Article
Biochemistry & Molecular Biology
Ella Larissa Ndoricyimpaye, Jacques Van Snick, Jean de Dieu Niyoyita, Philbert Kanimba, Jean Bosco Mbonimpa, Robert Rutayisire, Reverien Rutayisire, Vedaste Ndahindwa, Pamela Cheou, Jean Paul Coutelier, Nadine Rujeni
Summary: This study found that the stimulation of regulatory T cells through TGF-beta 1/TGF-beta 3 and IL-9 is crucial for an effective and balanced protective immunity in natural human malaria infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Cody D. Moorman, Sue J. Sohn, Hyewon Phee
Summary: This article discusses the current status of autoimmune diseases, the standard treatments, and potential future directions for therapy. The focus is on three main areas of research in immune tolerance: tolerogenic vaccines, T cell therapies, and IL-2 therapies aiming at expanding regulatory T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Mostafa G. G. Aly, Eman H. H. Ibrahim, Hristos Karakizlis, Rolf Weimer, Gerhard Opelz, Christian Morath, Martin Zeier, Naruemol Ekpoom, Volker Daniel
Summary: In this study, the relationship between regulatory cells and immunosuppressive drugs in transplant recipients was investigated. The results showed a negative correlation between CD4+CD25+CD127-Foxp3+ Tregs and CD19+IL-10+ Bregs in early transplant recipients, with Tregs being affected by steroid dose and tacrolimus levels, while Bregs seemed less affected by potent immunosuppression. It was also found that CD4+CD25+CD127-Foxp3+ Tregs were lower in patients treated with certain antibodies compared to end-stage kidney disease patients. Early transplant recipients exhibited different patterns of Tregs and Bregs within the first 3 months post-transplant, indicating a complex relationship between these regulatory cells and immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xia Zhang, Daji Liu, Minghong He, Mao Lin, Caixia Tu, Baoxiang Zhang
Summary: In summary, the synthesized nanoparticles NPHEL46-61/Rapa were found to ameliorate vitiligo by promoting Treg production, suppressing CD4(+) T cell proliferation, and inducing immunosuppressive IL-10 production.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Immunology
Shuai Wang, Yubin Shi, Yanqi Zhang, Fengyun Yuan, Mintao Mao, Jun Ma
Summary: This study investigated the potential of Tregs in inhibiting the activation of astrocytes after focal cerebral infarction. The depletion of Tregs in the tMCAO mouse model protected against astrocyte activation and decreased expression levels of FSP1, IL-6, IL-2, and NLRP3, while partially reversing the changes in Tregs. Mechanistically, Tregs depletion attenuated renal fibrosis by modulating IL-10/GPX4 following cerebral infarction.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Rajeev K. Tyagi, Justin Jacobse, Jing Li, Margret M. Allaman, Kevin L. Otipoby, Erik R. Sampson, Keith T. Wilson, Jeremy A. Goettel
Summary: Regulatory T cells play a crucial role in maintaining immune homeostasis in the intestine, and dysfunction of T-reg cells is linked to various inflammatory and autoimmune disorders. Treatment with low-dose IL-2 may be a promising therapeutic strategy for inflammatory conditions, but its effectiveness in treating IBD is still uncertain.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Zheng-Tao Zhang, Dan-Ying Zhang, Ke Xie, Chuan-Jiang Wang, Fang Xu
Summary: The study demonstrated that Luteolin has significant anti-inflammatory effects and can alleviate CLP-induced lung injury by increasing Treg frequencies and IL-10 levels, reducing caspase-related protein levels in the lungs, and mitigating lung pyroptosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Urology & Nephrology
Charles G. Rickert, James F. Markmann
Summary: Solid organ transplantation has been successful in immunosuppression, but there are significant costs and challenges. Immunosuppression and tolerance based on regulatory T cells provide an attractive alternative.
