Review
Biochemistry & Molecular Biology
Rok Herman, Nika Aleksandra Kravos, Mojca Jensterle, Andrej Janez, Vita Dolzan
Summary: This review discusses the mechanisms of action of metformin, focusing on changes in insulin signaling pathway mediators, AMPK, GLUT4 translocation mediators, and the impact of posttranscriptional modifications. It aims to provide a comprehensive understanding of the interactions between metformin action, GLUT4 expression, GLUT4 translocation, and peripheral insulin sensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Christopher M. Schaupp, Dianne Botta, Collin C. White, David K. Scoville, Sengkeo Srinouanprachanh, Theo K. Bammler, James MacDonald, Terrance J. Kavanagh
Summary: Antioxidant signaling is a crucial cellular defense pathway, and its importance in aging has been well-documented. This study investigated the effect of aging on the favorable phenotypes observed in young Gclm null mice, including increased antioxidant activity and improved glucose homeostasis. The results showed that these phenotypes persisted into old age and were associated with transcriptional activation of the Nrf2, AMPK, and PPAR gamma pathways.
Article
Biochemistry & Molecular Biology
Cho-Cho Aye, Dean E. Hammond, Sergio Rodriguez-Cuenca, Mary K. Doherty, Phillip D. Whitfield, Marie M. Phelan, Chenjing Yang, Rafael Perez-Perez, Xiaoxin Li, Angels Diaz-Ramos, Gopal Peddinti, Matej Oresic, Antonio Vidal-Puig, Antonio Zorzano, Cristina Ugalde, Silvia Mora
Summary: CBL is rapidly phosphorylated upon insulin receptor activation. Mice with whole body CBL depletion show improved insulin sensitivity and glucose clearance, but the precise mechanisms are unknown. Depletion of CBL or its associated protein SORBS1/CAP in myocytes leads to increased mitochondrial mass, greater proton leak, reduced activity and assembly of mitochondrial respiratory complex I, and alterations in proteins involved in glycolysis and fatty acid degradation. These findings demonstrate that the CBL/CAP pathway links insulin signaling to efficient mitochondrial function and metabolism in muscle.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Paola A. Ramos, Kelli A. Lytle, Danae Delivanis, Soren Nielsen, Nathan K. LeBrasseur, Michael D. Jensen
Summary: The study found that there were no defects in insulin receptor signaling at the Akt/AS160 level in the muscles of obese individuals, indicating uncertainties in the mechanism of muscle insulin resistance in obesity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Amy Zheng, Haiyan Wang, Edward B. Arias, Gengfu Dong, Jiahui Zhao, Gregory D. Cartee
Summary: The effects of calorie restriction on female wildtype and Akt substrate of 160 kDa knockout rats were evaluated. The results showed that calorie restriction increased muscle glucose uptake and GLUT4 protein abundance, and AS160 expression was essential for these increases.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2023)
Article
Cell Biology
Kiyoto Nishi, Akira Yoshii, Lauren Abell, Bo Zhou, Ricardo Frausto, Julia Ritterhoff, Timothy S. McMillen, Ian Sweet, Yibin Wang, Chen Gao, Rong Tian
Summary: It was found that deficiency of Ppm1k leads to reduced metabolism of branched-chain amino acids (BCAAs) and protects against obesity-induced glucose intolerance. Accumulation of branched-chain keto acids (BCKAs) inhibits glucose production in liver cells. It was observed that BCKAs suppress the activity of liver mitochondrial pyruvate carrier (MPC) and pyruvate-supported respiration. Selective suppression of pyruvate-supported gluconeogenesis was seen in Ppm1k-deficient mice and could be restored through pharmacological activation of BCKA catabolism by BT2. Furthermore, liver MPC was found to be most sensitive to circulating BCKA levels, making it a sensor of BCAA metabolism.
