Article
Agriculture, Multidisciplinary
Jeong Ho Kim, Yu Jeong Jeong, Yong Hyun Lee, Abdul Bari Shah, Cha Young Kim, Ki Hun Park
Summary: The low levels of bioactive metabolites in target plants pose a problem for the functional food industry. Despite having a high content of flavonols, soy leaves have low phytoestrogen content. However, our study found that spraying soy plants with ACC significantly increased phytoestrogen levels in the entire plant, especially in the leaves. ACC also accelerated the biosynthesis pathway of isoflavones in the leaves. This was evidenced by quantitative and metabolomic analyses, which showed changes in metabolite levels and activation of specific genes along the pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agronomy
Arafat Goja, Sara Al-Otaishan, Layla Al-Awami, Nirjes Ali, Zainab Al-Faraj, Eman Al-Kulayf, Zahraa Al-Sukairi, Omar Abuzaid, Tunny Sebastian, Rabie Khattab
Summary: Low bone mineral density is becoming more common in young women. Soy isoflavones have been shown to have a positive effect on bone health in postmenopausal women, but their effect on premenopausal women is unclear. This study found that soy isoflavone supplementation can be beneficial in reducing the risk of osteopenia among premenopausal women.
EMIRATES JOURNAL OF FOOD AND AGRICULTURE
(2023)
Review
Pharmacology & Pharmacy
Putri Ayu Jayusman, Nurrul Shaqinah Nasruddin, Badiah Baharin, Nurul Izzah Ibrahim, Haryati Ahmad Hairi, Ahmad Nazrun Shuid
Summary: Osteoporosis and periodontitis are often seen in postmenopausal women and are related to systemic bone loss and alveolar bone loss. Phytoestrogens, which are plant-based estrogen-like compounds, have been widely studied for the treatment of menopause-related symptoms, but there is limited research on their effect on alveolar bone in postmenopausal osteoporosis. Further studies are needed to explore the therapeutic effects of phytoestrogens on bone protection.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Hao Li, Changyuan Wang, Yue Jin, Yuanqing Cai, Jialin Yao, Qiang Meng, Jingjing Wu, Huihan Wang, Huijun Sun, Mozhen Liu
Summary: Isopsoralen, derived from Psoralea corylifolia, has been found to have anti-postmenopausal osteoporosis effects. It targets multiple proteins and exhibits antioxidative and anti-apoptotic effects.
PHYTOTHERAPY RESEARCH
(2023)
Review
Food Science & Technology
Sina Naghshi, Helda Tutunchi, Mojtaba Yousefi, Fatemeh Naeini, Sara Mobarak, Masoomeh Asadi, Omid Sadeghi
Summary: The intake of soy isoflavones is associated with a lower risk of cardiovascular disease in adults, especially among Western populations.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Nutrition & Dietetics
Lu-lu Li, Yang Yang, Chun-min Ma, Xiao-mei Li, Xin Bian, Yu Fu, Li-kun Ren, Ru-meng Wang, Yan-guo Shi, Na Zhang
Summary: Postmenopausal osteoporosis is a common metabolic disease in old women. Estrogen supplementation through bioactive substances, such as soybean isoflavone aglycones, has been studied for improving menopausal syndrome. This study evaluated the effect of different doses of high-purity soybean isoflavone aglycones on a rat model of osteoporosis. The results showed that the AFDP-H group had a similar intervention effect as the EE group and showed improvement in bone microstructure and prevented weight gain and increased cholesterol levels.
