Review
Chemistry, Analytical
Zhi-Fang Sun, Yong Chang, Ning Xia
Summary: This review summarizes the recent development of nanomaterials-based optical and electrochemical analytical techniques for CTCs detection, aiming at amplifying the signal and enhancing the sensitivity.
Review
Engineering, Biomedical
Fariborz Sharifianjazi, Azadeh Jafari Rad, Ameneh Bakhtiari, Firoozeh Niazvand, Amirhossein Esmaeilkhanian, Leila Bazli, Milad Abniki, Mohammad Irani, Amirhossein Moghanian
Summary: Cancer, the second leading cause of death globally, is on the rise. Early detection using nanomaterial-based nanobiosensors can effectively enhance treatment outcomes. This review highlights the latest advancements in using nanoparticles for the detection of cancer biomarkers.
BIOMEDICAL MATERIALS
(2022)
Review
Oncology
Eshwari Dathathri, Khrystany T. Isebia, Fikri Abali, Martijn P. Lolkema, John W. M. Martens, Leon W. M. M. Terstappen, Ruchi Bansal
Summary: Prostate cancer is a common male malignancy with diverse clinical presentations and challenging treatment options. Liquid biopsy provides opportunities for early diagnosis and personalized treatments.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Wojciech A. Cieslikowski, Andrzej Antczak, Michal Nowicki, Maciej Zabel, Joanna Budna-Tukan
Summary: CTC enumeration shows promise in the management of prostate cancer, particularly in monitoring treatment outcomes. However, most data come from randomized studies of anticancer agents and may not directly translate into clinical practice. Further research is needed to understand the role of CTC in early-stage prostate cancer.
Article
Biochemistry & Molecular Biology
Young Hoon Choi, Tae Ho Hong, Seung Bae Yoon, In Seok Lee, Myung Ah Lee, Ho Joong Choi, Moon Hyung Choi, Eun Sun Jung
Summary: Portal venous circulating tumor cells (CTCs) can serve as a biomarker for early recurrence and poor prognosis in patients with resectable pancreatic cancer. The number of CTCs is associated with stage and regional lymph node metastasis, and low portal venous CTCs are associated with better overall and recurrence-free survival.
Review
Biochemistry & Molecular Biology
Wojciech Jelski, Barbara Mroczko
Summary: Gastric cancer is a highly malignant tumor with poor prognosis, and early diagnosis and effective monitoring are crucial for reducing disease burden and mortality. Blood-based biomarker assays have the potential for early-stage detection of gastric cancer. However, the currently used tumor marker assays have limitations in sensitivity and specificity. In recent years, multiple markers have been identified and tested for their clinical relevance in gastric cancer management. This review summarizes the available literature on various blood-based biomarkers and discusses their potential for early diagnosis and accurate prediction of therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Vera Mugoni, Yari Ciani, Caterina Nardella, Francesca Demichelis
Summary: The identification of prostate cancer biomarkers in patients' blood and urine can significantly improve PCa diagnosis and monitoring. Using EV-RNAs as biomarkers in PCa shows great potential, but faces challenges of EV heterogeneity and complexity.
Article
Oncology
Rebeca Lozano, David Lorente, Isabel M. Aragon, Nuria Romero-Laorden, Paz Nombela, Joaquim Mateo, Alison H. M. Reid, Ylenia Cendon, Diletta Bianchini, Casilda Llacer, Shahneen K. Sandhu, Adam Sharp, Pasquale Rescigno, Teresa Garces, Maria I. Pacheco, Penelope Flohr, Christophe Massard, Pedro P. Lopez-Casas, Elena Castro, Johann S. de Bono, David Olmos
Summary: CTC enumeration and changes following treatment have shown superiority over PSA response in determining the outcome of mCRPC patients receiving AR signaling inhibitors but not taxanes. Early changes in CTCs were found to be better predictors of overall survival in mCRPC patients treated with docetaxel compared to PSA response endpoints.
Article
Oncology
Brian S. Henick, Franz Villarroel-Espindola, Ila Datar, Miguel F. Sanmamed, Jovian Yu, Shruti Desai, Alice Li, Adam Aguirre-Ducler, Konstantinos Syrigos, David L. Rimm, Lieping Chen, Roy S. Herbst, Kurt A. Schalper
Summary: QIF was used to measure the distribution and clinical significance of major myeloid cell subsets in human NSCLC. M1-like macrophages were lower and MDSC-like cells were higher in tumor tissues. Stromal CD11b was higher in SCC than in ADC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biotechnology & Applied Microbiology
Zheng Chen, Jue Wang, Yangbai Lu, Caiyong Lai, Lijun Qu, Yumin Zhuo
Summary: This study found that Ezrin expression is significantly upregulated in PCa tissues and cells, and promotes the migration and invasion abilities of PCa cells. Clinical data revealed that Ezrin expression in CTCs is associated with the metastatic degree of PCa. Therefore, Ezrin expression in CTCs may have potential roles in the prognosis and management of PCa.