Review
Biochemistry & Molecular Biology
Rok Herman, Jaka Sikonja, Mojca Jensterle, Andrej Janez, Vita Dolzan
Summary: Polycystic ovary syndrome (PCOS) is a common disorder in women of reproductive age, characterized by hyperandrogenemia, reproductive changes, polycystic ovary morphology, and insulin resistance (IR). The primary pathophysiological process in its etiology has not yet been identified, but it is believed to involve insulin metabolism disruption and hyperandrogenemia. This review focuses on the role of insulin secretion, clearance, and decreased sensitivity in target cells as potential primary insults in PCOS pathogenesis, as well as the molecular mechanism behind IR in PCOS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Yanting Ding, Sijing Xia, Haowen Fang, Bing Niu, Qin Chen
Summary: Loureirin B was found to have positive effects on glucose metabolism in insulin-resistant cells by promoting AKT phosphorylation, inhibiting ROS production, and regulating the expression of key genes, potentially ameliorating type 2 diabetes symptoms.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Paniz Anvarifard, Alireza Ostadrahimi, Mohammadreza Ardalan, Maryam Anbari, Zohreh Ghoreishi
Summary: This study aimed to evaluate the efficacy of propolis on various parameters in patients with CKD. The results showed that propolis supplementation significantly improved the health-related quality of life in CKD patients, but had no significant effects on other parameters such as kidney function and blood pressure.
SCIENTIFIC REPORTS
(2023)
Review
Pharmacology & Pharmacy
Guilherme Pegas Teixeira, Robson Xavier Faria
Summary: This article discusses the impact of metabolic disorders on glucose metabolism and the regulatory role of purinergic signaling in this process. The activity of purinergic signaling can affect the homeostasis of sugar metabolism and is related to metabolic disorders such as insulin resistance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Geriatrics & Gerontology
Christie M. Penniman, Gourav Bhardwaj, Colette J. Nowers, Chandler U. Brown, Taylor L. Junck, Cierra K. Boyer, Jayashree Jena, Jordan D. Fuqua, Vitor A. Lira, Brian T. O'Neill
Summary: This study investigates the role of FoxOs in regulating muscle strength and mitochondrial function with age. The results show that deletion of FoxOs increases muscle strength and improves mitochondrial function in both young and aged mice. This is partly due to the suppression of atrophic pathways and the maintenance of OXPHOS.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Biochemistry & Molecular Biology
Kazushi Yamamoto, Masashi Yamashita, Masataka Oda, Vindy Tjendana Tjhin, Hiroyuki Inagawa, Gen-Ichiro Soma
Summary: This study confirms that oral administration of lipopolysaccharide (LPS) does not worsen type 2 diabetes mellitus (T2DM) and investigates the possible mechanisms. Oral LPS administration for 8 weeks suppresses abnormal glucose tolerance, insulin resistance, and T2DM progression in KK/Ay mice. In addition, the expression of insulin signaling-related factors is upregulated in adipose tissues, where an increase in adiponectin expression is observed for the first time with oral LPS administration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Nicholas A. Hulett, Rebecca L. Scalzo, Jane E. B. Reusch
Summary: This review examines the physiological mechanisms of glucose uptake in healthy individuals and individuals with type 2 diabetes, highlighting insulin resistance as a key factor. The review also emphasizes the importance of exercise in enhancing glucose uptake.
