Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions

Ghrelin Signaling Affects Feeding Behavior, Metabolism, and Memory through the Vagus Nerve

(2020) Elizabeth A. Davis et al.   CURRENT BIOLOGY

Metabolic insights from a GHSR-A203E mutant mouse model

(2020) Lola J. Torz et al.   Molecular Metabolism

Growth hormone acts on liver to stimulate autophagy, support glucose production, and preserve blood glucose in chronically starved mice

(2019) Fei Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ghrelin receptor in agouti‐related peptide neurones regulates metabolic adaptation to calorie restriction

(2019) Chia‐Shan Wu et al.   JOURNAL OF NEUROENDOCRINOLOGY

Ghrelin and Orexin Interact to Increase Meal Size Through a Descending Hippocampus to Hindbrain Signaling Pathway

(2019) Andrea N. Suarez et al.   BIOLOGICAL PSYCHIATRY

Acyl-ghrelin is Permissive for the Normal Counterregulatory Response to Insulin-induced Hypoglycemia

(2019) Kripa Shankar et al.   DIABETES

LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor

(2018) Xuecai Ge et al.   Cell Metabolism

aP2-Cre Mediated Ablation of GHS-R Attenuates Adiposity and Improves Insulin Sensitivity during Aging

(2018) Ligen Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Kisspeptin Stimulates Growth Hormone Release by Utilizing Neuropeptide Y Pathways and Is Dependent on the Presence of Ghrelin in the Ewe

(2017) Chad D Foradori et al.   ENDOCRINOLOGY

Suppression of GHS-R in AgRP Neurons Mitigates Diet-Induced Obesity by Activating Thermogenesis

(2017) Chia-Shan Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clarifying the Ghrelin System’s Ability to Regulate Feeding Behaviours Despite Enigmatic Spatial Separation of the GHSR and Its Endogenous Ligand

(2017) Alexander Edwards et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ghrelin as a Survival Hormone

(2017) Bharath K. Mani et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Plurihormonal cells of normal anterior pituitary: Facts and conclusions

(2017) Lubov B. Mitrofanova et al.   Oncotarget

The role of ghrelin-responsive mediobasal hypothalamic neurons in mediating feeding responses to fasting

(2017) Bharath K. Mani et al.   Molecular Metabolism

Neuronal Deletion of Ghrelin Receptor Almost Completely Prevents Diet-Induced Obesity

(2016) Jong Han Lee et al.   DIABETES

Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

(2016) Alice E. Adriaenssens et al.   DIABETOLOGIA

β1-Adrenergic receptor deficiency in ghrelin-expressing cells causes hypoglycemia in susceptible individuals

(2016) Bharath K. Mani et al.   JOURNAL OF CLINICAL INVESTIGATION

Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets

(2016) Michael R. DiGruccio et al.   Molecular Metabolism

Reduced autophagy in livers of fasted, fat-depleted, ghrelin-deficient mice: Reversal by growth hormone

(2015) Yuanyuan Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ghrelin

(2015) T.D. Müller et al.   Molecular Metabolism

The β-cell GHSR and downstream cAMP/TRPM2 signaling account for insulinostatic and glycemic effects of ghrelin

(2015) Tomoyuki Kurashina et al.   Scientific Reports

Neuroanatomical characterization of a growth hormone secretagogue receptor-green fluorescent protein reporter mouse

(2014) Bharath K. Mani et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Actions of NPY, and Its Y1 and Y2 Receptors on Pulsatile Growth Hormone Secretion during the Fed and Fasted State

(2014) Lili Huang et al.   JOURNAL OF NEUROSCIENCE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin

(2013) Qian Wang et al.   Molecular Metabolism

Ghrelin Regulates the Hypothalamic-Pituitary-Adrenal Axis and Restricts Anxiety After Acute Stress

(2012) Sarah J. Spencer et al.   BIOLOGICAL PSYCHIATRY

Profound Hypoglycemia in Starved, Ghrelin-deficient Mice Is Caused by Decreased Gluconeogenesis and Reversed by Lactate or Fatty Acids

(2012) Robert Lin Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hindbrain Ghrelin Receptor Signaling Is Sufficient to Maintain Fasting Glucose

(2012) Michael M. Scott et al.   PLoS One

Development of a Method for the Determination of Pulsatile Growth Hormone Secretion in Mice

(2011) F. J. Steyn et al.   ENDOCRINOLOGY

Ghrelin mediates stress-induced food-reward behavior in mice

(2011) Jen-Chieh Chuang et al.   JOURNAL OF CLINICAL INVESTIGATION

Ghrelin Directly Stimulates Glucagon Secretion from Pancreatic α-Cells

(2011) Jen-Chieh Chuang et al.   MOLECULAR ENDOCRINOLOGY

Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice

(2010) T.-J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor

(2010) B. P. Barnett et al.   SCIENCE

Ghrelin Increases the Rewarding Value of High-Fat Diet in an Orexin-Dependent Manner

(2009) Mario Perello et al.   BIOLOGICAL PSYCHIATRY

Reduction in hypophyseal growth hormone and prolactin expression due to deficiency in ghrelin receptor signaling is associated with Pit-1 suppression: Relevance to the immune system

(2008) Hyunwon Yang et al.   BRAIN BEHAVIOR AND IMMUNITY

The aging population – Is there a role for endocrine interventions?

(2008) Ralf Nass et al.   GROWTH HORMONE & IGF RESEARCH

Novel Ghrelin Assays Provide Evidence for Independent Regulation of Ghrelin Acylation and Secretion in Healthy Young Men

(2008) Jianhua Liu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

(2008) Qingchun Tong et al.   NATURE NEUROSCIENCE