Article
Cell Biology
Yuhei Uda, Vaibhav Saini, Christopher A. Petty, Majed Alshehri, Chao Shi, Jordan M. Spatz, Roberto Santos, Carly M. Newell, Tim Y. Huang, Alejandro Kochen, Ji W. Kim, Christodoulos K. Constantinou, Hiroaki Saito, Kathryn D. Held, Eric Hesse, Paola Divieti Pajevic
Summary: The study revealed that PTH signaling in mature osteoblasts/osteocytes is crucial for protecting the skeleton from age-induced bone loss by restraining osteoclast activity and protecting osteocytes from oxidative stresses.
Review
Endocrinology & Metabolism
Jialiang S. Wang, Courtney M. Mazur, Marc N. Wein
Summary: The skeleton serves as an endocrine organ controlling mineral metabolism and energy homeostasis. Different bone cell types secrete factors that affect multiple target organs, with osteocalcin and sclerostin playing key roles.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Physiology
Ahmed M. Wafi
Summary: Redox imbalance plays a crucial role in cardiovascular diseases, and Nrf2 is a key regulator. Interorgan communication via extracellular vesicle pathways mediates central redox imbalance through Nrf2 signaling. This review discusses the role of Nrf2 in regulating oxidative stress in the brain and its impact on sympathoexcitation in chronic heart failure and hypertension.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Orthopedics
Lei Qin, Zecai Chen, Dazhi Yang, Tailin He, Zhen Xu, Peijun Zhang, Di Chen, Weihong Yi, Guozhi Xiao
Summary: Cell culture studies demonstrate the importance of osteocyte 83 integrin in bone homeostasis and mechanotransduction. In this study, deletion of 83 integrin in osteocytes resulted in low bone mass and impaired biomechanical properties in mice. Furthermore, the loss of 83 integrin affected bone marrow stromal cell differentiation and reduced osteoblast-mediated bone formation rate.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Plant Sciences
Yi-Fei Wang, Yue-yue Chang, Xue-meng Zhang, Meng-Ting Gao, Qiu-lan Zhang, Xin Li, Li Zhang, Wei-Feng Yao
Summary: The study found that Salidroside (SAL) can protect bone mass by inhibiting oxidative stress, promoting osteogenesis, and intervening in galactose metabolism and fatty acid metabolism. This suggests that SAL may be a potential drug for the treatment of osteoporosis.
Article
Engineering, Biomedical
Jian Dong, Lijun Zhang, Binjia Ruan, Zhongyang Lv, Hongwei Wang, Yongxiang Wang, Qing Jiang, Wangsen Cao
Summary: This study explores the role of NRF2 in a mouse model of osteolysis caused by wear particles from metal implants. Results show that NRF2 suppression is a critical factor in the development of bone damage, and restoring NRF2 can effectively alleviate osteolysis and reduce the incidence of implant loosening.
Article
Biochemistry & Molecular Biology
Aryatara Shakya, Pengfei Liu, Jack Godek, Nicholas W. Mckee, Matthew Dodson, Annadurai Anandhan, Aikseng Ooi, Joe G. N. Garcia, Max Costa, Eli Chapman, Donna D. Zhang
Summary: The study found that p97 is a ubiquitin-targeted ATP-dependent segregase that regulates proteostasis, in addition to other cellular functions. It negatively regulates NRF2 by extracting ubiquitylated NRF2 from the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex, facilitating proteasomal destruction. The study also identified p97 as an NRF2-target gene that maintains redox homeostasis through a negative feedback loop, and found a positive correlation between NRF2 activation and p97 expression in human cancer patients. Inhibition of both NRF2 and p97 could be a promising treatment strategy for cancer patients.
Article
Biochemistry & Molecular Biology
Zhou-Shan Tao, Tian-Lin Li, Shan Wei
Summary: The study found that Probucol (PBC) can suppress cellular resistance to oxidative stress, promote osteogenic differentiation, and improve osteoporosis by inhibiting oxidative stress. This provides a new perspective for the treatment of osteoporosis.
MOLECULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Jiacong Xiao, Gangyu Zhang, Bohao Chen, Qi He, Jiale Mai, Weijian Chen, Zhaofeng Pan, Junzheng Yang, Jianliang Li, Yanhuai Ma, Ting Wang, Haibin Wang
Summary: The aim of this study was to investigate the therapeutic effects of quercetin (QUE) against iron overload-induced osteoporosis and its potential molecular mechanisms. The results showed that QUE can attenuate oxidative stress damage induced by iron overload by activating the Nrf2/HO-1 signaling pathway, thus protecting bone health.
