Review
Otorhinolaryngology
Nadim Khoueir, Michel G. Khalaf, Ralph Assily, Simon Rassi, Walid Abou Hamad
Summary: This systematic review and meta-analysis examined the effects of intranasal antihistamines (INAH) on idiopathic rhinitis (IR). The study found that INAH had a beneficial effect on improving nasal symptoms compared to placebo. No significant difference in efficacy was observed between different types of INAH. The most commonly reported adverse event was bitter taste sensation.
Article
Oncology
Qiling Zheng, Dijiang Ma, Qi Zhu, Shenjun Tang, Chengbo Chen
Summary: The combination therapy of azelastine hydrochloride and montelukast sodium significantly improves clinical symptoms and inflammatory reactions in patients with allergic rhinitis, showing higher effectiveness compared to using azelastine hydrochloride alone. The clinical therapeutic effect and symptom scores were significantly improved after treatment, as well as a noticeable decrease in serum levels of inflammatory factors.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Review
Otorhinolaryngology
Kachorn Seresirikachorn, Joaquim Mullol, Kanda Limitlaohaphan, Vararuthai Asvapoositkul, Kornkiat Snidvongs
Summary: The combination of INCS and LTRA showed no difference compared to INCS in monotherapy in improving nasal symptoms and patient's quality of life, but may be more effective in improving ocular symptoms.
Article
Medicine, Research & Experimental
Hui Chen, Luo Zhang, Hongfei Lou, Yang Wang, Feifei Cao, Chengshuo Wang
Summary: The combination of budesonide and montelukast may have superior efficacy in treating seasonal allergic rhinitis compared to budesonide monotherapy, especially in improving nasal blockage and itching. Nasal cavity volume and nasal airway resistance can be used to assess nasal blockage more accurately.
Article
Otorhinolaryngology
Hossein Esmaeilzadeh, Nasrin Mortazavi Far, Seyed Hesamedin Nabavizadeh, Masroor Babaeian, Maryam Hadipour, Soheila Alyasin
Summary: This study investigates the efficacy of Montelukast and intranasal antihistamine in combination with intranasal corticosteroid in treating moderate to severe allergic rhinitis. The findings suggest that the combination of Azelastine and intranasal corticosteroid is recommended for the treatment of moderate to severe allergic rhinitis. Montelukast has no greater impact than intranasal corticosteroid in managing moderate to severe allergic rhinitis or asthma.
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2022)
Article
Health Care Sciences & Services
Senthilraj Retinasekharan, Norasnieda Md Shukri, Ahmad Filza Ismail, Baharudin Abdullah
Summary: A new questionnaire was developed and validated to assess the knowledge, attitude, and practice of allergic rhinitis patients using intranasal corticosteroids. The questionnaire consists of 3 domains with 12 items and has demonstrated validity and reliability, making it a useful tool to improve patient treatment by understanding compliance factors.
Article
Allergy
Min-Hye Kim, Kyoung-Hee Sohn, Hye Jung Park, Young Hee Nam, Mi-Hye Kim, Jae-Woo Jung, Jae-Woo Kwon, Yoo Seob Shin, Jong-Sook Park, Young-Joo Cho, Choon-Sik Park, Byoung Whui Choi
Summary: The study evaluated the treatment effects and adverse events of a combination drug called Monterizine (R) (a combination of montelukast and levocetirizine) in patients with perennial allergic rhinitis and asthma. The results showed that TNSS score and quality of life significantly improved after 3-6 months of treatment with Monterizine without significant adverse reactions.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Min Zhang, Jing-Zi Ni, Lei Cheng
Summary: Intranasal corticosteroids (INCSs) have a favorable safety profile and high local-systemic balance of bioavailability with a low incidence of adverse events in the treatment of pediatric allergic rhinitis (AR). However, the use of INCSs should be individualized based on patient response and adverse effects. Evaluation of the benefits and risks of INCSs is necessary to ensure clinical efficacy and prevent potential events.
