Review
Oncology
Yuhe Lei, Lei Chen, Junshan Liu, Yinqin Zhong, Lijuan Deng
Summary: This article discusses the importance of chemoresistance in cancer treatment, introduces the dual roles of autophagy and miRNA in chemoresistance, and explores the potential of miRNA as a target to overcome chemoresistance.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Hiroto Tominaga, Juntaro Matsuzaki, Chihiro Oikawa, Kensho Toyoshima, Haruki Manabe, Eriko Ozawa, Atsushi Shimamura, Riko Yokoyama, Yusuke Serizawa, Takahiro Ochiya, Yoshimasa Saito
Summary: Pancreatic and biliary tract cancers are malignant tumors with poor prognosis and limited treatment options. Research on non-invasive cancer biomarkers is ongoing, but there are few specific biomarkers for these types of cancers. Studies have shown distinct nucleic acid, protein, and immune cell profiles in pancreatic and biliary tract cancers compared to healthy individuals, suggesting the potential for cancer-specific biomarkers in blood samples. Further research is needed to enhance the understanding of diagnosis and prognosis for these types of cancers.
Review
Biochemistry & Molecular Biology
Mehrdad Hashemi, Sepideh Mirzaei, Mohammad Arad Zandieh, Sahar Rezaei, Amirabbas Kakavand, Amir Dehghanpour, Negin Esmaeili, Azin Ghahremanzade, Hamidreza Saebfar, Hajar Heidari, Shokooh Salimimoghadam, Afshin Taheriazam, Maliheh Entezari, Kwang Seok
Summary: Liver is a vital organ in the body and is susceptible to the development of liver cancer, specifically hepatocellular carcinoma (HCC). Long non-coding RNAs (lncRNAs) are epigenetic factors that play a role in cancer therapy and understanding their function in HCC is of great importance. LncRNAs regulate cell cycle, growth, apoptosis, invasion, and metastasis in HCC, and their altered expression is associated with drug resistance and radio-resistance.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
(2023)
Article
Cell Biology
Milad Ashrafizadeh, Ali Zarrabi, Kiavash Hushmandi, Farid Hashemi, Ebrahim Rahmani Moghadam, Marzieh Owrang, Fardin Hashemi, Pooyan Makvandi, Mohammad Ali Sheikh Beig Goharrizi, Masoud Najafi, Haroon Khan
Summary: Cisplatin is an effective chemotherapeutic agent, but resistance in cancer cells limits its efficacy. MicroRNAs play a crucial role in regulating cisplatin resistance/sensitivity by targeting various signaling pathways.
CELLULAR SIGNALLING
(2021)
Review
Cell Biology
Jihui Lee, Hara Kang
Summary: Sarcopenia is an age-related disease that can be regulated by alterations in the expression levels of non-coding RNAs, leading to muscle atrophy and dysfunction. Exercise can affect the expression patterns of non-coding RNAs involved in sarcopenia.
Article
Multidisciplinary Sciences
Lei Shi, Peter Magee, Matteo Fassan, Sudhakar Sahoo, Hui Sun Leong, Dave Lee, Robert Sellers, Laura Brulle-Soumare, Stefano Cairo, Tiziana Monteverde, Stefano Volinia, Duncan D. Smith, Gianpiero Di Leva, Francesca Galuppini, Athanasios R. Paliouras, Kang Zeng, Raymond O'Keefe, Michela Garofalo
Summary: This study reveals the role of KIMAT1 in maintaining KRAS signaling in lung cancer progression, suggesting that targeting it may be a strategy to prevent KRAS-induced tumorigenesis.
