Peanut allergen inhibition prevents anaphylaxis in a humanized mouse model

Efficacy and safety of oral immunotherapy in children aged 1–3 years with peanut allergy (the Immune Tolerance Network IMPACT trial): a randomised placebo-controlled study

(2022) Stacie M Jones et al.   LANCET

Structure-guided design of ultrapotent disruptive IgE inhibitors to rapidly terminate acute allergic reactions

(2021) Luke F. Pennington et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Insights from IgE Immune Surveillance in Allergy and Cancer for Anti-Tumour IgE Treatments

(2021) Alex J. McCraw et al.   Cancers

Food reactions during avoidance

(2020) Peter Capucilli et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab

(2020) Pascal Gasser et al.   Nature Communications

Conducting an Oral Food Challenge: An Update to the 2009 Adverse Reactions to Foods Committee Work Group Report

(2020) J. Andrew Bird et al.   Journal of Allergy and Clinical Immunology-In Practice

Peanut Oral Immunotherapy: a Current Perspective

(2020) Meera Patrawala et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Ara h 2 is the dominant peanut allergen despite similarities with Ara h 6

(2020) Oliver Hemmings et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Bruton’s tyrosine kinase inhibition effectively protects against human IgE-mediated anaphylaxis

(2020) Melanie C. Dispenza et al.   JOURNAL OF CLINICAL INVESTIGATION

Harnessing Therapeutic IgE Antibodies to Re-educate Macrophages against Cancer

(2020) Giulia Pellizzari et al.   TRENDS IN MOLECULAR MEDICINE

Chemokines during anaphylaxis: the importance of CCL2 and CCL2-dependent chemotactic activity for basophils

(2020) Romana Vantur et al.   Clinical and Translational Allergy

Designer covalent heterobivalent inhibitors prevent IgE-dependent responses to peanut allergen

(2019) Peter E. Deak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Individually dosed omalizumab facilitates peanut oral immunotherapy in peanut allergic adolescents

(2019) Josef Brandström et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Sustained outcomes in oral immunotherapy for peanut allergy (POISED study): a large, randomised, double-blind, placebo-controlled, phase 2 study

(2019) R Sharon Chinthrajah et al.   LANCET

Targeting IgE in allergic disease

(2018) Pascal Gasser et al.   CURRENT OPINION IN IMMUNOLOGY

Human mast cells and basophils-How are they similar how are they different?

(2018) Gilda Varricchi et al.   IMMUNOLOGICAL REVIEWS

Markers Involved in Innate Immunity and Neutrophil Activation are Elevated during Acute Human Anaphylaxis: Validation of a Microarray Study

(2018) Abbie Francis et al.   Journal of Innate Immunity

IgE-Mediated Food Allergy

(2018) Sara Anvari et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

AR101 Oral Immunotherapy for Peanut Allergy

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Peanut allergen–specific antibodies go public

(2018) Hannah J. Gould et al.   SCIENCE

High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes

(2018) Derek Croote et al.   SCIENCE

The pathophysiology of anaphylaxis

(2017) Laurent L. Reber et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Basophils, high-affinity IgE receptors, and CCL2 in human anaphylaxis

(2017) Peter Korosec et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A humanized mouse model of anaphylactic peanut allergy

(2017) Oliver T. Burton et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Determination of Crucial Immunogenic Epitopes in Major Peanut Allergy Protein, Ara h2, via Novel Nanoallergen Platform

(2017) Peter E. Deak et al.   Scientific Reports

Immunoglobulin E, what is it good for?

(2016) Brian T. Kelly et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Fifty years later: Emerging functions of IgE antibodies in host defense, immune regulation, and allergic diseases

(2016) Hans C. Oettgen   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Anti-hIgE gene therapy of peanut-induced anaphylaxis in a humanized murine model of peanut allergy

(2016) Odelya E. Pagovich et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Humanized mouse model of mast cell–mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis

(2016) Paul J. Bryce et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effect of Avoidance on Peanut Allergy after Early Peanut Consumption

(2016) George Du Toit et al.   NEW ENGLAND JOURNAL OF MEDICINE

Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses

(2016) Alejandra Urrutia et al.   Cell Reports

Ara h 2 and Ara 6 are the best predictors of severe peanut allergy: a double-blind placebo-controlled study

(2015) A. K. Kukkonen et al.   ALLERGY

Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy

(2015) George Du Toit et al.   NEW ENGLAND JOURNAL OF MEDICINE

Two-Allergen Model Reveals Complex Relationship between IgE Crosslinking and Degranulation

(2014) Michael W. Handlogten et al.   CHEMISTRY & BIOLOGY

A Heterobivalent Ligand Inhibits Mast Cell Degranulation via Selective Inhibition of Allergen-IgE Interactions In Vivo

(2014) M. W. Handlogten et al.   JOURNAL OF IMMUNOLOGY

Anaphylaxis: Clinical patterns, mediator release, and severity

(2013) Simon G.A. Brown et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Inhibition of weak-affinity epitope-IgE interactions prevents mast cell degranulation

(2013) Michael W Handlogten et al.   Nature Chemical Biology

Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation

(2012) S. Takagi et al.   BLOOD

Use of Omalizumab in the Treatment of Food Allergy and Anaphylaxis

(2012) Jay A. Lieberman et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Kinetics of mast cell, basophil, and oral food challenge responses in omalizumab-treated adults with peanut allergy

(2012) Jessica H. Savage et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Evaluation of Ara h2 IgE thresholds in the diagnosis of peanut allergy in a clinical population

(2012) Corinne A. Keet et al.   Journal of Allergy and Clinical Immunology-In Practice

The Prevalence, Severity, and Distribution of Childhood Food Allergy in the United States

(2011) R. S. Gupta et al.   PEDIATRICS

IgE Influences the Number and Function of Mature Mast Cells, but Not Progenitor Recruitment in Allergic Pulmonary Inflammation

(2009) C. B. Mathias et al.   JOURNAL OF IMMUNOLOGY

Advances in mast cell biology: new understanding of heterogeneity and function

(2009) T C Moon et al.   Mucosal Immunology

Peanut allergy

(2008) A Wesley Burks   LANCET