Review
Immunology
Pooja Choudhary, Donaldson Magloire, Glenn Hamonic, Heather L. Wilson
Summary: The immune system in the upper reproductive tract provides protection against pathogens and immune tolerance against sperm and fetus. The timing of exposure to pathogens is most likely during estrus and breeding when the cervix is semi-permissive. The goal of intrauterine immunization is to induce local or systemic immunity and/or promote passive protection for suckling offspring.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Christoph M. Janitzek, Philip H. R. Carlsen, Susan Thrane, Vijansh M. Khanna, Virginie Jakob, Christophe Barnier-Quer, Nicolas Collin, Thor G. Theander, Ali Salanti, Morten A. Nielsen, Adam F. Sander
Summary: This study compared the humoral immune responses in mice elicited against two different vaccine antigens delivered on an AP205 CLP platform using six different adjuvant formulations. The results showed that the effect of the external adjuvant does not always synergize with the adjuvant effect of the CLP display, highlighting the need for empirical testing of different extrinsic adjuvants.
Article
Chemistry, Multidisciplinary
Anne Huppertsberg, Leonard Kaps, Zifu Zhong, Sascha Schmitt, Judith Stickdorn, Kim Deswarte, Francis Combes, Christian Czysch, Jana De Vrieze, Sabah Kasmi, Niklas Choteschovsky, Adrian Klefenz, Carolina Medina-Montano, Pia Winterwerber, Chaojian Chen, Matthias Bros, Stefan Lienenklaus, Niek N. Sanders, Kaloian Koynov, Detlef Schuppan, Bart N. Lambrecht, Sunil A. David, Bruno G. De Geest, Lutz Nuhn
Summary: pH-responsive nanogels were fabricated for safe delivery of TLR7/8-stimulating imidazoquinolines, showing a spatially controlled immunostimulatory activity in the spleen after intravenous injection, without causing systemic off-target inflammatory responses. This approach highlights the potential of pH-degradable nanogels as a promising platform for intravenous administration of small-molecular TLR7/8 agonists in immune therapeutic applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Immunology
Brandi T. Johnson-Weaver, Hae Woong Choi, Hang Yang, Josh A. Granek, Cliburn Chan, Soman N. Abraham, Herman F. Staats
Summary: Through high-throughput screening, three novel small molecule mast cell activators were identified, which showed efficacy comparable to traditional mast cell activators and provided similar levels of protective immune responses in nasal vaccines.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Andre Perez-Potti, Manuel Rodriguez-Perez, Ester Polo, Beatriz Pelaz, Pablo del Pino
Summary: This review focuses on recent advances in preclinical research for the application of nanoparticles to modulate immune responses, emphasizing the need to consider the development and regulation of immune responses in the design and application of nanoparticles. By characterizing the physicochemical features and studying the induced immune response, the review discusses the key features of nanoparticles and their relevance in modulating immune responses.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Wandi Zhu, Chunhong Dong, Lai Wei, Bao-Zhong Wang
Summary: Influenza poses a major threat to public health, and current vaccines have limitations against varying strains. Researchers are exploring strategies involving fewer variable viral antigens and the inclusion of adjuvants for improved vaccine efficacy. While adjuvants show promise in enhancing immune responses, only a few are currently licensed for influenza vaccines.
Article
Medicine, Research & Experimental
Pengfei Gu, Yue Zhang, Gaofeng Cai, Zhenguang Liu, Yuanliang Hu, Jiaguo Liu, Deyun Wang
Summary: Research has shown that both subcutaneous and intramuscular administration of NPs vaccines can elicit strong antigen-specific IgG, IgG1, and IgG2a antibody responses, while subcutaneous administration significantly enhances immune responses by increasing the recruitment and activation of dendritic cells (DCs) in lymph nodes, promoting antigen transport, boosting cytokine secretion, improving CD4(+)T cell to CD8(+)T cell ratio, activating cytotoxic T lymphocyte response, and inducing a robust cellular immune response.
MOLECULAR PHARMACEUTICS
(2021)
Review
Immunology
Jang Hyun Park, Heung Kyu Lee
Summary: The development of COVID-19 vaccines includes various types such as subunit vaccines, inactivated vaccines, and nucleic acid vaccines, but currently only intramuscular vaccination is available. Research suggests that mucosal vaccination may enhance local immune responses, but the lack of understanding of mucosal immunity combined with the urgent need for a COVID-19 vaccine has resulted in the limited delivery options available at present.
