Article
Clinical Neurology
Gonzalo Salazar de Pablo, Ana Pascual-Sanchez, Urvashi Panchal, Bruce Clark, Georgina Krebs
Summary: Remotely-delivered CBT has been found to be effective in reducing symptoms of OCD and other related outcomes. There is no significant difference in efficacy between remotely-delivered CBT and face-to-face CBT, but individuals with severe OCD may benefit more from face-to-face treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Medicine, Research & Experimental
Markus Harboe Olsen, Julie Hagstrom, Nicole Nadine Lonfeldt, Camilla Uhre, Valdemar Uhre, Linea Pretzmann, Sofie Heidenheim Christensen, Christine Thoustrup, Nicoline Locke Jepsen Korsbjerg, Anna-Rosa Cecilie Mora-Jensen, Melanie Ritter, Janus Engstrom, Jane Lindschou, Hartwig Roman Siebner, Frank Verhulst, Pia Jeppesen, Jens Richardt Mollegaard Jepsen, Signe Vangkilde, Per Hove Thomsen, Katja Hybel, Line Katrine Harder Clemmesen, Christian Gluud, Kerstin Jessica Plessen, Anne Katrine Pagsberg, Janus Christian Jakobsen
Summary: The TECTO trial aims to compare the benefits and harms of family-based cognitive behavioural therapy (CBT) versus family-based psychoeducation/relaxation training (FPRT) in children and adolescents with obsessive-compulsive disorder (OCD). The trial is a single-centre, randomised clinical trial with two parallel groups. The primary outcome is the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) score, and secondary outcomes include health-related quality of life and adverse events. The statistical analysis plan includes detailed methods for data analysis and aims to limit selective reporting bias.
Article
Psychiatry
Eric A. Storch, Jessica C. Sheu, Andrew G. Guzick, Sophie C. Schneider, Sandra L. Cepeda, Bianca R. Rombado, Rohit Gupta, Connor T. Hoch, Wayne K. Goodman
Summary: The COVID-19 pandemic has negative impact on the progress of ERP treatment for OCD patients, especially for those who suffer from financial distress and medical risks. Adults experienced worse ERP course than youth during the pandemic. Further research is needed to understand the impact of the pandemic on OCD symptoms and treatment trajectory.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Sonal Mathur, Mahendra P. Sharma, Srinivas Balachander, Thennarasu Kandavel, Y. C. Janardhan Reddy
Summary: The study indicates that mindfulness-based cognitive therapy is more effective in treating OCD compared to stress management training, with significant efficacy. Despite limitations such as a small sample size and high attrition rate in the control group, future research should compare the efficacy of MBCT with CBT and examine the sustainability of change in longitudinal studies.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Psychiatry
Jemma E. Reid, Keith R. Laws, Lynne Drummond, Matteo Vismara, Benedetta Grancini, Davis Mpavaenda, Naomi A. Fineberg
Summary: The study found a large effect size for CBT with ERP in reducing OCD symptoms, but this effect depends on the choice of comparator control. The meta-analysis also raises concerns about the methodological rigor and reporting of published studies on CBT with ERP in OCD, highlighting a strong link between efficacy and researcher allegiance that requires further investigation.
COMPREHENSIVE PSYCHIATRY
(2021)
Article
Oncology
Selin Akkol-Solakoglu, David Hevey
Summary: This study evaluated the effectiveness of internet-delivered cognitive behavioural therapy (iCBT) in reducing depression and anxiety, improving quality of life, reducing fear of recurrence, and enhancing coping and perceived social support in breast cancer survivors. The results showed that the iCBT intervention demonstrated its preliminary effectiveness in reducing distress in breast cancer survivors.
Article
Psychology, Clinical
Danielle E. Katz, Neil A. Rector, Randi E. McCabe, Lance L. Hawley, Karen Rowa, Margaret A. Richter, Tish Ornstein, Rotem Regev, Margaret McKinnon, Judith M. Laposa
Summary: The purpose of this research was to examine the effects of exercise alone and in combination with cognitive behavioural therapy (CBT) on OCD symptoms and secondary symptoms. The results showed that CBT alone and combined with exercise led to significantly greater reduction in OCD symptoms compared to exercise alone or the control group. Exercise frequency and participation in CBT predicted OCD symptom reduction.
