4.0 Article

Extra- and intracellular antimycobacterial activity of Arbutus unedo L.

Journal

AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH
Volume 6, Issue 6, Pages 1283-1290

Publisher

ACADEMIC JOURNALS
DOI: 10.5897/AJMR11.1540

Keywords

Antimycobacterial activity; Arbutus unedo L.; rat peritoneal macrophages

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This study aims to evaluate extra- and intracellullar antimycobacterial activity of Arbutus unedo L. leaves-extracts. We tested the aqueous and ethanol extracts of Arbutus leaves effect against three mycobacteria growth, and showed that aqueous extract and the part I of ethanol extract have a remarkable extracellular antimycobacterial activity. The MIC (Minimum inhibitory concentration) of the part I of ethanol extract is 5.59 +/- 0.69 mg/ml for Mycobacterium aurum A + and 6.02 +/- 0.76 mg/ml for Mycobacterium smegmatis MC2 and Mycobacterium bovis PPI. The part I of arbutus ethanol-extract, used at 6.02 +/- 0.76 mg/ml, has a bactericidal effect on M. smegmatis MC2 located within the rat peritoneal macrophages.

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