Chemoenzymatic Approaches to the Synthesis of the Calcimimetic Agent Cinacalcet Employing Transaminases and Ketoreductases

Identification of Novel Bacterial Members of the Imine Reductase Enzyme Family that Perform Reductive Amination

(2018) Scott P. France et al.   ChemCatChem

One-step asymmetric synthesis of (R)- and (S)-rasagiline by reductive amination applying imine reductases

(2017) P. Matzel et al.   GREEN CHEMISTRY

A reductive aminase from Aspergillus oryzae

(2017) Godwin A. Aleku et al.   Nature Chemistry

Discovery, Engineering, and Synthetic Application of Transaminase Biocatalysts

(2017) Iustina Slabu et al.   ACS Catalysis

Syntheses of Cinacalcet: An Enantiopure Active Pharmaceutical Ingredient (API)

(2016) Santiago Vázquez et al.   SYNTHESIS-STUTTGART

Stereoselectivity and Structural Characterization of an Imine Reductase (IRED) from Amycolatopsis orientalis

(2016) Godwin A. Aleku et al.   ACS Catalysis

A roadmap for biocatalysis - functional and spatial orchestration of enzyme cascades

(2016) Claudia Schmidt-Dannert et al.   Microbial Biotechnology

Fluorescence-Based Kinetic Assay for High-Throughput Discovery and Engineering of Stereoselective ω-Transaminases

(2015) Thomas Scheidt et al.   ADVANCED SYNTHESIS & CATALYSIS

Biocatalysis: Successfully Crossing Boundaries

(2015) Uwe T. Bornscheuer   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expanding the Imine Reductase Toolbox by Exploring the Bacterial Protein-Sequence Space

(2015) Dennis Wetzl et al.   CHEMBIOCHEM

Development of an Immobilized Ketoreductase for Enzymatic (R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanol Production

(2015) Hongmei Li et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Cinacalcet hydrochloride for the treatment of hyperparathyroidism

(2013) Nicolas Verheyen et al.   EXPERT OPINION ON PHARMACOTHERAPY

Asymmetric Synthesis of Nonracemic Primary Amines via Spiroborate-Catalyzed Reduction of Pure (E)- and (Z)-O-Benzyloximes: Applications toward the Synthesis of Calcimimetic Agents

(2013) Wenhua Ou et al.   JOURNAL OF ORGANIC CHEMISTRY

The role of biocatalysis in the asymmetric synthesis of alkaloids

(2013) Joerg H. Schrittwieser et al.   RSC Advances

Cinacalcet in Patients with Chronic Kidney Disease: A Cumulative Meta-Analysis of Randomized Controlled Trials

(2013) Suetonia C. Palmer et al.   PLOS MEDICINE

Synthesis of silica particles and their application as supports for alcohol dehydrogenases and cofactor immobilizations: Conformational changes that lead to switch in enzyme stereoselectivity

(2012) Galina A. Petkova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

A Versatile Ru Catalyst for the Asymmetric Transfer Hydrogenation of Both Aromatic and Aliphatic Sulfinylimines

(2012) Óscar Pablo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Engineering the third wave of biocatalysis

(2012) U. T. Bornscheuer et al.   NATURE

Hydrolases in the Stereoselective Synthesis ofN-Heterocyclic Amines and Amino Acid Derivatives

(2011) Eduardo Busto et al.   CHEMICAL REVIEWS

Treatment of Alcohols with Tosyl Chloride Does Not always Lead to the Formation of Tosylates

(2011) Rui Ding et al.   MOLECULES

Iridium-catalysed amine alkylation with alcohols in water

(2010) Ourida Saidi et al.   CHEMICAL COMMUNICATIONS

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

(2010) C. K. Savile et al.   SCIENCE

Optical resolution of 1-(1-naphthyl)ethylamine by its dicarboxylic acid derivatives: Structural features of the oxalic acid derivative diastereomeric salt pair

(2008) Laura Bereczki et al.   CHIRALITY

Cp∗Ir-catalyzed N-alkylation of amines with alcohols. A versatile and atom economical method for the synthesis of amines

(2007) Ken-ichi Fujita et al.   TETRAHEDRON