Article
Gastroenterology & Hepatology
Teruyuki Takeda, Masahiro Kishi, Noritaka Takatsu, Yasumichi Takada, Tsuyoshi Beppu, Masaki Miyaoka, Takashi Hisabe, Toshiharu Ueki, Hisatomi Arima, Fumihito Hirai, Kenshi Yao
Summary: The study investigated the long-term efficacy and safety of endoscopic balloon dilation (EBD) for intestinal strictures in patients with Crohn's disease (CD) receiving anti-tumor necrosis factor alpha antibodies (anti-TNF) as maintenance therapy. The results showed that EBD was an effective and safe treatment for CD patients with intestinal strictures, with 3- and 5-year cumulative surgery-free rates of 81.1% and 73.5%, respectively.
DIGESTIVE ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Martin Lukas, Martin Kolar, Ondrej Ryska, Stefan Juhas, Jana Juhasova, Jaroslav Kalvach, Jaroslav Pazin, Tereza Kocisova, Ondrej Foltan, Hana Kristianova, Jan Ptacnik, Ivana Vitkova, Martin Bortlik, Milan Lukas
Summary: The study created a large animal model of anastomotic stricture with Crohn's disease properties, allowing for the development of new techniques and endoscopic interventions. The model demonstrated histologically verified changes similar to CD and maintained stable diameter for over 6 months, confirming the feasibility of endoscopic therapeutic interventions.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Hironori Yamamoto, Tomonori Yano, Akihiro Araki, Motohiro Esaki, Kazuo Ohtsuka, Naoki Ohmiya, Shiro Oka, Hiroshi Nakase, Shigeki Bamba, Fumihito Hirai, Naoki Hosoe, Tomoki Matsuda, Keigo Mitsui, Kenji Watanabe, Haruhiko Ogata, Shinichi Katsuki, Takayuki Matsumoto, Mitsuhiro Fujishiro, Kazuma Fujimoto, Haruhiro Inoue
Summary: This guideline provides a summary of new scientific techniques and evidence regarding endoscopic balloon dilation for the treatment of Crohn's disease-associated small intestinal strictures.
DIGESTIVE ENDOSCOPY
(2022)
Article
Surgery
Anupam Kumar Singh, Yalaka Rami Reddy, Anuraag Jena, Sreekanth Appasani, Pankaj Gupta, Saroj Kant Sinha, Rakesh Kochhar
Summary: For the treatment of caustic esophageal strictures (CES), the use of bougie dilators was found to have higher rates of technical success, short-term clinical success, and long-term clinical success compared to balloon dilators. However, the rates of adverse events were similar between the two groups.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Microbiology
Shukai Zhan, Caiguang Liu, Jixin Meng, Ren Mao, Tong Tu, Jianming Lin, Minhu Chen, Zhirong Zeng, Xiaojun Zhuang
Summary: Intestinal stricture is a challenging complication in Crohn's disease, with poorly understood mechanisms. The gut microbiota has been implicated in the development of intestinal fibrosis. This study investigated the specific mucosa-associated microbiota associated with strictures and their role in predicting postoperative disease course.
Review
Gastroenterology & Hepatology
Bo Shen
Summary: Endoscopic therapy has become the main treatment for inflammatory bowel diseases and associated complications, such as strictures, fistulas, abscesses, bleeding lesions, and polyps. The development of interventional IBD is supported by a better understanding of the disease process, advancements in endoscopic technology, and the training of next-generation specialists.
GASTROENTEROLOGY REPORT
(2022)
Article
Medicine, General & Internal
Xin Miao, Li Liu, Xiang Wang, Zhining Fan, Lin Miao, Jiankun Wang
Summary: This study investigated the feasibility of endoscopic dilation combined with bleomycin injection for benign anastomotic stricture after rectal surgery. The results showed that compared to simple endoscopic dilation, endoscopic dilation combined with bleomycin injection may reduce the treatment times and prolong the reintervention interval. This is a safe and effective treatment method.