Review
Genetics & Heredity
Mingchao Hu, Zhili Wang, Zeen Wu, Pi Ding, Renjun Pei, Qiang Wang, Chungen Xing
Summary: Colorectal cancer is a leading cause of cancer-related morbidity and mortality globally. Circulating tumor cells (CTCs) have the potential to play a significant role in the early diagnosis, prognosis, and treatment response prediction of CRC. Efficient CTC isolation platforms have been developed for capturing and identifying CTCs.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Oncology
Biagio Ricciuti, Greg Jones, Mariano Severgnini, Joao Alessi, Gonzalo Recondo, Marissa Lawrence, Tim Forshew, Christine Lydon, Mizuki Nishino, Michael Cheng, Mark Awad
Summary: In patients with advanced NSCLC, changes in ctDNA levels after pembrolizumab treatment may predict treatment response before radiological assessment. Early decreases in ctDNA corresponded with clinical benefit, suggesting a potential role for ctDNA as an early pharmacodynamic biomarker of response or resistance to immunotherapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Levi Groen, Iris Kloots, David Englert, Kelly Seto, Lana Estafanos, Paul Smith, Gerald W. Verhaegh, Niven Mehra, Jack A. Schalken
Summary: The clinical utility of circulating tumor cells (CTC) as a non-invasive multipurpose biomarker is well recognized. The earliest methods for enriching CTCs relied on antibody-based positive selection, but it has limitations in capturing the heterogeneity of cancer. This study used the recently FDA-approved Parsortix (R) technology to enrich CTCs from prostate cancer patients and found that targeted CTC transcriptome profiling may be predictive of therapy response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Lin Shi, Jinying Lu, Da Zhong, Meijuan Song, Jian Liu, Wenhua You, Wen-Hui Li, Lin Lin, Dongyan Shi, Yun Chen
Summary: Mucosal-associated invariant T (MAIT) cells in non-small cell lung cancer (NSCLC) patients exhibit an exhausted tumor-promoting phenotype and the subset of circulating MAIT cells can predict the response to anti-PD-1 immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Changshu Li, Jun Shao, Peiyi Li, Jiaming Feng, Jingwei Li, Chengdi Wang
Summary: Despite advancements in diagnosis and treatment, lung cancer still has a high morbidity and mortality rate worldwide. Tissue biopsy, the current gold standard for diagnosis, has limitations. Liquid biopsy, particularly the use of circulating tumor DNA, has emerged as a promising tool for early diagnosis and monitoring of lung cancer. This review explores the biological characteristics of ctDNA, detection methods, and its role in lung cancer management.
Article
Engineering, Electrical & Electronic
Alberto Della Torre, Remi Armand, Milan Sinobad, Kokou Firmin Fiaboe, Barry Luther-Davies, Stephen Madden, Arnan Mitchell, Thach G. Nguyen, David Moss, Jean-Michel Hartmann, Vincent Reboud, Jean-Marc Fedeli, Christelle Monat, Christian Grillet
Summary: We successfully generated a broadband and flat mid-infrared supercontinuum in a silicon-germanium-on-silicon two-stage waveguide. Our design utilizing a short and narrow waveguide section and an inverse tapered section led to a broader and flatter supercontinuum with two spectrally shifted dispersive waves. The experimentally generated supercontinuum ranged from 2.4 to 5.5 µm, but numerical simulations predict it can extend to 7.8 µm. We demonstrated the potential of our supercontinuum for gas spectroscopy of water vapor and carbon dioxide.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2023)
Review
Optics
Xu Han, Mingrui Yuan, Huifu Xiao, Guanghui Ren, Thach Giang Nguyen, Andreas Boes, Yikai Su, Arnan Mitchell, Yonghui Tian
Summary: Thin-film lithium niobate on insulator (LNOI) shows promise as an integrated photonics platform due to the excellent properties of lithium niobate. However, the scalability of LNOI is currently limited due to incompatibility with standard CMOS fabrication processes. Dielectrically loaded LNOI waveguides offer an alternative with simplified fabrication processes and competitive performance. In this review, we summarize recent progress in dielectrically loaded LNOI waveguides, compare different loading materials, platforms, and discuss their future in photonic integrated circuits.
