Review
Cell Biology
Rafal Filip
Summary: The microbial population in the human intestinal tract has significant impacts on infant development and the maturity of the gut immune system. Bacteria influence the host gut immune system through the release of extracellular vesicles (EVs), which can vary in content, size, and bacterial species origin, impacting intestinal cells and potentially leading to inflammation or pathogen entry into the gut wall. Additionally, maternal milk EVs may play a role in maintaining the integrity of the gut barrier in mammals. The use of EVs has also been explored as a novel therapeutic approach in conditions such as necrotizing enterocolitis (NEC) and inflammatory bowel disease (IBD).
Review
Immunology
Mecklin V. Ragan, Samantha J. Wala, Steven D. Goodman, Michael T. Bailey, Gail E. Besner
Summary: This article introduces a new delivery system for L. reuteri that enhances the efficacy of the probiotic by inducing biofilm formation. The study shows promising results in rat and mouse models, demonstrating the preventive and therapeutic effects of L. reuteri in its biofilm state. Furthermore, an ongoing clinical trial may support the future use of L. reuteri in preventing NEC in preterm infants.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yan Hui, Birgitte Smith, Martin Steen Mortensen, Lukasz Krych, Soren J. Sorensen, Gorm Greisen, Karen Angeliki Krogfelt, Dennis Sandris Nielsen
Summary: The study found that probiotic supplementation in preterm neonates affected gut colonization by certain bacteria, but did not change the overall longitudinal bacterial progression during the neonatal period.
Article
Nutrition & Dietetics
Marwyn Sowden, Mirjam Maria van Weissenbruch, Andre Nyandwe Hamama Bulabula, Lizelle van Wyk, Jos Twisk, Evette van Niekerk
Summary: The study found that a multi-strain probiotic formulation is effective in preventing necrotizing enterocolitis and feeding intolerances in premature neonates. This research is of great importance in exploring treatment methods for preventing intestinal diseases in premature infants.
Article
Surgery
Bing Tian, Yunfei Zhang, Chun Deng, Chunbao Guo
Summary: This study compared the effects of fecal microbiota transplantation (FMT) and probiotic consortium transplantation (PCT) on oxidative stress in neonatal necrotizing enterocolitis (NEC). The results showed that FMT more effectively modulated oxidative stress in the intestine than PCT. However, the difference between the two treatments was not significant. The protective effect was associated with enhanced antioxidant capacity, regulation of the main components of the mucus layer, reduced inflammatory reactions, and improved intestinal integrity.
JOURNAL OF SURGICAL RESEARCH
(2022)
Review
Pediatrics
Nitin Sajankila, Samantha Jane Wala, Mecklin Victoria Ragan, Samuel Grant Volpe, Zachary Dumbauld, Nanditha Purayil, Belgacem Mihi, Gail E. Besner
Summary: Necrotizing enterocolitis (NEC) is a complex intestinal disease that primarily affects premature neonates. The use of probiotics is a potential preventative strategy for NEC, but clear guidelines and FDA-approved products are currently lacking. There is ongoing debate about the benefits, safety, and efficacy of probiotics, and further research and product development is needed to support their use in the preterm population.
FRONTIERS IN PEDIATRICS
(2023)
Article
Nutrition & Dietetics
Annika Mutanen, Helene Engstrand Lilja, Tomas Wester, Heimir Norrby, Helena Borg, Sara Persson, Kristin Bjornland, Anne Charlotte Brun, Lovisa Telborn, Pernilla Stenstrom, Mikko P. Pakarinen
Summary: This multicenter study aimed to assess key outcomes and clinical prognostic factors in a recent Nordic pediatric SBS-IF population. The results showed that despite multidisciplinary management, septic complications and intestinal failure associated liver disease (IFALD) are still associated with a low mortality rate.
CLINICAL NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Shaghayegh Baradaran Ghavami, Hamid Asadzadeh Aghdaei, Dario Sorrentino, Shabnam Shahrokh, Maryam Farmani, Fatemeh Ashrafian, Maria Pina Dore, Shahrbanoo Keshavarz Azizi Raftar, Seyed Mobin Khoramjoo, Mohammad Reza Zali
Summary: Inflammatory bowel diseases (IBDs) are immune-mediated, chronic relapsing diseases with a rising prevalence worldwide. Probiotic bacteria may impact immunomodulation by regulating dendritic cells to produce tolerogenic DCs, which could play a role in the treatment of IBD and associated conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Huifang Dong, Lingling Zhang, Bingbing Li, Jing Li, Yanshan Chen, Seidu A. A. Richard, Yiran Xu, Changlian Zhu
Summary: This study aimed to identify potential inflammatory biomarkers for early prediction of necrotizing enterocolitis (NEC) in premature infants. The researchers evaluated 92 inflammatory-related proteins using a high-throughput OLINK proteomics platform and found 11 proteins that showed significant differences among NEC, sepsis, and control preterm infants. A combination of these proteins had a high diagnostic potential for differentiating NEC from controls or sepsis, as well as for distinguishing different stages of NEC.