Article
Gastroenterology & Hepatology
Salam P. Bachour, Ravi Shah, Florian Rieder, Taha Qazi, Jean Paul Achkar, Jessica Philpott, Bret Lashner, Stefan D. Holubar, Amy L. Lightner, Edward L. Barnes, Jordan Axelrad, Miguel Regueiro, Benjamin Click, Benjamin L. Cohen
Summary: Immediate postoperative intra-abdominal septic complications (IASC) increase the risk of endoscopic and surgical recurrence in patients with Crohn's disease. Preoperative optimization to prevent IASC, along with postoperative biological prophylaxis, may help reduce the risk of endoscopic and surgical recurrence.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Gastroenterology & Hepatology
Shuji Hibiya, Kazuo Ohtsuka, Kento Takenaka, Ami Kawamoto, Yusuke Matsuyama, Yumi Udagawa, Maiko Motobayashi, Hiromichi Shimizu, Toshimitsu Fujii, Eiko Saito, Masakazu Nagahori, Ryuichi Okamoto, Mamoru Watanabe
Summary: This study aimed to investigate the impact of mucosal healing defined by the presence of ulcers at the small intestinal stricture site on the prognosis of endoscopic balloon dilation (EBD) in Crohn's disease (CD) patients. The results showed that patients with ulcers at the stricture site had a significantly higher risk for surgery than those without ulcers.
BMC GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Bing Wang, Wenzhi Gao, Kunlin Yang, Honglei Liu, Yangjun Han, Mingxin Diao, Chao Zuo, Minghua Zhang, Yingzhi Diao, Zhihua Li, Xinfei Li, Gang Wang, Peng Zhang, Chunji Wang, Chunjuan Xiao, Chen Huang, Yaming Gu, Xuesong Li
Summary: This study aimed to investigate the efficacy of balloon dilation in ureteral stricture and analyze the risk factors for its failure. A retrospective analysis of 196 patients who underwent balloon dilation was conducted, with 127 patients having complete data. The success rates of balloon dilation and balloon dilation combined with endoureterotomy for lower ureteral stricture were higher compared to other cases. Balloon circumference and multiple ureteral strictures were identified as risk factors for balloon dilation failure.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Jintao Hu, Cong Lai, Mingchao Gao, Kaiwen Li, Wang He, Dingjun Zhu, Wenlian Xie, Haihua Wu, Meijuan Xu, Jian Huang, Jinli Han
Summary: This study developed a clinical nomogram to predict stricture-free survival in patients with ureteral stricture after balloon dilation. The model showed good discrimination and calibration, with five significant predictors identified. It is helpful in identifying optimal candidates for balloon dilation and improving treatment outcomes, but external validation is still needed.
Review
Cell Biology
Giovanni Santacroce, Marco Vincenzo Lenti, Antonio Di Sabatino
Summary: Intestinal fibrosis is a threatening complication of Crohn's disease. The mechanisms underlying its development are not fully understood, and targeted therapies are currently lacking. This review provides an overview of the main therapeutic targets and the most promising anti-fibrotic therapies for intestinal fibrosis.
Article
Surgery
Yuki Kawasaki, Susumu Hijioka, Yosikuni Nagashio, Akihiro Ohba, Yuta Maruki, Kosuke Maehara, Motohiro Yoshinari, Yuya Hisada, Shota Harai, Hidetoshi Kitamura, Yumi Murashima, Takehiko Koga, Shun Kawahara, Syunsuke Kondo, Chigusa Morizane, Hideki Ueno, Jun Ushio, Kiichi Tamada, Shunsuke Sugawara, Miyuki Sone, Takeshi Takamoto, Satoshi Nara, Daisuke Ban, Minoru Esaki, Yasuaki Arai, Kazuaki Shimada, Yutaka Saito, Takuji Okusaka
Summary: This study assessed the efficacy and safety of a new saddle-cross technique using two fully covered self-expandable metallic stents for the treatment of hepaticojejunostomy anastomotic strictures. The results showed promising long-term stricture resolution with a high technical success rate, although there were some procedure-related adverse events.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Surgery
Jiankun Wang, Lili Zhao, Rui Wu, Min Wang, Li Liu, Xiang Wang, Wenjie Liu, Kexin He, Lin Miao, Zhining Fan
Summary: Benign esophageal strictures are common complications after esophageal surgery or extensive endoscopic submucosal dissection. This study retrospectively analyzed patients with such strictures and found that a 3-minute duration for endoscopic dilation was considered safe and effective for treatment.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Sara El Ouali, Mark E. Baker, Ruishen Lyu, Joel G. Fletcher, David H. Bruining, Stefan D. Holubar, Benjamin Click, Taha Qazi, Benjamin L. Cohen, Florian Rieder
Summary: This study aimed to describe the rates and risk factors of symptoms or need for intervention in patients with stricturing Crohn's disease. The results showed that obstructive symptoms, stricture duration, and length were independent predictors of the need for intervention.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Anders Forss, Mark Clements, Par Myrelid, Hans Strid, Charlotte Soderman, Agnieszka Wagner, David Andersson, Fredrik Hjelm, Ola Olen, Jonas Halfvarson, Jonas F. Ludvigsson