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA B-OPTICAL PHYSICS
(2023)
Article
Optics
Mingyang Ma, Mingrui Yuan, Xudong Zhou, Huifu Xiao, Pengfei Cao, Lin Cheng, Thach Giang Nguyen, Andreas Boes, Guanghui Ren, Yikai Su, Arnan Mitchell, Yonghui Tian
Summary: Lithium niobate on insulator (LNOI) is a promising platform for high-performance photonic integrated circuits (PICs) in communication applications. Multimode waveguide bends with double air grooves are proposed and demonstrated to achieve low crosstalk for three different transverse electric (TE) modes in the wavelength range of 1525-1575 nm. The demonstrated device provides a compact solution for multimode waveguide bends, paving the way for high-speed, high-data-capacity PICs in on-chip communication systems.
LASER & PHOTONICS REVIEWS
(2023)
Article
Optics
Antoine Henry, David Barral, Isabelle Zaquine, Andreas Boes, Arnan Mitchell, Nadia Belabas, Kamel Bencheikh
Summary: Photon-pair sources based on thin film lithium niobate on insulator technology have the potential to revolutionize integrated optical quantum information processing. In this study, we present a source of correlated twin-photon pairs generated by spontaneous parametric down conversion in a silicon nitride rib loaded thin film periodically poled lithium niobate waveguide. The generated correlated photon pairs possess a wavelength compatible with current telecom infrastructure, a large bandwidth, and high brightness. Furthermore, our findings also demonstrate heralded single photon emission with a high degree of autocorrelation.
Article
Optics
Mingrui Yuan, Xu Han, Huifu Xiao, Thach Giang Nguyen, Andreas Boes, Guanghui Ren, Qinfen Hao, Jiuzhi Xue, Arnan Mitchell, Yonghui Tian
Summary: A high-performance polarization beam splitter (PBS) is designed and demonstrated using a photonic crystal-assisted multimode interference (MMI) coupler. It is suitable for high-speed and large data capacity photonic integrated circuits (PICs) in future communication systems. The PBS enables polarization division multiplexing (PDM) systems and can be integrated with other circuit components for routing and (de)multiplexing optical signals.
Article
Multidisciplinary Sciences
Andreas Boes, Lin Chang, Carsten Langrock, Mengjie Yu, Mian Zhang, Qiang Lin, Martin Fejer, John Bowers, Arnan Mitchell
Summary: This article reviews the history of lithium niobate as an optical material, covering its various photonic platforms, engineering concepts, spectral coverage, and major applications, while also providing a glimpse into its future prospects.
Review
Nanoscience & Nanotechnology
Yunping Bai, Xingyuan Xu, Mengxi Tan, Yang Sun, Yang Li, Jiayang Wu, Roberto Morandotti, Arnan Mitchell, Kun Xu, David J. Moss
Summary: The simultaneous advances in artificial neural networks and photonic integration technologies have spurred extensive research in optical computing and optical neural networks (ONNs). The potential to simultaneously exploit multiple physical dimensions of time, wavelength and space give ONNs the ability to achieve computing operations with high parallelism and large-data throughput. Different photonic multiplexing techniques based on these multiple degrees of freedom have enabled ONNs with large-scale interconnectivity and linear computing functions. This article reviews the recent advances of ONNs based on different approaches to photonic multiplexing, and presents an outlook on key technologies needed to further advance these photonic multiplexing/hybrid-multiplexing techniques of ONNs.