JOURNAL OF ANXIETY DISORDERS
(2023)
Review
Pediatrics
Francesco Demaria, Maria Pontillo, Maria Cristina Tata, Prisca Gargiullo, Francesco Mancini, Stefano Vicari
Summary: This article discusses the important role of family in the development and maintenance of pediatric OCD, highlighting the influences of parental modeling and family accommodation on children, as well as the negative impact of high levels of family accommodation.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Article
Psychiatry
Huicong Ren, Haibin Li, Jin Huang, Nan Zhang, Ruiqin Chen, Wenjuan Liu, Zhaohui Zhang, Chencheng Zhang
Summary: Studies have shown that Chinese patients with OCD do not exhibit significant differences in executive functioning compared to healthy controls, and cognitive performance does not vary significantly between patients with relatively mild symptoms and those with severe symptoms.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Jingzhi Zou, Bin Yuan, Maorong Hu, Xin Yuan, Jun Tang, Jinyuan Chen, Zhizhong Hu
Summary: This study compared the cognitive functions of patients with schizophrenia (SZ) and obsessive-compulsive disorder (OCD). The results showed that both SZ and OCD patients have cognitive impairments in reasoning and problem-solving, but SZ patients performed worse in other domains compared to OCD patients.
Article
Psychiatry
K. Deepthi, Bangalore N. Roopesh, Srinivas Balachander, John K. Vijay Sagar, Thennarasau Kandavel, Y. C. Janardhan Reddy
Summary: This study found that youth with OCD performed significantly worse in neuropsychological functions compared to controls, particularly in the 'behavioral reversal' test. Certain comorbid disorders, medication use, and age of onset did not have a significant impact on neuropsychological performance.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychology, Clinical
Shiu F. Wong, Sandra Krause, David Marishel, Jessica R. Grisham
Summary: This study aimed to examine the effectiveness of reducing disgust through modifying disgust appraisals in individuals with moderate to high OCD-relevant contamination fears. Results indicated that interventions targeting secondary disgust appraisals showed significantly less disgust-related avoidance and reported significantly less disgust compared to primary appraisal conditions.
JOURNAL OF ANXIETY DISORDERS
(2021)
Article
Psychology, Multidisciplinary
Mustafa Kerim Simsek, Ismail Secer
Summary: This study developed a CBT-based psychoeducation practice to reduce obsessive-compulsive symptoms in Turkish adolescents. The effectiveness of the practice was tested using both quantitative and qualitative methods. It was found that the practice was effective in reducing OCD symptoms in the Turkish adolescent sample, except for the neutralizing dimension.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Medicine, General & Internal
Francesco Demaria, Paolo Alfieri, Maria Cristina Digilio, Maria Pontillo, Cristina Di Vincenzo, Federica Alice Maria Montanaro, Valentina Ciullo, Giuseppe Zampino, Stefano Vicari
Summary: KBG syndrome is a rare disease characterized by short stature, facial dysmorphism, and other symptoms. This study found that a subset of patients with KBGS exhibited peculiar behaviors related to paper handling, reminiscent of symptoms seen in obsessive compulsive disorder.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Lena Jelinek, Johanna Schroeder, Lara Buecker, Franziska Miegel, Anna Baumeister, Steffen Moritz, Arne Sibilis, Josephine Schultz
Summary: This study aimed to test whether varying the degree of autonomy in which modules are completed could improve adherence and effects of unguided internet-based cognitive-behavioral therapy (iCBT) for obsessive compulsive disorder (OCD). The results showed that both iCBT programs significantly reduced OCD severity. Although there were no differences in utilization time and number of modules completed, the fixed order of modules was associated with greater improvement in OCD severity and quality of life.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Moshgan Amiri, Patrick M. Fisher, Federico Raimondo, Annette Sidaros, Melita Cacic Hribljan, Marwan H. Othman, Ivan Zibrandtsen, Simon A. Albrechtsen, Ove Bergdal, Adam Espe Hansen, Christian Hassager, Joan Lilja S. Hojgaard, Elisabeth Waldemar Jakobsen, Helene Ravnholt Jensen, Jacob Moller, Vardan Nersesjan, Miki Nikolic, Markus Harboe Olsen, Sigurdur Thor Sigurdsson, Jacobo D. Sitt, Christine Solling, Karen Lise Welling, Lisette M. Willumsen, John Hauerberg, Vibeke Andree Larsen, Martin Ejler Fabricius, Gitte Moos Knudsen, Jesper Kjaergaard, Kirsten Moller, Daniel Kondziella
Summary: This study aimed to assess the accuracy of fMRI and EEG in identifying residual consciousness in patients with acute disorders of consciousness (DoC) in the intensive care unit (ICU). The study found that a combination of fMRI and EEG features can predict the level of consciousness in patients, which is important for clinical decision-making.