Summary: This study demonstrates the long-term clinical effectiveness of ustekinumab in patients with active Crohn's disease, as well as its improvement in Health-related Quality of Life (HRQoL) measures.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Johanna Holmgren, Anna Froborg, Isabella Visuri, Jonas Halfvarson, Henrik Hjortswang, Pontus Karling, Par Myrelid, Ola Olen, Jonas F. Ludvigsson, Olof Grip
Summary: In patients with inflammatory bowel disease, the incidence rate of serious infection did not increase with the use of anti-TNF therapy and actually decreased more than 1 year after treatment initiation.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Laurent Peyrin-Biroulet, Jean-Francois Rahier, Julien Kirchgesner, Vered Abitbol, Sebastian Shaji, Alessandro Armuzzi, Konstantinos Karmiris, Javier P. Gisbert, Peter Bossuyt, Ulf Helwig, Johan Burisch, Henit Yanai, Glen A. Doherty, Fernando Magro, Tamas Molnar, Mark Lowenberg, Jonas Halfvarson, Edyta Zagorowicz, Helene Rousseau, Cedric Baumann, Filip Baert, Laurent Beaugerie
Summary: The I-CARE study aims to evaluate the benefit-risk ratio of current therapies in IBD patients. It collected data from 10,206 patients and observed the treatment risks of anti-tumor necrosis factor and other biologic therapies, particularly the risks of cancer/lymphoma and serious infections. The results showed that different treatment regimens had varying effects on patients, and further research is needed to assess specific risks.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jie Chen, Yajing Zhou, Yuhao Sun, Shuai Yuan, Rahul Kalla, Jing Sun, Jianhui Zhao, Lijuan Wang, Xuejie Chen, Xuan Zhou, Siqi Dai, Yu Zhang, Gwo-tzer Ho, Dajing Xia, Qian Cao, Zhanju Liu, Susanna C. Larsson, Xiaoyan Wang, Kefeng Ding, Jonas Halfvarson, Xue Li, Evropi Theodoratou, Jack Satsangi
Summary: This study identified 14 proteins associated with the risk of ulcerative colitis (UC) through the analysis of serum proteomic profiling data. Further analysis using Mendelian randomisation confirmed the causal relationship between two chemokines and the increased risk of UC. Additionally, a new protein associated with UC risk was identified. Reverse Mendelian randomisation analysis did not find any influence of genetic predisposition to UC on these three inflammation proteins.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Obstetrics & Gynecology
K. Hilden, A. Magnuson, S. Montgomery, E. Schwarcz, U. Hanson, D. Simmons, H. Backman
Summary: This study investigates the associations between pre-eclampsia, gestational diabetes mellitus (GDM), and cardiovascular disease (CVD). The results show that both pre-eclampsia and GDM are independent risk factors for later CVD. The association between pre-eclampsia and CVD is not modified by body mass index (BMI). Effective CVD preventive programs for high-risk women are urgently needed.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Medicine, General & Internal
Jiangwei Sun, Fang Fang, Ola Olen, Mingyang F. Song, Jonas Halfvarson, Bjorn Roelstraete, Hamed Khalili, Jonas Ludvigsson
Summary: In this study, individuals who underwent endoscopic biopsy with normal mucosa were followed up for a median of 10 years. The study found that these individuals had an elevated risk of inflammatory bowel disease (IBD) for at least 30 years. These findings imply the presence of a substantial symptomatic period before the diagnosis of IBD and emphasize the importance of considering the long-term risk of IBD in patients with symptoms but normal mucosa on gastrointestinal investigation.
Article
Gastroenterology & Hepatology
Aiva Lundberg Bave, Ola Olen, Jonas Soederling, Jonas F. Ludvigsson, Annika Bergquist, Caroline Nordenvall
Summary: Colectomy in UC patients was not associated with a decreased risk of subsequent PSC. The observed differences in the risk of PSC development over calendar periods are likely due to changes in PSC-diagnosis and UC-treatment.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Jamie M. Horrigan, Edouard Louis, Antonino Spinelli, Simon Travis, Bjorn Moum, Jessica Salwen-Deremer, Jonas Halfvarson, Remo Panaccione, Marla C. Dubinsky, Pia Munkholm, Corey A. Siegel
Summary: This study investigated the global use and barriers to using patient-reported outcomes (PROs) in clinical practice for inflammatory bowel disease (IBD). The majority of healthcare providers use PROs in clinical practice, but there are variations in which PROs are used and how they influence management. Barriers to using PROs include lack of familiarity, integration issues, and time constraints. Education about PROs and the use of an accepted set of PROs can help overcome these barriers and achieve global harmonization.
