Article
Biochemistry & Molecular Biology
Maria Maddalena Sirufo, Francesca De Pietro, Lia Ginaldi, Massimo De Martinis
Summary: Gender differences are increasingly recognized in medicine, but specific gender-targeted studies are lacking. Considering gender pharmacology is crucial for optimizing drug therapies. Further development of gender research can identify potential risks and benefits between genders and enable personalized medicine.
Review
Pharmacology & Pharmacy
Yasuhiro Gon, Shuichiro Maruoka, Kenji Mizumura
Summary: Omalizumab is a therapeutic agent for severe bronchial asthma. It improves symptoms, reduces exacerbation risk, and enhances quality of life. However, it is associated with high treatment costs and lacks clear methods to identify responders.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Mohammed Zghaebi, Maria Byazrova, Sabine Flicker, Sergio Villazala-Merino, Nicholas J. Campion, Victoria Stanek, Aldine Tu, Heimo Breiteneder, Alexander Filatov, Musa Khaitov, Verena Niederberger-Leppin, Julia Eckl-Dorna, Rudolf Valenta
Summary: A new sequential gating strategy was developed to detect cells bearing the IgE BCR on their surface, using a monoclonal anti-IgE antibody. This strategy allowed for the clear identification of allergen-specific IgE(+) memory B cells and plasma cells in human PBMCs, offering new insights into allergic responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Nada S. Alakhras, Jaeho Shin, Scott A. Smith, Anthony L. Sinn, Wenwu Zhang, Gyoyeon Hwang, Jenna Sjoerdsma, Emily K. Bromley, Karen E. Pollok, Basar Bilgicer, Mark H. Kaplan
Summary: Peanut-induced allergy is a type I hypersensitivity reaction mediated by IgE, which can range from local edema to life-threatening anaphylaxis. There are currently few preventive therapies for this type of allergy, but a covalent heterobivalent inhibitor (cHBI) has shown promise in both in vitro and in vivo models. In this study, a humanized mouse model expressing human mast cells was developed and used to demonstrate that cHBI can prevent allergic reactions, including fatal anaphylaxis, when administered before or shortly after allergen exposure.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Tiffany Kirkaldy Spaanager Sztuk, Neil Marcus Rigby, Lasse Norskov-Nielsen, Stef J. Koppelman, Ana Isabel Sancho, Niels-Peter Hell Knudsen, Justin Marsh, Philip Johnson, Shashank Gupta, Alan Robert Mackie, Jeppe Madura Larsen, Katrine Lindholm Bogh
Summary: This study compared the preventive effect of allergen-specific immunotherapy through different routes of peanut allergen delivery in rats. Results showed that high dose oral and sublingual administration, as well as high and medium dose intragastric administration, prevented peanut allergy. Therefore, the route of allergen delivery plays a significant role in preventing peanut allergy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Christopher Warren, Dawn Lei, Scott Sicherer, Robert Schleimer, Ruchi Gupta
Summary: The prevalence of self-reported peanut allergy among US adults is 2.9%, with over 17% of cases being adult-onset. Adults with childhood-onset PA are more likely to have received a physician diagnosis, have an epinephrine prescription, and use an epinephrine autoinjector compared to those with adult-onset PA.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Laurent Guilleminault, Marine Michelet, Laurent Lionel Reber
Summary: Food allergy, especially in children, poses a significant public health challenge globally, with limited treatment options available. Combining oral immunotherapy with omalizumab may represent a safer approach in managing severe food allergy cases, offering potential benefits in terms of safety, efficacy, and quality of life improvement.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2022)
Article
Allergy
Monali Manohar, Diane Dunham, Sheena Gupta, Zheng Yan, Wenming Zhang, Samantha Minnicozzi, Matthew Kirkey, Bryan Bunning, Roshni Roy Chowdhury, Stephen J. Galli, Scott D. Boyd, Laurie Elizabeth Kost, R. Sharon Chinthrajah, Manisha Desai, Hans C. Oettgen, Holden T. Maecker, Wong Yu, Rosemarie H. DeKruyff, Sandra Andorf, Kari C. Nadeau
Summary: The study found that adjunctive anti-IgE treatment with oral immunotherapy can reduce inflammatory cytokines and specific immune cell populations, producing positive effects during desensitization.
