Article
Oncology
Qiling Zheng, Dijiang Ma, Qi Zhu, Shenjun Tang, Chengbo Chen
Summary: The combination therapy of azelastine hydrochloride and montelukast sodium significantly improves clinical symptoms and inflammatory reactions in patients with allergic rhinitis, showing higher effectiveness compared to using azelastine hydrochloride alone. The clinical therapeutic effect and symptom scores were significantly improved after treatment, as well as a noticeable decrease in serum levels of inflammatory factors.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Huan Wang, Qing Ji, Chao Liao, Li Tian
Summary: The meta-analysis results showed that the loratadine-montelukast combination therapy is superior to loratadine monotherapy, montelukast monotherapy, or placebo in improving allergic rhinitis symptoms. This combination therapy can be considered as an option for patients with moderate-severe allergic rhinitis or those who do not respond well to monotherapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Otorhinolaryngology
Nadim Khoueir, Michel G. Khalaf, Ralph Assily, Simon Rassi, Walid Abou Hamad
Summary: This systematic review and meta-analysis examined the effects of intranasal antihistamines (INAH) on idiopathic rhinitis (IR). The study found that INAH had a beneficial effect on improving nasal symptoms compared to placebo. No significant difference in efficacy was observed between different types of INAH. The most commonly reported adverse event was bitter taste sensation.
Article
Otorhinolaryngology
Miaomiao Zhao, Hao Li, Hui Li
Summary: The study found that the polymorphism of rs321029 on the CYSLTR1 gene is not associated with the susceptibility and severity of allergic rhinitis (AR) in children, but it is closely related to the efficacy of montelukast on AR. The total montelukast effective rate of wide-type genotype TT children was significantly higher than variants genotype CC children.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Cell Biology
Ewa Trybus, Wojciech Trybus, Teodora Krol
Summary: This study focused on the cytological analysis of nasal mucosa swabs from patients with allergic rhinitis (AR) and nonallergic/vasomotor rhinitis (NAR/VMR) who received azelastine therapy for 4 weeks. The results demonstrated therapeutic benefits of azelastine, including regeneration of ciliated cells and induction of autophagy and apoptosis in epithelial cells. The study provides new insights into the mechanisms of action of azelastine and contributes to the understanding of prognostic indicators in different types of rhinitis.
Review
Allergy
Ludger Klimek, William E. Berger, Jean Bousquet, Paul K. Keith, Peter Smith, Dirceu Sole, Glenis Scadding, Hans Christian Kuhl, Duc Tung Nguyen, Ferdinand Kopietz, Arkady Koltun
Summary: The study systematically reviewed the efficacy and safety of MP-AzeFlu for treating allergic rhinitis, finding that it provides effective relief of nasal and ocular symptoms, acts quickly, and controls allergic rhinitis faster. Long-term use is safe and beneficial for children, adults, and those over 65 years old.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Hui Chen, Luo Zhang, Hongfei Lou, Yang Wang, Feifei Cao, Chengshuo Wang
Summary: The combination of budesonide and montelukast may have superior efficacy in treating seasonal allergic rhinitis compared to budesonide monotherapy, especially in improving nasal blockage and itching. Nasal cavity volume and nasal airway resistance can be used to assess nasal blockage more accurately.
Article
Cell Biology
Xikun Yao, Yan Liu, Hong Jiao, Wenjie Ma, Minliang Chen
Summary: This study analyzed the association of lysyl oxidase gene G473A polymorphism with susceptibility to allergic rhinitis (AR) in children and investigated the therapeutic effect of montelukast sodium. The results showed that children carrying the AA gene had an increased risk of AR, while those carrying the GG gene had a decreased risk. Furthermore, children with the GG gene had lower levels of inflammatory factors and better clinical outcomes. The LOX gene G473A polymorphism may have research value in antagonizing the therapeutic effect of montelukast sodium.