CROHNS & COLITIS 360
(2023)
Article
Gastroenterology & Hepatology
Joel Thunberg, Olle Granno, Daniel Bergemalm, Carl Eriksson, Isabella Visuri, Michael Eberhardson, Jonas Halfvarson
Summary: This study examined the agreement between a point-of-care test (POCT) by ProciseDx and the in-house enzyme-linked immunosorbent assay (ELISA) for infliximab (IFX) quantification. The results showed good agreement between the two methods, supporting the use of ProciseDx's POCT for rapid IFX quantification.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
Jiangwei Sun, Bjorn Roelstraete, Emma Svennberg, Jonas Halfvarson, Johan Sundstrom, Anders Forss, Ola Olen, Jonas F. Ludvigsson
Summary: This study found that patients with inflammatory bowel disease (IBD) have an increased risk of developing arrhythmias. This increased risk persists even 25 years after the diagnosis of IBD.
Article
Medicine, General & Internal
Ferdinando D'Amico, Virginia Solitano, Fernando Magro, Pablo A. Olivera, Jonas Halfvarson, David Rubin, Axel Dignass, Sameer Al Awadhi, Taku Kobayashi, Natalia Sousa Freitas Queiroz, Marta Calvo, Paulo Gustavo Kotze, Subrata Ghosh, Laurent Peyrin-Biroulet, Silvio Danese
Summary: As the patents for biologic originator drugs expire, biosimilars are emerging as cost-effective alternatives within healthcare systems. A global survey was conducted to shed light on physicians' knowledge, beliefs, practical approaches, and concerns related to biosimilar adoption. Based on the survey results, a consensus was reached on key statements covering biosimilar effectiveness, safety, indications, rationale, multiple switches, therapeutic drug monitoring, non-medical switching, and future perspectives. The consensus affirmed that biosimilars are equally effective and safe compared to originator drugs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Isabella Visuri, Carl Eriksson, Sara Karlqvist, Byron Lykiardopoulos, Per Karlen, Olof Grip, Charlotte Soderman, Sven Almer, Erik Hertervig, Jan Marsal, Carolina Malmgren, Jenny Delin, Hans Strid, Mats Sjoberg, Daniel Bergemalm, Henrik Hjortswang, Jonas Halfvarson
Summary: This study assessed the long-term outcomes of vedolizumab in treating inflammatory bowel disease. The results showed that vedolizumab had high continuation rates and was associated with improvements in clinical outcomes, health-related quality of life measures, and inflammatory markers at 2 and 3 years after treatment initiation.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Archana Shubhakar, Bas C. Jansen, Alex T. Adams, Karli R. Reiding, Nicholas T. Ventham, Rahul Kalla, Daniel Bergemalm, Paulina A. Urbanowicz, Richard A. Gardner, Manfred IBD BIOM Consortium, Manfred Wuhrer, Jonas Halfvarson, Jack Satsangi, Daryl L. Fernandes, Daniel I. R. Spencer
Summary: This study investigated a composite serum N-glycomic biomarker to predict future disease course in newly diagnosed IBD patients. The biomarker showed a predictive capacity for treatment escalation in both the discovery and replication cohorts of patients.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Public, Environmental & Occupational Health
Sall Olof, Eriksson Lorraine, A. Idosa Berhane, Persson Alexander, Magnuson Anders, Thulin Hedberg Sara, Sundqvist Martin, Olcen Per, Fredlund Hans, Stenmark Bianca, Sarndahl Eva, Molling Paula, Jacobsson Susanne
Summary: The aim of this study was to examine the prevalence, risk factors, distribution of meningococcal lineages, and persistence of N. meningitidis carriage among university students in Sweden. The carriage rate was 9.1%, with factors such as younger age, previous tonsillectomy, smoking, alcohol consumption, and attending parties, pubs, and clubs associated with higher carriage. Female gender and sharing a household with young children were associated with lower carriage. Further studies with longer follow-up times are recommended to investigate long-term carriage of N. meningitidis.
EPIDEMIOLOGY AND INFECTION
(2023)
Article
Gastroenterology & Hepatology
Amiko M. Uchida, John J. Garber, Ashley Pyne, Kathryn Peterson, Bjorn Roelstraete, Ola Olen, Jonas Halfvarson, Jonas F. Ludvigsson
Summary: In this nationwide cohort study, EoE was found to be associated with a 3.5-fold increased risk of later IBD diagnosis, possibly due to genetic or early environmental risk factors.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)