FRONTIERS IN NUTRITION
(2023)
Review
Oncology
Chengying Jiang, Fangke Hu, Jiazhen Li, Guangshen Gao, Xiaojing Guo
Summary: The purpose of this meta-analysis was to summarize the diagnostic value of serum alkaline phosphatase (ALP) and bone-specific isoforms (BAP) in metastatic breast cancer (BC), with a focus on bone metastases. High levels of ALP and BAP in serum were found to be associated with a higher detection rate of bone metastatic BC patients. Although not highly reliable, serum ALP and BAP still provide some useful information for early detection of BC metastases, especially bone metastases.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Review
Food Science & Technology
Xiaoying Wang, Baiyan Chen, Xiang Fang, Qingping Zhong, Zhenlin Liao, Jie Wang, Xuejiao Wu, Yuhao Ma, Pengzhen Li, Xiaoxuan Feng, Li Wang
Summary: Regular intake of soy isoflavones may reduce the incidence of estrogen-dependent and aging-associated disorders, but only a fraction of people can produce the metabolite equol, which has higher biological activity. This review summarizes recent advances in equol research, including its chemical properties, physiological functions, conversion mechanisms, and metabolic regulatory pathways. It also provides a fundamental basis for understanding individual differences in equol production and fermentation production of equol in vitro.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Reproductive Biology
Katharine E. Reed, Juliana Camargo, Jill Hamilton-Reeves, Mindy Kurzer, Mark Messina
Summary: Studies have shown that regardless of the dose and duration of soy protein or isoflavone intake, there is no significant effect on testosterone or estrogen levels in men.
REPRODUCTIVE TOXICOLOGY
(2021)
Review
Medicine, Research & Experimental
Aditi Sharma, Chakshu Sharma, Om Praksah Shah, Sridevi Chigurupati, Bhaskaran Ashokan, Semmal Syed Meerasa, Summya Rashid, Tapan Behl, Simona Gabriela Bungau
Summary: Postmenopausal osteoporosis, a prevalent disorder in older women, is characterized by a decrease in bone mineral density and increased risk of fractures. Insufficiency of estrogen hormone leads to postmenopausal osteoporosis. Hormone replacement therapy is the most effective treatment, but it carries the risk of breast cancer and cardiovascular disorders. This review compiles recent information on herbal and natural compounds used to treat and prevent postmenopausal osteoporosis, discussing their origin, chemical constituents, and molecular mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Cristina Sanchez-de-Diego, Leonardo Pedrazza, Carolina Pimenta-Lopes, Arturo Martinez-Martinez, Norma Dahdah, Jose Antonio Valer, Pablo Garcia-Roves, Jose Luis Rosa, Francesc Ventura
Summary: The study unveils that increased NRF2 activity during osteocytogenesis leads to elevated ROS levels, promoting the expression of osteocyte-specific genes. Ablation of Nfe2l2 can result in osteopenia and mitigate bone loss induced by ovariectomy.
Article
Biology
Turki M. Al-Shaikh
Summary: This research found that testicular function and structure can be harmed by aging, but can be prevented through oral administration of soy isoflavone. Soy isoflavone exerts protective effects by reducing oxidative stress, increasing antioxidants, and promoting testicular cell proliferation.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Endocrinology & Metabolism
Fulong Zhao, Lijuan Guo, Xuefei Wang, Yakui Zhang
Summary: This study aimed to quantitatively and comprehensively assess the roles of OS-related biomarkers in postmenopausal osteoporosis. A total of 36 studies involving 16 OS-related biomarkers were investigated, showing significant differences in certain markers in patients with postmenopausal osteoporosis.
ARCHIVES OF OSTEOPOROSIS
(2021)
Review
Multidisciplinary Sciences
Flavia Ramos Kazan Oliveira, Ana Flora Silva e Gustavo, Renan Braga Goncalves, Fernanda Bolfi, Adriana Lucia Mendes, Vania dos Santos Nunes-Nogueira
Summary: This systematic review evaluated the association between a soy-based infant diet and the onset of puberty, finding no significant impact of soy consumption on the risk of precocious puberty or age at menarche.
Article
Biochemistry & Molecular Biology
Zhou-Shan Tao, Tian-Lin Li, Shan Wei
Summary: The study found that Probucol (PBC) can suppress cellular resistance to oxidative stress, promote osteogenic differentiation, and improve osteoporosis by inhibiting oxidative stress. This provides a new perspective for the treatment of osteoporosis.
