Article
Oncology
Ivonne Nel, Erik W. Morawetz, Dimitrij Tschodu, Josef A. Kas, Bahriye Aktas
Summary: This study focused on the mechanical characterization of circulating non-hematopoietic cells from breast cancer patients to evaluate its utility for CTC detection. Results showed that CTCs have significantly different mechanical fingerprints compared to healthy white blood cells, and the mechanical fingerprint may be an appropriate tool for marker-free CTC detection.
Review
Oncology
Tao Jin, Yao Chen, Qing-Yan Chen, Yang Xiong, Ji-Qiao Yang
Summary: A meta-analysis confirmed that circulating tumor cells (CTCs) were an important component of noninvasive methods for diagnosing breast cancer, with a high sensitivity (0.69), specificity (0.93), and area under the curve (0.81).
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ines Martinez-Pena, Pablo Hurtado, Nuria Carmona-Ule, Carmen Abuin, Ana Belen Davila-Ibanez, Laura Sanchez, Miguel Abal, Anas Chaachou, Javier Hernandez-Losa, Santiago Ramon Y. Cajal, Rafael Lopez-Lopez, Roberto Pineiro
Summary: The study using zebrafish embryo as a model system revealed the metastatic competency and molecular mechanisms of breast cancer CTCs and CTC-clusters. While CTC-clusters showed lower dissemination and invasion abilities, they demonstrated enhanced survival and proliferation capacities, along with increased resistance to fluid shear stress. These findings were confirmed in mouse studies, emphasizing the importance of understanding the biology of CTCs and CTC-clusters in metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Ying Xu, Xue Ren, Tong Jiang, Shuang Lv, Kuanke Gao, Yunen Liu, Ying Yan
Summary: This study showed a high rate of positive CTC detection in patients with lung cancer, and the number, subtype, and hTERT-positive expression of CTCs were closely related to patients' overall response rate, progression-free survival, and overall survival with radiotherapy. EMCTCs and hTERT-positive expression of CTCs are expected to be important biological indicators for predicting radiotherapy efficacy and the prognosis in patients with lung cancer. These results may be useful in improving disease stratification for future clinical trials and may help in clinical decision-making.
Review
Biochemistry & Molecular Biology
Justyna Topa, Peter Gresner, Anna J. Zaczek, Aleksandra Markiewicz
Summary: Circulating tumor cells (CTCs) are mediators of solid tumor dissemination and serve as early indicators of disease progression. This article provides a comprehensive review of the clinical significance of mesenchymal CTCs in breast cancer (BC) and analyzes various methods and markers used for CTC isolation. The results suggest that mesenchymal CTCs can be more efficiently captured using methods not solely based on epithelial enrichment.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Plant Sciences
Zu-Jun Que, Yun Yang, Hai-Tao Liu, Wen-Ji Shang-Guan, Pan Yu, Li-Hua Zhu, He-Gen Li, Huai-Min Liu, Jian-Hui Tian
Summary: The study aimed to investigate the anti-metastatic mechanism of Jinfukang in lung cancer by intervening in circulating tumor cells (CTCs). Results showed that Jinfukang inhibited the proliferation, migration, and invasion of CTCs, as well as inducing anoikis through suppression of the integrin/Src pathway. This suggests that Jinfukang may exert its anti-metastatic effects in lung cancer through anoikis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Oncology
Kai Luo, Xiangkun Wang, Xudong Zhang, Zhongyuan Liu, Shuai Huang, Renfeng Li
Summary: In the past few decades, there have been developments in tumor diagnosis and treatment theory. However, pancreatic cancer mortality is increasing while the mortality rate of other common tumors is decreasing. Traditional imaging methods and biomarkers lack sensitivity and specificity for early micrometastasis detection. Circulating tumor cells (CTCs) have emerged as a non-invasive and real-time liquid biopsy technique with potential for analyzing tumor characteristics and serving as an independent prognostic factor.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yang Li, Zhenxing Wang, Rao Fu, Shuang Wang, Tingting Zhang, Xudong Tian, Dawei Yang
Summary: Detection of CTCs using NE-FISH could be helpful in the diagnosis of EC. The proportion of CTCs with chromosome 7 triploidy was related to distant metastasis and TNM stage. Patients with CTCs ≥ 3 had short OS, while distant metastasis was an independent factor indicating a poor prognosis for patients with EC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biophysics
Syed Harris Hussain, Cesar S. Huertas, Arnan Mitchell, Anne-Laure Deman, Emmanuelle Laurenceau
Summary: Analysis of circulating tumor cells (CTCs) and their associated biomarkers can provide valuable information for lung and prostate cancer, aiding in early detection and personalized treatment selection. Biosensors offer an elegant alternative to conventional methods for real-time, multiplexed analysis of cancer biomarkers at lower concentrations.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Oncology
Yuanrui Liu, Rong Zhao, Zaichun Xie, Zhiyu Pang, Shengjie Chen, Qian Xu, Zhanfeng Zhang
Summary: In this study, circulating tumor cells (CTCs) were detected in the peripheral blood of tumor patients, and their numbers and subtypes were found to be related to different tumor diseases and stages. CTCs with mesenchymal phenotypes were closely associated with lymph node or vascular metastasis. CTC detection can aid in early diagnosis of tumor diseases and monitoring of disease progression.
