Article
Neurosciences
David E. Moorman, Gary Aston-Jones
Summary: The prefrontal cortex plays a critical role in the execution and inhibition of reward seeking. This study investigates the neural activity in different subregions of the medial prefrontal cortex (PL and IL) during various stages of cocaine seeking. The results reveal complex functions and contributions of both PL and IL regions to drug seeking and addiction.
PSYCHOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Soichiro Ide, Noriaki Iwase, Kenichi Arai, Masahiro Kojima, Shigeru Ushiyama, Kaori Taniko, Kazutaka Ikeda
Summary: Despite the widespread use of opioids for pain management, opioid addiction and the overdose crisis are becoming increasingly serious. A new nonpeptide ligand, UD-030, has been found to be a selective mu-opioid receptor antagonist and shows promise as a treatment option for opioid use disorder, with different characteristics from traditional medications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Kathrine Louise Jensen, Soren Brogger Jensen, Kenneth Lindegaard Madsen
Summary: Psychostimulant use disorder is a major global health issue with no effective pharmacological treatments available. This review provides an overview of pharmacological treatments targeting different aspects of psychostimulant addiction, including the dopamine system, the glutamate system, and the severe side effects of quitting long-term use. Promising results have been found with drugs modulating the dopamine system, cognitive enhancers, and drugs targeting the glutamate system, but further research is needed for sufficient evidence of efficacy and tolerability.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
H. Z. Rosa, H. J. Segat, R. C. S. Barcelos, Kr Roversi, D. R. Rossato, M. E. Burger
Summary: Addiction is a serious public health problem, and current pharmacotherapy is ineffective in preventing drug relapse. Recent research has shown that physical exercise can activate the endogenous opioid system, potentially preventing relapse in drug addiction. In rat experiments, physical exercise led to changes in neurotrophins and the dopaminergic system, which effectively prevented drug relapse behavior.
NEUROTOXICITY RESEARCH
(2023)
Article
Behavioral Sciences
Mandy Rita LeCocq, Sophie Sun, Nadia Chaudhri
Summary: This study examines the reinstatement of conditioned responding elicited by an appetitive conditioned stimulus (CS) through re-exposure to an unconditioned stimulus (US) and finds that the reinstatement is driven by an excitatory association formed between the US and the context in which the US was ingested.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Psychiatry
Kailash Sureshkumar, Pranab Kumar Dalal, Shabeeba Z. Kailash, Vidyendaran Rudhran
Summary: This study found that factors such as high-risk situations, undesirable stressful life events, and self-efficacy were significantly associated with relapse in opioid dependence. The results suggest that a comprehensive, multimodal, and individualized treatment plan addressing these factors might help in reducing relapse rates.
INDIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Behavioral Sciences
John T. Madden, Nicole C. Reyna, Emerald Goranson, Tiffany A. Gonzalez, Arturo R. Zavala, Nathan S. Pentkowski
Summary: Research has shown that pretreatment with the selective 5-HT2A receptor antagonist M100907 dose-dependently attenuated the acquisition of methamphetamine-induced CPP in adult female rats, indicating the involvement of the 5-HT2A receptor subtype in the behavioral effects of methamphetamine.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
D. R. Rossato, H. Z. Rosa, J. L. O. Rosa, L. H. Milanesi, V. G. Metz, L. F. D'Avila, M. E. Burger
Summary: Tactile stimulation (TS) may have positive effects on addiction recovery by preventing or reducing amphetamine (AMPH) relapse behavior and inducing molecular neuroadaptations in the brain. Further research can include TS as a useful tool in the treatment of psychostimulant addiction, alongside conventional detoxification programs with pharmacotherapies and psychological treatments.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bart de Laat, Nabeel Nabulsi, Yiyun Huang, Stephanie S. O'Malley, Janice C. Froehlich, Evan D. Morris, Suchitra Krishnan-Sarin
Summary: The efficacy of naltrexone in treating alcohol use disorder is modest, but its effects on the kappa opioid receptor (KOR) occupancy may impact patient response. Research using PET scans found that high KOR occupancy by naltrexone was associated with increased alcohol craving and reduced drinking, providing insight into potential mechanisms for clinical response.
MOLECULAR PSYCHIATRY
(2021)
Article
Pharmacology & Pharmacy
Andrey Sequeira-Cordero, Juan C. Brenes
Summary: The study focused on the time-dependent neurochemical changes induced by amphetamine which revealed region and dose-dependent alterations in gene expression. Individual differences in neurotransmission and gene expression in brain pathways may influence behavioral sensitization to amphetamine.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Surgery
Jacqueline J. Chu, Jeffrey E. Janis, Roman Skoracki, Jenny C. Barker
Summary: Opioid overprescribing is common in plastic surgery, with a significant excess of pills per patient and a high percentage of unused medication. Patients show varying opioid consumption patterns postoperatively, highlighting the need for improved patient education on proper storing and disposal of opioids.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Alex Disney, Keith M. Olson, Amanda M. Shafer, Sierra C. Moore, Jessica P. Anand, John R. Traynor, Stephen M. Husbands
Summary: The study designed and synthesized an orvinol antagonist, 14, which showed no agonist activity in vitro, and was at least equally effective as naloxone in reversing the effects of mu-opioid receptor agonists in vivo.
