Journal
ACTA PSYCHIATRICA SCANDINAVICA
Volume 120, Issue 6, Pages 456-463Publisher
WILEY
DOI: 10.1111/j.1600-0447.2009.01390.x
Keywords
bipolar disorder; psychopharmacology; neuropsychology; cognitive impairment
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Funding
- Indian National Science Academy
- University Grants Commission
- Royal Society London
- Tees Esk and Wear Valleys NHS Foundation Trust's Research and Development department
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Objective: Although it is established that euthymic bipolar patients have neurocognitive deficits, the influence of medication on their cognitive performance is uncertain and requires investigation. Method: Neuropsychological tests of executive function, memory and attention were performed on 44 prospectively verified, euthymic bipolar I patients, 22 of whom were drug-free. Residual mood symptom effects were controlled statistically using ancova. Results: Drug-free and medicated patients differed only in delayed verbal recall (Rey AVLT list A7, drug-free > medicated), and perseverations during the five-point test (drug-free > medicated). When residual mood symptoms were controlled statistically, differences between drug-free and medicated subjects became insignificant. Medication effect sizes were modest. Significant correlations were found between residual depression scores and measures of verbal learning. Conclusion: Medications did not have any significant influence on neurocognitive performance, suggesting that neurocognitive deficits are an integral part of bipolar disorder.
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