Review
Medicine, Research & Experimental
Shreyasi Gupta, Sanchari Mukhopadhyay, Arkadeep Mitra
Summary: This review summarizes the role and therapeutic potential of growth hormone secretagogue receptor type 1A (GHSR-1A) in alcohol abuse.
Article
Behavioral Sciences
Maria P. Cornejo, Emilio R. Mustafa, Franco Barrile, Daniela Cassano, Pablo N. De Francesco, Jesica Raingo, Mario Perello
Summary: The GHSR, a highly expressed GPCR in the brain, regulates the activity of the mesocorticolimbic pathway and modulates reward-related behaviors by interacting with the hormone ghrelin.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Maria Fernanda Garces, Julieth Daniela Buell-Acosta, Edith Angel-Mueller, Arturo Jose Parada-Banos, Jaidy Acosta-Alvarez, Harold Felipe Saavedra-Lopez, Roberto Franco-Vega, Luis Miguel Maldonado-Acosta, Franklin Escobar-Cordoba, Keydy Vasquez-Romero, Ezequiel Lacunza, Sofia Alexandra Caminos-Cepeda, Ruben Nogueiras, Carlos Dieguez, Ariel Ivan Ruiz-Parra, Jorge Eduardo Caminos
Summary: This study found that the Ghrelin/LEAP-2 ratio reaches its peak after mid-pregnancy in humans and rats, and it is associated with weight gain during pregnancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Anuhya S. Kotta, Abigail S. Kelling, Karen A. Corleto, Yuxiang Sun, Erin D. Giles
Summary: Ghrelin, a hormone produced and secreted from the stomach, is known as an appetite stimulant, but recent research suggests it may also play a role in cancer progression. This article summarizes the relationships between ghrelin and various cancers and provides important considerations for future research.
Review
Endocrinology & Metabolism
Andrea Smith, Barbara Woodside, Alfonso Abizaid
Summary: Ghrelin is a potent orexigenic hormone that promotes food intake, but its role in females and its interaction with ovarian hormones is not well understood.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Zachary Silver, Sam Abbott-Tate, Lindsay Hyland, Frances Sherratt, Barbara Woodside, Alfonso Abizaid
Summary: Chronic exposure to high circulating glucocorticoid or ghrelin concentrations did not have an effect on GHSR signaling in female mice, with no differences observed in weight gain, adiposity, and other metabolic effects compared to male mice.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Oncology
Yuanyuan Lang, Yanling Liu, Chunfeng Ye, Xiaomin Tang, Zugen Cheng, Lixin Xie, Lihua Feng, Yang Liu
Summary: This study confirms the association between obesity and myocardial injury, and demonstrates that silencing LEAP-2 can ameliorate obesity-induced hyperlipidemia, inflammation, and myocardial injury. Furthermore, it reveals that LEAP-2 exerts its effects by promoting M2 polarization in macrophages. These findings contribute to a better understanding of the mechanisms underlying obesity-induced myocardial injury.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Gimena Fernandez, Agustina Cabral, Pablo N. De Francesco, Maia Uriarte, Mirta Reynaldo, Daniel Castrogiovanni, Guillermina Zubiria, Andres Giovambattista, Sonia Cantel, Severine Denoyelle, Jean-Alain Fehrentz, Virginie Tolle, Helgi B. Schioth, Mario Perello
Summary: Food deprivation-induced activation of PVHCRF neurons involves GHSR signaling and a decrease in plasma LEAP2 levels, independent of ghrelin.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Endocrinology & Metabolism
Deepali Gupta, Anna M. Patterson, Sherri Osborne-Lawrence, Angie L. Bookout, Salil Varshney, Kripa Shankar, Omprakash Singh, Nathan P. Metzger, Corine P. Richard, Steven C. Wyler, Joel K. Elmquist, Jeffrey M. Zigman
Summary: The study investigated the role of acyl-ghrelin on GH secretion and metabolic actions by selectively deleting GHSR from somatotrophs. Results suggest that the direct engagement of GHSR-expressing somatotrophs is essential for acyl-ghrelin to stimulate GH secretion and influence its metabolic actions.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Soichiro Ide, Noriaki Iwase, Kenichi Arai, Masahiro Kojima, Shigeru Ushiyama, Kaori Taniko, Kazutaka Ikeda
Summary: Despite the widespread use of opioids for pain management, opioid addiction and the overdose crisis are becoming increasingly serious. A new nonpeptide ligand, UD-030, has been found to be a selective mu-opioid receptor antagonist and shows promise as a treatment option for opioid use disorder, with different characteristics from traditional medications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hao-Zheng Li, Xiao-Xia Shao, Ya-Fen Wang, Ya-Li Liu, Zeng-Guang Xu, Zhan-Yun Guo
Summary: By studying fish GHSRs, we found that LEAP2 is a more conserved ligand than ghrelin, which provides new insights into the functions of LEAP2 and ghrelin in different fish species.
Article
Biochemistry & Molecular Biology
Hao-Zheng Li, Ya-Fen Wang, Yong-Shan Zheng, Ya-Li Liu, Zeng-Guang Xu, Zhan-Yun Guo
Summary: The present study found that the GHSRs of fish have different binding properties to ghrelin. The GHSRs of zebrafish and large yellow croaker have lost their binding ability to ghrelin, while the GHSR of the lobe-finned fish Latimeria chalumnae can efficiently bind to ghrelin. Instead of ghrelin, motilin is an efficient agonist for GHSR in Latimeria chalumnae. This suggests that GHSR might have two efficient agonists, ghrelin and motilin, in ancient fishes, but this feature might only be preserved in some extant fishes with ancient evolutionary origins.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Psychiatry
Dirk Alexander Wittekind, Juergen Kratzsch, Roland Mergl, Ronny Baber, Kerstin Wirkner, Matthias L. Schroeter, A. Veronica Witte, Arno Villringer, Michael Kluge
Summary: Ghrelin and leptin, two peptide hormones, have opposing roles in hunger and food addiction. The study found a positive association between leptin serum levels and food addiction scores in men, while no association was found between ghrelin serum levels and food addiction scores.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Genetics & Heredity
Xiangcang Ye, Zeyu Liu, Hye Won Han, Ji Yeon Noh, Zheng Shen, Da Mi Kim, Hongying Wang, Huiping Guo, Johnathan Ballard, Andrei Golovko, Benjamin Morpurgo, Yuxiang Sun
Summary: This study found that BPA promotes intestinal inflammation, leading to increased expression of GHSR and pro-inflammatory genes, as well as an increase in inflammatory cells in the colon. Both short- and long-term BPA exposure also elevated pro-inflammatory cells in the blood and peritoneal macrophages. The deletion of GHSR in macrophages resulted in a reduced pro-inflammatory response to BPA, suggesting that GHSR plays a key role in BPA-induced inflammation. Further research on the GHSR signaling mechanism in BPA intestinal immunotoxicity can help develop strategies to mitigate BPA toxicity and provide policy guidance for biosafety.
Article
Endocrinology & Metabolism
Deepali Gupta, Georgina K. C. Dowsett, Bharath K. Mani, Kripa Shankar, Sherri Osborne-Lawrence, Nathan P. Metzger, Brian Y. H. Lam, Giles S. H. Yeo, Jeffrey M. Zigman
Summary: Islets are important sites for the action of the hormone ghrelin, with expression of the ghrelin receptor (GHSR) found in alpha, beta, and somatostatin-secreting delta cells. Further analysis revealed that PP-expressing gamma cells in mice and humans are also likely direct targets for ghrelin and its antagonist LEAP2.