Article
Health Care Sciences & Services
Serafeim Chrysovalantis Kotoulas, Ioanna Tsiouprou, Eva Fouka, Athanasia Pataka, Despoina Papakosta, Konstantinos Porpodis
Summary: This review summarizes the knowledge of almost two decades of use of omalizumab in patients with severe allergic asthma. Evidence suggests that omalizumab improves asthma control and reduces the incidence and frequency of exacerbations. It is also effective in reducing corticosteroid use and healthcare utilization.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Allergy
Amy M. Scurlock, A. Wesley Burks, Scott H. Sicherer, Donald Y. M. Leung, Edwin H. Kim, Alice K. Henning, Peter Dawson, Robert W. Lindblad, M. Cecilia Berin, Christine B. Cho, Wendy F. Davidson, Marshall Plaut, Hugh A. Sampson, Robert A. Wood, Stacie M. Jones
Summary: In this study, extended treatment with VP250 was well tolerated, and desensitization observed at week 52 persisted between weeks 52 and 130. Treatment success was predominantly observed in younger participants.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Immunology
Marine Michelet, Bianca Balbino, Laurent Guilleminault, Laurent L. Reber
Summary: Food allergy poses a significant public health issue without an approved therapy, with IgE antibodies playing a crucial role in diagnosis and treatment. Recent advances in regulating IgE production and understanding its function in food allergy offer hope for better management and treatment options. Clinical studies on anti-IgE therapeutic monoclonal antibodies provide insights into blocking IgE effector functions and improving outcomes for individuals with food allergies.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Allergy
Marie Bastin, Warner W. W. Carr, Carla M. M. Davis, David M. M. Fleischer, Jay A. A. Lieberman, S. Shahzad Mustafa, Thibault Helleputte, Timothee Bois, Dianne E. E. Campbell, Todd D. D. Green, Matthew Greenhawt
Summary: This study examined the serum-specific IgG4 and IgE levels in peanut-allergic children receiving Viaskin Peanut treatment, and found that IgG4 rise most clearly differentiated treatment responders from non-responders. IgG4/IgE ratios >20.1 and the combination of Ara h 1 and peanut IgG4/IgE showed moderate ability to predict treatment response.
Review
Medicine, General & Internal
Adnan Liaqat, Mathew Mason, Brian Foster, Grant Gregory, Avani Patel, Aisha Barlas, Sagar Kulkarni, Rafaela Basso, Pooja Patak, Hamza Liaqat, Muhammad Qureshi, Abdelrahman Shehata, Yousef Awad, Mina Ghaly, Qamar Gulzar, Walter Doty
Summary: The use of biologic agents in the treatment of bronchial asthma has greatly improved the quality of life and reduced morbidity and healthcare utilization. These therapies target specific inflammatory pathways, particularly improving outcomes in severe eosinophilic asthma. Tezepelumab, a newer agent targeting thymic stromal lymphoprotein, has shown effectiveness in patients regardless of asthma phenotype and serum biomarker levels.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Kamal Srivastava, Mingzhuo Cao, Ozkan Fidan, Yanmei Shi, Nan Yang, Anna Nowak-Wegrzyn, Mingsan Miao, Jixun Zhan, Hugh A. Sampson, Xiu-Min Li
Summary: This study evaluated the combination of oral Berberine-containing natural medicine with a boiled peanut oral immunotherapy as a treatment for food allergy in a murine model. The results showed that the treatment induced long-term tolerance to peanut and was associated with significant reduction in IgE levels and symptom scores. The changes in gut microbiota were found to be correlated with therapeutic outcomes.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Angela Rizzi, Elena Lo Presti, Raffaella Chini, Luca Gammeri, Riccardo Inchingolo, Franziska Michaela Lohmeyer, Eleonora Nucera, Sebastiano Gangemi
Summary: Food allergies are immune reactions to ingested or contacted foods, and they are a widespread health issue. The role of inflammatory mediators in the pathogenesis of food allergies has been studied, and some of these mediators may serve as markers for the disease or response to therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)