An individual based computational model of intestinal crypt fission and its application to predicting unrestrictive growth of the intestinal epithelium

Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion

(2013) Hugo J. Snippert et al.   EMBO REPORTS

Buckling of a growing tissue and the emergence of two-dimensional patterns

(2013) M.R. Nelson et al.   MATHEMATICAL BIOSCIENCES

Intestinal label-retaining cells are secretory precursors expressing Lgr5

(2013) Simon J. A. Buczacki et al.   NATURE

A unifying theory for the crypt

(2013) Hans Clevers   NATURE

Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution

(2013) A. Humphries et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium

(2012) A. Hirata et al.   DEVELOPMENT

On the biomechanics of stem cell niche formation in the gut - modelling growing organoids

(2012) Peter Buske et al.   FEBS Journal

Identification of a cKit+ Colonic Crypt Base Secretory Cell That Supports Lgr5+ Stem Cells in Mice

(2012) Michael E. Rothenberg et al.   GASTROENTEROLOGY

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

(2012) Johan H. van Es et al.   NATURE CELL BIOLOGY

Paneth Cells in Intestinal Homeostasis and Tissue Injury

(2012) Sabrina Roth et al.   PLoS One

Modelling the Spatio-Temporal Cell Dynamics Reveals Novel Insights on Cell Differentiation and Proliferation in the Small Intestinal Crypt

(2012) Carmen Pin et al.   PLoS One

Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1)

(2012) A. Durand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt5a Potentiates TGF-  Signaling to Promote Colonic Crypt Regeneration After Tissue Injury

(2012) H. Miyoshi et al.   SCIENCE

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Wnt Blockade With Dickkopf Reduces Intestinal Crypt Fission and Intestinal Growth in Infant Rats

(2011) Jane K. Fauser et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Modelling the role of the basement membrane beneath a growing epithelial monolayer

(2011) Sara-Jane Dunn et al.   JOURNAL OF THEORETICAL BIOLOGY

Instabilities of Monolayered Epithelia: Shape and Structure of Villi and Crypts

(2011) E. Hannezo et al.   PHYSICAL REVIEW LETTERS

Expansion of Intestinal Epithelial Stem Cells during Murine Development

(2011) Jeffrey J. Dehmer et al.   PLoS One

A Comprehensive Model of the Spatio-Temporal Stem Cell and Tissue Organisation in the Intestinal Crypt

(2011) Peter Buske et al.   PLoS Computational Biology

Growth-induced buckling of an epithelial layer

(2010) M. R. Nelson et al.   Biomechanics and Modeling in Mechanobiology

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

A hybrid approach to multi-scale modelling of cancer

(2010) J. M. Osborne et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Chaste: A test-driven approach to software development for biological modelling

(2009) Joe Pitt-Francis et al.   COMPUTER PHYSICS COMMUNICATIONS

Crypt Fission Peaks Early During Infancy and Crypt Hyperplasia Broadly Peaks During Infancy and Childhood in the Small Intestine of Humans

(2009) Adrian G Cummins et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

(2009) Akifumi Ootani et al.   NATURE MEDICINE

AFM indentation study of breast cancer cells

(2008) Q.S. Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ectopic Expression of P-Cadherin Correlates with Promoter Hypomethylation Early in Colorectal Carcinogenesis and Enhanced Intestinal Crypt Fission In vivo

(2008) A. Milicic et al.   CANCER RESEARCH

From single cells to tissue architecture—a bottom-up approach to modelling the spatio-temporal organisation of complex multi-cellular systems

(2008) J. Galle et al.   JOURNAL OF MATHEMATICAL BIOLOGY

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE