Article
Endocrinology & Metabolism
Xiaoqin Xu, Dandan Luo, Qiuhui Xuan, Peng Lu, Chunxiao Yu, Qingbo Guan
Summary: In recent years, the impact of lipotoxicity on male fertility, especially on Sertoli cells, has been extensively studied. Researchers found that palmitic acid treatment inhibits fatty acid beta-oxidation in Sertoli cells, leading to mitochondrial dysfunction and increased apoptosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Wanhong Li, Yongyu Yao, Xiuiu Weng, Xiangpeng Yue, Fadi Li
Summary: The study demonstrates that ALA can promote the proliferation of TM4 Sertoli cells through various pathways, including enhancing antioxidant capacity, inducing mitochondrial membrane hyperpolarization, and inhibiting cell apoptosis.
ANIMAL BIOTECHNOLOGY
(2022)
Article
Medicine, General & Internal
O. Sena Aydos, Yunus Yukselten, Tulin Ozkan, Sinan Ozkavukcu, Meltem Tuten Erdogan, Asuman Sunguroglu, Kaan Aydos
Summary: This study found that adding FSH/testosterone to the culture medium can promote the differentiation and maturation of germ cells, and co-culturing with healthy SCs does not provide additional benefits. Additionally, the freezing-thawing process does not affect the viability and proliferation of SCs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Yunsheng Liu, Xiangping Xu, Han Tang, Yuchen Pan, Bing Hu, Guodong Huang
Summary: The study found that RA, as a Fyn inhibitor, has anti-tumor effects in U251 and U343 glioma cells, significantly suppressing cell proliferation, migration, and invasion, and inducing apoptosis. Additionally, RA exerts its cytotoxicity by modulating the PI3K/Akt/NF-kappa B signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Polymer Science
Marta G. Fuster, Guzman Carissimi, Mercedes G. Montalban, Gloria Villora
Summary: Rosmarinic acid-loaded silk fibroin nanoparticles (RA-SFNs) exhibit rapid drug release under physiological conditions and show significant antitumor activity against human cervical carcinoma and breast cancer cell lines. Additionally, RA-SFNs increase cellular uptake, inhibit cell proliferation, and induce apoptosis in cancer cells.
Article
Biochemistry & Molecular Biology
Xiaomei Xie, Longjie Sun, Yixi Duan, Zheng Lv, Xiaohong Yao, Chaofan Wang, Xuexue Chen, Shuang Tian, Lu Yan, Yujing Shao, Haoshu Luo, Jiali Liu
Summary: SRSF2 plays a crucial role in supporting testis development and normal spermatogenesis. Its deficiency impairs fetal Sertoli cell proliferation, induces abnormal apoptosis and severe DNA damage, resulting in testicular dysplasia, seminiferous tubule atrophy, and infertility.
Review
Medicine, Research & Experimental
Shumaila Ijaz, Javed Iqbal, Banzeer Ahsan Abbasi, Zakir Ullah, Tabassum Yaseen, Sobia Kanwal, Tariq Mahmood, Sandugash Sydykbayeva, Alibek Ydyrys, Zainab M. Almarhoon, Javad Sharifi-Rad, Christophe Hano, Daniela Calina, William C. Cho
Summary: Cancer remains a major cause of death globally, and rosmarinic acid (RA) is a bioactive compound found in plants. This review highlights the chemopreventive and chemotherapeutic effects of RA and its derivatives, providing clues for the development of complementary drugs for cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biotechnology & Applied Microbiology
Lin Huang, Jiangyan Chen, Jin Quan, Debing Xiang
Summary: The study demonstrated that Rosmarinic acid (RA) significantly reduced cell viability, migration, invasion, and increased apoptosis in melanoma cells. This effect may rely on inhibiting the expression of the ADAM17/EGFR/AKT/GSK3 beta axis, suggesting a potential anti-cancer property of RA.
Article
Environmental Sciences
Sujuan Zhao, Chunyang Yuan, Xun Tuo, Chengfan Zhou, Qihong Zhao, Tong Shen
Summary: The study demonstrated that MCLR induced an increase in Ca2+ concentration in TM4 cells, leading to activation of apoptotic pathways. The use of the Ca2+ chelator Bapta-AM partially reversed MCLR-induced apoptosis, confirming the involvement of calcium homeostasis disruption. Additionally, MCLR activated the ER apoptotic pathway by activating caspase-12.