Article
Medicine, Research & Experimental
Maliheh Entezari, Danial Hashemi, Afshin Taheriazam, Amirhossein Zabolian, Shima Mohammadi, Farima Fakhri, Mehrdad Hashemi, Kiavash Hushmandi, Milad Ashrafizadeh, Ali Zarrabi, Yavuz Nuri Ertas, Sepideh Mirzaei, Saeed Samarghandian
Summary: AMPK plays a crucial role in diabetes mellitus by promoting glucose metabolism, enhancing insulin sensitivity, inhibiting stress and cell death in beta cells, and improving diabetic complications in patients.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Hemant Srivastava, Alexander Tate Lasher, Akash Nagarajan, Liou Y. Sun
Summary: Alzheimer's disease (AD) is a prevalent form of dementia that is characterized by cognitive decline with age. Treatment options for AD are limited, making it a significant public health concern. Recent research has shown that metabolic dysfunction and insulin therapy may play a role in the development of AD. In this study, the TgF344-AD rat model was used to examine the relationship between body composition, insulin sensitivity, glucose tolerance, and behavioral assessments of learning, memory, and anxiety. The results showed that female TgF344-AD rats exhibited impaired glucose clearance and reduced insulin sensitivity, while male rats showed no differences or improved glucose clearance. Male rats also displayed impairments in learning and memory, while female rats showed impairments only at a later age. Additionally, female rats displayed increased anxiety at a younger age, but no differences were detected in males. These findings suggest that metabolic impairments occur before or simultaneously with cognitive decline and anxiety, in a sexually dimorphic manner, in the TgF344-AD rat model.
Article
Endocrinology & Metabolism
Carlos M. Castorena, Edward B. Arias, Naveen Sharma, Jonathan S. Bogan, Gregory D. Cartee
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2015)
Article
Endocrinology & Metabolism
Naveen Sharma, Haiyan Wang, Edward B. Arias, Carlos M. Castorena, Gregory D. Cartee
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2015)
Article
Nutrition & Dietetics
Carlos M. Castorena, Edward B. Arias, Naveen Sharma, Gregory D. Cartee
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2015)
Article
Geriatrics & Gerontology
Haiyan Wang, Naveen Sharma, Edward B. Arias, Gregory D. Cartee
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2016)
Article
Nutrition & Dietetics
Naveen Sharma, Edward B. Arias, Gregory D. Cartee
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2016)
Article
Sport Sciences
Jenna Sessions, Kelsey Bourbeau, Mattina Rosinski, Taylor Szczygiel, Rachael Nelson, Naveen Sharma, Micah Zuhl
EUROPEAN JOURNAL OF SPORT SCIENCE
(2016)
Meeting Abstract
Sport Sciences
Gavin Power, Gavin Connolly, Lea Haverbeck, Brendan Farley, Roop Jayaraman, Naveen Sharma, Rachael K. Nelson
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2019)
Article
Biochemistry & Molecular Biology
Dubek Kazyken, Brian Magnuson, Cagri Bodur, Hugo A. Acosta-Jaquez, Deqiang Zhang, Xin Tong, Tammy M. Barnes, Gabrielle K. Steinl, Nicole E. Patterson, Christopher H. Altheim, Naveen Sharma, Ken Inoki, Gregory D. Cartee, Dave Bridges, Lei Yin, Steven M. Riddle, Diane C. Fingar
Editorial Material
Education, Scientific Disciplines
Steven J. Elmer, Cassandra R. Gohn, John J. Durocher, Naveen Sharma
ADVANCES IN PHYSIOLOGY EDUCATION
(2023)
Meeting Abstract
Sport Sciences
Mikaela C. Gabler, Gavin Connolly, Shane F. O'Riordan, Tomas Barrett, Naveen Sharma, Paul L. O'Connor
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2018)
Meeting Abstract
Sport Sciences
Lea Haverbeck, Gavin Connolly, Brendan J. Farley, Roop C. Jayaraman, Naveen Sharma, Rachael K. Nelson
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2018)
Meeting Abstract
Sport Sciences
Katarina T. Borer, Naveen Sharma, Andrew Stefan
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2018)
Meeting Abstract
Biochemistry & Molecular Biology
Nicole D. Noble, Ryan J. Pettit-Mee, Rory P. Cunningham, Naveen Sharma
Meeting Abstract
Biochemistry & Molecular Biology
Ryan J. Pettit-Mee, Rory P. Cunningham, Naveen Sharma
Meeting Abstract
Biochemistry & Molecular Biology
Kaitlyn Stevens, Danielle Weaver, Megan Grainer, Adrienne Bradley, Colin Wilson, Tyler Ballard, Naveen Sharma