Review
Microbiology
Tetsuya Terada, Ryo Kawata
Summary: Local allergic rhinitis (LAR) is a unique form of chronic rhinitis that is neither classical allergic rhinitis (AR) nor non-AR. LAR is often underdiagnosed and affects children and adults worldwide. It shares many features with AR, including positive nasal allergen provocation test (NAPT) and presence of type 2 inflammatory markers.
Review
Allergy
Sophia Linton, Lubnaa Hossenbaccus, Anne K. Ellis
Summary: H1 antihistamines, available since the 1940s, are mainstay treatments for allergic conditions. Newer generation drugs are recommended due to their safety and efficacy. Patient preference, access, and costs should be considered in drug selection. H1 antihistamines can also be used in other allergic conditions.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Yakui Mou, Qing Song, Chunying Zhao, Han Fang, Chao Ren, Xicheng Song
Summary: The use of montelukast as a cause of neuropsychiatric events in patients with asthma or allergic rhinitis is controversial. However, a meta-analysis of randomized controlled trials found no significant increase in neuropsychiatric events compared with placebo. Further research is needed, particularly in children, to verify the association between neuropsychiatric events and montelukast use.
Article
Medicine, General & Internal
Xiuhua Mao, Wenjuan Zhao
Summary: Montelukast combined with sublingual immunotherapy can effectively control symptoms of obstructive sleep apnea hypopnea syndrome (OSAHS) complicated with allergic rhinitis, reduce IL-4 and IL-17 levels, and improve sleep quality.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yara Zoabi, Francesca Levi-Schaffer, Ron Eliashar
Summary: Allergic rhinitis is a common nasal disorder affecting up to 30% of adults. Mast cells play a crucial role in allergic inflammation and are involved in the development of symptoms. This review provides a comprehensive summary of mast cells' involvement in allergic rhinitis and the modulation of mast cells by current and emerging therapies.
Article
Immunology
Yanlu Che, Nan Wang, Qianzi Ma, Junjie Liu, Zhaonan Xu, Qiuying Li, Jingting Wang, Yanan Sun
Summary: This study investigated the differences in nasal flora composition between patients with allergic rhinitis (AR) and non-allergic rhinitis (nAR) and their role in pathogenesis. The results showed that AR patients had a significantly higher abundance of Vibrio vulnificus and Acinetobacter baumanni in the nasal cavity compared to nAR patients, while the abundance of Lactobacillus murinus, Lactobacillus iners, Proteobacteria, Pseudomonadales, and Escherichia coli was lower. The study also identified specific bacterial models associated with AR and nAR, providing new insights for their treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Pediatrics
Ugur Altas, Zeynep Meva Altas, Firat Oz, Mehmet Yasar Ozkars
Summary: This study aimed to evaluate the neuropsychiatric effects of montelukast-levocetirizine combination therapy in children. The most common finding before and after treatment was irritable behavior. Approximately one in five children developed at least one neuropsychiatric symptom after treatment.
Article
Allergy
M. Nabavi, S. Arshi, M. H. Bemanian, A. Aghamohammadi, D. Mansouri, M. Hedayat, A. Nateghian, S. Noorbakhsh, F. Ehsanipour, M. Faranoush, R. Shakeri, M. Mesdaghi, B. Taghvaei, B. Ghalebaghi, D. Babaie, A. Bahrami, M. Fallahpour, H. Esmaeilzadeh, A. Ali Hamidieh, M. Rekabi, J. Ahmadian, N. Eslami, S. Shokri, M. Afshar, F. Jalali, N. Akbarpour, R. Molatefi, N. Rezaei
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2016)
Article
Allergy
Saba Arshi, Mohammad Nabavi, Mohammad Hasan Bemanian, Ramin Shakeri, Behrang Taghvaei, Babak Ghalebaghi, Delara Babaie, Ahmad Bahrami, Morteza Fallahpour, Hossein Esmaeilzadeh, Mahsa Rekabi, Javad Amadian, Narjes Esiami, Sima Shokri, Farhad Jalali, Nadieh Akbarpour, Rasol Molatefi, Nima Rezaei
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2016)
Article
Allergy
Hossein Esmaeilzadeh, Soheila Alyasin, Mahmoud Haghighat, Hesamodin Nabavizadeh, Elmira Esmaeilzadeh, Fereshteh Mosavat
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2018)
Article
Allergy
S. Alyasin, H. Esmaeilzadeh, N. Ebrahimi, S. H. Nabavizadeh, S. Kashef, E. Esmaeilzadeh, M. Babaei, R. Amin
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2019)
Article
Biochemical Research Methods
Narjes Ebrahimi, Navid Nezafat, Hossein Esmaeilzadeh, Younes Ghasemi, Seyed Hesamodin Nabavizadeh, Soheila Alyasin
MOLECULAR AND CELLULAR PROBES
(2019)
Article
Dermatology
Sayed Hesamedin Nabavizadeh, Masroor Babaeian, Hossein Esmaeilzadeh, Nasrin Mortazavifar, Soheila Alyasin
Summary: In cases of chronic urticaria, colchicine was found to effectively manage symptoms and improve patients' quality of life, although it did not affect the overall UQL-Q score changes.