Article
Environmental Sciences
Xu Yang, Pengli Liu, Xuliang Zhang, Jian Zhang, Yilong Cui, Miao Song, Yanfei Li
Summary: The study revealed that T-2 toxin induces dysfunction in TM4 cells through ROS-induced apoptosis. It not only decreases cell viability, but also impacts oxidative stress status and apoptosis rate in the cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Pharmacology & Pharmacy
Tina Blazevic, Gottfried Reznicek, Limin Ding, Gangqiang Yang, Patricia Haiss, Elke H. Heiss, Verena M. Dirsch, Rongxia Liu
Summary: This study demonstrates that esterification is a promising approach to enhance the in vivo bioavailability of rosmarinic acid in rats and the in vitro biological activity in rat vascular smooth muscle cells. The optimal alkyl chain length for esterification is between C1 and C4, while longer alkyl chains may lead to cytotoxicity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Reproductive Biology
Hongyan Xue, Yuannan Huo, Yu Hu, Jinlong Zhang, Chengchen Deng, Jiaojiao Zhang, Xianzhong Wang
Summary: Heat stress reduces Sertoli cells and impairs spermatogenesis. Lipid peroxides are found to play a crucial role in the heat stress-induced apoptosis of Sertoli cells.
Article
Pharmacology & Pharmacy
Changlun Chen, Yilin Liu, Yi Shen, Lili Zhu, Lumeng Yao, Xingxing Wang, Anna Zhang, Jiao Li, Jianjun Wu, Luping Qin
Summary: Rosmarinic acid (RA) was isolated from Rubi Fructus for the first time and was found to induce apoptosis in SGC-7901 and HepG2 cells through the mitochondrial pathway.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wenbin Luo, Yu Tao, Shengnan Chen, Hao Luo, Xiaoping Li, Shuang Qu, Ken Chen, Chunyu Zeng
Summary: This study found that rosmarinic acid (RA) can effectively protect against pulmonary ischemia/reperfusion (IR) injury by activating the PI3K/Akt signaling pathway for antioxidation and anti-apoptosis, suggesting its potential therapeutic value.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Reproductive Biology
Huihui Gao, Heran Cao, Zhenpeng Li, Long Li, Yingjie Guo, Yining Chen, Guofan Peng, Wenxian Zeng, Jian Du, Wuzi Dong, Fangxia Yang
Summary: Spermatogenesis is a complex process regulated by endocrine and paracrine factors, with Sertoli cells playing a crucial role. The molecular pathways of Sertoli cell action in spermatogenesis remain controversial. Recent studies have focused on exosomes as a mechanism of intercellular communication.
Article
Andrology
M. Shokoohi, A. Khaki, H. Shoorei, A. A. Khaki, M. Moghimian, S-H Abtahi-Eivary
Article
Urology & Nephrology
Kamyar Ghabili, Henry S. Park, James B. Yu, Preston C. Sprenkle, Simon P. Kim, Kevin A. Nguyen, Xiaomei Ma, Cary P. Gross, Michael S. Leapman
Summary: In patients with positive surgical margins, the use of planned post-operative radiation therapy is associated with clinical and pathological characteristics, as well as the treatment center. Patients with high-risk features are more likely to receive additional androgen deprivation therapy.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Oncology
Nancy N. Wang, Steve R. Zhou, Leo Chen, Robert Tibshirani, Richard E. Fan, Pejman Ghanouni, Alan E. Thong, Katherine J. To'o, Kamyar Ghabili, Jeffrey W. Nix, Jennifer B. Gordetsky, Preston Sprenkle, Soroush Rais-Bahrami, Geoffrey A. Sonn
Summary: The study aimed to develop and validate a nomogram combining PIRADS scores and clinical data to predict the probability of prostate cancer detection in men. Results showed that the nomogram, named SPCC, provided stronger predictive accuracy than using PSA density or PIRADS alone, with robust AUC values in external validation.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Urology & Nephrology
Benjamin H. Press, Ghazal Khajir, Kamyar Ghabili, Cynthia Leung, Richard E. Fan, Nancy N. Wang, Michael S. Leapman, Geoffrey A. Sonn, Preston C. Sprenkle
Summary: The study aimed to investigate the role of PSA density in predicting biopsy upgrade risk among AS patients, and the results showed that PSAD reliably discriminated the risk of Gleason upgrade, suggesting its potential use in reducing surveillance intensity.
Article
Oncology
Andreas G. Wibmer, Michael W. Kattan, Francesco Alessandrino, Alexander D. J. Baur, Lars Boesen, Felipe Boschini Franco, David Bonekamp, Riccardo Campa, Hannes Cash, Violeta Catala, Sebastien Crouzet, Sounil Dinnoo, James Eastham, Fiona M. Fennessy, Kamyar Ghabili, Markus Hohenfellner, Angelique W. Levi, Xinge Ji, Vibeke Logager, Daniel J. Margolis, Paul C. Moldovan, Valeria Panebianco, Tobias Penzkofer, Philippe Puech, Jan Philipp Radtke, Olivier Rouviere, Heinz-Peter Schlemmer, Preston C. Sprenkle, Clare M. Tempany, Joan C. Vilanova, Jeffrey Weinreb, Hedvig Hricak, Amita Shukla-Dave
Summary: In this study, a nomogram combining MRI findings with other patient data was developed to accurately diagnose extraprostatic tumor growth in patients with newly diagnosed prostate cancer. The nomogram showed significantly greater accuracy compared to clinical benchmark models, providing a valuable tool for physicians in predicting extraprostatic extension of prostate cancer.
Article
Oncology
Soum D. Lokeshwar, Justin Nguyen, Syed N. Rahman, Ghazal Khajir, Richard Ho, Kamyar Ghabili, Michael S. Leapman, Jeffrey C. Weinreb, Preston C. Sprenkle
Summary: This study retrospectively analyzed the utility of MRI-guided prostate biopsy and evaluated relevant factors for prostate cancer patients. The results demonstrated the usefulness of integrated PSAD in identifying patients at high risk of upgrade. Biopsy necessity can be determined based on PSAD values for specific PI-RADS grades.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kamyar Ghabili, Jamil Shaikh, Jeffrey Pollak, David Elwood, Bill S. Majdalany, Nariman Nezami
Summary: The study aimed to test the feasibility, safety, and effectiveness of percutaneous combined chemical and mechanical necrosectomy using Malecot anchor drain and Arrow-Trerotola percutaneous thrombolytic device (PTD) in patients with walled-off pancreatic necrosis (WOPN) compared to mechanical necrosectomy alone. The results showed a clinical success rate of 100% in the case group, indicating that percutaneous combined chemical and mechanical necrosectomy is a feasible, safe, and effective treatment for WOPN.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Urology & Nephrology
Walter Hsiang, Kamyar Ghabili, Jamil S. Syed, Justin Holder, Kevin A. Nguyen, Alfredo Suarez-Sarmiento, Steffen Huber, Michael S. Leapman, Preston C. Sprenkle
Summary: The study found that progression on serial mpMRI is not associated with pathological upgrade in men with GG1 PCa on active surveillance. However, a high initial PI-RADS score on mpMRI is predictive of subsequent pathological progression. Both systematic and fusion biopsies are necessary to monitor progression during active surveillance.
EUROPEAN UROLOGY FOCUS
(2021)
Meeting Abstract
Medicine, Research & Experimental
Ghazal Khajir, Kamyar Ghabili, Olayemi Olubowale, Michael Leapman, Angelique Levi, Peter Humphrey, Preston Sprenkle
LABORATORY INVESTIGATION
(2021)
Meeting Abstract
Pathology
Ghazal Khajir, Kamyar Ghabili, Olayemi Olubowale, Michael Leapman, Angelique Levi, Peter Humphrey, Preston Sprenkle
Review
Reproductive Biology
Nava Ainehchi, Azizeh Farshbaf-Khalili, Aliyeh Ghasemzadeh, Kobra Hamdi, Arash Khaki, Elaheh Ouladsahebmadarek, Abbas Delazar, Fahimeh Bakhtyari, Masoumeh Mazandarani
INTERNATIONAL JOURNAL OF WOMENS HEALTH AND REPRODUCTION SCIENCES
(2019)
Article
Medicine, General & Internal
Fariba Khodaeifar, Seyyed Mohammad Bagher Fazljou, Arash Khaki, Mohammadali Torbati, Elaheh Olad Saheb Madarek, Amir Afshin Khaki, Majid Shokoohi, Amir Hossein Dalili
CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES
(2019)
Article
Medicine, General & Internal
Majid Shokoohi, Mohammad Sadegh Gholami Farashah, Arash Khaki, Amir Afshin Khaki, Elaheh Ouladsahebmadarek, Reza Aref Nezhad
CRESCENT JOURNAL OF MEDICAL AND BIOLOGICAL SCIENCES
(2019)
Article
Cell Biology
Abbas Majdi Seghinsara, Hamed Shoorei, Mohammad Mehdi Hassanzadeh Taheri, Arash Khaki, Majid Shokoohi, Moloud Tahmasebi, Amir Afshin Khaki, Hossein Eyni, Sadegh Ghorbani, Khadijeh Riahi Rad, Hossein Kalarestaghi, Leila Roshangar
Article
Reproductive Biology
Fariba Khodaeifar, Seyyed Mohammad Bagher Fazljou, Arash Khaki, Mohammadali Torbati, Elahe Olad Saheb Madarek, Amir Afshin Khaki, Majid Shokoohi, Amir Hossein Dalili
INTERNATIONAL JOURNAL OF WOMENS HEALTH AND REPRODUCTION SCIENCES
(2019)