Editorial Material
Psychology, Developmental
Nina Tejs Jorring, Soren Dalsgaard, Pia Jeppesen, Charlotte Ulrikka Rask, Anne Katrine Pagsberg, Per Hove Thomsen, Niels Bilenberg, Anne Marie Raaberg Christensen
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Neurosciences
Anna Plachti, William F. C. Baare, Louise Baruel Johansen, Wesley K. Thompson, Hartwig R. Siebner, Kathrine Skak Madsen
Summary: Adolescence is a critical period for brain development and is associated with a higher risk of mood disorders, especially in females. Previous research has shown that individuals with high neuroticism exhibit left-right asymmetry in the fronto-limbic white matter. In this study, using longitudinal data, we found that this association remains stable in females throughout adolescence and becomes more prominent in males.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Nina Rostgaard, Markus Harboe Olsen, Maud Ottenheijm, Lylia Drici, Anja Hviid Simonsen, Peter Plomgaard, Hanne Gredal, Helle Harding Poulsen, Henrik Zetterberg, Kaj Blennow, Steen Gregers Hasselbalch, Nanna MacAulay, Marianne Juhler
Summary: This study aimed to compare the molecular composition of cerebrospinal fluid (CSF) obtained from the ventricular and the lumbar compartments and evaluate the feasibility of using lumbar CSF as a proxy for ventricular CSF. Results showed differences in protein composition and distribution of clinically employed biomarkers between the two compartments. However, for certain proteins and biomarkers, lumbar CSF can be reliably used as a proxy for ventricular CSF if a lumbar/cranial index has been established. It is important to verify the compartmental preference before extrapolating from lumbar CSF to ventricular fluid.
FLUIDS AND BARRIERS OF THE CNS
(2023)
Article
Clinical Neurology
Andreas Vinther Thomsen, Oula Puonti, David Gaist, Kirsten Ohm Kyvik, Kristoffer Madsen, Axel Thielscher, Hartwig Roman Siebner, Messoud Ashina, Anders Hougaard
Summary: In this study, we compared the distances between visual cortical areas and overlying dura mater in female patients with migraine aura without headache and female patients with migraine aura with headache. The results showed no significant differences in distances or volumes between the two groups. Therefore, we conclude that there may not be a direct connection between migraine aura and headache.
Article
Neurosciences
Anna Plachti, Robert D. Latzman, Somayeh Maleki Balajoo, Felix Hoffstaedter, Kathrine Skak Madsen, William Baare, Hartwig R. Siebner, Simon B. Eickhoff, Sarah Genon
Summary: By using Connectivity-Based Parcellation (CBP) method, this study examined the differentiation of hippocampal subregions during childhood and adolescence. The results showed that in late childhood, the hippocampus mainly differentiated along the anterior-posterior axis, while in adolescence, a differentiation along the medial-lateral axis was evident. Further analysis revealed that the hippocampal head is related to higher order functions in late childhood, while posterior subicular networks are associated with action-oriented and reward systems in early adolescence.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Medicine, Research & Experimental
Isak Mazanti Cold, Joshua Buron Feinberg, Axel Brandes, Ulla Davidsen, Ulrik Dixen, Helena Dominguez, Uffe Jakob Ortved Gang, Christian Gluud, Rakin Hadad, Kit Engedal Kristensen, Doan Tuyet van Le, Emil Eik Nielsen, Michael Hecht Olsen, Ole Dyg Pedersen, Ilan Esra Raymond, Ahmad Sajadieh, Anne Merete Boas Soja, Janus Christian Jakobsen
Summary: This study aims to compare strict rate control with lenient rate control in patients with atrial fibrillation. The primary outcome is the physical component score of the SF-36 questionnaire. All secondary outcomes will be hypothesis-generating. The analysis will be based on the intention-to-treat principle and use linear regression for adjustment.
Review
Medicine, General & Internal
Johanne Juul Petersen, Caroline Kamp Jorgensen, Pascal Faltermeier, Faiza Siddiqui, Joshua Feinberg, Emil Eik Nielsen, Andreas Torp Kristensen, Sophie Juul, Johan Holgersson, Niklas Nielsen, Peter Bentzer, Lehana Thabane, Steven Kwasi Korang, Sarah Klingenberg, Christian Gluud, Janus C. Jakobsen
Summary: This study assessed the effects of interventions authorised by EMA or FDA for preventing COVID-19 progression to severe disease in outpatients. Molnupiravir and ritonavir-boosted nirmatrelvir showed potential benefits in reducing the risk of death and serious adverse events.
Article
Biochemistry & Molecular Biology
Nina Rostgaard, Markus Harboe Olsen, Tenna Capion, Nanna MacAulay, Marianne Juhler
Summary: This study aimed to identify inflammatory biomarkers in cerebrospinal fluid (CSF) that can predict the development of post-hemorrhagic hydrocephalus (PHH) and shunt-dependency, as well as functional outcome in patients with subarachnoid hemorrhage (SAH). Proximity extension assay (PEA) was used to analyze CSF samples from 31 SAH patients, and 7 markers were identified as predictors of shunt dependency and 4 markers as predictors of functional outcome. These inflammatory biomarkers hold potential as predictive tools in the clinic.
