Article
Nutrition & Dietetics
Hannes Hoelz, Jeannine Heetmeyer, Anastasia Tsakmaklis, Andreas Hiergeist, Kolja Siebert, Federica De Zen, Deborah Haecker, Amira Metwaly, Klaus Neuhaus, Andre Gessner, Maria J. G. T. Vehreschild, Dirk Haller, Tobias Schwerd
Summary: Background: Exclusive enteral nutrition (EEN) is effective for pediatric Crohn's disease (CD) but relapse rates are high after return to regular diet. This study explored the use of autologous fecal microbiota transfer (FMT) for maintaining the benefits of EEN. Methods: Fecal material from pediatric CD patients was turned into FMT capsules, with microbial composition analyzed before and after processing. Results: FMT capsules were successfully generated in most deliveries, but there was variability in stool weight and consistency. Microbial composition was not significantly altered by processing, but samples often had low microbial richness and positive results for potential pathogens or drug resistance genes. Conclusions: Autologous capsule-FMT may not be suitable for maintenance therapy in pediatric CD patients due to high pathogen burden, low microbial diversity, and practical limitations of EEN-conditioned fecal material.
Article
Immunology
Biao Zou, Shengxuan Liu, Xuesong Li, Jiayi He, Chen Dong, Mengling Ruan, Zhihua Huang, Sainan Shu
Summary: This study investigated the efficacy of fecal microbiota transplantation (FMT) plus partial enteral nutrition (PEN) as a first-line treatment for active Crohn's disease (CD) in children. The results showed that FMT plus PEN can be used as a first-line treatment for active CD in children.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Sara Sila, Marko Jelic, Ivana Trivic, Arjana Tambic Andrasevic, Sanja Kolacek, Iva Hojsak
Summary: This study investigated the changes in the intestinal microbiota of children with Crohn's disease (CD) before, during, and after exclusive enteral nutrition (EEN). Stool samples were collected at different time points and a molecular approach was used for analysis. The study found that the microbiota composition changed significantly after two months of EEN discontinuation and remained mostly unchanged over a year of follow-up.
Article
Nutrition & Dietetics
Yao Lv, Yue Lou, Ana Liu, Qi Cheng, Gan Yang, Cuifang Xu, Youyou Luo, Jingan Lou, Jindan Yu, Youhong Fang, Hong Zhao, Kerong Peng, Yan Ni, Jie Chen
Summary: Exclusive enteral nutrition (EEN) treatment can improve gut microbiome and bile acid (BA) metabolism of patients with Crohn's disease (CD). The study involved 27 newly diagnosed pediatric CD patients and 27 healthy controls. The findings suggest that EEN treatment can restore GM structure and secondary BA metabolism, and the abundance of Firmicutes bacteria and the balance of primary and secondary BAs are associated with CD severity and mucosal inflammation.
CLINICAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Tena Niseteo, Sara Sila, Ivana Trivic, Zrinjka Misak, Sanja Kolacek, Iva Hojsak
Summary: This study compared the efficacy of CDED + PEN and EEN in inducing remission in children with Crohn's disease. The results showed that CDED + PEN had similar efficacy to EEN therapy alone and led to better weight gain in patients. Further studies are needed to confirm these findings.
NUTRITION IN CLINICAL PRACTICE
(2022)
Article
Endocrinology & Metabolism
Lei Wu, Man-Qing Li, Ya-Ting Xie, Qing Zhang, Xin-Jian Lu, Tao Liu, Wen-Ying Lin, Jia-Ting Xu, Qing-Ping Wu, Xing-Xiang He
Summary: This study investigated the feasibility and efficacy of washed microbiota transplantation (WMT) in treating abnormal blood glucose metabolism in a southern Chinese population. The results showed that WMT significantly improved blood glucose levels in patients with high blood glucose and reduced the risk of high risk classes of Atherosclerotic Cardiovascular Disease (ASCVD). These findings suggest that regulating gut microbiota through WMT could provide a new clinical approach for the treatment of abnormal blood glucose metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Chemistry, Multidisciplinary
You Yu, Weihong Wang, Faming Zhang
Summary: Fecal microbiota transplantation (FMT) has emerged as a promising approach for dysbiosis-related diseases. Advanced methods, such as washed microbiota transplantation, bacteria spores treatment, and fecal virome transplantation, provide more acceptable options for patients and minimize research heterogeneity.