Article
Biochemistry & Molecular Biology
Qiyu Tian, Zhixin Xu, Qi Sun, Alejandro Bravo Iniguez, Min Du, Mei-Jun Zhu
Summary: The etiology of inflammatory bowel diseases (IBD) is drawing increasing attention as its prevalence rises. A study found that dietary supplementation of glucoraphanin (GRP) from cruciferous vegetables can prevent mitochondrial dysfunction and oxidative stress in an acute colitis mouse model induced by dextran sulfate sodium (DSS). GRP supplementation showed positive effects in reducing body weight loss, disease activity index, and colon shortening caused by DSS. It also protected the colonic histological structure and suppressed the release of inflammatory cytokines. Additionally, GRP activated key pathways associated with mitochondrial function and oxidative stress in the mice treated with DSS.
Review
Biochemistry & Molecular Biology
Lei Xiong, Jin-Xiu Pan, Hao-han Guo, Lin Mei, Wen-Cheng Xiong
Summary: Patients with Parkinson's disease exhibit systemic deficits, including arthritis and osteoporosis-like symptoms. Understanding the relationship between peripheral tissue deficits and brain pathology in PD development is still at an early stage, highlighting the complex interaction of genetic and environmental risk factors. Genetic mutations in various genes have been identified in PD patients, some of which are involved in regulation of bone metabolism, indicating potential links between PD risk genes and bone health.
CELL AND BIOSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Hong Wang, Qianqian Wang, Guodi Cai, Zhijian Duan, Zoann Nugent, Jie Huang, Jianwei Zheng, Alexander D. Borowsky, Jian Jian Li, Peiqing Liu, Hsing-Jien Kung, Leigh Murphy, Hong-Wu Chen, Junjian Wang
Summary: Metabolic and epigenetic reprogramming contribute to cancer therapeutic resistance. In this study, it was found that TIGAR, an antioxidant and glucose metabolic regulator, interacts with NRF2 to stimulate NSD2 expression. Nuclear accumulation of TIGAR is associated with therapeutic resistance and poor survival.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Engineering, Biomedical
Xi Chen, Yasuko Moriyama, Yoko Takemura, Maho Rokuta, Yasunori Ayukawa
Summary: This study aimed to evaluate the influence of estrogen deficiency and mechanical loading on bone around osseointegrated dental implants in a rat jaw model. The results showed that estrogen deficiency could affect the long-term stability of implants, while mechanical loading could attenuate the negative effects of estrogen deficiency on bone formation and osseointegration.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Benedetta Fibbi, Giada Marroncini, Cecilia Anceschi, Laura Naldi, Alessandro Peri
Summary: Hyponatremia is common in the elderly and hospitalized patients, and can have detrimental effects on cellular homeostasis, potentially elicited by oxidative stress. Symptoms of acute hyponatremia are mainly related to central nervous system involvement, while decreased extracellular osmolality can lead to neuronal swelling. Oxidative stress appears to play a key role in impairing cell and tissue functions in hyponatremic conditions.
Review
Biochemistry & Molecular Biology
Teresa Iantomasi, Cecilia Romagnoli, Gaia Palmini, Simone Donati, Irene Falsetti, Francesca Miglietta, Cinzia Aurilia, Francesca Marini, Francesca Giusti, Maria Luisa Brandi
Summary: Osteoporosis is a condition characterized by an imbalance in bone homeostasis, which involves oxidative stress, inflammation, and dysregulation of microRNA expression. Oxidative stress and inflammation enhance bone resorption and reduce bone formation through the activation of MAPK and transcription factors. This review summarizes the molecular mechanisms of oxidative stress and inflammation in osteoporosis and highlights the interplay between altered microRNA expression, oxidative stress, and inflammation. It also discusses the potential for targeting these mechanisms in the development of new therapeutic approaches to osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Eva M. Perez-Villegas, Rocio Ruiz, Sara Bachiller, Francesc Ventura, Jose A. Armengol, Jose Luis Rosa
Summary: The HERC protein family plays important roles in neurodevelopment and neurodegenerative diseases. Mutations in HERC genes can lead to intellectual disability, epilepsy, dementia, and dysregulation of autophagy, resulting in cerebellar cell death and impaired motor control.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Diana Sanz-Serrano, Cristina Sanchez-de-Diego, Montse Mercade, Francesc Ventura
Summary: This study aims to establish and fully characterize a new cell line derived from human stem cells of the apical papilla (SCAPs) through immortalization with an SV40 large T antigen. The new cell line named Dental Stem Cells SV40 (DSCS) retains its morphology and expression of mesenchymal surface markers, shows higher proliferative capacity even at late passages, and has the potential for trilineage differentiation.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Cell Biology
