Article
Chemistry, Applied
Tatjana Juric, Nikola Micic, Aleksandar Potkonjak, Dubravka Milanov, Jelena Dodic, Zorana Trivunovic, Boris M. Popovic
Summary: The study found that choline chloride-based natural deep eutectic solvents (NADES) can more effectively extract bioactive compounds from peppermint leaves and have the potential to be used for the separation of targeted major compounds. Additionally, NADES exhibit microbial growth inhibition at lower concentrations and show antioxidant and reducing activities.
Article
Plant Sciences
Ziggiju Mesenbet Birhanie, Aiping Xiao, Dawei Yang, Siqi Huang, Chao Zhang, Lining Zhao, Liangliang Liu, Jianjun Li, Anguo Chen, Huijuan Tang, Li Chang, Gen Pan, Cuiping Zhang, Ashok Biswas, Susmita Dey, Defang Li, Yong Deng
Summary: Kenaf, a plant rich in bioactive compounds, has been found to exhibit antioxidant and antibacterial activities in leaf extracts. Some genotypes showed higher antioxidant activity, suggesting they can be used as natural antioxidants and antimicrobials in the food industry.
Article
Plant Sciences
Shachi Singh, Mukesh Kumar, Seema Dwivedi, Anjali Yadav, Sarika Sharma
Summary: In this study, a rapid and effective metabolomic method was used to screen the chemical characterization of all parts of B. prionitis, including leaf, root, stem, and inflorescence. Bioactive iridoid glycosides and phenolic compounds were identified in all parts, with root showing the highest antioxidant and antibacterial activity. Some of the identified compounds were positively correlated with the tested biological activity. Principal component analysis of the chemical profiles revealed variability in compound distribution.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Polymer Science
Betul Ari, Mehtap Sahiner, Sahin Demirci, Nurettin Sahiner
Summary: The combination of PVA with TA and Cur in cryogel composites showed high antioxidant and antibacterial activities, with potential for blood contacting applications. Release of TA and Cur from the composites was quantified at different pH conditions, showing concentration-dependent enzyme inhibition against alpha-glucosidase.
Article
Biochemistry & Molecular Biology
Alexandra Ciorita, Cezara Zagrean-Tuza, Augustin C. Mot, Rahela Carpa, Marcel Parvu
Summary: The phytochemical analysis of Vinca minor, V. herbacea, V. major, and V. major var. variegata leaf extracts revealed species-specific antioxidant, antibacterial, and cytotoxic effects correlated with the identified phytoconstituents. V. herbacea showed the highest antioxidant activity and antibacterial potential, while V. minor exhibited the most significant inhibitory effect against Staphylococcus aureus and E. coli.
Article
Biotechnology & Applied Microbiology
Mariem Ben Salah, Chedia Aouadhi, Ayda Khadhri
Summary: A simple and eco-friendly method for synthesizing silver nanoparticles using the lichen Roccella phycopsis was developed in this study. The synthesized AgNPs demonstrated strong antioxidant and antibacterial activities, especially against Gram-negative bacteria. Additionally, the silver nanoparticles showed potent inhibition of acetylcholinesterase enzyme.
BIOPROCESS AND BIOSYSTEMS ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Doungporn Amornlerdpison, Vachira Choommongkol, Kanjana Narkprasom, Susanha Yimyam
Summary: Banana inflorescence is extracted and developed into a beverage rich in bioactive compounds, showing high antioxidant activity and phenolic compounds in aqueous extract; it serves as a convenient and alternative drink for postpartum mothers feeding their infants.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemical Research Methods
Narimane Segueni, Merve Keskin, Saban Keskin, Benlabed Kadour, Sevgi Kolayli, Akkal Salah
Summary: The study compared the phenolic content, antioxidant, and antibacterial activity of propolis samples collected from different localities of Algeria and Turkey. Results showed that Algerian propolis had stronger antibacterial activity against S. aureus compared to Anatolian propolis, while Anatolian propolis was more active against P. aeruginosa.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2021)
Article
Plant Sciences
Jameel M. Al-Khayri, Arzu Kavaz Yuksel, Mehmet Yuksel, Mesut Isik, Emrah Dikici
Summary: Corn tassel (CT) is a waste part of the corn plant that contains bioactive compounds and phytochemicals. This research analyzed the phenolic profile, antioxidants, anticholinergic activities, and antibacterial properties of CT ethanol extract. The results showed that the ethanol extract of CT contains various phenolic compounds and exhibits strong antioxidant and antibacterial activities.
