Article
Chemistry, Medicinal
Rania M. Yehia, Dalia A. Attia, Mohamed M. Elmazar, Mohamed A. El-Nabarawi, Mahmoud H. Teaima
Summary: This study investigated the use of microsponges as a carrier system for the drug Adapalene. The Plackett-Burman design was employed to identify key variables affecting the formulation of ADA-MS, with significant effects found for drug percentage, polymer type, and surfactant concentration. Furthermore, ADA-MS exhibited significant cytotoxicity against cell lines and enhanced antimicrobial activity.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Chemistry, Applied
Okon Johnson Esua, Da-Wen Sun, Jun-Hu Cheng, Huifen Wang, Chen Chen
Summary: The study evaluates the hybridization of plasma functionalized water and ultrasound pretreatment for enzymatic hydrolysis of Larimichthys polyactis. The results show that this method improves the hydrolysis, protein recovery, soluble protein content, and antioxidant activity.
Article
Biochemistry & Molecular Biology
Mohamed Hamdi, Enas Elmowafy, Hend Mohamed Abdel-Bar, Akram M. ElKashlan, Khuloud T. Al-Jamal, Gehanne A. S. Awad
Summary: Drug covalently bound to polymers has formed a promising drug delivery platform with targeting ability, boosting drug loading and controlled release. This study demonstrated that entecavir conjugated to hyaluronic acid in lipid nanohybrids can target Kupffer cells and hepatocytes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Valentina Andretto, Mathieu Repellin, Marine Pujol, Eyad Almouazen, Jacqueline Sidi-Boumedine, Thierry Granjon, Heyang Zhang, Katrien Remaut, Lars Petter Jordheim, Stephanie Briancon, Isabel Sofia Keil, Fulvia Vascotto, Kerstin C. Walzer, Ugur Sahin, Heinrich Haas, David Kryza, Giovanna Lollo
Summary: mRNA-based infectious disease vaccines have opened up new possibilities for the development of novel nucleic acids-based therapeutics. Hybrid nanoparticles with complex nanostructures, such as lipid-polymer hybrids, offer tailored properties for efficient delivery of mRNA. Surface modifications of liposome-mRNA complexes can fine-tune the physicochemical characteristics of nanoparticles, providing stable and optimized systems for future therapeutic interventions using mRNA-based nanomedicines.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Physical
Franciele Pereira Camargo, Isabel Kimiko Sakamoto, Ariane Bize, Iolanda Cristina Silveira Duarte, Edson Luiz Silva, Maria Bernadete Amancio Varesche
Summary: Different conditions for obtaining H2 from Citrus Peel Waste were evaluated, with pH 8.5, allochthonous inoculum of 3 gTVS.L-1, and substrate concentration of 15 g CPW.L-1 found to be the most significant factors for higher H2 and acetic acid production. Escherichia and Clostridium were the main genera identified under these conditions.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Biochemistry & Molecular Biology
Yuan Ma, Ailian Meng, Ping Liu, Yuanyuan Chen, Anqi Yuan, Yemei Dai, Kunyue Ye, Yi Yang, Yiping Wang, Zhuoman Li
Summary: Phenols were extracted from Pleioblastus amarus (Keng) shell using ethanol. The best extraction parameters were determined, and the phenol composition and antioxidant activity were analyzed. The polyphenol extract from Pleioblastus amarus (Keng) shell displayed excellent antioxidant activity, enhancing its practical application.
Article
Chemistry, Multidisciplinary
Bastian Haehnle, Philipp A. Schuster, Lisa Chen, Alexander J. C. Kuehne
Summary: A synthetic toolbox has been developed to create monodisperse core-shell and core-shell-shell particles composed entirely of different types of conjugated polymers. Seeded and fed-batch dispersion polymerizations based on Suzuki-Miyaura-type cross-coupling allow precise control over the interface between conjugated polymer phases, facilitating control over energy transfer phenomena. This new approach offers synthetic freedom for fine-tuning the optical properties of CPP, potentially enabling the synthesis of individual white light-emitting particles.