Article
Medicine, General & Internal
Roma Herman, Paulina Dumnicka, Stanislaw Pieczarkowski, Krzysztof Fyderek
Summary: Mucosal healing is the main treatment goal of Crohn's disease, and the Mucosal Inflammation Noninvasive Index (MINI) shows promise in distinguishing mucosal healing from inflammation. This study evaluated MINI in monitoring remissions induced by exclusive enteral nutrition in pediatric CD patients, and found that MINI is superior to fecal calprotectin in predicting disease relapse.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Muna Shakhshir, Sa'ed H. Zyoud
Summary: This study utilizes bibliometric analysis to examine the knowledge structure and trends in nutrition and Crohn's disease research over the past two decades. The findings reveal that current research hotspots include exclusive enteral nutrition for complicated Crohn's disease and manipulation of the gut microbiota, which are expected to be further investigated in the future. Additionally, research on malnutrition in patients with Crohn's disease has attracted significant attention in previous years.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Nutrition & Dietetics
Sara Sila, Marko Jelic, Ivana Trivic, Arjana Tambic Andrasevic, Sanja Kolacek, Iva Hojsak
Summary: The study found that EEN treatment has a significant impact on the microbiota composition of healthy children and children with CD, with differences in the timing of effectiveness. Changes in microbiota composition occur more rapidly in healthy children, whereas children with CD show significant changes at the end of EEN treatment.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Jair G. Marques, Tobias Schwerd, Philip Bufler, Sibylle Koletzko, Berthold Koletzko
Summary: Exclusive enteral nutrition therapy leads to changes in the metabolic profile of pediatric Crohn's Disease patients, including a decrease in compounds related to diet and a bacterial metabolite. The reduction of phosphatidic acid metabolite PA(15:1/18:0) is correlated with disease activity. During exclusive enteral nutrition therapy, there is an increase in phosphatidylethanolamines and one lactosylceramide.
Review
Gastroenterology & Hepatology
Sasha R. Fehily, Chamara Basnayake, Emily K. Wright, Michael A. Kamm
Summary: Fecal microbiota transplantation (FMT) shows potential as an effective therapy for Crohn's disease in preliminary studies, but larger controlled trials are needed to confirm its efficacy. No serious safety concerns have been identified so far.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Soumaya Kouidhi, Oumaima Zidi, Muhanad Alhujaily, Nessrine Souai, Amor Mosbah, Tareg M. Belali, Kais Ghedira, Imene El Kossai, Jamelddine El Manaa, Wissem Mnif, Ameur Cherif
Summary: This study found significant differences in fecal metabolites between kidney transplant recipients and healthy individuals, particularly in lipids. Changes in metabolic pathways also provide potential biomarkers for transplant recipients. Therefore, metabolomics may play a crucial role in monitoring kidney transplants.
Article
Endocrinology & Metabolism
Fenfen Liang, Xinjian Lu, Zhiliang Deng, Hao-Jie Zhong, Wei Zhang, Qing Li, Hong-Hao Zhou, Yu-Ligh Liou, Xing-Xiang He
Summary: The study investigated the feasibility and effectiveness of washed microbiota transplantation (WMT) on lipid metabolism in the Chinese population. WMT showed significant therapeutic effects in reducing blood lipid levels in patients with hyperlipidemia and hypolipidemia in the short- and medium term. The treatment did not increase the risk of blood lipid and atherosclerotic cardiovascular disease (ASCVD) in the long-term.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Erika Salciute-Simene, Raimundas Stasiunaitis, Eduardas Ambrasas, Jonas Tutkus, Ignas Milkevicius, Gintare Sostakaite, Andrius Klimasauskas, Gintautas Kekstas
Summary: The study shows that episodes of ENI in critically ill patients are frequent and prolonged, often leading to underfeeding. The proportion of underfeeding is higher on trial days with ENI, with lower caloric and protein intake.
CLINICAL NUTRITION
(2021)
Editorial Material
Gastroenterology & Hepatology
Faming Zhang, Quan Wen, Bota Cui
Article
Medicine, General & Internal
Yun Wang, Bota Cui, Faming Zhang
Summary: Ulcerative colitis is an autoimmune inflammatory disorder affected by the gut microbiota. Washed microbiota transplantation (WMT) has shown potential as a treatment for refractory ulcerative colitis.
CURRENT MEDICAL RESEARCH AND OPINION
(2022)
Article
Engineering, Environmental
Zehua Yan, Yafei Liu, Ting Zhang, Faming Zhang, Hongqiang Ren, Yan Zhang
Summary: The study found that the concentration of fecal microplastics in patients with inflammatory bowel disease was significantly higher than in healthy individuals, with poly(ethylene terephthalate) and polyamide being the main components in the feces. A positive correlation between fecal microplastics concentration and the severity of IBD was also observed. Plastic packaging of drinking water and food, as well as dust exposure, were identified as important sources of human exposure to microplastics.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Letter
Cell Biology
Xiaolin Liu, Yue Ma, Ying Yu, Wenhui Zhang, Jingjing Shi, Xuan Zhang, Min Dai, Yuhan Wang, Hao Zhang, Jiahe Zhang, Jianghua Shen, Faming Zhang, Moshi Song, Jun Wang
Review
Medicine, General & Internal
Weihong Wang, Gaochen Lu, Xia Wu, Quan Wen, Faming Zhang
Summary: The limitation of traditional delivery methods for fecal microbiota transplantation (FMT) has led to the development of colonic transendoscopic enteral tubing (TET) to meet the need for frequent FMTs. Colonic TET is a novel endoscopic intervention that has gained attention in China since 2015. Studies have shown that colonic TET is a promising and safe delivery method for microbial therapy and medication administration, with high patient satisfaction. It has also been used to rescue endoscopy-related perforations and facilitate microbial research.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, Research & Experimental
Gaochen Lu, Quan Wen, Bota Cui, Qianqian Li, Faming Zhang
Summary: This article reports a female case with ALS who benefited from washed microbiota transplantation (WMT) as a treatment. The case provides direct clinical evidence on using WMT for treating ALS, indicating that WMT may be a novel treatment strategy for controlling this supposedly incurable disease.