Article
Food Science & Technology
Eugenia Telis de Vilela Silva, Alexandre Jose Melo de Queiroz, Rossana Maria Feitosa de Figueiredo, Henrique Valentim Moura, Francislaine Suelia dos Santos, Aline Priscila de Franca Silva, Cristina Fernandes Cavalcanti, Mailson Goncalves Gregorio, Pluvia Oliveira Galdino, Josivanda Palmeira Gomes
Summary: Germinated peanut flours produced through convective drying at 70 degrees C showed high levels of minerals, total phenolic compounds, and antioxidant potential. The BRS Havana cultivar exhibited elevated levels of flavonoids, while the BR1 cultivar was more susceptible to degradation reactions during storage at higher temperatures.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jin-Sol Kim, Chulyung Choi, Hyun-Hwa Lee
Summary: This study investigated the antioxidant, antiaging, and antibacterial properties of different extractions from Gracilaria verrucosa. The results showed that the methanol and ethanol extractions had stronger antioxidant activities, while the hot water extraction had the highest content of 4-hydroxy benzoic acid. The methanol extraction exhibited the strongest anti-wrinkle and skin-whitening activities, and the ethanol extraction showed the strongest antimicrobial activity against six foodborne bacteria.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Donporn Wongwaiwech, Sudthida Kamchonemenukool, Chi-Tang Ho, Shiming Li, Tipawan Thongsook, Nutthaporn Majai, Duangporn Premjet, Kawee Sujipuli, Monthana Weerawatanakorn
Summary: This study investigated the nutraceutical contents of two popular Kluai Namwa varieties, Mali Ong and Nuanchan, at different ripening stages, and compared the dried banana products made from these varieties. The results showed that both varieties had increasing moisture, total sugar, and total soluble solids during ripening, while total solids and texture values decreased. Rutin was the major flavonoid found in both varieties, and all flavonoids increased with ripening. There were no significant differences in flavonoid contents between the two varieties. Tannic acid, ellagic acid, gallic acid, chlorogenic acid, and ferulic acid were the main phenolic acids found in both varieties, and dopamine contents increased during ripening. Inulin as fructooligosaccharide increased with ripening. The study concluded that the two varieties could be used interchangeably in terms of nutraceutical contents in dried banana products.
Article
Biochemistry & Molecular Biology
Celina Habryka, Robert Socha, Leslaw Juszczak
Summary: The study confirmed that enriching honey with bee pollen significantly increased the content of phenolic compounds, improving its antioxidant and antiradical activities, but resulting in a deterioration of its sensory properties.
Article
Food Science & Technology
Mehdi Akbari, Seyed Hadi Razavi, Faramarz Khodaiyan, Jesus Blesa, Maria J. Esteve
Summary: This study evaluated the potential of solid-state fermentation with Lactobacillus reuteri and Lactobacillus plantarum for improving phenolic compounds and antioxidant activity in corn bran. The results showed that fermentation significantly increased the total phenolic content and antioxidant activity of the fermented samples. It also increased the concentration of free phenolic acids. Therefore, solid-state fermentation is an effective method for enhancing phenolic compounds and antioxidant activity.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Engineering, Chemical
Morayma Ramirez Damian, Ofelia Gabriela Meza-Marquez, Guillermo Osorio-Revilla, Tzayhri Gallardo-Velazquez, Dario Iker Tellez-Medina, Oswaldo Arturo Ramos-Monroy
Summary: The study focused on extracting and microencapsulating bioactive compounds from red banana peel, and evaluating their bioaccessibility through in vitro digestion. The results showed that microencapsulation using gum arabic and soy protein isolate effectively protected the phenolic compounds, flavonoids, and antioxidant capacity of the banana peel extract during digestion.