NATURE COMMUNICATIONS
(2021)
Article
Veterinary Sciences
Zhaobo Zhang, Sishi Zhang, Guoshuai Wang, Siyu Feng, Kexin Han, Limei Han, Liping Han
Summary: Marek's disease virus (MDV) causes Marek's disease (MD), which involves highly infectious tumor lesions. Noncoding RNAs play a significant role in the pathogenesis of MD, with specific miRNAs and lncRNAs participating in various cellular processes.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Cell Biology
Xijuan Chen, Yingqiang Liu, Qinglan Zhang, Baoxing Liu, Yan Cheng, Yonglei Zhang, Yanan Sun, Junqi Liu, Hong Gen
Summary: This study found that in colorectal cancer, HOTTIP enhances mitomycin resistance by affecting the miR-214/KPNA3 signaling pathway. The promotive effects of EV-carried HOTTIP on mitomycin resistance were confirmed, suggesting targeting HOTTIP as a promising strategy to overcome drug resistance in CRC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hongwei Yan, Qi Liu, Jieming Jiang, Xufang Shen, Lei Zhang, Zhen Yuan, Yumeng Wu, Ying Liu
Summary: This study utilized high-throughput sequencing to analyze the transcriptome of tiger pufferfish gonads, identifying numerous miRNAs and lncRNAs potentially involved in regulating sex-related gene expression. Differential expression analysis revealed specific miRNAs and lncRNAs that were up-regulated or down-regulated in male gonads compared to female gonads. These findings could lead to further research on the function of miRNAs and lncRNAs in sex determination and differentiation.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Soudeh Ghafouri-Fard, Amin Agabalazadeh, Atefe Abak, Hamed Shoorei, Mohammad Mehdi Hassanzadeh Taheri, Mohammad Taheri, Guive Sharifi
Summary: Tumors of the nervous system can originate from various locations and have high mortality and morbidity rates. Long non-coding RNAs (lncRNAs) play a role in influencing the responsiveness of glioma/glioblastoma and neuroblastoma to chemotherapy, aiding in the design of more effective therapeutic regimens.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Heejin Lee, Hoin Kang, Chongtae Kim, Ja-Lok Ku, Sukwoo Nam, Eun Kyung Lee
Summary: This study found that long non-coding RNA (lncRNA) GAS5 is downregulated in colon cancer cell lines resistant to 5-fluorouracil (5-FU). GAS5 downregulation decreased the viability of HCT116 cells and the level of the pro-apoptotic protein BAX, while GAS5 overexpression promoted cell death in response to 5-FU. GAS5 promoted cell death by interfering with miR-128-3p-mediated BAX downregulation, suggesting that GAS5 overexpression in chemo-resistant cancer cells may improve the efficacy of anti-cancer drugs.
Article
Biochemistry & Molecular Biology
Bayram Bayramov, Nuru Bayramov, Hazi Aslanov, Nigar Karimova, Karim Gasimov, Ilham Shahmuradov, Christoph Reissfelder, Vugar Yagublu
Summary: The study investigated the relationship between miR-149 and miR-196a2 small non-coding RNA polymorphisms and the risk of developing colorectal cancer in the Azerbaijani population. The findings suggest that the miR-149 gene mutation may have a protective role in female colorectal cancer, while the miR-196a2 gene polymorphism is associated with an increased risk of colorectal cancer in women.
Review
Cell Biology
Sepideh Mirzaei, Mahshid Deldar Abad Paskeh, Farhad Adhami Moghadam, Maliheh Entezari, Zeinab Khazaei Koohpar, Elahe Sadat Hejazi, Shamin Rezaei, Amirabbas Kakavand, Maryam Aboutalebi, Mohammad Arad Zandieh, Romina Rajabi, Shokooh Salimimoghadam, Afshin Taheriazam, Mehrdad Hashemi, Saeed Samarghandian
Summary: The response of cancer cells to doxorubicin chemotherapy is determined by non-coding RNAs, with microRNAs playing a key role. These microRNAs can be influenced by lncRNAs and circRNAs, showing interaction among non-coding RNAs in the regulation of doxorubicin sensitivity. Phytochemicals can enhance drug efficacy by regulating miRNA expression. Nanoparticles have been introduced for drug sensitivity in combination with other drugs and genes.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2023)
Review
Cell Biology
Ling Wei, Jujie Sun, Nasha Zhang, Yue Shen, Teng Wang, Zengjun Li, Ming Yang
Summary: Esophageal cancer is a common malignancy with chemotherapy and immunotherapy improving prognosis for some patients, while others develop drug resistance leading to poor outcomes. Non-coding RNAs like miRNAs, lncRNAs, and circRNAs have been identified as key players in mediating drug resistance in esophageal cancer. Some of these RNAs could serve as potential biomarkers and therapeutic targets for the disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Meng Zhou, Gan Zhang, Jun Hu, Yanzhi Zhu, Haoming Lan, Xianfeng Shen, Yi Lv, Linsheng Huang
Summary: This study found that rutin can regulate autophagy by modulating the BANCR/miRNA-590-5P/OLR1 axis, potentially enhancing sensitivity to chemotherapy in hepatocellular carcinoma.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)