Article
Gastroenterology & Hepatology
Mohammad Hassan Sohouli, Somaye Fatahi, Fatemeh Farahmand, Hosein Alimadadi, Shaikh Sanjid Seraj, Pejman Rohani
Summary: This study investigated the potential effects of EEN on pediatric Crohn's disease activity index (PCDAI), inflammation, and biochemical parameters. The results showed that EEN significantly improved the PCDAI score and biochemical parameters, indicating its beneficial effects as induction therapy in pediatric patients with CD.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Microbiology
Sara Sila, Marko Jelic, Ivana Trivic, Arjana Tambic Andrasevic, Sanja Kolacek, Iva Hojsak
Summary: This study investigated the changes in the intestinal microbiota of children with Crohn's disease (CD) before, during, and after exclusive enteral nutrition (EEN). Stool samples were collected at different time points and a molecular approach was used for analysis. The study found that the microbiota composition changed significantly after two months of EEN discontinuation and remained mostly unchanged over a year of follow-up.
Article
Nutrition & Dietetics
Darja Urlep, Rok Orel, Patricija Kunstek, Evgen Benedik
Summary: This study evaluated the clinical and endoscopic rates of remission in children with active Crohn's disease (CD) treated with partial enteral nutrition (PEN) combined with a modified Crohn's disease exclusion diet (mCDED). The study found that PEN + mCDED could potentially induce clinical and endoscopic remission in pediatric CD patients. The results provide evidence for the use of PEN + mCDED in the treatment of pediatric CD.
Review
Nutrition & Dietetics
Giacomo Caio, Lisa Lungaro, Fabio Caputo, Eleonora Zoli, Fiorella Giancola, Giuseppe Chiarioni, Roberto De Giorgio, Giorgio Zoli
Summary: Crohn's disease is a chronic inflammatory bowel disease that can cause malnutrition in a significant percentage of patients, highlighting the importance of diet in managing the condition. This review aims to cover recent findings in nutrition for CD treatment, including established diets, new nutritional theories, and advancements in areas like nutrigenomics.
Article
Immunology
Biao Zou, Shengxuan Liu, Xuesong Li, Jiayi He, Chen Dong, Mengling Ruan, Zhihua Huang, Sainan Shu
Summary: This study investigated the efficacy of fecal microbiota transplantation (FMT) plus partial enteral nutrition (PEN) as a first-line treatment for active Crohn's disease (CD) in children. The results showed that FMT plus PEN can be used as a first-line treatment for active CD in children.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Jair G. Marques, Tobias Schwerd, Philip Bufler, Sibylle Koletzko, Berthold Koletzko
Summary: Exclusive enteral nutrition therapy leads to changes in the metabolic profile of pediatric Crohn's Disease patients, including a decrease in compounds related to diet and a bacterial metabolite. The reduction of phosphatidic acid metabolite PA(15:1/18:0) is correlated with disease activity. During exclusive enteral nutrition therapy, there is an increase in phosphatidylethanolamines and one lactosylceramide.
Article
Nutrition & Dietetics
Yao Lv, Yue Lou, Ana Liu, Qi Cheng, Gan Yang, Cuifang Xu, Youyou Luo, Jingan Lou, Jindan Yu, Youhong Fang, Hong Zhao, Kerong Peng, Yan Ni, Jie Chen
Summary: Exclusive enteral nutrition (EEN) treatment can improve gut microbiome and bile acid (BA) metabolism of patients with Crohn's disease (CD). The study involved 27 newly diagnosed pediatric CD patients and 27 healthy controls. The findings suggest that EEN treatment can restore GM structure and secondary BA metabolism, and the abundance of Firmicutes bacteria and the balance of primary and secondary BAs are associated with CD severity and mucosal inflammation.
