Article
Biochemistry & Molecular Biology
Yasmin Pedra-Rezende, Michelle C. Fernandes, Camila Mesquita-Rodrigues, Renata Stiebler, Ana Cristina S. Bombaca, Nathalia Pinho, Patricia Cuervo, Solange L. De Castro, Rubem F. S. Menna-Barreto
Summary: Chagas disease is a neglected illness mainly affecting rural populations in Latin America, caused by the protozoan Trypanosoma cruzi. The parasite's life cycle involves stress conditions such as variations in nutrient availability and pH, impacting mitochondrial function and autophagy. Acidic and nutritional stress induced metacyclogenesis phenotypes, while alkaline stress led to an increase in autophagic flux as a survival mechanism.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Immunology
Maria Cristina Vanrell, Santiago Jose Martinez, Lucila Ibel Munoz, Betiana Nebai Salassa, Julian Gambarte Tudela, Patricia Silvia Romano
Summary: In this study, ursolic acid (UA) was found to reduce Trypanosoma cruzi infection in vitro by decreasing the number of intracellular amastigotes through the induction of autophagy. UA also induced autophagy response in both macrophages and cardiac cells, and inhibition of this pathway restored the level of infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Biology
Oscar Hernan Rodriguez-Bejarano, Catalina Avendano, Manuel Alfonso Patarroyo
Summary: Chagas disease, caused by Trypanosoma cruzi parasite, is mainly transmitted by insect bites. The parasite's lifecycle includes an intracellular phase and infective forms, involving various signaling cascades and intracellular associations for recognition and internalization in host cells.
Article
Parasitology
Carlos J. Bethencourt-Estrella, Samuel Delgado-Hernandez, Atteneri Lopez-Arencibia, Desiree San Nicolas-Hernandez, David Tejedor, Fernando Garcia-Tellado, Jacob Lorenzo-Morales, Jose E. Pinero
Summary: Chagas disease is a serious illness that can cause megacolon, heart disease, and even death. Current therapies for this disease are outdated and have significant side effects. Therefore, there is a need to search for new compounds that are safer, less toxic, and more effective against the parasite. This study investigated the antichagasic activity of 46 novel cyanomethyl vinyl ether derivatives and identified four compounds that showed selective activity and triggered programmed cell death in the parasites, making them potential candidates for future Chagas disease therapeutics.
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE
(2023)
Article
Chemistry, Medicinal
Desiree San Nicolas-Hernandez, Ruben L. Rodriguez-Exposito, Atteneri Lopez-Arencibia, Carlos J. Bethencourt-Estrella, Ines Sifaoui, Lizbeth Salazar-Villatoro, Maritza Omana-Molina, Jose J. Fernandez, Ana R. Diaz-Marrero, Jose E. Pinero, Jacob Lorenzo-Morales
Summary: In this study, four meroterpenoids were isolated and purified from a brown alga, and their activity and toxicity were evaluated. The results showed that these meroterpenoids could induce apoptosis and autophagy, indicating their potential value in the treatment of parasitic infections.
Article
Biochemistry & Molecular Biology
Marilia L. Cirqueira, Leandro O. Bortot, Mayte Bolean, Mariana A. A. Aleixo, Pedro H. Luccas, Antonio J. Costa-Filho, Ana Paula Ramos, Pietro Ciancaglini, M. Cristina Nonato
Summary: Due to its severe burden and geographic distribution, Chagas disease has a significant social and economic impact on low-income countries. This study aims to understand the role of TcNTR in the basic parasite biology, investigate its potential as a drug target, and contribute to the fight against neglected tropical diseases. The results showed that TcNTR interacts with membranes, with a preference for those containing cardiolipin, and a 23-residue long insertion is involved in enzyme specificity and protein-membrane interaction.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Roberto Docampo, Anibal Eugenio Vercesi
Summary: This review discusses the mechanisms of mitochondrial oxidant generation and removal, and the involvement of Ca2+ in trypanosome cell death, highlighting the need for further studies on ROS generation, defense mechanisms, and mitochondrial permeability transition pore in trypanosomatids.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Mylla Spirandelli da Costa, Bruna Cristina Borges, Isabella Teixeira Marques, Rayane Cristina de Oliveira, Thaise Lara Teixeira, Julia de Gouveia Santos, Claudio Vieira da Silva
Summary: PClP treatment is non-toxic to both Trypanosoma cruzi and host cells, but inhibits parasite motility, host cell adhesion, and invasion, affecting fundamental processes necessary for a successful T. cruzi infection.