MOLECULAR MEDICINE
(2022)
Article
Engineering, Biomedical
Mona Navaei-Nigjeh, Soheyl Mirzababaei, Mohammad Adel Ghiass, Kaveh Roshanbinfar, Mahdi Gholami, Mohammad Abdollahi
Summary: Islet-laden fibers generated with microfluidic technology can protect pancreatic islet cells from the immune response. Adding mesenchymal stromal cells (MSCs) improves cell function and suppresses the immune response in diabetic rats, leading to better treatment outcomes.
Review
Pharmacology & Pharmacy
Taraneh Mousavi, Shekoufeh Nikfar, Mohammad Abdollahi
Summary: With the rise in aging population and chronic diseases, the use and abuse of opioids have increased worldwide, leading to an increase in opioid-related adverse events, specifically opioid-induced bowel dysfunction. This calls for a rational clinical management strategy.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Mahban Rahimifard, Maryam Baeeri, Taraneh Mousavi, Asaad Azarnezhad, Hamed Haghi-Aminjan, Mohammad Abdollahi
Summary: Gastric cancer is a medical dilemma with a high economic and global burden. Conventional chemotherapy regimens containing cisplatin have limited effectiveness and cause adverse drug reactions. This study tested the biological efficacy of the cisplatin-resveratrol combination.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Mahmood Alizadeh Sani, Gholamreza Jahed-Khaniki, Ali Ehsani, Nabi Shariatifar, Mohammad Hadi Dehghani, Mohammad Hashemi, Hedayat Hosseini, Mohammad Abdollahi, Shokoufeh Hassani, Zahra Bayrami, David Julian McClements
Summary: A simple, label-free, and ultra-sensitive fluorescent platform based on a metal-organic framework (MOF) was developed to detect melamine in milk powder. The fluorescence sensor was fabricated from sensitized terbium (Tb)@NH2-MIL-253 (Al) MOF using a hydrothermal method. It showed high accuracy, sensitivity, and reproducibility compared to the high-performance liquid chromatography (HPLC) method. The sensor had a linear range and lower limit of detection (LLOD) much lower than the maximum residual level (MRL) for melamine detection in infant formula and other foods/feeds.
Article
Engineering, Environmental
Farzaneh Kefayati, Atoosa Karimi Babaahmadi, Taraneh Mousavi, Mahshid Hodjat, Mohammad Abdollahi
Summary: Environmental toxicants can regulate gene expression through epigenetic mechanisms. This article discusses the impact of three epigenetic modifications on seven important categories of diseases and the influence of eleven main environmental factors on epigenetic modifications. These epigenetic-related mechanisms play a crucial role in the development of common diseases, aiding in diagnosis and treatment, as well as predicting transgenerational and intergenerational effects. However, more well-designed research is needed to determine the precise role of environmentally-induced epigenetic alterations in disease etiology.
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING
(2023)
Article
Toxicology
Marzieh Daniali, Mona Navaei-Nigjeh, Maryam Baeeri, Soheyl Mirzababaei, Mahdi Gholami, Mahban Rahimifard, Mohammad Abdollahi
Summary: In this study, the protective effects of Levosimendan (LEVO) on pancreatic islets exposed to sodium arsenite (NaAsO2) were investigated. The results showed that LEVO improved the viability and functionality of pancreatic islets and modulated oxidative stress and inflammatory biomarkers.
Review
Toxicology
Sara Mostafalou, Mohammad Abdollahi
Summary: This article reviews the role of organophosphorus (OP) compounds in the development of neurological disorders and explores how genetic variations can affect susceptibility to OP pesticide neurotoxicity. It discusses the various neurological disorders associated with OP compound exposure and the pathological mechanisms involved. Specific genetic polymorphisms have been found to increase the risk of developing OP-related neurological disorders.