Article
Engineering, Electrical & Electronic
Linyu Pu, Jingyuan Tang, Xiaochun Gu, Tingting Jin, Benlan Zeng, Jingsong Liu, Xu Huang
Summary: In this study, PI composite films embedded with BaTiO3 were prepared by in-situ polymerization, with BaTiO3 nanofillers modified with paraffin to improve dispersion and compatibility with PI matrix. The composites exhibit high permittivity and stable capacitance, with the energy storage density of paraffin@BT/PI composite films higher than that of pristine PI by 2.4 times.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2021)
Article
Pharmacology & Pharmacy
Sameer J. Nadaf, Suresh G. Killedar, Vijay M. Kumbar, Durgacharan A. Bhagwat, Shailendra S. Gurav
Summary: This study successfully prepared pazopanib-loaded solid lipid nanoparticles with high drug loading and entrapment efficiency, showing significant cytotoxicity to lung cancer cells through apoptotic mode.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Hongda Lu, Shi-Yang Tang, Jiayuan Zhu, Xumin Huang, Helen Forgham, Xiangke Li, Ao Shen, Guolin Yun, Jinming Hu, Shiwu Zhang, Thomas P. Davis, Weihua Li, Ruirui Qiao
Summary: By nanoengineering liquid metal nanoparticles and using galvanic replacement, diverse core-shell nanostructures including LM@Au, Au@Ga oxide, and hollow Ga oxide nanoparticles are successfully fabricated. LM@Au exhibits exceptional photothermal performance with a conversion efficiency of 65.9%, which is five times that of gold nanoparticles. The high photothermal conversion efficiency and biocompatibility of LM@Au show promising applications in hyperthermia cancer therapy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Microbiology
Jie Tang, Bin Lin, Wei Jiang, Qun Li, Liping Zhu, Gang Zhang, Qianjin Chen, Qiang Yang, Shengzhi Yang, Shenxi Chen
Summary: This study investigates the change of beta-damascenone during the brewing process of light-flavor Baijiu and aims to optimize fermentation parameters for higher production. The highest beta-damascenone production was observed in Wickerhamomyces anomalus YWB-1. After optimization, beta-damascenone production increased 3.02-fold under the optimum conditions.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Arti Mehandole, Nikita Walke, Srushti Mahajan, Mayur Aalhate, Indrani Maji, Ujala Gupta, Neelesh Kumar Mehra, Pankaj Kumar Singh
Summary: Amongst the various nano-drug delivery systems, lipid or polymer-based core-shell nanocapsules (NCs) have gained significant attention due to their multidisciplinary properties and wide application. This review focuses on the fabrication methods and characterization techniques of lipidic and polymeric NC (LNCs and PNCs) systems, and demonstrates their extensive applications as carriers or delivery systems for oral, parenteral, nasal, and transdermal routes of administration. It provides in-depth understanding of the absorption mechanism, surface modification, size tuning, and toxicity moderation of core-shell NCs, and highlights the current challenges and future applications in this field.
Article
Geochemistry & Geophysics
Marwa Zribi, Basma Samet, Samir Baklouti
Summary: This study investigated phosphate-based geopolymers obtained from two aluminosilicate precursors with different mineralogical compositions. The experimental methods used were X-ray fluorescence, X-ray diffraction, atomic absorption measurements, and experimental designs. Nine factors influencing the dealumination process during geopolymer formation were screened, and the control factors were found to be the P/Al molar ratio, curing temperature, and curing time. Further optimization using a central composite design revealed that increasing the curing temperature and curing time led to an increase in the response, regardless of the P/Al molar ratio used. The variation in P/Al molar ratio strongly affected aluminum removal only at low curing temperatures and short curing times. The curing time parameter was found to be the most significant factor. The optimal conditions for maximum aluminum release were determined to be a P/Al molar ratio of 2.0, curing temperature approximately 70 degrees C, and curing time of 4.76 hours.
Article
Pharmacology & Pharmacy
Min Wang, Wensong Hao, Lei Zhang, Yanong Zhu, Kun Chen, Shuai Ma, Xinfeng Cheng, Jinsheng Zhao
Summary: The study demonstrated that sodium alginate coated nanoparticles have potential therapeutic effects in colon-targeted drug delivery, reducing pathological damage and inflammatory cell infiltration in colitis.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Polymer Science
Melinda Einsla, Vlad Telyatnikov, Johnpeter Ngunjiri, Sipei Zhang, Gary Dombrowski
Summary: In this study, a series of soluble-shell polymers were synthesized using an acrylic composition with an end-chain alkoxysilane crosslinkable moiety. The crosslinking was achieved by using MPTMS as a chain transfer agent, which effectively reduced the molecular weight of the acrylic. The resulting dried films showed improved mechanical properties and thermo-mechanical stability.