Article
Biochemistry & Molecular Biology
Naiara Dutra Barroso Gomes, Emanuel Paula Magalhaes, Lyanna Rodrigues Ribeiro, John Washington Cavalcante, Marcelo Morais Gomes Maia, Felipe Ramon Cunha da Silva, Arif Ali, Marcia Machado Marinho, Emmanuel Silva Marinho, Helcio Silva dos Santos, Alice Maria Costa Martins, Ramon Roseo Paula Pessoa Bezerra de Menezes
Summary: This study evaluated the activity of synthetic p-aminochalcones against T. cruzi and found that they have a trypanocidal effect by causing membrane damage and oxidative stress. Their mechanism of action may be related to inhibition of cruzain and TR.
BIOORGANIC CHEMISTRY
(2023)
Article
Immunology
Carezza Botto-Mahan, Juana P. Correa, Raul Araya-Donoso, Francisca Farias, Esteban San Juan, Nicol Quiroga, Ricardo Campos-Soto, Claudio Reyes-Olivares, Daniel Gonzalez-Acuna
Summary: In this study, we assessed 4 lizard species in Chile for Trypanosoma cruzi and found that all species were infected. We also discovered that one species had the ability to transmit the protozoan, highlighting their role as reservoirs for T. cruzi.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Microbiology
Lucas Vellasco, Erik Svensjo, Carlos Alberto Bulant, Pablo Javier Blanco, Fabio Nogueira, Gilberto Domont, Natalia Pinto de Almeida, Clarissa Rodrigues Nascimento, Danielle Silva-dos-Santos, Carla Eponina Carvalho-Pinto, Emiliano Horacio Medei, Igor C. Almeida, Julio Scharfstein
Summary: Microangiopathy may worsen the clinical outcome of Chagas disease. This study used intravital microscopy to investigate microcirculatory alterations in the hamster cheek pouch infected by GFP-expressing T. cruzi. The findings suggest that intracellular amastigotes stimulate angiogenesis and enhance the delivery of plasma-borne nutrients and factors, benefiting the host-parasite relationship.
Article
Chemistry, Analytical
Tra D. Nguyen, Yunpeng Lan, Shelley S. Kane, Jacob J. Haffner, Renmeng Liu, Laura-Isobel McCall, Zhibo Yang
Summary: This study revealed heterogeneity in the metabolic response of host cells to Trypanosoma cruzi infection, with uninfected cells also showing metabolic impacts. These findings provide novel insights into the pathogenesis of Chagas disease.
ANALYTICAL CHEMISTRY
(2022)
Article
Immunology
Cynthia Vanesa Rivero, Santiago Jose Martinez, Paul Novick, Juan Agustin Cueto, Betiana Nebai Salassa, Maria Cristina Vanrell, Xiaomo Li, Carlos Alberto Labriola, Luis Mariano Polo, David M. Engman, Joachim Clos, Patricia Silvia Romano
Summary: T. cruzi, the causal agent of Chagas disease, poses challenges due to its ability to infect different host cells and its resistance to current treatments. Carvedilol, identified through virtual screening, shows promising in vitro and in vivo activity against T. cruzi, making it a potential lead for Chagas disease treatment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Nubia Carolina Manchola Varon, Guilherme Rodrigo R. M. dos Santos, Walter Colli, Maria Julia M. Alves
Summary: The interaction between Trypanosoma cruzi and mammalian cells involves adhesion to the extracellular matrix (ECM) and an early phase of calcium signaling. The increase in intracellular calcium concentration during this interaction depends on Ca2+ uptake from the medium and is crucial for host cell invasion. The mitochondrion plays a significant role in Ca2+ homeostasis in Trypomastigotes during their interaction with ECM.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Jose Mateus, Paola Nocua, Paola Lasso, Manuel Carlos Lopez, M. Carmen Thomas, Adriana Egui, Claudia Cuervo, John Mario Gonzalez, Concepcion J. Puerta, Adriana Cuellar
Summary: The study investigates the relationship between parasite control and immune T cell responses in Chagas disease by using distinct infection approaches in an animal model. Different infection outcomes were observed in single or mixed T. cruzi infection with different genotypes, leading to differential immune CD8(+) T cell responses. This suggests that the quality of the CD8(+) T cell response may dictate differences in infection outcomes during chronic T. cruzi infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Polymer Science
Giovanna Amaral Filipe, Victoria Akemi Itakura Silveira, Marcelly Chue Goncalves, Rayanne R. Beltrame Machado, Celso Vataro Nakamura, Cristiani Baldo, Suzana Mali, Renata Katsuko Takayama Kobayashi, Maria Antonia P. Colabone Celligoi
Summary: This study aims to develop biodegradable films based on cassava starch, pullulan, and sophorolipids for the treatment of skin infections. By adding sophorolipids and citric acid, the properties of the films were modified, resulting in antimicrobial effects. The results of the study show that these films can inhibit the growth of common skin pathogens.
Article
Polymer Science
Flavia Amanda Pedroso de Morais, Ana Carolina Vieira De Oliveira, Rodolfo Bento Balbinot, Danielle Lazarin-Bidoia, Tania Ueda-Nakamura, Sueli de Oliveira Silva, Katieli da Silva Souza Campanholi, Ranulfo Combuca da Silva Junior, Renato Sonchini Goncalves, Wilker Caetano, Celso Vataru Nakamura
Summary: Biotin, spermine, and folic acid were covalently linked to the F127 copolymer to form a drug delivery system for treating B16F10 cells with HY-loaded PDT. Spectroscopy and spectrophotometric techniques were used to analyze the chemical structures and binders quantification. The hydrophobicity of the binders was found to affect the physicochemical parameters such as critical micelle concentration, critical micelle temperature, size, polydispersity, and zeta potential. The modification with spermine resulted in less changes in the physical and chemical parameters of the micelles.
Article
Biochemistry & Molecular Biology
Elisa Parcero Hernandes, Danielle Lazarin-Bidoia, Raquel Dosciatti Bini, Celso Vataru Nakamura, Luiz Fernando Cotica, Sueli De Oliveira Silva Lautenschlager
Summary: In this study, the in vitro effects of iron-oxide magnetic nanoparticles conjugated with the antitumor drug doxorubicin on human breast cancer cells were evaluated. The results showed that these nanoparticles induced cellular redox imbalance and oxidative stress, leading to DNA damage, lipid peroxidation, cell membrane disruption, and loss of mitochondria potential in MCF-7 cells. The association of iron-oxide nanoparticles and doxorubicin may be a potential candidate for anticancer therapy.
Article
Biochemistry & Molecular Biology
Regina G. G. Dare, Elayaraja Kolanthai, Craig J. J. Neal, Yifei Fu, Sudipta Seal, Celso V. V. Nakamura, Sueli O. S. Lautenschlager
Summary: Exposure to ultraviolet radiation can cause photodamage to cellular macromolecules, leading to photoaging and photocarcinogenesis. Cerium oxide nanoparticles (CNPs) exhibit antioxidant activity due to their enzyme-like properties. This study aimed to synthesize CNPs associated with tannic acid (TA) and investigate their photoprotective effects in UVB-exposed L929 fibroblasts.
Article
Biochemistry & Molecular Biology
Aline Pinto Zani, Caroline Pinto Zani, Zia Ud Din, Edson Rodrigues-Filho, Tania Ueda-Nakamura, Francielle Pelegrin Garcia, Sueli de Oliveira Silva, Celso Vataru Nakamura
Summary: In this study, a new synthetic compound A3K2A3 was found to have anti-tumor activity against cervical cancer cells. The potential mechanism of action includes regulation of redox balance, damage to cell membrane and DNA, and inhibition of cell division leading to apoptosis. These findings suggest that A3K2A3 could be a promising alternative for the treatment of cervical cancer.
Article
Virology
Thalita Zago Oliveira, Dyenefer Pereira Fonseca, Andre Henrique dos Santos, Thays Rosa da Silva, Danielle Lazarin-Bidoia, Zia Ud Din, Benedito Prado Dias Filho, Celso Vataru Nakamura, Edson Rodrigues-Filho, Tania Ueda-Nakamura
Summary: We report the in vitro anti-HSV-1 activity of two dibenzylideneketone compounds, DBK1 and DBK2, for the first time. DBK1 demonstrated virucidal activity and caused morphological changes in the HSV-1 envelope. DBK2 reduced HSV-1 plaque size in vitro. The DBKs are promising anti-HSV-1 candidates due to their low toxicity and ability to exert an antiviral effect at the early stages of HSV-1-host cell interaction.
