Review article: the benefits of pharmacogenetics for improving thiopurine therapy in inflammatory bowel disease

Assessment of Thiopurine S-Methyltransferase Activity in Patients Prescribed Thiopurines: A Systematic Review

(2013) Ronald A. Booth et al.   ANNALS OF INTERNAL MEDICINE

Thiopurine methyl-transferase activity and azathioprine metabolite concentrations do not predict clinical outcome in thiopurine-treated inflammatory bowel disease patients

(2011) Y. González-Lama et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Limitations of extensive TPMT genotyping in the management of azathioprine-induced myelosuppression in IBD patients

(2011) O. Dewit et al.   CLINICAL BIOCHEMISTRY

Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing

(2011) M V Relling et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Use of thiopurine testing in the management of inflammatory bowel diseases in clinical practice: A worldwide survey of experts

(2011) Xavier Roblin et al.   INFLAMMATORY BOWEL DISEASES

Low-dose azathioprine or mercaptopurine in combination with allopurinol can bypass many adverse drug reactions in patients with inflammatory bowel disease

(2010) A. ANSARI et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Influence of 5-aminosalicylic acid on 6-thioguanosine phosphate metabolite levels: a prospective study in patients under steady thiopurine therapy

(2010) P de Graaf et al.   BRITISH JOURNAL OF PHARMACOLOGY

Differences among allelic variants of human glutathione transferase A2-2 in the activation of azathioprine

(2010) Wei Zhang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Thiopurine metabolism monitoring: implications in inflammatory bowel diseases

(2010) Olivier Dewit et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Thiopurines in Crohn's disease, is there something new?

(2010) Pal Miheller et al.   Expert Opinion on Drug Metabolism & Toxicology

Azathioprine versus mesalazine for prevention of postoperative clinical recurrence in patients with Crohn's disease with endoscopic recurrence: efficacy and safety results of a randomised, double-blind, double-dummy, multicentre trial

(2010) W. Reinisch et al.   GUT

Thiopurine therapy in inflammatory bowel disease patients: Analyses of two 8-year intercept cohorts

(2010) B. Jharap et al.   INFLAMMATORY BOWEL DISEASES

Thiopurine maintenance therapy for ulcerative colitis

(2010) Hiroyuki Hanai et al.   INFLAMMATORY BOWEL DISEASES

Incidence of nodular regenerative hyperplasia in inflammatory bowel disease patients treated with azathioprine

(2010) Philippe Seksik et al.   INFLAMMATORY BOWEL DISEASES

Steady-state of azathioprine during initiation treatment of pediatric inflammatory bowel disease

(2010) O. Pozler et al.   Journal of Crohns & Colitis

The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease

(2010) Hiromistu Ban et al.   JOURNAL OF GASTROENTEROLOGY

Azathioprine and allopurinol: A two-edged interaction

(2010) Richard B Gearry et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Infliximab, Azathioprine, or Combination Therapy for Crohn's Disease

(2010) Jean Frédéric Colombel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Very important pharmacogene summary: thiopurine S-methyltransferase

(2010) Liewei Wang et al.   Pharmacogenetics and Genomics

Characterization of a novel sequence variant, TPMT*28, in the human thiopurine methyltransferase gene

(2010) Malin Lindqvist Appell et al.   Pharmacogenetics and Genomics

Are patients with intermediate TPMT activity at increased risk of myelosuppression when taking thiopurine medications?

(2010) Jenny E Higgs et al.   PHARMACOGENOMICS

Novel pharmacogenetic markers for treatment outcome in azathioprine-treated inflammatory bowel disease

(2009) M. A. SMITH et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Mercaptopurine rescue after azathioprine-induced liver injury in inflammatory bowel disease

(2009) F. BERMEJO et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Azathioprine and 6-Mercaptopurine for the Prevention of Postoperative Recurrence in Crohn's Disease: A Meta-Analysis

(2009) Laurent Peyrin-Biroulet et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

TPMT*26 (208F→L), a novel mutation detected in a Chinese

(2009) Shirley Kow Yin Kham et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

MTHFR and TYMS genotypes influence TPMT activity and its differential modulation in males and females

(2009) Natasa Karas-Kuzelicki et al.   CLINICAL BIOCHEMISTRY

TPMT but not ITPA gene polymorphism influences the risk of azathioprine intolerance in renal transplant recipients

(2009) Mateusz Kurzawski et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Thiopurine-methyltransferase and inosine triphosphate pyrophosphatase polymorphism in a liver transplant recipient developing nodular regenerative hyperplasia on low-dose azathioprine

(2009) Erik H.C.J. Buster et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Genetic polymorphism of inosine-triphosphate-pyrophosphatase influences mercaptopurine metabolism and toxicity during treatment of acute lymphoblastic leukemia individualized for thiopurine-S-methyl-transferase status

