The role of stromal fibroblasts in lung carcinogenesis: A target for chemoprevention?

Matrix metalloproteinase-9 activates TGF-β and stimulates fibroblast contraction of collagen gels

(2014) Tetsu Kobayashi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hypoxia increases membrane metallo-endopeptidase expression in a novel lung cancer ex vivo model – role of tumor stroma cells

(2014) Katharina Leithner et al.   BMC CANCER

Immunophenotypic features of metastatic lymph node tumors to predict recurrence in N2 lung squamous cell carcinoma

(2014) Rie Matsuwaki et al.   CANCER SCIENCE

A Phase I/II, Multiple-Dose, Dose-Escalation Study of Siltuximab, an Anti-Interleukin-6 Monoclonal Antibody, in Patients with Advanced Solid Tumors

(2014) E. Angevin et al.   CLINICAL CANCER RESEARCH

Antitumor Efficacy of the Anti-Interleukin-6 (IL-6) Antibody Siltuximab in Mouse Xenograft Models of Lung Cancer

(2014) Lanxi Song et al.   Journal of Thoracic Oncology

Lung Cancer–Associated Myofibroblasts Reveal Distinctive Ultrastructure and Function

(2014) Henna M. Karvonen et al.   Journal of Thoracic Oncology

The Clinical Implication of Cancer-Associated Microvasculature and Fibroblast in Advanced Colorectal Cancer Patients with Synchronous or Metachronous Metastases

(2014) Yoonjin Kwak et al.   PLoS One

Development of an Innovative 3D Cell Culture System to Study Tumour - Stroma Interactions in Non-Small Cell Lung Cancer Cells

(2014) Arno Amann et al.   PLoS One

Prognostic relevance of cancer-associated fibroblasts in human cancer

(2014) Janna Paulsson et al.   SEMINARS IN CANCER BIOLOGY

Transforming growth factor-β1 and α-smooth muscle actin in stromal fibroblasts are associated with a poor prognosis in patients with clinical stage I–IIIA nonsmall cell lung cancer after curative resection

(2014) Yongbing Chen et al.   TUMOR BIOLOGY

A paracrine network regulates the cross-talk between human lung stem cells and the stroma

(2014) E. Josue Ruiz et al.   Nature Communications

The Role of STAT3 in Non-Small Cell Lung Cancer

(2014) Daijiro Harada et al.   Cancers

Pulmonary Fibroblasts Induce Epithelial Mesenchymal Transition and Some Characteristics of Stem Cells in Non-Small Cell Lung Cancer

(2013) Yasushi Shintani et al.   ANNALS OF THORACIC SURGERY

New Perspectives of Curcumin in Cancer Prevention

(2013) W. Park et al.   Cancer Prevention Research

Forkhead box P3 regulatory T cells coexisting with cancer associated fibroblasts are correlated with a poor outcome in lung adenocarcinoma

(2013) Tomonari Kinoshita et al.   CANCER SCIENCE

Human lung fibroblasts increase CD4(+)CD25(+)Foxp3(+) T cells in co-cultured CD4(+) lymphocytes

(2013) Enrico Conte et al.   CELLULAR IMMUNOLOGY

Tetraspanin protein CD9 interacts with metalloprotease CD10 and enhances its release via exosomes

(2013) Dmitriy Mazurov et al.   FEBS Journal

Mechanisms of Action of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Mesalazine in the Chemoprevention of Colorectal Cancer

(2013) Carmine Stolfi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical implications of fibroblast activation protein-α in non-small cell lung cancer after curative resection: a new predictor for prognosis

(2013) Yida Liao et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Interaction between non-small-cell lung cancer cells and fibroblasts via enhancement of TGF-β signaling by IL-6

(2013) Abulimiti Abulaiti et al.   LUNG CANCER

Metabolic Alterations in Lung Cancer–Associated Fibroblasts Correlated with Increased Glycolytic Metabolism of the Tumor

(2013) Virendra K. Chaudhri et al.   MOLECULAR CANCER RESEARCH

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

YAP forces fibroblasts to feel the tension

(2013) Ori Maller et al.   NATURE CELL BIOLOGY

Co-Culture of Human Bronchial Fibroblasts and CD4+ T Cells Increases Th17 Cytokine Signature

(2013) Lionel Loubaki et al.   PLoS One

Carcinoma-Associated Fibroblasts Are a Promising Therapeutic Target

(2013) Shinsaku Togo et al.   Cancers

Caveolin-1 and Accelerated Host Aging in the Breast Tumor Microenvironment

(2012) Isabelle Mercier et al.   AMERICAN JOURNAL OF PATHOLOGY

Characterization of human lung cancer-associated fibroblasts in three-dimensional in vitro co-culture model

(2012) Masafumi Horie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non-Small Cell Lung Cancer In Vivo

(2012) S. Vicent et al.   CANCER RESEARCH

Prognostic Impact of Cancer-Associated Stromal Cells in Patients With Stage I Lung Adenocarcinoma

(2012) Masami Ito et al.   CHEST

Integrin α3β1 regulates tumor cell responses to stromal cells and can function to suppress prostate cancer metastatic colonization

(2012) Afshin Varzavand et al.   CLINICAL & EXPERIMENTAL METASTASIS

Paracrine Receptor Activation by Microenvironment Triggers Bypass Survival Signals and ALK Inhibitor Resistance in EML4-ALK Lung Cancer Cells

(2012) T. Yamada et al.   CLINICAL CANCER RESEARCH

EGCG blocks TGFβ1-induced CCN2 by suppressing JNK and p38 in buccal fibroblasts

(2012) Jenny Zwei-Chieng Chang et al.   Clinical Oral Investigations

Tumor–stromal interactions in lung cancer: novel candidate targets for therapeutic intervention