ARCHIVES OF VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alex Graca Contato, Vanessa Kaplum, Debora Botura Scariot, Francielle Pelegrin Garcia, Hugo Falzirolli, Fabio Vandresen, Tania Ueda-Nakamura, Sueli de Oliveira Silva, Cleuza Conceicao da Silva, Celso Vataru Nakamura
Summary: Leishmaniasis is a tropical disease that affects approximately 1.3 million people annually. Current treatments for this disease have dangerous side effects. This study discovered that a limonene-acylthiosemicarbazide compound (ATZ-S-04) shows promising antiproliferative activity against Leishmania parasites and affects their morphology.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Biochemistry & Molecular Biology
Caroline Pinto Zani, Aline Pinto Zani, Cristiane Melissa Thomazini, Karina Miyuki Retamiro, Aline Rufino de Oliveira, Debora Lais Goncalves, Maria Helena Sarragiotto, Francielle Pelegrin Garcia, Sueli de Oliveira Silva, Celso Vataru Nakamura, Tania Ueda-Nakamura
Summary: In this study, the cytotoxic potential and mechanism of action of a compound called BCP-1 were analyzed in breast cancer cells and non-tumor breast cells. The results showed that BCP-1 inhibited cancer cell proliferation, induced cell cycle arrest and oxidative stress, and activated apoptosis and autophagy pathways. BCP-1 also demonstrated antimetastatic potential.
Article
Pharmacology & Pharmacy
Rafaela Said dos Santos, Jessica Bassi da Silva, Camila Felix Vecchi, Katieli da Silva Souza Campanholi, Helen Cassia Rosseto, Mariana Carla de Oliveira, Francielle Pelegrin Garcia, Rodolfo Bento Balbinot, Lidiane Vizioli de Castro Hoshino, Tania Ueda Nakamura, Celso Vataru Nakamura, Mauro Luciano Baesso, Wilker Caetano, Marcos Luciano Bruschi
Summary: The environment has the ability to modify the physiology and protective function of the skin. Combining propolis and curcumin with photodynamic therapy can provide important antioxidant and antimicrobial properties. Emulgels, which control drug release, can serve as an effective platform for delivering propolis and curcumin together. This study investigated the effects of different emulgels on stability, antioxidant activity, drug release, antimicrobial activity, and skin permeation and retention of propolis and curcumin. The formulations containing C974P or PC exhibited improved stability, antioxidant activity, antimicrobial activity, and modified drug release, making them good candidates for further research on their benefits to skin health.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2023)
Review
Chemistry, Medicinal
Naiara Cassia Gancedo, Raquel Isolani, Natalia Castelhano de Oliveira, Celso Vataru Nakamura, Daniela Cristina de Medeiros Araujo, Andreia Cristina Conegero Sanches, Fernanda Stumpf Tonin, Fernando Fernandez-Llimos, Danielly Chierrito, Joao Carlos Palazzo de Mello
Summary: This study aimed to synthesize the anticancer and anti-proliferative potential of Limonium species through a systematic review. The results indicate that Limonium species have the potential to be a source of new potential cytotoxic and anticancer agents. However, further research and improved experimental designs are needed to better understand the mechanism of action of these compounds.