JOURNAL OF BIOMEDICAL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Yujie Liu, Xinghui Ji, Yihao Huang, Qianqian Li, Xiao Ding, Yun Wang, Sheng Zhang, Quan Wen, Bota Cui, Xiang Lu, Faming Zhang
Summary: This study aimed to assess the clinical factors affecting the long-term efficacy of FMT for patients with UC. The results showed that patients aged 60 years and older, with mild disease severity, and undergoing two or more courses of WMT were more likely to achieve steroid-free clinical remission after 6 months.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Cell Biology
Junpeng Yang, Xueli Yang, Guojun Wu, Fenglian Huang, Xiaoyang Shi, Wei Wei, Yingchao Zhang, Haihui Zhang, Lina Cheng, Lu Yu, Jing Shang, Yinghua Lv, Xiaobing Wang, Rui Zhai, Pan Li, Bota Cui, Yuanyuan Fang, Xinru Deng, Shasha Tang, Limin Wang, Qian Yuan, Liping Zhao, Faming Zhang, Chenhong Zhang, Huijuan Yuan
Summary: The pathogenesis of DSPN in diabetes mellitus patients is associated with gut microbiota. Fecal microbiota transplant can alleviate DSPN and improve gut barrier integrity.
Article
Gastroenterology & Hepatology
Xia Wu, Ru Jun Ai, Jie Xu, Quan Wen, Hua Qin Pan, Zhi Hua Zhang, Wang Ning, Ying Fang, Da Fa Ding, Quan Wang, Shuang Han, Xiao Liu, Mei Wu, Zhen Yu Jia, Song Jia, Tao Lin, Bo Ta Cui, Yong Zhan Nie, Xin Wang, Fa Ming Zhang
Summary: This study evaluated the therapeutic efficacy and safety of washed microbiota transplantation (WMT) for recurrent Clostridioides difficile infection (CDI). The results showed that 90.7% of CDI patients achieved clinical cure after WMT treatment. WMT may be particularly recommended for patients with severe conditions or complex comorbidities.
JOURNAL OF DIGESTIVE DISEASES
(2023)
Article
Nutrition & Dietetics
Gaochen Lu, Sheng Zhang, Rui Wang, Zulun Zhang, Weihong Wang, Quan Wen, Faming Zhang, Pan Li
Summary: This study used bibliometrics to analyze the scientific literature on the relationship between gut microbiota and chronic painful conditions, revealing that only 122 papers discussed how nutritional interventions can modulate this link. The findings enrich the evidence in the field of microbiota medicine and contribute to the development of clinical medicine.
Article
Nutrition & Dietetics
Xia Wu, Pan Li, Weihong Wang, Jie Xu, Rujun Ai, Quan Wen, Bota Cui, Faming Zhang
Summary: FMT is an effective treatment for UC, and the serum metabolites can be used as non-invasive predictors of FMT efficacy for UC.
Review
Cell Biology
Weihong Wang, Bota Cui, Yongzhan Nie, Lijuan Sun, Faming Zhang
Summary: Exposure to medical sources or accidental radiation can lead to varying degrees of radiation injury (RI). RI is a common disease involving multiple human body parts and organs, for which effective treatments are limited. Evidence suggests a close association between gut microbiota and the development and prevention of various RI. This article summarizes 10 common types of RI, possible mechanisms, and highlights microbiota-based treatments including probiotics, metabolites, and microbiota transplantation. Additionally, a comprehensive strategy for managing RI, called the 5P-Framework, is proposed.
Review
Chemistry, Multidisciplinary
You Yu, Weihong Wang, Faming Zhang
Summary: Fecal microbiota transplantation (FMT) has emerged as a promising approach for dysbiosis-related diseases. Advanced methods, such as washed microbiota transplantation, bacteria spores treatment, and fecal virome transplantation, provide more acceptable options for patients and minimize research heterogeneity.
Editorial Material
Biotechnology & Applied Microbiology
Faming Zhang, Weihong Wang, Yongzhan Nie, Jingnan Li, Xingxiang He
MICROBIAL BIOTECHNOLOGY
(2023)
Review
Medicine, General & Internal
Yun Wang, Sheng Zhang, Thomas J. Borody, Faming Zhang
Summary: This review provides a comprehensive overview of the clinical applications of fecal microbiota transplantation (FMT) from 2011 to 2021. The study examines the clinical benefits, processing methodology, usage strategies, and global regulations of FMT. The findings suggest that while further controlled trials are needed, FMT shows promising potential for treating dysbiosis-related diseases in the gut or beyond.
CHINESE MEDICAL JOURNAL
(2022)