CLINICAL NUTRITION
(2023)
Article
Gastroenterology & Hepatology
David I. F. Wands, Laura Gianolio, David C. Wilson, Richard Hansen, Iain Chalmers, Paul Henderson, Konstantinos Gerasimidis, Richard K. Russell
Summary: In pediatric patients with CD in Scotland, the usage rates of EEN have not changed over the past 7.5 years, except during the COVID-19 pandemic, despite an increase in biologic use. Combination induction has emerged as a new trend.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Marialaura Cuomo, Alessandra Carobbio, Marina Aloi, Patrizia Alvisi, Claudia Banzato, Luca Bosa, Matteo Bramuzzo, Angelo Campanozzi, Giulia Catassi, Lorenzo D'Antiga, Monica Di Paola, Enrico Felici, Maria Teresa Fioretti, Simona Gatti, Francesco Graziano, Sara Lega, Paolo Lionetti, Antonio Marseglia, Massimo Martinelli, Francesca Musto, Naire Sansotta, Luca Scarallo, Giovanna Zuin, Lorenzo Norsa
Summary: Exclusive enteral nutrition is the first choice for inducing remission in pediatric Crohn's disease, but adherence to this treatment can be challenging for children. This study aimed to identify factors predictive of nonadherence and nonremission. The results showed that colonic involvement and high fecal calprotectin levels at diagnosis were associated with reduced adherence to exclusive enteral nutrition.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Chemistry, Medicinal
Agata Wasilewska, Katarzyna Ponanta-Gawron, Beata Burtan, Charissa Stephen Chandra Sagaran, Mariusz Duplaga, Kinga Kowalska-Duplaga
Summary: This study retrospectively analyzed liver enzyme abnormalities in pediatric CD patients during exclusive enteral nutrition (EEN). The study found that 42% of the children had elevated liver enzymes, with 38% experiencing transient elevation. Patients with higher protein/energy ratio were more likely to have liver enzyme abnormalities.
JOURNAL OF MEDICINAL FOOD
(2022)
Article
Nutrition & Dietetics
Hannes Hoelz, Jeannine Heetmeyer, Anastasia Tsakmaklis, Andreas Hiergeist, Kolja Siebert, Federica De Zen, Deborah Haecker, Amira Metwaly, Klaus Neuhaus, Andre Gessner, Maria J. G. T. Vehreschild, Dirk Haller, Tobias Schwerd
Summary: Background: Exclusive enteral nutrition (EEN) is effective for pediatric Crohn's disease (CD) but relapse rates are high after return to regular diet. This study explored the use of autologous fecal microbiota transfer (FMT) for maintaining the benefits of EEN. Methods: Fecal material from pediatric CD patients was turned into FMT capsules, with microbial composition analyzed before and after processing. Results: FMT capsules were successfully generated in most deliveries, but there was variability in stool weight and consistency. Microbial composition was not significantly altered by processing, but samples often had low microbial richness and positive results for potential pathogens or drug resistance genes. Conclusions: Autologous capsule-FMT may not be suitable for maintenance therapy in pediatric CD patients due to high pathogen burden, low microbial diversity, and practical limitations of EEN-conditioned fecal material.
Article
Medicine, General & Internal
Liyuan Xiang, Yan Yu, Xiao Ding, Hui Zhang, Quan Wen, Bota Cui, Faming Zhang
Summary: In patients with Crohn's disease (CD) complicated with malnutrition, this study found that exclusive enteral nutrition (EEN) combined with immediate washed microbiota transplantation (WMT) intervention could rapidly improve the nutritional status and induce clinical remission.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Shuyan Li, Peiwei Li, Hongling Sun, Wen Hu, Shurong Hu, Yan Chen, Minfang Lv
Summary: This study investigated the adherence to EEN among CD patients and its relationship with medication belief, finding that high medication belief, residency, medical insurance, and history of enteral nutrition therapy were factors affecting EEN adherence. The study also showed that the type of enteral nutrition, taste, storage, and convenience of purchase were not associated with EEN adherence. More research is needed to explore the role of improving patients' beliefs in increasing adherence.
PATIENT PREFERENCE AND ADHERENCE
(2021)
Article
Nutrition & Dietetics
Tena Niseteo, Sara Sila, Ivana Trivic, Zrinjka Misak, Sanja Kolacek, Iva Hojsak
Summary: This study compared the efficacy of CDED + PEN and EEN in inducing remission in children with Crohn's disease. The results showed that CDED + PEN had similar efficacy to EEN therapy alone and led to better weight gain in patients. Further studies are needed to confirm these findings.
NUTRITION IN CLINICAL PRACTICE
(2022)
Editorial Material
Gastroenterology & Hepatology
Alexandra S. Hudson, Eytan Wine
Summary: This article is related to the papers of Sohouli et al. To view these papers, please visit the provided link.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Pediatrics
Tomasz Dziodzio, Friederike Martin, Safak Guel-Klein, Brigitta Globke, Paul Viktor Ritschl, Maximilian Jara, Karl-Herbert Hillebrandt, Maximilian Noesser, Georgios Koulaxouzidis, Uli Fehrenbach, Alexander Gratopp, Stephan Henning, Philipp Bufler, Wenzel Schoening, Moritz Schmelzle, Johann Pratschke, Christian Witzel, Robert Oellinger
Summary: In pediatric liver transplantation, hepatic artery reconstruction with an operating microscope is associated with a lower incidence of hepatic artery thrombosis, improved survival rates, and reduced risk of complications compared to using surgical loupes.