Article
Pharmacology & Pharmacy
Camila Felix Vecchi, Rafaela Said dos Santos, Jessica Bassi da Silva, Camila Patricio Rissi, Rayanne Regina Beltrame Machado, Lidiane Vizioli de Castro-Hoshino, Mauro Luciano Baesso, Danielle Lazarin Bidoia, Sueli de Oliveira Silva Lautenschlager, Marcos Luciano Bruschi
Summary: Microneedles (MN) were prepared and optimized for controlled delivery of propolis (PROP) extracts. MN containing PROP ethanolic extract displayed better structuring, quicker disintegration, and higher skin permeation compared to glycolic extract. The optimized MN also exhibited the ability to generate reactive oxygen species and stimulate immune cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Flavia Amanda Pedroso de Morais, Rodolfo Bento Balbinot, Amanda Beatriz Kawano Bakoshi, Danielle Lazarin-Bidoia, Katieli da Silva Souza Campanholi, Ranulfo Combuca da Silva Junior, Renato Sonchini Goncalves, Tania Ueda-Nakamura, Sueli de Oliveira Silva, Wilker Caetano, Celso Vataru Nakamura
Summary: The study developed biomodified coated-lipid vesicles with the photosensitizer hypericin (HY) incorporated. The results demonstrated good stability, low tendency to form complexes with proteins, and promising photodynamic potential. These nanosystems hold potential for future therapeutic and diagnostic applications.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Karina Miyuki Retamiro, Karine Campos Nunes, Aline Pinto Zani, Caroline Pinto Zani, Laiza Bergamasco Beltran, Sueli de Oliveira Silva, Francielle Pelegrin Garcia, Tania Ueda-Nakamura, Rosangela Bergamasco, Celso Vataru Nakamura
Summary: Ionized water has been found to aid in tissue repair and wound healing. Water purifiers can produce ionized water by using activated charcoal with silver and minerals to reduce contaminants. Additionally, subjecting water to a magnetic field causes a reorganization of water molecules, resulting in alkaline water that has been shown to be non-toxic to mice and can extend survival.
Article
Parasitology
Gabriela Martinez Moura Tavares, Hannar Angelica de Melo Alverga, Estela Moraes Felix, Giovana de Oliveira Dichman, Gabriel Monteiro Pinheiro, Yara Juliano, Priscila Paruci, Dennis Minoru Fujita, Lucas Melo Neves, Marina Tiemi Shio, Luiz Henrique da Silva Nali
Summary: This study investigated the frequency of N. gonorrhoeae infection in women in a poor area of São Paulo and found that most of the strains detected showed resistance to one or more antimicrobials.
Article
Parasitology
Qian Yao, Ying-Ying Fan, Shuang Huang, Gui-Rong Hu, Jun-Ke Song, Xin Yang, Guang-Hui Zhao
Summary: This study found that the expression of miR-4521 was upregulated during C. parvum infection, and this upregulation was related to the TLR/NF-kappa B signal pathway. Additionally, miR-4521 promoted the propagation of C. parvum in HCT-8 cells by regulating BCL2-mediated cell apoptosis through targeting foxm1.
Article
Parasitology
Cho Naing, Maxine A. Whittaker, Wong Siew Tung, Htar Aung, Joon Wah Mak
Summary: This study aimed to estimate the prevalence of zoonotic brugian filariasis in animals and compare it with the prevalence in humans in the same area. The findings suggest that cats, dogs, and leaf-eating monkeys may serve as potential reservoirs for human brugian filariasis.
Review
Parasitology
Raissa Nogueira de Brito, Susan Tanner, Julie Velasquez Runk, Juliana Hoyos
Summary: This study conducted a scoping review to identify major research themes and knowledge gaps in the social science literature on leishmaniases or Chagas disease. The findings showed that research in this field mainly focuses on the sociocultural, economic, historical, and political dimensions of the diseases. Future research should pay more attention to how social institutions and economic factors shape disease education, control measures, healthcare access, and quality of life of affected individuals.
Article
Parasitology
Minghao Zheng, Mengyao Zhang, Hao Li, Shipo Wu, Yuee Zhao, Jinlong Zhang, Yunyue Zhou, Mohamed Boie Jalloh, Kun Zhang, Lina Chen, Zhiqiang Mi, Yong Cui, Lihua Hou
Summary: Rapid and convenient detection of Plasmodium falciparum, the deadliest malaria parasite in Africa, is crucial for malaria eradication efforts in medical resource-limited settings. A CRISPR-based diagnostic method that can detect P. falciparum without nucleic acid extraction was developed and showed high sensitivity and consistency with qPCR test. It can also detect artemisinin-resistant strains and other laboratory-cultured strains. This method has great potential for clinical testing and large-scale community screening in Africa and other regions.
Article
Parasitology
Fabian Correa-Morales, Cassandra Gonzalez-Acosta, David Ibarra-Ojeda, Miguel Moreno-Garcia
Summary: Since 2002, West Nile Virus (WNV) has been reported in 18 states in Mexico. This paper discusses the proposed hypotheses for the absence of WNV outbreaks in Latin America and provides a context-specific explanation for Mexico.