ACS CHEMICAL NEUROSCIENCE
(2022)
Review
Pharmacology & Pharmacy
Saeideh Karimi-haghighi, Maedeh Mahmoudi, Fatemeh Sayehmiri, Roghayeh Mozafari, Abbas Haghparast
Summary: The mechanism behind relapse in addiction treatment with psychostimulant drugs is not fully understood, and there is conflicting evidence regarding the role of the endocannabinoid system in regulating relapse in preclinical studies. This systematic review evaluated the effect of endocannabinoid modulators on the reinstatement of commonly abused psychostimulants. Thirty-nine articles using different animal models were selected, and the results suggest that cannabinoid receptor antagonists and agonists may have potential in inhibiting the reinstatement of cocaine and methamphetamine addiction, but the effectiveness depends on time, dose, and route of administration.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Priya Jain, Kimberley McKinnell, Rose Marino, Prashanthi Vunnava, Marie A. Liles-Burden, Avani Desai, Made Wenten, James Fratantonio, Sarah C. Akerman, Maria A. Sullivan, Gary Bloomgren
Summary: This study analyzed reporting rates of opioid overdose during treatment with and after discontinuation of XR-NTX over a 12-year period, and found that the rates were similar in different latency groups, with overall rates less than 10/10,000 patients exposed. The findings are limited by the nature of spontaneously reported safety data.
Article
Substance Abuse
Hudson Reddon, Jo-Hanna Ivers
Summary: Increased levels of hope are associated with slower rates of relapse among individuals with opioid dependence following discharge from detoxification programs. The hope-agency subdomain is significantly associated with lower rates of relapse.
ADDICTION RESEARCH & THEORY
(2023)
Article
Clinical Neurology
Carl Bjorkholm, Kent Jardemark, Bjorn Schilstrom, Torgny H. Svensson
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2015)
Article
Clinical Neurology
Monica M. Marcus, Carl Bjorkholm, Anna Malmerfelt, Annie Moller, Ninni Pahlsson, Asa Konradsson-Geuken, Kristin Feltmann, Kent Jardemark, Bjorn Schilstrom, Torgny H. Svensson
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2016)
Review
Neurosciences
Carl Bjorkholm, Lisa M. Monteggia
Article
Neurosciences
Pia Steensland, Ida Fredriksson, Sarah Holst, Kristin Feltmann, Johan Franck, Bjorn Schilstrom, Arvid Carlsson
BIOLOGICAL PSYCHIATRY
(2012)
Article
Clinical Neurology
Carl Bjorkholm, Kent Jardemark, Monica M. Marcus, Anna Malmerfelt, Svante Nyberg, Bjorn Schilstrom, Torgny H. Svensson
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2013)
Article
Clinical Neurology
Carl Bjorkholm, Olivia Franberg, Anna Malmerfelt, Monica M. Marcus, Asa Konradsson-Geuken, Bjorn Schilstrom, Kent Jardemark, Torgny H. Svensson
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2015)
Article
Multidisciplinary Sciences
Petra Suchankova, Pia Steensland, Ida Fredriksson, Jorgen A. Engel, Elisabet Jerlhag
Article
Endocrinology & Metabolism
Emil Egecioglu, Pia Steensland, Ida Fredriksson, Kristin Feltmann, Jorgen A. Engel, Elisabet Jerlhag
PSYCHONEUROENDOCRINOLOGY
(2013)
Article
Neurosciences
Ji-Woon Kim, Anita E. Autry, Elisa S. Na, Megumi Adachi, Carl Bjorkholm, Ege T. Kavalali, Lisa M. Monteggia
Summary: This study shows that MeCP2 phosphorylation at a specific site downstream of BDNF is essential for the sustained antidepressant effects of ketamine and scopolamine, and plays a critical role in long-term regulation of synaptic strength. These findings highlight the importance of MeCP2 and associated synaptic plasticity in mediating sustained antidepressant effects of ketamine and scopolamine.
NATURE NEUROSCIENCE
(2021)
Article
Clinical Neurology
Carl Bjorkholm, Monica M. Marcus, Asa Konradsson-Geuken, Kent Jardemark, Torgny H. Svensson
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2017)
Meeting Abstract
Substance Abuse
P. Steensland, I. Fredriksson, E. Nystrom, E. Nylander, M. Wirf, N. Jayaram-Lindstrom
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2014)
Meeting Abstract
Neurosciences
Pia Steensland, Kristin Feltmann, Ida Fredriksson, Malin Wirf, Bjorn Schilstrom, Arvid Carlsson
BIOLOGICAL PSYCHIATRY
(2014)
Meeting Abstract
Substance Abuse
P. Steensland, I. Fredriksson, S. Holst, K. Feltmann, J. Franck, B. Schilstrom, A. Carlsson
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2013)
Meeting Abstract
Substance Abuse
P. Steensland, I. Fredriksson, K. Feltmann, S. Holst, J. Franck, B. Schilstrom, A. Carlsson
ALCOHOL AND ALCOHOLISM
(2013)