Article
Spectroscopy
Baoping Zhang, Zhanqin Zhang, Bingran Gao, Furong Zhang, Lu Tian, Haishan Zeng, Shuang Wang
Summary: This study conducted a spectral histopathological analysis to connect Raman micro spectroscopy with the breast cancer TNM system. By evaluating the spectral variations and establishing a GDA pathological diagnostic model, the study successfully discriminated different TNM stages and grades of breast cancer. Micro-Raman images were reconstructed using K-means clustering analysis, allowing for visualization of structural differences between healthy tissue and breast cancer tissue. Univariate imaging techniques were used to describe the distribution differences of biochemical components in the scanned regions.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Biochemistry & Molecular Biology
Julianne D. Twomey, Baolin Zhang
Summary: Circulating tumor cells (CTCs) are the source of metastasis and can be used as a liquid biopsy for monitoring cancer progression and treatment response. However, accurately detecting CTCs has been challenging due to their low frequency and heterogeneity. In this study, an in vitro model of CTCs was developed using non-adherent suspension culture to study breast cancer cell lines of different molecular subtypes. It was found that detached breast cancer cells accumulated cancer stem cells (CSCs) expressing stem cell markers and exhibiting high expressions of hypoxia-inducible gene products, especially CAIX. Inhibiting CAIX activity reduced CAIX expression and stem cell phenotypes in the targeted CTCs.
Review
Medicine, Research & Experimental
Fatemeh Farshchi, Mohammad Hasanzadeh
Summary: This review provides an overview of the current state of microfluidic biosensors for screening CTCs and briefly discusses the future outlook for the development of microfluidics biosensing.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Medicine, Research & Experimental
Qian Deng, Bo Jiang, Haijiao Yan, Jun Wu, Zhenzhen Cao
Summary: Circulating tumor cells (CTCs) are shed from primary tumor or metastatic sites into the bloodstream and subsequently seed into distant tissues, serving as precursors of metastases. Gastric cancer (GC) is highly heterogeneous, making secondary pathological biopsy difficult and invasive examination harmful. In recent years, CTCs have shown great potential for tumor diagnosis, prognosis prediction, efficacy detection, and treatment guidance, although their role in GC remains limited. This review focuses on landmark studies demonstrating the technical approaches of CTCs monitoring in GC and highlights the clinical application of CTCs numbers and phenotypes in monitoring therapeutic efficacy and predicting patient prognosis through sequential blood analyses.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Jozsef Petrik, Donatella Verbanac, Marija Fabijanec, Andrea Hulina-Tomaskovic, Andrea Ceri, Anita Somborac-Bacura, Roberta Petlevski, Marija Grdic Rajkovic, Lada Rumora, Bozo Kruslin, Mario Stefanovic, Neven Ljubicic, Neven Barsic, Antonija Hanzek, Luka Bockor, Ivana Celap, Alma Demirovic, Karmela Barisic
Summary: This review provides an overview of the research conducted on circulating tumor cells (CTCs) with the aim of finding suitable detection systems and assessing the possibility of clinical applications in patients with colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)