Review
Medicine, General & Internal
Caroline Kamp Jorgensen, Sophie Juul, Faiza Siddiqui, Mark Abie Horowitz, Joanna Moncrieff, Klaus Munkholm, Michael Pascal Hengartner, Irving Kirsch, Christian Gluud, Janus Christian Jakobsen
Summary: This study aims to assess the risks of adverse events with venlafaxine or mirtazapine in adults with major depressive disorder through systematic reviews. The effects of venlafaxine and mirtazapine will be evaluated separately in two reviews. The assessment of bias risk will be conducted using the Cochrane risk-of-bias tool version 2, and clinical significance will be assessed using an eight-step procedure. The results of this study will provide important information for the treatment of major depressive disorder.
SYSTEMATIC REVIEWS
(2023)
Article
Physiology
Michala Dalsgaard Schultz, Morten Alstrup, Markus Harboe Olsen, Ronan M. G. Berg, Jesper Mehlsen, Kirsten Moller, Christian Gunge Riberholt
Summary: Patients with severe traumatic brain injury (TBI) may experience autonomic dysfunction, such as orthostatic intolerance, which can affect their physical rehabilitation. The mechanisms behind this are not fully understood. A study involving 30 TBI patients and 15 healthy volunteers found that heart rate variability changed differently between upright and supine positions for TBI patients, while the changes were minimal for the healthy volunteers.
PHYSIOLOGICAL REPORTS
(2023)
Article
Medicine, Research & Experimental
Markus Harboe Olsen, Thomas P. Almdal, Sten Madsbad, Christian Ovesen, Christian Gluud, Simone B. Sneppen, Leif Breum, Christoffer Hedetoft, Thure Krarup, Louise Lundby-Christensen, Elisabeth R. Mathiesen, Michael E. Roder, Henrik Vestergaard, Niels Wiinberg, Janus C. Jakobsen
Summary: This study conducted at eight hospitals in Denmark aims to investigate the effects of metformin and insulin on quality of life, patient satisfaction, and cardiovascular outcomes in type 2 diabetes patients. The results of this study are crucial for further post-hoc analyses.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Linea Pretzmann, Sofie Heidenheim Christensen, Anne Bryde Christensen, Camilla Funch Uhre, Valdemar Uhre, Christine Lykke Thoustrup, Iben Thiemer Clemmesen, Tin Aaen Gudmandsen, Melanie Ritter, Markus Harboe Olsen, Line Katrine Harder, Nicoline Locke Jepsen Korsbjerg, Anna-Rosa Cecilie Mora-Jensen, Line Katrine Harder Clemmensen, Jane Lindschou, Christian Gluud, Per Hove Thomsen, Signe Vangkilde, Julie Hagstrom, Alexander Rozental, Pia Jeppesen, Frank Verhulst, Katja Anna Hybel, Nicole Nadine Lonfoldt, Kerstin Jessica Plessen, Stig Poulsen, Anne Katrine Pagsberg
Summary: This mixed methods study aims to expand knowledge on adverse events in psychotherapy for youth with OCD. The study plans to analyze at least 128 youth with OCD through quantitative monitoring of adverse events and qualitative interviews on their experiences. The findings can inform safer and more effective psychotherapy, monitoring tools and guidelines for adverse events, and patient information on potential adverse events.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2023)
Article
Neurosciences
Anke Ninija Karabanov, Gaetana Chillemi, Kristoffer Hougaard Madsen, Hartwig Roman Siebner
Summary: The study investigated bimanual control during dynamic changes in motor output generated by both hands. The results showed that the bilateral dorsal premotor cortex plays a role in increasing complexity of bimanual coordination by increasing coupling to the supplementary motor area (SMA), while SMA provides feedback about motor actions to the sensory system. The study used functional magnetic resonance imaging (MRI) to map the functional activity and connectivity of premotor and motor areas during bimanual pinch force control in different task contexts.
Article
Medicine, Research & Experimental
Marie Isabel Rasmussen, Mathias Luhr Hansen, Adelina Pellicer, Christian Gluud, Eugene Dempsey, Jonathan Mintzer, Simon Hyttel-Sorensen, Anne Marie Heuchan, Cornelia Hagmann, Ebru Ergenekon, Gabriel Dimitriou, Gerhard Pichler, Gunnar Naulaers, Guoqiang Cheng, Jakub Tkaczyk, Hans Fuchs, Monica Fumagalli, Saudamini Nesargi, Siv Fredly, Tomasz Szczapa, Anne Mette Plomgaard, Bo Molholm Hansen, Janus Christian Jakobsen, Gorm Greisen
Summary: The SafeBoosC-III follow-up study aims to assess mortality, neurodevelopmental disability, or any harm in trial participants at 2 years of corrected age. The lack of funding for trial-specific assessment local costs is a challenge that needs to be addressed.