PEDIATRIC TRANSPLANTATION
(2022)
Article
Urology & Nephrology
Caroline Kempf, Johannes Holle, Susanne Berns, Stephan Henning, Philip Bufler, Dominik Mueller
Summary: The safety of PEG insertion in pediatric PD patients can be improved by implementing a prophylactic antibiotic and antifungal regimen as well as modifying the PD program, which may help reduce the risk of peritonitis.
PERITONEAL DIALYSIS INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Simon Moosburner, Leke Wiering, Safak Guel-Klein, Paul Ritschl, Tomasz Dziodzio, Nathanael Raschzok, Christian Witzel, Alexander Gratopp, Stephan Henning, Philip Bufler, Moritz Schmelzle, Georg Lurje, Wenzel Schoening, Johann Pratschke, Brigitta Globke, Robert oellinger
Summary: This study analyzed the short- and long-term outcomes of pediatric liver transplantation over a 30-year period. The results showed excellent long-term survival rates in pediatric patients undergoing liver transplantation. The improvement in patient survival can be attributed to advancements in surgical techniques, improved interdisciplinary collaboration, and better management of perioperative complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Lucas Griessmair, Laura Pirringer, Steffeni Mountford, Andrea Sendelhofert, Marie-Christine Makeschin, Sibylle Koletzko, Doris Mayr, Philip Bufler
Summary: This study characterized the hepatic inflammatory infiltrate and expression of IL-37 in children with autoimmune liver diseases. IL-37 expression correlated positively with liver inflammation and fibrosis, the number of infiltrating immune cells, and serum markers for hepatic inflammation. IL-37 was mainly expressed in hepatocytes, cholangiocytes, and infiltrating immune cells. Additionally, IL-37 colocalized with intranuclear pSmad3L in areas of liver inflammation. These findings suggest that IL-37 may play a modulating role to limit hepatic inflammation and fibrosis in pediatric autoimmune liver diseases.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Multidisciplinary Sciences
Maryam Ghalandary, Yue Li, Thomas Frohlich, Thomas Magg, Yanshan Liu, Meino Rohlfs, Sebastian Hollizeck, Raffaele Conca, Tobias Schwerd, Holm H. Uhlig, Philip Bufler, Sibylle Koletzko, Aleixo M. Muise, Scott B. Snapper, Fabian Hauck, Christoph Klein, Daniel Kotlarz
Summary: NOD2 polymorphisms may affect the perception of bacterial MDP and trigger inflammatory responses. A rare homozygous missense mutation in the first CARD domain of NOD2 was found in a patient with immunodeficiency and enteropathy. The mutation impaired NOD2-dependent signaling and proinflammatory cytokine production. The study also discovered that VCP is a novel interaction partner of NOD2, and VCP-mediated inflammatory responses upon ER stress are NOD2-dependent.
SCIENTIFIC REPORTS
(2022)
Letter
Gastroenterology & Hepatology
Eberhard Lurz, Dominic Lenz, Philip Bufler, Alexander Fichtner, Stephan Henning, Martin Jankofsky, Simone Kathemann, Michael Melter, Jun Oh, Eva Doreen Pfister, Ekkehard Sturm, Birgit Knoppke, Elke Lainka
JOURNAL OF HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nikolaus Berndt, Christian A. Hudert, Johannes Eckstein, Christoph Loddenkemper, Stephan Henning, Philip Bufler, David Meierhofer, Ingolf Sack, Susanna Wiegand, Iwona Wallach, Hermann-Georg Holzhutter
Summary: This study used a mathematical model to analyze liver metabolism in children with NAFLD, showing significant alterations in carbohydrate, lipid, and ammonia metabolism that increase with obesity and NAFLD severity. NASH and IR have opposite associations with carbohydrate and lipid metabolism, while simultaneously decreasing urea synthesis and increasing glutamine release.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Johannes Holle, Hendrik Bartolomaeus, Ulrike Loeber, Felix Behrens, Theda U. P. Bartolomaeus, Harithaa Anandakumar, Moritz I. I. Wimmer, Dai Long Vu, Mathias Kuhring, Ulrike Bruening, Andras Maifeld, Sabrina Geisberger, Stefan Kempa, Fabian Schumacher, Burkhard Kleuser, Philip Bufler, Uwe Querfeld, Stefanie Kitschke, Denise Engler, Leonard D. D. Kuhrt, Oliver Drechsel, Kai-Uwe Eckardt, Sofia K. K. Forslund, Andrea Thuermer, Victoria McParland, Jennifer A. A. Kirwan, Nicola Wilck, Dominik Mueller
Summary: Patients with chronic kidney disease (CKD) exhibit a proinflammatory immune response, potentially associated with gut dysbiosis, leading to gut barrier dysfunction and microbial metabolite imbalance, which significantly influences susceptibility to cardiovascular disease.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Gastroenterology & Hepatology
Aline Azabdaftari, Henrike L. L. Sczakiel, Magdalena Danyel, Benno Kohlmaier, Christoph J. J. Mache, Amelie Stalke, Eva-Doreen Pfister, Julia Thumfart, Stephan Henning, A. S. Knisely, Philip Bufler
Summary: Neonatal sclerosing cholangitis (NSC) is a liver disease associated with biliary fibrosis that often requires liver transplantation in childhood. Recent studies have discovered variants in the DCDC2 gene, which is involved in syndromic disease and NSC. This report presents four patients with hepatobiliary disease associated with novel variants in the DCDC2 gene, expanding the phenotypic spectrum of this disease. Testing for DCDC2 expression and variants should be considered in the evaluation of unknown cholangiopathy in childhood.
