Randomised clinical trial: arbaclofen placarbil in gastro-oesophageal reflux disease - insights into study design for transient lower sphincter relaxation inhibitors

Failure of reflux inhibitors in clinical trials:baddrugs or wrong patients?

(2012) Peter J Kahrilas et al.   GUT

Randomised clinical trial: effects of monotherapy with ADX10059, a mGluR5 inhibitor, on symptoms and reflux events in patients with gastro-oesophageal reflux disease

(2011) F. Zerbib et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Arbaclofen Placarbil in GERD: A Randomized, Double-Blind, Placebo-Controlled Study

(2011) Nimish B Vakil et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Effects of Lesogaberan on Reflux and Lower Esophageal Sphincter Function in Patients With Gastroesophageal Reflux Disease

(2010) Guy E. Boeckxstaens et al.   GASTROENTEROLOGY

Arbaclofen Placarbil Decreases Reflux With Good Tolerability in Patients With Gastroesophageal Reflux Disease (Am J Gastroenterol 2010;105:1266-1275)

(2010) Gwang Ha Kim   Journal of Neurogastroenterology and Motility

Arbaclofen Placarbil Decreases Postprandial Reflux in Patients With Gastroesophageal Reflux Disease

(2009) Lauren B Gerson et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Does the Presence of a Hiatal Hernia Affect the Efficacy of the Reflux Inhibitor Baclofen During Add-On Therapy?

(2009) Hanneke Beaumont et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease

(2009) C Keywood et al.   GUT

Arbaclofen Placarbil, a Novel R-Baclofen Prodrug: Improved Absorption, Distribution, Metabolism, and Elimination Properties Compared with R-Baclofen

(2009) R. Lal et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS