. However, caution should be exercised in interpreting these findings due to the generally low quality of evidence.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Anesthesiology
Sine Wichmann, Martin Schonemann-Lund, Anders Perner, Theis S. Itenov, Theis Lange, Christian Gluud, Rasmus E. Berthelsen, Anne C. Brochner, Jorgen Wiis, Morten H. Bestle
Summary: This study aimed to evaluate the effects of diuretics on fluid overload in ICU patients. The results showed that diuretics did not have a significant impact on the number of days alive and out of hospital at 90 days.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Review
Multidisciplinary Sciences
Jehad Barakji, Steven Kwasi Korang, Joshua Feinberg, Mathias Maagaard, Ole Mathiesen, Christian Gluud, Janus Christian Jakobsen
Summary: This study assessed the benefits and harms of cannabinoids in pain patients. The results showed that cannabinoids reduced chronic pain and improved quality of sleep, but the effect sizes were small. However, cannabinoids had no effects on acute pain or cancer pain and increased the risks of non-serious adverse events. The harmful effects of cannabinoids seem to outweigh the potential benefits in pain treatment.
Article
Medicine, Research & Experimental
Anders Kirkegaard-Klitbo, Daniel Monsted Shabanzadeh, Markus Harboe Olsen, Jane Lindschou, Christian Gluud, Lars Tue Sorensen
Summary: This study aims to compare the effectiveness of the one-step approach and the two-step approach in treating common bile duct stones. A total of 150 participants will be randomly assigned to either the one-step approach or the two-step approach. The primary outcome measure is the occurrence of postoperative complications within 90 days.
PILOT AND FEASIBILITY STUDIES
(2023)
Article
Medicine, Research & Experimental
Isak Mazanti Cold, Joshua Buron Feinberg, Axel Brandes, Ulla Davidsen, Ulrik Dixen, Helena Dominguez, Uffe Jakob Ortved Gang, Christian Gluud, Rakin Hadad, Kit Engedal Kristensen, Doan Tuyet van Le, Emil Eik Nielsen, Michael Hecht Olsen, Ole Dyg Pedersen, Ilan Esra Raymond, Ahmad Sajadieh, Anne Merete Boas Soja, Janus Christian Jakobsen
Summary: This study aims to compare strict rate control with lenient rate control in patients with atrial fibrillation. The primary outcome is the physical component score of the SF-36 questionnaire. All secondary outcomes will be hypothesis-generating. The analysis will be based on the intention-to-treat principle and use linear regression for adjustment.
Review
Medicine, General & Internal
Caroline Kamp Jorgensen, Sophie Juul, Faiza Siddiqui, Mark Abie Horowitz, Joanna Moncrieff, Klaus Munkholm, Michael Pascal Hengartner, Irving Kirsch, Christian Gluud, Janus Christian Jakobsen
Summary: This study aims to assess the risks of adverse events with venlafaxine or mirtazapine in adults with major depressive disorder through systematic reviews. The effects of venlafaxine and mirtazapine will be evaluated separately in two reviews. The assessment of bias risk will be conducted using the Cochrane risk-of-bias tool version 2, and clinical significance will be assessed using an eight-step procedure. The results of this study will provide important information for the treatment of major depressive disorder.
SYSTEMATIC REVIEWS
(2023)
Article
Health Care Sciences & Services
Caroline Kamp Jorgensen, Markus Harboe Olsen, Niklas Nielsen, Theis Lange, Lawrence Mbuagbaw, Lehana Thabane, Laurent Billot, Nadine Binder, Silvio Garattini, Rita Banzi, Jacques Demotes, Elena Biagioli, Eliana Rulli, Guido Bertolini, Giovanni Nattino, Ole Mathiesen, Valter Torri, Christian Gluud, Janus Christian Jakobsen
Summary: The Centre for Statistical and Methodological Excellence (CESAME) aims to improve the accuracy and reliability of clinical trial results by developing standardized methods and guidelines. CESAME's work will benefit patients worldwide in various medical specialties by enhancing the internal and external validity of randomized clinical trials.
HEALTH SERVICES INSIGHTS
(2023)