Article
Immunology
Sergi Lopez-Serrano, Lorena Cordoba, Monica Perez-Maillo, Patricia Pleguezuelos, Edmond J. Remarque, Thomas Ebensen, Carlos A. Guzman, Dennis Christensen, Joaquim Segales, Ayub Darji
Summary: This study found that pigs vaccinated with NG34 vaccine in combination with CAF(R)01 or CDA/alpha GCM exhibited different immune responses, with animals in the NG34 + CAF(R)01 group showing lower lung lesions and viral shedding post-infection, while pigs in the NG34 + CDA/alpha GCM group showing more severe pathology and viral shedding.
Article
Immunology
Chelsea Sanders, Rebecca L. Matthews, Sayyed Hamid Zarkesh Esfahani, Nazneen Khan, Nimit L. Patel, Joseph D. Kalen, Reinhard Kirnbauer, Richard B. Roden, Simone Difilippantonio, Ligia A. Pinto, Robert H. Shoemaker, Jason D. Marshall
Summary: This study expanded the application of the HPV pseudovirus (PsV) challenge model to include oral and vaginal inoculation, and demonstrated its effectiveness in testing vaccine-mediated dual-site immune protection against various HPV PsV types. Passive transfer of sera from mice vaccinated with the experimental HPV vaccine RG1-VLPs conferred HPV16-neutralizing and cross-neutralizing antibodies against HPV39 in naive recipient mice. Active vaccination with RG1-VLPs also provided protection against challenge with HPV16 or HPV39 PsVs at both vaginal and oral sites. These findings support the use of the HPV PsV challenge model for testing diverse HPV types at two sites associated with the most common HPV-associated cancers.
Article
Oncology
Sapna P. Patel, Gina R. Petroni, Jason Roszik, Walter C. Olson, Nolan A. Wages, Kimberly A. Chianese-Bullock, Mark Smolkin, Nikole Varhegyi, Elizabeth Gaughan, Kelly T. Smith, Kathleen Haden, Emily H. Hall, Sacha Gnjatic, Patrick Hwu, Craig L. Slingluff
Summary: This study evaluated the safety and immunogenicity of a novel long peptide vaccine with different adjuvants, showing that the LPV7 vaccine induced certain immune responses under various adjuvant strategies, but did not significantly enhance T cell responses compared to vaccines using short peptides.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Chemistry, Multidisciplinary
Fei Peng, Yuqiang Xiang, Hui Wang, Yanjie Hu, Rui Zhou, Yonggang Hu
Summary: Vaccines, especially subunit vaccines, are crucial for defending against infectious diseases. The Bacillus amyloliquefaciens spore@zeolitic imidazolate framework-8 (ZIF-8) vaccine platform, with ovalbumin (OVA) encapsulated in the ZIF-8 shells, shows several advantages and enhances immunization efficacy.