Leonardo Pedrazza, Arturo Martinez-Martinez, Cristina Sanchez-de-Diego, Jose Antonio Valer, Carolina Pimenta-Lopes, Joan Sala-Gaston, Michal Szpak, Chris Tyler-Smith, Francesc Ventura, Jose Luis Rosa
Summary: Bone remodeling is a continuous process involving osteoblasts and osteoclasts, and imbalances can cause metabolic bone diseases like osteopenia. The HERC1 gene encodes an E3 ubiquitin ligase that affects cellular processes by regulating the ubiquitination of target proteins. Pathogenic variants in HERC1 have been associated with the neurodevelopmental disorder MDFPMR syndrome. This study shows that HERC1 regulates osteoblastogenesis and osteoclastogenesis, and its depletion increases gene expression of osteoblastic markers, leading to imbalanced bone homeostasis and osteopenia.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Teresa Villanueva-Carmona, Lidia Cedo, Ana Madeira, Victoria Ceperuelo-Mallafre, M. -Mar Rodriguez-Pena, Catalina Nunez-Roa, Elsa Maymo-Masip, Maria Repolles-de-Dalmau, Joan Badia, Noelia Keiran, Mercedes Mirasierra, Carolina Pimenta-Lopes, Joan Sabadell-Basallote, Ramon Bosch, Laura Caubet, Joan Carles Escola-Gil, Jose-Manuel Fernandez-Real, Nuria Vilarrasa, Francesc Ventura, Mario Vallejo, Joan Vendrell, Sonia Fernandez-Veledo
Summary: Adipose tissue secretes leptin to modulate energy homeostasis, and this process is regulated by succinate through its receptor SUCNR1. Deletion of Sucnr1 in adipocytes affects metabolic health based on nutritional status. Activation of SUCNR1 controls leptin expression via the circadian clock in an AMPK/JNK-C/EBPa-dependent manner. Succinate/SUCNR1 axis serves as a metabolite-sensing pathway mediating nutrient-related leptin dynamics to maintain whole-body homeostasis.
Editorial Material
Biochemistry & Molecular Biology
Jose Luis Rosa
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Joan Sala-Gaston, Laura Costa-Sastre, Leonardo Pedrazza, Arturo Martinez-Martinez, Francesc Ventura, Jose Luis Rosa
Summary: Large HERC ubiquitin ligases, belonging to the HECT E3 protein family, play a crucial role in different pathologies, including cancer and neurological diseases. Understanding the alterations in cell signaling in these diseases is important for identifying potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
A. Martinez Cutillas, D. Sanz-Serrano, S. Oh, F. Ventura, A. Martinez de Ilarduya
Summary: Synthetic and functional grafts, such as the RGD-PEG-PLA-PGl-PLA-PEG-RGD scaffold used in this study, are a great alternative to conventional grafts. This multifunctional polymer provides physical support and precise signaling for cells to heal damaged tissues. The presence of PGl inner block enhances the toughness of the scaffold, while PEGylation improves its hydrophilicity. The functionalized RGD peptides on the scaffold surface significantly enhance cell adhesion and proliferation. These results make it a great candidate for temporary graft preparation.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Biotechnology & Applied Microbiology
Carolina Pimenta-Lopes, Cristina Sanchez-de-Diego, Alexandre Deber, Andrea Egea-Cortes, Jose Antonio Valer, Albert Alcala, Andres Mendez-Lucas, Anna Esteve-Codina, Jose Luis Rosa, Francesc Ventura
Summary: Age-related and chemotherapy-induced bone loss is influenced by cellular senescence and the secretion of specific factors. The alternative complement system is found to play a central role in skeletal bone loss, with complement factor D being one of the most responsive factors. Osteoblasts and osteocytes activate complement, while monocytes and osteoclasts are the primary targets. Inhibition of the alternative complement pathway may have therapeutic benefits in osteopenic disorders.
Article
Multidisciplinary Sciences
Joan Roig-Soriano, Cristina Sanchez-de-Diego, Jon Esandi-Jauregui, Sergi Verdes, Carmela R. Abraham, Assumpcio Bosch, Francesc Ventura, Miguel Chillon
Summary: The gene alpha-Klotho produces two main transcripts, one encoding a transmembrane protein detected in serum as processed Klotho (p-KL), and the other coding for a putatively secreted protein (s-KL). While p-KL showed negative effects on mineral homeostasis and bone microstructure, s-KL demonstrated no apparent negative effects on mineral metabolism and presented unexpected beneficial effects on bone microstructure. These findings suggest that s-KL (but not p-KL) may be a safe therapeutic strategy for exploiting KL anti-aging protective effects.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Cristina Sanchez-de-Diego, Maria Virumbrales-Munoz, Brock Hermes, Terry D. Juang, Duane S. Juang, Jeremiah Riendeau, Emmanuel Contreras Guzman, Catherine A. Reed-McBain, Sara Abizanda-Campo, Janmesh Patel, Nicholas J. Hess, Melissa C. Skala, David J. Beebe, Jose M. Ayuso
Summary: Microenvironmental gradients play a crucial role in various physiological and pathological processes, but current in vitro technologies are limited in capturing their complexity. Therefore, Griddient is a user-friendly platform capable of generating controllable and reversible gradients in a 3D microenvironment.
COMMUNICATIONS BIOLOGY
(2023)