Article
Parasitology
Umberto Molini, Lauren M. Coetzee, Vernon Christians, Maria Y. Hemberger, Bernard Chiwome, Maria Amukwaya, Siegfried Khaiseb, Giovanni Cattoli, William G. Dundon, Giovanni Franzo
Summary: Porcine circovirus 3 (PCV-3) has been reported globally since its first identification in 2015. Limited data on PCV-3 in Africa led to a study in Namibia, which found a high prevalence of PCV-3 in backyard piggeries, but not in commercial farms with higher biosecurity measures. The source of viral introduction and factors such as semen importation, feeding backyard pigs with human food waste, pig exchanges, and wildlife movements may be involved in the dispersal of PCV-3 within Namibia. Further studies are needed to understand the epidemiology and impact of PCV-3 on pig productivity and wildlife health.
Article
Parasitology
Chutchai Piewbang, Panida Poonsin, Pattiya Lohavicharn, Panitnan Punyathi, Sawang Kesdangsakonwut, Tanit Kasantikul, Somporn Techangamsuwan
Summary: This study provides insights into the pathology of natural SARS-CoV-2 infection in dogs, revealing severe damage to the lungs and involvement of multiple organs. The findings suggest the potential utility of dogs as a model for studying SARS-CoV-2 infection in humans, highlighting the need for further investigation.
Article
Parasitology
Julian Avila-Jimenez, Juan David Gutierrez, Mariano Altamiranda-Saavedra
Summary: Leishmaniasis is a parasitic disease transmitted to humans by sandfly vectors and vertebrate hosts. This study used ecological niche modeling to investigate the potential distribution of host and vector species associated with cutaneous leishmaniasis transmission, revealing different distribution patterns under varying climatic conditions.
Article
Parasitology
Luis A. Gomez-Puerta, Juan Olazabal, Santiago Paredes, Juan Lopez, Miguel Anampa, Angelica Mondragon, Ana Vargas-Calla, Hugo Castillo
Summary: This study reports the first detection of Candidatus M. haemolamae infection in vicunas from the Pampa Galeras National Reserve in Peru, using molecular diagnosis. Tick-infested vicunas had a higher likelihood of being infected with Candidatus M. haemolamae compared to tick-free vicunas. Gender and age were not associated with infection.
Article
Parasitology
Berlin Londono-Renteria, Zakaria Seidu, Helena Lamptey, Michael F. Ofori, Lars Hviid, Mary Lopez-Perez
Summary: Heterozygous carriers of HbAS and HbAC have a reduced risk of severe malaria, but not immunity against Plasmodium falciparum infection. Antibody levels against gSG6-P1 peptide in Anopheles mosquito saliva can serve as a serological biomarker for exposure to Plasmodium infection. This study highlights the importance of studying the role of hemoglobinopathies in malaria transmission for improving control interventions.
Article
Parasitology
Imane Belbacha, Meryem El Azzouzi, Rajae Bensghir, Kamal Filali Marhoum, Khadija Hajjout, El Mir Elharti, Khalid Sadki, Hicham Oumzil
Summary: This study investigates the association of three SNPs in the APOBEC3G gene with disease outcomes in Moroccan HIV-1 infected patients. The rs2294367 CG genotype is strongly associated with protection against HIV-1 infection, particularly in older individuals.
Article
Parasitology
Tan Luong, Do Kien Tran, Anh Hung Pham, Thi Thu-Ha Hoang, Van Khang Pham, Quang Thai Pham, Thi Mai Hung Tran, Minh Hoa Luong, Thanh Long Pham, Jason K. Blackburn
Summary: This study examined the epidemiology of anthrax in Lai Chau province, Vietnam, using historical data. Spatial clusters of human and livestock anthrax were identified, and the characteristics of the disease were described. The study found that there were distinct differences between the high-risk areas for human and livestock anthrax, and most human cases occurred during specific seasons. Additionally, the decrease in livestock anthrax vaccine coverage was associated with an increase in disease incidence.
Article
Parasitology
Jin-tao Chen, Jian-bo Zhan, Ming-chao Zhu, Kai-ji Li, Man-qing Liu, Bin Hu, Kun Cai, Hai-rong Xiong, Shu-liang Chen, Wei-long Tan, Liang-jun Chen, Wei Hou
Summary: This study investigated the prevalence and variation of orthohantavirus in rodents and humans in Hubei province, China. It identified the diversity of orthohantaviruses circulating in the region, with the HV004-like subtype being the main genotype in rodents and patients. This highlights the importance of continued attention and research on orthohantaviruses, especially newly identified strains.