LIVER INTERNATIONAL
(2023)
Article
Pediatrics
Norman Junge, Hanna Hentschel, Dorothee Krebs-Schmitt, Amelie Stalke, Eva-Doreen Pfister, Bjoern Hartleben, Martin Classen, Alexander Querfurt, Veronika Muench, Philip Bufler, Jun Oh, Enke Grabhorn
Summary: A study found that patients with mild Crigler-Najjar Syndrome (CNS) carrying the c.115C>G variant have a higher risk of progressive liver disease, despite having a very mild CNS phenotype. Currently, there are no identifiable predictors or causes for disease progression, but close follow-up can help identify patients with progressive liver disease at an early stage.
Article
Immunology
Laura Kroehn, Aline Azabdaftari, Julian Heuberger, Christian Hudert, Matthias Zilbauer, Tilman Breiderhoff, Philip Bufler
Summary: IL-37 plays its anti-inflammatory role in the intestines mainly by protecting the intestinal epithelial integrity through lamina propria immune cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Jair G. Marques, Tobias Schwerd, Philip Bufler, Sibylle Koletzko, Berthold Koletzko
Summary: Exclusive enteral nutrition therapy leads to changes in the metabolic profile of pediatric Crohn's Disease patients, including a decrease in compounds related to diet and a bacterial metabolite. The reduction of phosphatidic acid metabolite PA(15:1/18:0) is correlated with disease activity. During exclusive enteral nutrition therapy, there is an increase in phosphatidylethanolamines and one lactosylceramide.
Article
Surgery
Arne Sattler, Julia Thumfart, Laura Toth, Eva Schrezenmeier, Vanessa Pross, Carolin Stahl, Janine Siegle, An He, Linda Marie Laura Thole, Carolin Ludwig, Henriette Straub-Hohenbleicher, Frank Friedersdorff, Bernd Jahrsdoerfer, Hubert Schrezenmeier, Philip Bufler, Katja Kotsch
Summary: Protection against SARS-CoV2 is impaired in kidney transplant recipients due to low vaccine reactogenicity. After two doses of BNT162b2 vaccine, 90% of transplanted adolescents showed IgG seroconversion, but the response was significantly reduced compared to healthy controls. Spike-specific B cells were decreased and enriched for non-isotype-class-switched memory cells in patients. Although limitations in vaccine-specific immunity were identified, most adolescent patients showed robust humoral responses.
TRANSPLANT INTERNATIONAL
(2022)
Article
Pediatrics
Lotta Elonen, Lena Woelfle, Jan de Laffolie, Carsten Posovszky, CEDATA-GPGE-Study-Grp
Summary: This study investigates the clinical features of isolated Crohn's colitis in pediatric patients, finding that the disease is characterized by extraintestinal manifestations, mainly joint involvement and perianal fistulas or abscesses requiring surgery and biologic therapy, which can influence treatment strategies.
FRONTIERS IN PEDIATRICS
(2022)
Article
Gastroenterology & Hepatology
Georg Beyer, Albrecht Hoffmeister, Patrick Michl, Thomas Mathias Gress, Wolfgang Huber, Hana Alguel, Albrecht Neesse, Alexander Meining, Thomas W. Seufferlein, Jonas Rosendahl, Stefan Kahl, Jutta Keller, Jens Werner, Helmut Friess, Philip Bufler, Matthias J. Loehr, Alexander Schneider, Petra Lynen Jansen, Irene Esposito, Lars Grenacher, Joachim Moessner, Markus M. Lerch, Julia Mayerle
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2022)