Article
Immunology
Romina Cecilia Russi, Diego del Balzo, Ivana Gabriela Reidel, Mariano Alonso Bivou, Noelia Flor, Agustin Lujan, Diego Sanchez, Maria Teresa Damiani, Carolina Veaute
Summary: This study evaluated a vaccine based on a fragment of the Polymorphic membrane protein D (FPmpD) of C. trachomatis as an immunogen using a DNA prime-protein boost strategy. The results showed that both free recombinant FPmpD and recombinant FPmpD formulated with adjuvants increased the titers of anti-rFPmpD antibodies in mice and induced a rapid and robust humoral immune response upon Ct challenge. However, the adjuvant-containing vaccine formulations were more effective in reducing Ct shedding and preventing immunopathology compared to the vaccine with free rFPmpD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Shikhar Sharma, Vanndita Bahl, Gaurav Srivastava, Risha Shamim, Rakesh Bhatnagar, Deepak Gaur
Summary: This study designed several PA constructs and analyzed their vaccine potential. The results showed that PA-FL and PA63 addavax formulations effectively protected spore-challenged mice and had equivalent efficacy in neutralizing the anthrax lethal toxin. The study demonstrated that the expression of PA63 has translational advantages, which is significant for the development of protective antigen-based vaccines.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Mona Yazdani, Amin Reza Nikpoor, Zahra Gholizadeh, Nema Mohamadian Roshan, Alexander Seifalian, Mahmoud Reza Jaafari, Ali Badiee
Summary: The study compared the efficacy of different approaches in DC-based vaccine delivery for melanoma treatment, indicating that ex vivo pulsed DC vaccination was more effective than in vivo administration, resulting in delayed tumor growth and improved survival rate.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Mathurin Fumery, Stephane Nancey, Jerome Filippi, Romain Altwegg, Xavier Hebuterne, Gilles Boshetti, Mathilde Barraud, Jonathan Meynier, Stephane Paul, Xavier Roblin
Summary: This study evaluated the effectiveness and safety of golimumab intensification and identified the best threshold of serum golimumab before drug intensification. The results showed that after golimumab intensification, 40% of patients experienced clinical response, 10% experienced clinical remission, 33% experienced endoscopic response, and 23% experienced endoscopic remission.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Microbiology
Beatriz Miguelena Chamorro, Karelle De Luca, Gokul Swaminathan, Stephanie Longet, Egbert Mundt, Stephane Paul
Summary: Bordetella pertussis and Bordetella bronchiseptica are responsible for whooping cough in humans and chronic cough in dogs, respectively. Both can evade host immune responses, but this ability is more pronounced in B. bronchiseptica. Collaborative efforts between veterinary and human medical fields are essential to control these infections.
CLINICAL MICROBIOLOGY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Myriam Lamrayah, Capucine Phelip, Renaud Rovera, Celine Coiffier, Nora Lazhar, Francesca Bartolomei, Evelyne Colomb, Bernard Verrier, Claire Monge, Sophie Richard
Summary: Vaccine technology is facing challenges in infectious diseases, but innovative drug delivery systems such as nanoparticle-based vaccines with new adjuvants can improve immune protection. This study investigated the influence of poloxamers on the adaptive immune response in mice and showed that poloxamer-based formulations were stable and non-toxic. The presence of poloxamers positively influenced the biodistribution of nanoparticles and induced strong specific immune responses, indicating the promising role of these adjuvants in vaccine development.
Article
Multidisciplinary Sciences
Vincent Pavot, Catherine Berry, Michael Kishko, Natalie G. G. Anosova, Lu Li, Tim Tibbitts, Dean Huang, Alice Raillard, Sylviane Gautheron, Cindy Gutzeit, Marguerite Koutsoukos, Roman M. M. Chicz, Valerie Lecouturier
Summary: The rapid spread of the SARS-CoV-2 Omicron subvariants, despite booster vaccination, has raised concerns about vaccine durability. A monovalent Beta vaccine with AS03 adjuvant induces durable cross-neutralizing antibody responses against various SARS-CoV-2 variants, even 6 months post-booster. This study highlights the importance of developing vaccines that can induce robust and long-lasting immune responses against a broad spectrum of variants.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Xavier Roblin, Gerard Duru, Konstantinos Papamichael, Adam S. Cheifetz, Sandy Kwiatek, Anne-Emmanuelle Berger, Mathilde Barrau, Louis Waeckel, Stephane Nancey, Stephane Paul
Summary: Monitoring of anti-drug antibodies in patients on ustekinumab is not recommended due to low immunogenicity. This study aimed to investigate the relationship between anti-drug antibodies and loss of response to ustekinumab in patients with IBD. The results showed that ATU was an independent predictor of LOR to ustekinumab in IBD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Altan Yavuz, Celine Coiffier, Cynthia Garapon, Serra Gurcan, Claire Monge, Jean-Yves Exposito, Danielle Campiol Arruda, Bernard Verrier
Summary: mRNA-based vaccines have shown great potential for developing anti-infectious therapies since the SARS-CoV-2 pandemic. However, the optimal administration route for these vaccines remains unclear. This study investigated the influence of lipid components and immunization route on humoral immune responses in mice. The results suggest that the adjuvant effect of ionizable lipids may depend on the delivery route used, which is important for achieving potent and long-lasting immunity.