Article
Engineering, Electrical & Electronic
Xingyuan Xu, Weiwei Han, Mengxi Tan, Yang Sun, Yang Li, Jiayang Wu, Roberto Morandotti, Arnan Mitchell, Kun Xu, David J. Moss
Summary: Optical neural networks (ONNs) based on wavelength-division multiplexing (WDM) techniques offer high bandwidth and analog architecture for enhanced computing power and energy efficiency. Integrated microcombs have been used to implement ONNs, with successful applications such as optical convolution accelerators for human image processing at 11 Tera operations per second. However, challenges and limitations of ONNs still need to be addressed for future applications.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2023)
Article
Engineering, Electrical & Electronic
Xumeng Liu, Guanghui Ren, Xingyuan Xu, Aditya Dubey, Timothy Feleppa, Andreas Boes, Arnan Mitchell, Arthur Lowery
Summary: Photonic integrated circuits (PICs) with small footprints have advanced signal processing functions, but their operation is affected by fabrication tolerances and dynamic thermal and acoustic effects. This study demonstrates a 'dial-up' PIC filter that uses an on-chip optical reference path to accurately implement a wide range of filter functions. The method utilizes an independent feedback algorithm to control each tap in a finite impulse response (FIR) filter and enables the identification of phase and amplitude for each tap.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Article
Optics
Xu Han, Yongheng Jiang, Huifu Xiao, Mingrui Yuan, Thach Giang Nguyen, Andreas Boes, Guanghui Ren, Yong Zhang, Qinfen Hao, Yikai Su, Arnan Mitchell, Yonghui Tian
Summary: Grating-assisted contra-directional couplers are important optical components in photonic integrated circuits (PICs) and are used as fundamental building blocks for various applications. LNOI has emerged as an attractive PIC platform with multiple active photonic circuit components, but lacks some passive photonic circuit components. This study proposes, designs and experimentally demonstrates a subwavelength grating-assisted contra-directional coupler in a silicon nitride-loaded LNOI waveguide platform. A three-channel wavelength-division (de)multiplexer is fabricated and experimentally demonstrated using the proposed coupler.
LASER & PHOTONICS REVIEWS
(2023)
News Item
Optics
Arnan Mitchell, Heike Ebendorff-Heidepriem
Summary: The Ti:Sa laser, widely used in optics laboratories, is usually a bench-top system. However, a novel hybrid integration technique now allows for the development of a miniaturized Ti:Sa laser integrated with a low-threshold photonic circuit, comparable in size to a fingernail.
Article
Optics
Mohab Abdalla, Clement Zrounba, Raphael Cardoso, Paul Jimenez, Guanghui Ren, Andreas Boes, Arnan Mitchell, Alberto Bosio, Ian O'connor, Fabio Pavanello
Summary: Reservoir computing is an analog bio-inspired computation scheme that efficiently processes time-dependent signals. Photonic implementations of reservoir computing offer advantages such as massive parallel information processing, low power consumption, and high-speed operation. However, most implementations, especially for time-delay reservoir computing, require extensive parameter optimization. Here, we propose a novel, largely passive integrated photonic TDRC scheme based on an asymmetric Mach-Zehnder interferometer in a self-feedback configuration. This scheme achieves good performance on various tasks while reducing hardware and operational complexity.
Article
Engineering, Electrical & Electronic
Mingrui Yuan, Yiyang Li, Huifu Xiao, Xudong Zhou, Pengfei Cao, Lin Cheng, Guanghui Ren, Qinfen Hao, Jiuzhi Xue, Arnan Mitchell, Yonghui Tian
Summary: This paper proposes and experimentally demonstrates a reconfigurable optical directed logic circuit (RODLC) that performs arbitrary logic operations using an optical switch network. By utilizing an optical switch array and optical mode division multiplexing (MDM) technology, a RODLC with two optical mode (de)multiplexers and twelve thermo-optic microring resonators is fabricated based on standard microfabrication technology. Eight logic operations, including NOT, AND, NAND, OR, NOR, XOR, XNOR, and a combination operation of four operands, are successfully implemented at an operation speed of 10 Kbps. The demonstrated RODLC, characterized by reconfigurability, scalability, and ability for large-scale integration, will contribute to the flourishing development of optical computing and information processing in large-scale optical hybrid integrated circuits.
IEEE PHOTONICS JOURNAL
(2023)
Article
Optics
Phuong Tang, Steffen Schoenhardt, Guanghui Ren, Xu Han, Andreas Boes, Yonghui Tian, Thach g. Nguyen, Arnan Mitchell
Summary: This paper proposes a guided-mode waveguide structure that exhibits similar characteristics to BIC-based ridge resonators but with a significantly reduced size. The dimensions of the resonator are shown to have an influence on the bandwidth of the resonance, allowing for a wide range of achievable Q-factors. The guided-mode waveguide resonators are deemed valuable for silicon photonic circuits in terms of their reduced footprint and systematic filter design capabilities.
Article
Automation & Control Systems
Taimur Ahmed, Vaishnavi Krishnamurthi, Arnan Mitchell, Sumeet Walia
Summary: The alluring properties of low-dimensional materials have greatly advanced brain-inspired electronics, leading to the development of highly efficient neuromorphic devices. This review critically examines the mechanisms in state-of-the-art low-dimensional neuromorphic devices and discusses the factors that influence their working paradigm under different stimuli. Furthermore, it provides a forward-looking outlook on the challenges and perspectives in analyzing these mechanisms to drive next-generation neuromorphic computing.
ADVANCED INTELLIGENT SYSTEMS
(2023)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
