Review
Food Science & Technology
Chun-xiao Li, Tian-hao Li, Mei Zhu, Jiang Lai, Zhi-peng Wu
Summary: Glabridin, a major flavonoid in licorice, has a wide range of pharmacological properties but there are still controversies and unresolved issues regarding its specific mechanisms of action and clinical applications.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Chi-Li Chung, Jui-Hsuan Chen, Wei-Chieh Huang, Joen-Rong Sheu, Chih-Wei Hsia, Thanasekaran Jayakumar, Chih-Hsuan Hsia, Kuan-Rau Chiou, Shaw-Min Hou
Summary: This study demonstrates that glabridin can effectively inhibit platelet aggregation and activation through multiple signaling pathways. It shows promising potential as a therapeutic agent for thromboembolic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Yuliya Markina, Tatiana Kirichenko, Alexander M. Markin, Irina Y. Yudina, Antonina Starodubova, Igor A. Sobenin, Alexander N. Orekhov
Summary: Cardiovascular diseases associated with atherosclerosis are the leading cause of death in developed countries. Licorice has shown promising anti-atherosclerotic effects, including anti-inflammatory, antioxidant, and anti-platelet actions, making it a potential atheroprotective agent.
Article
Medicine, Research & Experimental
Yuichi Igarashi, Shiho Iida, Jian Dai, Jia Huo, Xiaoran Cui, Jinko Sawashita, Masayuki Mori, Hiroki Miyahara, Keiichi Higuchi
Summary: Long-term supplementation of Glavonoid-rich oil (GRO) derived from licorice root in obese and diabetic mice improved metabolic disorders by reducing body weight and white adipose tissue weight, lowering serum triglycerides and cholesterol levels, and enhancing glucose tolerance. The improved lipid profiles were attributed to reduced de novo lipogenesis in the liver and white adipose tissue, while glucose metabolism may benefit from increased glycolysis in the liver.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Lin Zhang, Haibo Zhang, Jinhua Gu, Wanqing Xu, Nianping Yuan, Jialin Sun, Hua Li
Summary: The study found that glabridin can inhibit liver fibrosis and hepatic stellate cells activation in CCl4-treated mice by suppressing inflammation and oxidative stress through the activation of PPARγ.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Infectious Diseases
Katy Vaillancourt, Genevieve LeBel, Genevieve Pellerin, Amel Ben Lagha, Daniel Grenier
Summary: Studies have shown that licoricidin and glabridin have antibacterial properties against the cariogenic bacterium Streptococcus mutans, reducing biofilm viability and dextran production. They also attenuated bacterial adherence and acid production, while showing low toxicity towards oral keratinocytes. These findings suggest that licoricidin and glabridin may be promising agents for controlling dental caries.
Article
Dentistry, Oral Surgery & Medicine
Shirui Ren, Yingming Yang, Mengying Xia, Yalan Deng, Yuling Zuo, Lei Lei, Tao Hu
Summary: This study aimed to investigate the antibiofilm and anticariogenic effects of honokiol, a traditional Chinese medicine, on the cariogenic bacterium Streptococcus mutans. The results showed that honokiol has inhibitory effects on S. mutans and favorable biocompatibility with human gingival fibroblasts. Therefore, honokiol has potential application as a novel anticaries agent.
ARCHIVES OF ORAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hongtao Tan, Junxian Chen, Yicong Li, Yingshan Li, Yunchang Zhong, Guangzhao Li, Lingling Liu, Yiqun Li
Summary: Through network pharmacology, the study revealed the protective effects of Glab on diabetic nephropathy, possibly by suppressing ferroptosis and the VEGF/Akt/ERK pathway.
MOLECULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Jihang Dai, Yaxin Zhang, Deng Chen, Duoyun Chen, Xiaolei Li, Jingcheng Wang, Yu Sun
Summary: This study found that Glabridin can increase the expression of extracellular matrix related genes and significantly reduce oxidative stress levels, decreasing apoptosis of chondrocytes. In animal experiments, Glabridin was observed to alleviate the progression of osteoarthritis and protect chondrocytes from apoptosis.
Article
Engineering, Biomedical
Junjie Chi, Lingyu Sun, Lijun Cai, Lu Fan, Changmin Shao, Luoran Shang, Yuanjin Zhao
Summary: The study introduces a novel Chinese herb microneedle patch, which promotes wound healing and has various medicinal effects such as heat clearing, detoxicating, and antibacterial properties. By integrating pure herbal compositions with advanced technologies, the research demonstrates the potential development and promotion of traditional Chinese medicine in modern society.
BIOACTIVE MATERIALS
(2021)
Article
Multidisciplinary Sciences
Corena Grant, Kelley Jordan, Melina Seng, Leah Pyter
Summary: Chemotherapy in cancer treatment has severe side effects, both physical and mental. The gut-brain axis plays a role in these behavioral side effects through communication with altered gut microbes. The study indicates that chemotherapy-altered gut microbes disrupt energy homeostasis, leading to fatigue-like behaviors in mice.
Article
Endocrinology & Metabolism
Leo Sungwong Choi, In Geun Jo, Ku Suk Kang, Jeong Ho Im, Jiyoung Kim, Jinyoung Kim, Jin Wook Chung, Sang-Ku Yoo
Summary: This study identified key chemical components of glabridin relevant to its weight loss effects, and proposed HSG4112 as a promising novel drug candidate for the pharmacological treatment of obesity. The optimized structural analog HSG4112 significantly exceeded glabridin in weight reduction efficacy and chemical stability, and its administration led to dose-dependent normalization of obesity-related parameters in mice.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Pharmacology & Pharmacy
Feng Zhang, Tiantian Zhang, Jiahao Gong, Qinqin Fang, Shenglan Qi, Mengting Li, Yan Han, Wei Liu, Guangbo Ge
Summary: This study demonstrates that the Chinese herb Styrax can efficiently inhibit hCYP3A4 enzyme and modulate the pharmacokinetic behavior of CYP3A-substrate drugs. It provides valuable insights for clinical pharmacologists to assess the potential herb-drug interactions triggered by Styrax or Styrax-related herbal products.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shundi Liu, Hao Lin, Yu Chen, Yuzhen Wang, Xiaoshan Zhang, Zheng Xiang, Xiaojun Cai
Summary: In this study, the metabolic profiles of glabridin in rat plasma, urine, bile, and feces were analyzed using UPLC-QTOF-MS. The main metabolic forms of glabridin in rats were identified, providing valuable data for future pharmacological studies of glabridin.
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
(2022)
Review
Pharmacology & Pharmacy
Yanwei Li, Qingwan Guo, Junqing Huang, Ziying Wang
Summary: Depression, a highly disabling and lethal mental illness, poses a serious threat to social stability and has become one of the most common disorders worldwide. Panax notoginseng, a traditional Chinese herbal medication, has been used for thousands of years to treat depression and has shown therapeutic effects. Recent research has focused on animal models and pathways influenced by Panax notoginseng, providing empirical evidence for its anti-depressive effects and suggesting new ideas for developing innovative clinical antidepressants with fewer side effects.
FRONTIERS IN PHARMACOLOGY
(2022)