(2012) Nefertiti El-Nikhely et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

CD99 is a novel prognostic stromal marker in non-small cell lung cancer

(2012) Karolina Edlund et al.   INTERNATIONAL JOURNAL OF CANCER

Significance of cancer-associated fibroblasts in the regulation of gene expression in the leading cells of invasive lung cancer

(2012) Jian An et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Dasatinib reverses Cancer-associated Fibroblasts (CAFs) from primary Lung Carcinomas to a Phenotype comparable to that of normal Fibroblasts

(2012) Silke Haubeiss et al.   Molecular Cancer

Cancer-Associated Fibroblasts Drive the Progression of Metastasis through both Paracrine and Mechanical Pressure on Cancer Tissue

(2012) G. S. Karagiannis et al.   MOLECULAR CANCER RESEARCH

Cancer Chemoprevention by Carotenoids

(2012) Takuji Tanaka et al.   MOLECULES

Studying primary tumor–associated fibroblast involvement in cancer metastasis in mice

(2012) Annique M M J Duyverman et al.   Nature Protocols

Human Lung Cancer Cells Grown in an Ex Vivo 3D Lung Model Produce Matrix Metalloproteinases Not Produced in 2D Culture

(2012) Dhruva K. Mishra et al.   PLoS One

Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications

(2011) Brahma N. Singh et al.   BIOCHEMICAL PHARMACOLOGY

ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma

(2011) Victoria Sanz-Moreno et al.   CANCER CELL

Tumor Cell Invasion Is Promoted by Interstitial Flow-Induced Matrix Priming by Stromal Fibroblasts

(2011) A. C. Shieh et al.   CANCER RESEARCH

Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44

(2011) Yuejuan Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hepatocyte Growth Factor Induces Resistance to Anti-Epidermal Growth Factor Receptor Antibody in Lung Cancer

(2011) Tadaaki Yamada et al.   Journal of Thoracic Oncology

JAK1 Activates STAT3 Activity in Non-Small-Cell Lung Cancer Cells and IL-6 Neutralizing Antibodies Can Suppress JAK1-STAT3 Signaling

(2011) L. Song et al.   MOLECULAR CANCER THERAPEUTICS

Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture

(2011) Aroumougame Asaithamby et al.   NUCLEIC ACIDS RESEARCH

Metformin and neoplasia: Implications and indications

(2011) Ahmad Aljada et al.   PHARMACOLOGY & THERAPEUTICS

Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer

(2011) R. Navab et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors

(2011) B. Diop-Frimpong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of TGF-β1/SMAD pathway and extracellular matrix production in primary keloid fibroblasts by curcuminoids: its potential therapeutic use in the chemoprevention of keloid

(2010) Yi-Chiang Hsu et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Forkhead Box F1 Regulates Tumor-Promoting Properties of Cancer-Associated Fibroblasts in Lung Cancer

(2010) Roy-Akira Saito et al.   CANCER RESEARCH

Imatinib mesylate inhibits the proliferation-stimulating effect of human lung cancer-associated stromal fibroblasts on lung cancer cells

(2010) Kinoshita   INTERNATIONAL JOURNAL OF ONCOLOGY

LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells

(2010) Rebecca W. Scott et al.   JOURNAL OF CELL BIOLOGY

TFPI-2 silencing increases tumour progression and promotes metalloproteinase 1 and 3 induction through tumour-stromal cell interactions

(2010) Guillaume Gaud et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Carcinoma-associated fibroblasts promoted tumor spheroid invasion on a microfluidic 3D co-culture device

(2010) Tingjiao Liu et al.   LAB ON A CHIP

Cancer-Associated Fibroblasts Derived from EGFR-TKI-Resistant Tumors Reverse EGFR Pathway Inhibition by EGFR-TKIs

(2010) S. R. Mink et al.   MOLECULAR CANCER RESEARCH

Preclinical model of organotypic culture for pharmacodynamic profiling of human tumors

(2010) V. Vaira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic and Genic Deletions of the FOX Gene Cluster on 16q24.1 and Inactivating Mutations of FOXF1 Cause Alveolar Capillary Dysplasia and Other Malformations

(2009) Paweł Stankiewicz et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Urokinase receptor mediates lung fibroblast attachment and migration toward provisional matrix proteins through interaction with multiple integrins

(2009) Sha Zhu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Highly variable response to cytotoxic chemotherapy in carcinoma-associated fibroblasts (CAFs) from lung and breast

(2009) Maike Sonnenberg et al.   BMC CANCER

Prognostic significance of carbonic anhydrase IX expression by cancer-associated fibroblasts in lung adenocarcinoma

(2009) Masayuki Nakao et al.   CANCER

Tumor-stromal interactions with direct cell contacts enhance proliferation of human pancreatic carcinoma cells

(2009) Hayato Fujita et al.   CANCER SCIENCE

Crosstalk to Stromal Fibroblasts Induces Resistance of Lung Cancer to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors

(2009) W. Wang et al.   CLINICAL CANCER RESEARCH

Statins inhibit matrix metalloproteinase release from human lung fibroblasts

(2009) K. Kamio et al.   EUROPEAN RESPIRATORY JOURNAL

Establishment and quantitative imaging of a 3D lung organotypic model of mammary tumor outgrowth

(2008) Michelle D. Martin et al.   CLINICAL & EXPERIMENTAL METASTASIS

Combination regimen with statins and NSAIDs: A promising strategy for cancer chemoprevention

(2008) Hang Xiao et al.   INTERNATIONAL JOURNAL OF CANCER

Podoplanin expression by cancer associated fibroblasts predicts poor prognosis of lung adenocarcinoma

(2008) Akikazu Kawase et al.   INTERNATIONAL JOURNAL OF CANCER