Article
Immunology
Carla Saade, Bruno Pozzetto, Melyssa Yaugel-Novoa, Guy Oriol, Laurence Josset, Bruno Lina, Stephane Paul, Antonin Bal, Sophie Trouillet-Assant
Summary: This study examines the humoral immune response in vaccinated patients who are simultaneously infected with Delta and Omicron BA.1 variants of SARS-CoV-2. The findings indicate that exposure to both Delta and BA.1 S proteins does not provide an additional immune advantage compared to exposure to BA.1 S protein alone.
Article
Immunology
Melyssa Yaugel-Novoa, Blandine Noailly, Fabienne Jospin, Anne-Emmanuelle Berger, Louis Waeckel, Elisabeth Botelho-Nevers, Stephanie Longet, Thomas Bourlet, Stephane Paul
Summary: The study found that prior immunization did not increase the risk of SARS-CoV-2 infection in COVID-19 patients and vaccinated individuals. There was no enhanced infection effect observed in serum samples from COVID-19 patients with any tested viral variants (Delta and Omicron). Some serum samples from vaccinated individuals showed a mild IgA-ADE effect with Omicron after the completion of the full vaccination scheme, but this effect disappeared.
Article
Immunology
Beatriz Miguelena Chamorro, Karelle De Luca, Gokul Swaminathan, Nicolas Rochereau, Jade Majorel, Herve Poulet, Blandine Chanut, Lauriane Piney, Egbert Mundt, Stephane Paul
Summary: In this study, the immune responses and protection offered by a canine mucosal vaccine against Bordetella bronchiseptica were investigated using a rat model. The results showed that mucosal vaccination can induce mucosal immune responses and provide protection against a Bb challenge.
Article
Biochemistry & Molecular Biology
Tristan Gabriel-Segard, Jessica Rontard, Louise Miny, Louise Dubuisson, Aurelie Batut, Delphine Debis, Melanie Gleyzes, Fabien Francois, Florian Larramendy, Alessandra Soriano, Thibault Honegger, Stephane Paul
Summary: This study presents a microfluidic technology that models bilateral neuro-immunological communication, confirming the communication between dendritic cells and neurons in inflammatory conditions such as IBD. The platform can be used for pharmacological compound screening and may help improve patient outcomes by blocking the gut-brain axis at a mucosal level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Gastroenterology & Hepatology
Xavier Roblin, Stephane Paul
JOURNAL OF CROHNS & COLITIS
(2023)
Editorial Material
Veterinary Sciences
Beatriz Miguelena Chamorro, Gokul Swaminathan, Egbert Mundt, Stephane Paul
Summary: Oral vaccines are convenient to administer and can activate mucosal immune responses. However, preclinical studies using gavage as a technique for oral vaccine administration have limitations. Alternative methods need to be explored.
Article
Medicine, Research & Experimental
Catherine Berry, Vincent Pavot, Natalie G. Anosova, Michael Kishko, Lu Li, Tim Tibbitts, Alice Raillard, Sylviane Gautheron, Sheila Cummings, Dinesh S. Bangari, Swagata Kar, Caroline Atyeo, Yixiang Deng, Galit Alter, Cindy Gutzeit, Marguerite Koutsoukos, Roman M. Chicz, Valerie Lecouturier
Summary: A bivalent vaccine containing Spike proteins from the original Wuhan strain and the Beta variant was developed and tested in macaques and hamsters. The vaccine elicited broader and durable neutralizing antibody responses against multiple variants, including Omicron, and provided protection against viral challenge.
COMMUNICATIONS MEDICINE
(2023)
Review
Medicine, General & Internal
Mathilde Barrau, Xavier Roblin, Leslie Andromaque, Aurore Rozieres, Mathias Faure, Stephane Paul, Stephane Nancey
Summary: Data on the long-term effects of in utero drug exposure on childhood development are lacking, but therapeutic drug monitoring during pregnancy can help limit fetal drug exposure. The levels and duration of drug exposure impact the outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Xavier Roblin, Stephane Nancey, Konstantinos Papamichael, Gerard Duru, Mathurin Flamand, Sandy Kwiatek, Adam Cheifetz, Nicole Fabien, Mathilde Barrau, Stephane Paul
Summary: Higher concentrations of subcutaneous infliximab are associated with better therapeutic outcomes in patients with inflammatory bowel disease, especially deep remission.
JOURNAL OF CROHNS & COLITIS
(2023)