INFLAMMATION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Kairuo Wang, Qian Chen, Li Ding, Yefei Zhu, Xinyue Wang, Mengting Zhou, Meiqi Chang, Manman Pei, Yuanyuan Zhang, Yang Zhang, Yu Chen, Huanlong Qin
Summary: This study developed a mucoadhesive probiotic-mediated therapeutic strategy to achieve bioadhesion and prolong the residence time of oral medication in the intestinal tract. It effectively modulated intestinal inflammation and microbiota, enhancing the therapeutic effect.
Article
Cell Biology
Jianglong Chen, Tong Chen, Jin Zhou, Xiuhao Zhao, Qingfeng Sheng, Zhibao Lv
Summary: The study revealed that miR-146a-5p can inhibit the expression of NLRP3 inflammasome and its downstream inflammatory factors in NEC patients' intestines, alleviating inflammation and intestinal injury.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Peng Lu, Yukihiro Yamaguchi, William B. Fulton, Sanxia Wang, Qinjie Zhou, Hongpeng Jia, Mark L. Kovler, Andres Gonzalez Salazar, Maame Sampah, Thomas Prindle, Peter Wipf, Chhinder P. Sodhi, David J. Hackam
Summary: NEC, a disease of prematurity, is associated with AHR signaling. Administration of AHR ligands during pregnancy and postnatally can prevent NEC. AHR signaling plays a crucial role in the development of NEC and may be a potential therapeutic target for NEC.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Jayshree Mishra, Madyson Stubbs, Longxiang Kuang, Nitza Vara, Priyam Kumar, Narendra Kumar
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract. Probiotics and their engineering show great potential in treating chronic inflammatory conditions, including IBD. Personalized probiotic treatment is important due to the diversity of the gut microbiome in different populations.
MEDIATORS OF INFLAMMATION
(2022)
Article
Pediatrics
Alain Cuna, Sherwin Chan, Jill Jones, Maura Sien, Amie Robinson, Karishma Rao, Erin Opfer
Summary: We conducted a diagnostic randomized clinical trial to examine the feasibility, acceptability, and preliminary outcomes of adding bowel ultrasound to the diagnostic evaluation for NEC. The study showed that conducting a full trial is feasible, and there were no significant differences in NEC diagnosis rates and treatment durations between the two groups.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Liz Kocjancic, Christoph Buehrer, Felix Berger, Vinzenz Boos
Summary: The study investigated the use of dual-strain probiotics for NEC prevention in newborns with ductal-dependent congenital heart disease (CHD), finding no significant overall benefit but a potential reduction in NEC frequency in infants with aortic arch malformations. Due to the rarity of concurrent CHD and NEC, a large-scale clinical trial would be needed to further confirm the findings.
Article
Biochemistry & Molecular Biology
Piotr Deptula, Lukasz Suprewicz, Tamara Daniluk, Andrzej Namiot, Sylwia Joanna Chmielewska, Urszula Daniluk, Dariusz Lebensztejn, Robert Bucki
Summary: This study focuses on the molecular mechanisms related to Helicobacter pylori infection and gastric cancer development. It suggests that the nanomechanical properties of infected tissues could serve as markers of H. pylori presence and the mechanical response of gastric cells to this infection may play a role in promoting cancer development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Jaroslaw Daniluk, Urszula Daniluk, Pawel Rogalski, Agnieszka Swidnicka-Siergiejko, Justyna Wasielica-Berger, Rafal Jacek Kucharski, Stefania Antonowicz, Joanna Reszec, Joanna Maria Lotowska, Piotr Zabielski, Agnieszka Blachnio-Zabielska, Andrzej Dabrowski
Summary: The study found that cigarette smoking promotes the development of chronic pancreatitis in mice exposed to repeated episodes of acute pancreatitis, possibly due to increased expression of K-Ras and NF-Kappa B proteins.
ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE
(2022)
Review
Medicine, General & Internal
Jaroslaw Daniluk, Urszula Daniluk, Pawel Rogalski, Andrzej Dabrowski, Agnieszka Swidnicka-Siergiejko
Summary: Pancreatic ductal adenocarcinoma is a deadly neoplasm with poor prognosis, and the human microbiome may play a role in its pathogenesis. This review summarizes the current understanding of how the microbiome influences pancreatic cancer development and progression, discusses its potential as a marker for diagnosis, progression, and survival, and explores the possibility of modifying the microbiome to improve treatment outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Urszula Daniluk, Kamila Kwiatek-Sredzinska, Piotr Jakimiec, Jaroslaw Daniluk, Aleksandra Czajkowska, Dariusz Marek Lebensztejn
Summary: The study revealed that a significant proportion of children with IBD have liver pathology, with the majority of cases being detected after the diagnosis of IBD. Patients with a specified diagnosis of liver pathology were typically younger and had higher ALT activity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Aleksandra Czajkowska, Katarzyna Guzinska-Ustymowicz, Anna Pryczynicz, Dariusz Lebensztejn, Urszula Daniluk
Summary: This study aimed to investigate the relationship between MMP-9 and TIMP-1 and UC phenotypes, disease activity index, and inflammatory markers. The results showed that children with UC had significantly higher levels of these markers in their serum and feces compared to the control group. Additionally, serum MMP-9 correlated with the severity of the disease and other markers, while serum TIMP-1 correlated with disease activity, inflammatory markers, and erythrocyte sedimentation rate. Serum and fecal levels of MMP-9 and TIMP-1 can be useful in distinguishing UC patients and evaluating disease phenotypes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Katarzyna Zdanowicz, Jaroslaw Daniluk, Dariusz Marek Lebensztejn, Urszula Daniluk
Summary: The incidence of gallstone disease is increasing, with complex pathogenesis influenced by both genetic and environmental factors. Research on cholelithiasis in children highlights the importance of understanding the disease course and predisposing factors for faster and appropriate diagnosis and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Katarzyna Zdanowicz, Anna Bobrus-Chcociej, Karolina Pogodzinska, Agnieszka Blachnio-Zabielska, Beata Zelazowska-Rutkowska, Dariusz Marek Lebensztejn, Urszula Daniluk
Summary: This study found that there are differences in the concentrations of serum sphingolipids in pediatric patients with cholelithiasis, suggesting that they may serve as potential biomarkers.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Urszula Daniluk, Paulina Krawiec, Elzbieta Pac-Kozuchowska, Lukasz Dembinski, Jan Stanislaw Bukowski, Aleksandra Banaszkiewicz, Anna Wozniuk-Kazmierczak, Elzbieta Czkwianianc, Jan Brylak, Jaroslaw Walkowiak, Agnieszka Borys-Iwanicka, Anna Kofla-Dlubacz, Tomasz Pytrus, Katarzyna Zdanowicz, Dariusz Marek Lebensztejn
Summary: The coexistence of inflammatory bowel disease (IBD) with pancreatic pathology is rare in children. A retrospective analysis of data from 1538 children diagnosed with IBD in 2014-2021 found that 11.4% of them had pancreatic involvement (PI), with acute pancreatitis (AP) diagnosed in 43.8% and asymptomatic hyperlipasemia (HL) or hyperamylasemia (HA) observed in 50.0%. Routine monitoring of pancreatic enzymes should be performed in patients with IBD, especially after the initiation of azathioprine (AZA) treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Magdalena Kucharska, Katarzyna Zdanowicz, Tamara Daniluk, Robert Bucki, Dariusz Marek Lebensztejn, Urszula Daniluk
Summary: This study assessed antibiotic resistance of Helicobacter pylori in previously untreated children in northeast Poland and found a high proportion of strains resistant to at least 1 antibiotic. These results may aid in the selection of appropriate antibiotics for the treatment of Helicobacter pylori infection in our region.
MEDICAL SCIENCE MONITOR
(2023)
Article
Medicine, General & Internal
Maciej Kaczmarski
Summary: Idiopathic nephrotic syndrome (INS) in children is associated with an allergic reaction, leading to kidney damage and excessive protein loss in the urine. This study investigates a child with INS who also has allergies to cow's milk proteins and other allergens. The study finds that the treatment of the allergic reaction, including medication and elimination diet, can improve the course of INS in this child.
Article
Allergy
Maciej Kaczmarski, Dorota Citko, Jolanta Wasilewska
Summary: This study aimed to retrospectively assess the incidence of IgE-dependent sensitization to food and airborne allergens over a 14-year period in a specific population in northeastern Poland. The results showed a significant increase in sensitization to food allergens, while the sensitization to airborne allergens remained similar throughout the study period.
POSTEPY DERMATOLOGII I ALERGOLOGII
(2023)
Article
Pediatrics
Joanna Ryzko, Katarzyna Zdanowicz, Dariusz Marek Lebensztejn, Urszula Daniluk
Summary: Extraintestinal manifestations (EIMs) are common in patients with inflammatory bowel disease (IBD), with myocarditis being one rare manifestation. We present a case of CD patient with hip joint inflammation and erythema nodosum, along with myopericarditis.
Review
Medicine, General & Internal
Piotr Jakimiec, Katarzyna Zdanowicz, Kamila Kwiatek-Sredzinska, Aleksandra Filimoniuk, Dariusz Lebensztejn, Urszula Daniluk
Summary: This study conducted a systematic review of the literature on pancreatic disorders associated with IBD in children, finding that acute pancreatitis is the most common pancreatic disease in pediatric IBD, with manifestations ranging from asymptomatic increase in pancreatic enzyme activity to severe pancreatitis. The involvement of the pancreas can be closely related to the activity of IBD, and it is recommended to include pancreatic enzyme level measurement in the workup of IBD.
MEDICINA-LITHUANIA
(2021)
Article
Allergy
Maciej Kaczmarski, Dorota Citko, Jolanta Wasilewska
POSTEPY DERMATOLOGII I ALERGOLOGII
(2020)
Article
Allergy
Maciej Kaczmarski, Dorota Citko, Jolanta Wasilewska
POSTEPY DERMATOLOGII I ALERGOLOGII
(2020)
