Genetic polymorphism of inosine-triphosphate-pyrophosphatase influences mercaptopurine metabolism and toxicity during treatment of acute lymphoblastic leukemia individualized for thiopurine-S-methyl-transferase status

Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia

(2009) M. Ansari et al.   BLOOD

Thiopurine methyltransferase genetics is not a major risk factor for secondary malignant neoplasms after treatment of childhood acute lymphoblastic leukemia on Berlin-Frankfurt-Munster protocols

(2009) M. Stanulla et al.   BLOOD

Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study

(2009) K. Schmiegelow et al.   BLOOD

The Increasing Complexity of Mercaptopurine Pharmacogenomics

(2009) S Marsh et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pro32Thr Polymorphism of Inosine Triphosphate Pyrophosphatase Gene Predicts Efficacy of Low-Dose Azathioprine for Patients With Systemic Lupus Erythematosus

(2009) Y Okada et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Improving pharmacovigilance in Europe: TPMT genotyping and phenotyping in the UK and Spain

(2009) David Gurwitz et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Genome-wide Interrogation of Germline Genetic Variation Associated With Treatment Response in Childhood Acute Lymphoblastic Leukemia

(2009) Jun J. Yang   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Association Between CYP2D6 Polymorphisms and Outcomes Among Women With Early Stage Breast Cancer Treated With Tamoxifen

(2009) Werner Schroth   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment

(2009) Kan Uchiyama et al.   JOURNAL OF GASTROENTEROLOGY

Functional Study of the P32T ITPA Variant Associated with Drug Sensitivity in Humans

(2009) Elena I. Stepchenkova et al.   JOURNAL OF MOLECULAR BIOLOGY

Genomewide Association Studies and Human Disease

(2009) John Hardy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treating Childhood Acute Lymphoblastic Leukemia without Cranial Irradiation

(2009) Ching-Hon Pui et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-wide association studies: powerful tools for improving drug safety and efficacy

(2009) David Gurwitz et al.   PHARMACOGENOMICS

Characterization of the Inosine Triphosphatase (ITPA) Gene: Haplotype Structure, Haplotype-Phenotype Correlation and Promoter Function

(2009) Nicolas von Ahsen et al.   THERAPEUTIC DRUG MONITORING

Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease

(2008) A. ANSARI et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Pharmacogenetics of minimal residual disease response in children with B-precursor acute lymphoblastic leukemia: a report from the Children's Oncology Group

(2008) S. M. Davies et al.   BLOOD

Transporter-Mediated Protection against Thiopurine-Induced Hematopoietic Toxicity

(2008) P. Krishnamurthy et al.   CANCER RESEARCH

Genetic Polymorphism of Inosine Triphosphate Pyrophosphatase Is a Determinant of Mercaptopurine Metabolism and Toxicity During Treatment for Acute Lymphoblastic Leukemia

(2008) G Stocco et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Acute lymphoblastic leukaemia

(2008) Ching-Hon Pui et al.   LANCET

Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study

(2008) K Schmiegelow et al.   LEUKEMIA

Genetic Determinants of Response to Warfarin during Initial Anticoagulation

(2008) Ute I. Schwarz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia

(2008) Landry K. Kamdem et al.   Pharmacogenetics and Genomics

Pharmacogenetics in Acute Lymphoblastic Leukemia

(2008) Meyling H. Cheok et al.   SEMINARS IN HEMATOLOGY

Genetic Analysis of Human Traits In Vitro: Drug Response and Gene Expression in Lymphoblastoid Cell Lines

(2008) Edwin Choy et al.   PLoS Genetics