DERMATOLOGIC THERAPY
(2021)
Article
Pediatrics
Hossein Esmaeilzadeh, Negar Mortazavi, Alireza Salehi, Hossein Fatemian, Seyed Mohsen Dehghani, Mohebat Vali, Hossein Molavi Vardanjani
Summary: This study assessed the association between KD and COVID-19 and found that during the COVID-19 pandemic, 68% of KD patients were positive for COVID-19. The age of onset for KD during the pandemic was lower compared to the previous year, and skin manifestations were more prominent.
Article
Pediatrics
Zahra Kanannejad, Mohammad Shomali, Hossein Esmaeilzadeh, Hesamedin Nabavizadeh, Koorosh Nikaein, Zahra Ghahramani, Mohammad Amin Ghatee, Soheila Alyasin
Summary: This study investigated the impact of geoclimatic factors on childhood asthma hospitalization in Fars province, southwest Iran. The results showed that urban setting was the most important risk factor associated with increased childhood asthma hospitalization.
PEDIATRIC PULMONOLOGY
(2022)
Article
Medicine, General & Internal
Sayyed Hesamedin Nabavizadeh, Rafat Noeiaghdam, Leila Johari, Seyed Ali Hosseini, Hossein Esmaeilzadeh, Soheila Sadat Alyasin
Summary: SRD5A3-CDG is an extremely rare congenital disease with common symptoms including developmental delay, intellectual disability, ophthalmological abnormalities, cerebellar abnormalities, ataxia, and hypotonia. We discuss a seven-year-old boy with SRD5A3-CDG (homozygous variant c.57G>A [p.Trp19Ter]) presenting the unprecedented finding of telangiectasia.
CLINICAL CASE REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Hossein Esmaeilzadeh, MReza Goodarzian, Alireza Abbasi, Mohammad Alamdari, Negar Mortazavi
Summary: This study discusses the effects of face masks on the severity of allergic rhinitis symptoms during the COVID-19 pandemic. The results show that face masks can improve the severity of allergic rhinitis symptoms during the pandemic.
HEALTH SCIENCE REPORTS
(2023)
Article
Immunology
Hossein Esmaeilzadeh, Sara Kashef, Hamid Reza Hatami, Soheila Alyasin, Hesamodin Nabavizadeh, Elmira Esmaeilzadeh
CASE REPORTS IN IMMUNOLOGY
(2018)
Article
Allergy
Delara Babaie, Mohammad Nabavi, Saba Arshi, Mehrnaz Mesdaghi, Zahra Chavoshzadeh, Mohammad Hasan Bemanian, Mitra Tafakori, Mehrdad Amirmoini, Hosein Esmailzadeh, Rasoul Molatefi, Mahsa Rekabi, Nadieh Akbarpour, Farimah Masoumi, Morteza Fallahpour
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
(2017)
Article
Allergy
Soheila Alyasin, Seyed Hesamedin Nabavizadeh, Hamidreza Houshmand, Hossein Esmaeilzadeh, Sina Jelodar, Reza Amin
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
(2016)