Article
Chemistry, Multidisciplinary
Khondker R. Hossain, Stetphen A. Holt, Anton P. Le Brun, Heba Al Khamici, Stella M. Valenzuela
Article
Materials Science, Biomaterials
Kerem Bray, Leonard Cheung, Khondker Rufaka Hossain, Igor Aharonovich, Stella M. Valenzuela, Olga Shimoni
JOURNAL OF MATERIALS CHEMISTRY B
(2018)
Article
Biochemistry & Molecular Biology
Alvaro Garcia, Bogdan Lev, Khondker R. Hossain, Amy Gorman, Dil Diaz, Thi Hanh Nguyen Pham, Flemming Cornelius, Toby W. Allen, Ronald J. Clarke
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Khondker Rufaka Hossain, Daniel R. Turkewitz, Stephen A. Holt, Leonie Herson, Louise J. Brown, Bruce A. Cornell, Paul M. G. Curmi, Stella M. Valenzuela
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2019)
Article
Biochemistry & Molecular Biology
Amy Gorman, Khondker R. Hossain, Flemming Cornelius, Ronald J. Clarke
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2020)
Article
Biochemistry & Molecular Biology
K. R. Hossain, X. Li, T. Zhang, S. Paula, F. Cornelius, R. J. Clarke
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2020)
Article
Chemistry, Multidisciplinary
Timothy S. Chisholm, Sameer S. Kulkarni, Khondker R. Hossain, Flemming Cornelius, Ronald J. Clarke, Richard J. Payne
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2020)
Article
Microbiology
Muhammad Yasir, Debarun Dutta, Khondker R. Hossain, Renxun Chen, Kitty K. K. Ho, Rajesh Kuppusamy, Ronald J. Clarke, Naresh Kumar, Mark D. P. Willcox
FRONTIERS IN MICROBIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
R. J. Clarke, K. R. Hossain, K. Cao
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2020)
Editorial Material
Biotechnology & Applied Microbiology
K. R. Hossain, J. D. Escobar Bermeo, K. Warton, S. M. Valenzuela
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Khondker R. Hossain, Daniel R. Turkewitz, Stephen A. Holt, Anton P. Le Brun, Stella M. Valenzuela
Summary: This study reveals the importance of the free sterol 3 beta-OH group for the interaction between CLIC1 protein and cholesterol. It also shows that the presence of additional hydroxyl groups, methylation of the sterol skeleton, and the structure of the sterol alkyl side chain modulate the magnitude of CLIC1 interaction with sterols and its membrane insertion. Furthermore, CLIC1 is able to interact with other naturally existing sterol molecules.
Article
Biochemistry & Molecular Biology
Khondker Rufaka Hossain, Amani Alghalayini, Stella M. Valenzuela
Summary: Cannabidiol (CBD) has gained significant attention for its potential therapeutic benefits, but its low bioavailability poses a challenge. Various approaches have emerged to enhance CBD's bioavailability and pave the way for novel formulations that maximize its therapeutic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Amani Alghalayini, Khondker Rufaka Hossain, Saba Moghaddasi, Daniel R. Turkewitz, Claudia D'Amario, Michael Wallach, Stella M. Valenzuela
Summary: Chloride intracellular ion channel (CLIC) proteins can exist both in soluble and integral membrane forms, with CLIC1 being able to switch between two different structural conformations. Recent evidence suggests that CLIC family members act as moonlighting proteins, performing multiple functions. In addition to their ion channel activity, CLIC proteins also possess oxidoreductase enzymatic activity and show variability in tissue distribution and cellular localization. This study characterizes the kinetic properties and the temperature and pH profiles of three CLIC family members (CLIC1, CLIC3, CLIC4) using the 2-hydroxyethyl disulfide (HEDS) assay system. The effects of the drugs rapamycin and amphotericin B on the enzymatic activity of the three CLIC proteins in the HEDS assay are also investigated. The results reveal individual differences in enzymatic activity among the three CLIC proteins, suggesting distinct regulation mechanisms involving changes in subcellular milieu and microenvironment.
Article
Chemistry, Physical
Khondker R. Hossain, Daniel Clayton, Sophia C. Goodchild, Alison Rodger, Richard J. Payne, Flemming Cornelius, Ronald J. Clarke
Summary: Membrane protein structure and function are modulated by interactions with the lipid environment, particularly for P-type ATPases. These ATPases play vital roles in cell physiology, with some pumps possessing polybasic domains that interact with phosphatidylserine in the plasma membrane, affecting ion pumping activity and acting as potential death sensors.
FARADAY DISCUSSIONS
(2021)
Article
Chemistry, Multidisciplinary
Alvaro Garcia, Haipei Zou, Khondker R. Hossain, Qikui Henry Xu, Annabelle Buda, Ronald J. Clarke