Article
Chemistry, Medicinal
Pooja Mittal, Harsh Vardhan, Gufran Ajmal, Gunjan Vasant Bonde, Ramit Kapoor, Ashu Mittal, Brahmeshwar Mishra
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2019)
Article
Pharmacology & Pharmacy
Pooja Mittal, Harsh Vrdhan, Gufran Ajmal, Gunjan Bonde, Ramit Kapoor, Brahmeshwar Mishra
CURRENT DRUG DELIVERY
(2019)
Article
Pharmacology & Pharmacy
Kanchan Bharti, Pooja Mittal, Brahmeshwar Mishra
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Sandeep Kumar Reddy Adena, Mansi Upadhyay, Harsh Vardhan, Brahmeshwar Mishra
Article
Biotechnology & Applied Microbiology
Gufran Ajmal, Gunjan Vasant Bonde, Sathish Thokala, Pooja Mittal, Gayasuddin Khan, Juhi Singh, Vivek Kumar Pandey, Brahmeshwar Mishra
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2019)
Article
Pharmacology & Pharmacy
Gufran Ajma, Gunjan Vasant Bonde, Pooja Mittal, Gayasuddin Khan, Vivek Kumar Pandey, Bharati Bakade, Brahmeshwar Mishra
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Article
Materials Science, Biomaterials
Mansi Upadhyay, Sandeep Kumar Reddy Adena, Harsh Vardhan, Sarita K. Yadav, Brahmeshwar Mishra
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Article
Biophysics
Gunjan Vasant Bonde, Gufran Ajmal, Sarita Kumari Yadav, Pooja Mittal, Juhi Singh, Bharati V. Bakde, Brahmeshwar Mishra
COLLOIDS AND SURFACES B-BIOINTERFACES
(2020)
Review
Pharmacology & Pharmacy
Manish Kumar, Abhishek Jha, Madhu, Brahmeshwar Mishra
EXPERT OPINION ON DRUG DELIVERY
(2020)
Review
Pharmacology & Pharmacy
D. R. Madhukiran, Abhishek Jha, Manish Kumar, Gufran Ajmal, Gunjan Vasant Bonde, Brahmeshwar Mishra
Summary: Electrospinning is a convenient method for fabricating nanofibers, with great potential in delivering drugs or therapeutic molecules to wound sites, especially in the treatment of diabetic foot ulcers. This review discusses the evolution of electrospinning techniques, various types of electrospun nanofibers used for DFU or chronic diabetic wounds, challenges in nanofiber preparation, and methods for evaluating their efficacy in diabetic wound healing. Expert opinions suggest that electrospinning-based nanofibers are safe, effective, and multifunctional for managing DFUs.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Review
Pharmacology & Pharmacy
Mohana Das, Manish Kumar, Abhishek Jha, D. R. Madhukiran, Kanchan Bharti, Shomedeep Mondal, Brahmeshwar Mishra
Summary: Coronaviruses are a group of RNA viruses that primarily infect the respiratory system. Recent outbreaks of Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome Coronaviruses have highlighted the urgent need for new screening models to identify potential drugs against COVID-19. The global spread of the SARS-CoV-2 virus has led to a massive pandemic with no successful treatment currently available.
CURRENT DRUG TARGETS
(2021)
Article
Pharmacology & Pharmacy
Rahul Hasija, Sundeep Chaurasia, Swati Gupta
Summary: The study successfully formulated and optimized colloidal polymeric nanocarriers co-encapsulating resveratrol and humic acid to improve stability, oral bioavailability, and antiradical activity. The optimized nanocarriers demonstrated significant improvement in oral bioavailability and enhanced radical-scavenging activity over time. Developed nanocarriers proved to be an efficient dosage form for enhancing the properties of resveratrol.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Manish Kumar, Abhishek Jha, Kanchan Bharti, Gourav Parmar, Brahmeshwar Mishra
Summary: Inflammatory lung disorders, such as chronic obstructive pulmonary disease, asthma, and pulmonary fibrosis, are a growing global health concern. The current therapeutic strategies and drugs used to manage these disorders face limitations. This review discusses the potential of lipid-based pulmonary nanomedicine as a platform to overcome these limitations and ensure targeted drug delivery with minimal side effects.
Article
Pharmacology & Pharmacy
Kanchan Bharti, Deepika Deepika, Manish Kumar, Abhishek Jha, Vinod Tiwari, Vikas Kumar, Brahmeshwar Mishra
Summary: In this study, polymers were screened to produce a stable amorphous solid dispersion (ASD) of a poorly water-soluble drug Riluzole (RLZ). Polyacrylic acid (PAA) was selected due to its strong drug-polymer interaction and wetting property. Experimental data and a physiologically based pharmacokinetic (PBPK) model showed that the RLZ:PAA ASD significantly enhanced drug concentration in the brain, suggesting improved biopharmaceutical performance and therapeutic efficacy.
Review
Multidisciplinary Sciences
Ashutosh Gupta, Shiran Shetty, Srinivas Mutalik, H. Raghu Chandrashekar, K. Nandakumar, Elizabeth Mary Mathew, Abhishek Jha, Brahmeshwar Mishra, Siddheesh Rajpurohit, Gundawar Ravi, Moumita Saha, Sudheer Moorkoth
Summary: This article introduces the background and treatment methods of peptic ulcer disease, with a focus on the challenges of H. pylori infection treatment and the current limitations. The article discusses novel formulation strategies such as extended-release drug delivery systems and nanoformulations to overcome the current bioavailability challenges, and proposes an innovative strategy to improve H. pylori eradication efficiency.