SEMINARS IN NEPHROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yuqian Li, Xue Li, Xiaokun Geng, Haiping Zhao
Summary: Murine myeloid cells develop from hemopoietic stem/progenitor cells, and different types of progenitor cells have varying differentiation potentials. Regulatory T cells (Tregs), an important cell subpopulation regulating immune responses, arise from hematopoietic stem cells in the bone marrow. The IL-2/IL-2R pathway plays a crucial role in regulating Tregs, and different subunit combinations of IL-2R can affect immune cell activation.
CYTOKINE & GROWTH FACTOR REVIEWS
(2022)
Review
Immunology
Laura A. Huppert, Michael D. Green, Luke Kim, Christine Chow, Yan Leyfman, Adil Daud, James C. Lee
Summary: Advancements in immuno-oncology have led to the development of immunotherapies for metastatic cancer patients, providing long-term treatment responses but with infrequent cures. Recent research indicates that tumors in certain organ sites may exhibit unique response patterns to immunotherapy and could reduce antitumor immunity in distant tumors, possibly due to the activation of tissue-specific immune tolerogenic mechanisms.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Immunology
Saul Arteaga-Cruz, Arimelek Cortes-Hernandez, Evelyn Katy Alvarez-Salazar, Katya Rosas-Cortina, Christian Aguilera-Sandoval, Luis E. Morales-Buenrostro, Josefina M. Alberu-Gomez, Gloria Soldevila
Summary: The development of new strategies involving Tr1 cells for inducing long-term tolerance in allogeneic stem cell transplantation is gaining importance. However, further characterization of Tr1 cells is needed to ensure their efficacy in solid organ transplantation. This study demonstrates that highly purified allospecific Tr1 cells can be efficiently expanded while maintaining stability and suppressive function, making them potentially useful for solid organ transplantation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Critical Care Medicine
Qiang Wei, Xi Chen, Xia Chen, Zhongzhen Yuan, Chuanjiang Wang
Summary: This study investigated the role of IL-38 in pneumonia caused by P. aeruginosa. The results showed that IL-38 levels were increased during the early stages of clinical P. aeruginosa pneumonia, but were lower in patients who died from the disease. IL-38 also showed correlations with severity of pneumonia and inflammation markers. Furthermore, IL-38 was found to improve survival, reduce inflammation and cell apoptosis, and increase bacterial clearance in experimental animal models. These findings suggest that IL-38 may have therapeutic potential in the treatment of P. aeruginosa pneumonia.
Editorial Material
Immunology
Annika Frede, Simon Milling
Summary: The fetal immune system shows higher tolerance to foreign antigens compared to the adult immune system, and neonates rely on maternal antibodies for protection. The establishment of tolerance during early life may have long-term implications for immune homeostasis and predisposition to autoimmune diseases, but the mechanisms underlying the switch from perinatal tolerogenic immune responses to adult-like effector immune responses are not well understood.
Article
Oncology
Xinmei Huang, Jiong Xu, Yueyue Wu, Li Sheng, Yue Li, Bingbing Zha, Tiange Sun, Ju Yang, Shufei Zang, Jun Liu
Summary: Invasive nonfunctioning pituitary adenomas (NFPAs) exhibit more visual deficits, larger tumor size, and lower white blood cell count compared to noninvasive NFPAs. Additionally, the levels of immune cells in both peripheral blood and pituitary tumor tissues are significantly associated with the invasiveness of NFPAs. Notably, CD3(-)CD56(+) NK cells, CD8(+) Tregs, and IL-10 levels could serve as potential diagnostic markers for invasive NFPAs.
PATHOLOGY & ONCOLOGY RESEARCH
(2021)
Article
Immunology
Nhi Ngo Thi Phuong, Vittoria Palmieri, Alexandra Adamczyk, Robert Klopfleisch, Jost Langhorst, Wiebke Hansen, Astrid M. Westendorf, Eva Pastille
Summary: The IL-33/ST2 pathway plays a crucial protective role in colitis by modulating the numbers of ILC2 and Treg cells, highlighting its potential as a novel therapeutic target in inflammatory bowel disease.
FRONTIERS IN IMMUNOLOGY
(2021)