ARCHIVES OF TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Shilan Mozaffari, Taraneh Mousavi, Shekoufeh Nikfar, Mohammad Abdollahi
Summary: Polypharmacy is common among elderly patients and can lead to severe drug interactions, posing significant challenges to healthcare providers. Understanding the underlying mechanisms of these interactions and designing personalized treatment plans is crucial.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2023)
Review
Pharmacology & Pharmacy
Taraneh Mousavi, Mohammadhossein Sharifnia, Shekoufeh Nikfar, Mohammad Abdollahi
Summary: Acute gastrointestinal cramping pain (GICP) is a common condition that significantly affects people's quality of life. This article explores the treatment options for GICP and discusses the use of antispasmodics as the primary treatment.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Review
Toxicology
Nader Rahimi Kakavandi, Taraneh Mousavi, Tayebeh Asadi, Ayda Moradi, Mahta Esmaeili, Ahmad Habibian Sezavar, Shekoufeh Nikfar, Mohammad Abdollahi
Summary: This study conducted a systematic review and dose-response meta-analysis on the association between arsenic exposure and the risk of type 2 diabetes. The results showed that arsenic in drinking water and urine were significantly associated with the risk of type 2 diabetes.
TOXICOLOGY LETTERS
(2023)
Article
Pharmacology & Pharmacy
Rasool Esmalipour, Pooneh Salari, Abbas Ebadi, Neda Mehrdad, Bagher Larijani
Summary: The purpose of this study was to design a valid and reliable questionnaire for measuring pharmacists' attitudes towards ethical challenges. Through semi-structured interviews and content analysis, the questionnaire was developed and evaluated for content, structure, and reliability among pharmacists working in community pharmacies in Tehran and Tabriz, Iran. The factor analysis results supported 22 items in four factors related to regulations and rules, professional communications, providing and supplying medicine, and consultation and providing pharmaceutical care.
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Pooneh Salari, Bagher Larijani, Farzaneh Zahedi, Mahshad Noroozi
Summary: This study aimed to develop an ethical guideline for off-label medication use and to create a valid instrument for evaluating physicians' and clinical pharmacists' knowledge and attitudes towards off-label medication use. The study resulted in a guideline with 24 recommendations, and a reliable questionnaire was developed to assess the ethical adherence of healthcare professionals to off-label medication use.
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2023)
Review
Endocrinology & Metabolism
Marzieh Daniali, Shekoufeh Nikfar, Mohammad Abdollahi
Summary: This study compares diabetes management between pediatric and adult patients and identifies treatment challenges and gaps. Research shows children have lower insulin sensitivity, clearance, and beta cell function than adults. Personalized and precise approaches are crucial in managing diabetes in pediatrics, and more research is necessary to assess the safety and efficacy of different antidiabetic drugs and improve diabetes treatment for children and adolescents.
EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM
(2023)
Article
Psychiatry
Ali Amirkafi, Faezeh Mohammadi, Arash Tehrani-Banihashemi, Maziar Moradi-Lakeh, Christopher J. L. Murray, Mohsen Naghavi, Ali H. Mokdad
Summary: The study investigates drug use disorders as a significant contributor to Disability Adjusted Life Years (DALYs) in the Eastern Mediterranean Region (EMR). The findings reveal a significant increase in the prevalence of drug use disorders since 1990, with opioid use being the most prevalent disorder. United Arab Emirates, Libya, and Iran are among the countries most affected by drug use disorders in the region.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Chemistry, Applied
Maryam Keykhaee, Mahban Rahimifard, Alireza Najafi, Maryam Baeeri, Mohammad Abdollahi, Fatemeh Mottaghitalab, Mehdi Farokhi, Mehdi Khoobi
Summary: The study proposes a novel approach using a multifunctional hydrogel to manage diabetic foot ulcers (DFUs). The hydrogel, made from a combination of alginate and gum arabic, is enhanced with nerve growth factor (NGF) immobilized in specially designed mesoporous silica nanoparticles (MSN). The hydrogel shows sustained release of NGF and significantly improves wound healing. The hydrogel also reduces inflammation, increases angiogenesis, and improves tissue pathology. This newly developed composite system holds promise as a potential treatment for non-healing diabetic wounds.
CARBOHYDRATE POLYMERS
(2023)