(2009) Gabriele Stocco et al.   Expert Opinion On Drug Safety

Endpoints for clinical trials evaluating disease modification and structural damage in adults with Crohnʼs disease

(2009) Geert R. DʼHaens et al.   INFLAMMATORY BOWEL DISEASES

Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study

(2009) Laurent Beaugerie et al.   LANCET

Influence of xanthine oxidase on thiopurine metabolism in Crohn’s disease

(2008) A. ANSARI et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Long-term outcome of using allopurinol co-therapy as a strategy for overcoming thiopurine hepatotoxicity in treating inflammatory bowel disease

(2008) A. ANSARI et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease

(2008) A. ANSARI et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Mercaptopurine treatment should be considered in azathioprine intolerant patients with inflammatory bowel disease

(2008) U. HINDORF et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Systematic review: does concurrent therapy with 5-ASA and immunomodulators in inflammatory bowel disease improve outcomes?

(2008) J. M. ANDREWS et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

A 6-Thioguanine Nucleotide Threshold Level of 400 pmol/8 × 108Erythrocytes Predicts Azathioprine Refractoriness in Patients With Inflammatory Bowel Disease and Normal TPMT Activity

(2008) Xavier Roblin et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Thiopurine-Induced Myelotoxicity in Patients With Inflammatory Bowel Disease: A Review

(2008) Javier P. Gisbert et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Glutathione transferase activity with a novel substrate mimics the activation of the prodrug azathioprine

(2008) Sanela Kurtovic et al.   ANALYTICAL BIOCHEMISTRY

Characterisation of novel defective thiopurine S-methyltransferase allelic variants

(2008) A. Garat et al.   BIOCHEMICAL PHARMACOLOGY

Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine

(2008) Ahmed F. Hawwa et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Transporter-Mediated Protection against Thiopurine-Induced Hematopoietic Toxicity

(2008) P. Krishnamurthy et al.   CANCER RESEARCH

Highly Multiplexed Genotyping of Thiopurine S-Methyltransferase Variants Using MALDI-TOF Mass Spectrometry: Reliable Genotyping in Different Ethnic Groups

(2008) E. Schaeffeler et al.   CLINICAL CHEMISTRY

Azathioprine Withdrawal in Patients With Crohn's Disease Maintained on Prolonged Remission: A High Risk of Relapse

(2008) Xavier Treton et al.   Clinical Gastroenterology and Hepatology

The Critical Path of Warfarin Dosing: Finding an Optimal Dosing Strategy Using Pharmacogenetics

(2008) LJ Lesko   CLINICAL PHARMACOLOGY & THERAPEUTICS

Genetic Polymorphism of Inosine Triphosphate Pyrophosphatase Is a Determinant of Mercaptopurine Metabolism and Toxicity During Treatment for Acute Lymphoblastic Leukemia

(2008) G Stocco et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Thiopurine methyltransferase activity combined with 6-thioguanine metabolite levels predicts clinical response to thiopurines in patients with inflammatory bowel disease

(2008) L.Y. Kwan et al.   DIGESTIVE AND LIVER DISEASE

Clinical pharmacology and pharmacogenetics of thiopurines

(2008) Srikumar Sahasranaman et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Thiopurine hepatotoxicity in inflammatory bowel disease: the role for adding allopurinol

(2008) Rupert WL Leong et al.   Expert Opinion On Drug Safety

6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4

(2008) Daniel Janke et al.   HUMAN MUTATION

Initial clinical experience with allopurinol-thiopurine combination therapy in pediatric inflammatory bowel disease

(2008) Riad M. Rahhal et al.   INFLAMMATORY BOWEL DISEASES

Monitoring 6-thioguanine nucleotide concentrations in Japanese patients with inflammatory bowel disease

(2008) Akira Andoh et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Functional characterization of human xanthine oxidase allelic variants

(2008) Mutsumi Kudo et al.   Pharmacogenetics and Genomics

Functional characterization of 23 allelic variants of thiopurine S-methyltransferase gene (TPMT*2 – *24)

(2008) Shuta Ujiie et al.   Pharmacogenetics and Genomics

Trinucleotide repeat variants in the promoter of the thiopurine S-methyltransferase gene of patients exhibiting ultra-high enzyme activity

(2008) Rebecca L. Roberts et al.   Pharmacogenetics and Genomics

Ethnic variation of thiopurine S-methyltransferase activity: a large, prospective population study

(2008) Sheldon C Cooper et al.   PHARMACOGENOMICS

Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine

(2007) Xing-Xiang Peng et al.   LEUKEMIA RESEARCH