EXPERT OPINION ON DRUG SAFETY
(2022)
Article
Pharmacology & Pharmacy
Prempreet Kaur Manjit Singh, Elang Kumaran Krishnan, Norhafiza Mat Lazim, Najib Majdi Yaacob, Baharudin Abdullah
Summary: The study found that medication adherence to intranasal corticosteroid spray among allergic rhinitis patients is associated with severe nasal symptoms, allergen sensitization, and elevated total serum IgE levels. Multiple medication use had no impact on adherence. Lack of symptoms was a significant barrier to adherence, highlighting the need to emphasize the benefits of using the prescribed dose and frequency of intranasal corticosteroid spray to patients with mild and moderate allergic rhinitis.
Article
Medicine, General & Internal
Salim Alkeraye, Danah K. AlRuhaimi
Summary: This study included nine patients who met the inclusion criteria. Four patients reported a good response to montelukast, and three patients reported full control of the disease. These findings suggest that leukotriene antagonists, such as montelukast, are effective as an add-on therapy to anti-histamines and can be justified for use in histamine resistant patients.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Pediatrics
Zhi-Min Chen, De-Yu Zhao, Li Xiang, Jian-Guo Hong
Summary: In the treatment of mild asthma in children, montelukast demonstrated better efficacy and adherence compared to BIS, showing improved asthma control and lower medical expenditures. The results suggest that montelukast may be a more effective treatment option for children with mild asthma.
WORLD JOURNAL OF PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Kenta Kachi, Hiroyuki Kato, Aya Naiki-Ito, Masayuki Komura, Aya Nagano-Matsuo, Itaru Naitoh, Kazuki Hayashi, Hiromi Kataoka, Shingo Inaguma, Satoru Takahashi
Summary: The study demonstrates that montelukast exerts a chemopreventive effect on pancreatic cancer via the LTD4-CYSLTR1 axis, with significantly decreased incidence of pancreatic cancer in high-dose montelukast group compared with controls. Additionally, high CYSLTR1 expression in pancreatic ductal adenocarcinoma patients is associated with an unfavorable clinical outcome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Allergy
Yan Feng, Ya-Ping Meng, Ying-Ying Dong, Chang-Yu Qiu, Lei Cheng
Summary: In allergic rhinitis patients, leukotriene receptor antagonists (LTRAs) were found to be more effective in improving nighttime symptoms but less effective in improving daytime nasal symptoms compared to selective H1-antihistamines (SAHs).
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Chaitanya Bhargave, Manish Verma, Rupert W. Jakes, Yoshitaka Okamoto
Summary: This study compared the knowledge and attitudes towards allergic rhinitis among patients and physicians in Brazil, Japan, Korea, Mexico, Saudi Arabia, Spain, United Arab Emirates, and the United Kingdom. The results showed differences in perception and attitudes towards allergic rhinitis between patients and physicians, indicating the need for improved education and communication between these groups to optimize disease management.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Review
Health Care Sciences & Services
Amir Hamzah Abdul Latiff, Salina Husain, Baharudin Abdullah, Palaniappan Suppiah, Vincent Tan, TangIng Ping, Kent Woo, Yoke-Yeow Yap, Claus Bachert, Holger J. Schunemann, Anna Bedbrook, Wienczyslawa Czarlewski, Jean Bousquet
Summary: The increase in global prevalence of allergic rhinitis (AR) has placed a significant burden on the healthcare system. In response to this, the Allergic Rhinitis and Its Impact on Asthma (ARIA) initiative was launched in Europe to develop internationally applicable guidelines based on evidence. The initiative focuses on empowering patients, utilizing digital mobile technology for personalized treatment, and establishing integrated care pathways. This review discusses the ARIA next-generation guideline and its relevance to the Malaysian healthcare system.
JOURNAL OF PERSONALIZED MEDICINE
(2023)