Review
Behavioral Sciences
Katelyne Tursini, Steven Le Cam, Raymund Schwan, Gregory Gross, Karine Angioi-Duprez, Jean-Baptiste Conart, Irving Remy, Florent Bernardin, Vincent Laprevote, Elea Knobloch, Tiphaine Ricaud, Aline Rahnema, Valerie Louis-Dorr, Thomas Schwitzer
Summary: This article discusses the use of visual electrophysiology and neuropsychological assessment to improve the diagnosis and treatment of patients with bipolar disorder. The results show that the combination of these measurement methods can provide more information about the specific damages and pathophysiological characteristics of bipolar disorder patients.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Psychology, Clinical
Julian Macoveanu, Jeff Zarp Petersen, Patrick M. Fisher, Lars Vedel Kessing, Gitte Moos Knudsen, Kamilla Woznica Miskowiak
Summary: This study used fMRI to investigate cognitive deficits in patients with bipolar disorder and unipolar disorder. The results showed that these patients had hypo-activity in certain brain regions associated with cognitive control, as well as hyper-activity in other brain regions associated with default mode network.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Kuniyoshi Toyoshima, Yuki Kako, Atsuhito Toyomaki, Yusuke Shimizu, Teruaki Tanaka, Shin Nakagawa, Takeshi Inoue, Anabel Martinez-Aran, Eduard Vieta, Ichiro Kusumi
Summary: The euthymic state of bipolar disorder is often characterized by impaired cognitive function. Cognitive complaints, objective cognitive functions, and illness awareness were found to be associated in Japanese patients. Both subjective and objective cognitive functions were found to be associated with illness awareness in remitted bipolar outpatients.
PSYCHIATRY RESEARCH
(2021)
Article
Medicine, General & Internal
Naoto Adachi, Yukihisa Kubota, Eiichiro Goto, Koichiro Watanabe, Reiji Yoshimura, Takashi Tsuboi, Norio Yasui-Furukori, Masaki Kato, Seiji Hongo, Takaharu Azekawa, Eiichi Katsumoto, Koji Edagawa, Atsuo Nakagawa, Toshiaki Kikuchi, Hitoshi Ueda, Kazuhira Miki
Summary: In Japan, the cost of outpatient treatments for bipolar disorder is mainly attributed to the expenses of medications, which are steadily increasing. Factors such as social adjustment, depressive symptoms, age, rapid cycling, psychotic symptoms, and comorbid mental disorders are strongly associated with the daily cost of psychotropic drugs. The annual cost of outpatient bipolar disorder treatments in Japan is equivalent to that of OECD countries (excluding the US) and higher than some Asian countries.
ANNALS OF MEDICINE
(2023)
Article
Psychiatry
Bernadette Wendel, Sergi Papiol, Till F. M. Andlauer, Joerg Zimmermann, Jens Wiltfang, Carsten Spitzer, Fanny Senner, Eva C. Schulte, Max Schmauss, Sabrina K. Schaupp, Jonathan Repple, Eva Reininghaus, Jens Reimer, Daniela Reich-Erkelenz, Nils Opel, Susanne Meinert, Carsten Konrad, Farahnaz Kloehn-Saghatolislam, Tilo Kircher, Janos L. Kalman, Georg Juckel, Andreas Jansen, Markus Jaeger, Maria Heilbronner, Martin von Hagen, Katrin Gade, Christian Figge, Andreas J. Fallgatter, Detlef E. Dietrich, Udo Dannlowski, Ashley L. Comes, Monika Budde, Bernhard T. Baune, Volker Arolt, Ion-George Anghelescu, Heike Anderson-Schmidt, Kristina Adorjan, Peter Falkai, Thomas G. Schulze, Heike Bickeboeller, Urs Heilbronner
Summary: The study found that executive functions improved across diagnostic groups and identified nine genome-wide significant SNPs associated with performance change over time. The findings were replicated in a separate study, demonstrating the potential of longitudinally measured phenotypes to reveal novel genetic associations.
TRANSLATIONAL PSYCHIATRY
(2021)
Review
Chemistry, Medicinal
Qin Xiang Ng, Ming Xuan Han, Seth En Teoh, Clyve Yu Leon Yaow, Yu Liang Lim, Kuan Tsee Chee
Summary: This systematic review found that gabapentin and pregabalin do not have significant clinical efficacy as either monotherapy or adjunctive therapy for bipolar disorder. While small open-label trials suggest a potential adjunctive role, their effectiveness in acute mania is questionable, and their long-term effects on bipolar disorder outcomes are unclear. The evidence base was limited by small sample sizes and heterogeneous trial designs with high risk of bias.
Article
Clinical Neurology
Shunkai Lai, Shuming Zhong, Ying Wang, Yiliang Zhang, Ying Xue, Hui Zhao, Hanglin Ran, Shuya Yan, Yange Luo, Jiali He, Yunxia Zhu, Sihui Lv, Zijing Song, Haofei Miao, Yilei Hu, Xiaosi Huang, Xiaodan Lu, Jiansong Zhou, Yanbin Jia
Summary: This study investigated the prevalence and characteristics of cognitive impairment in patients with bipolar disorder and major depressive disorder. The results showed that both groups had significantly reduced cognitive performance compared to the healthy control group. The cognitive impairments in both groups were clinically significant, but more common in patients with bipolar disorder. These findings suggest the importance of cognitive screening and intervention strategies for patients with mood disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Dimosthenis Tsapekos, Rebecca Strawbridge, Matteo Cella, Til Wykes, Allan H. Young
Summary: This study explored the relationship between cognitive difficulties and functional outcomes in patients with BD, finding that 34% of participants exhibited clinically significant cognitive impairment. Factors such as older age, lower estimated premorbid IQ, more psychotropic medications, fewer previous therapies, and current use of antipsychotics were associated with poorer cognitive performance. A predictive model including premorbid IQ, psychotropic medications, and previous therapies correctly classified 75% of participants with cognitive impairment.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
K. W. Miskowiak, A. E. Jespersen, K. Obenhausen, P. Hafiz, E. Hestbaek, L. Gulyas, L. Kessing, J. E. Bardram
Summary: ICAT is a sensitive and valid web-based tool for assessing cognition in patients with bipolar disorder, showing correlations with SCIP scores. Lower ICAT scores are associated with more subjective cognitive complaints and poorer psychosocial functioning.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Giulio E. Brancati, Beniamino Tripodi, Martina Novi, Margherita Barbuti, Pierpaolo Medda, Giulio Perugi
Summary: The study found that a history of multiple drug treatments during the current episode of bipolar depression may be associated with a greater resistance to all types of therapies, including ECT.
PSYCHIATRY RESEARCH
(2021)
Review
Clinical Neurology
Oliver Pearson, Nora Uglik-Marucha, Kamilla W. Miskowiak, Scott A. Cairney, Ivana Rosenzweig, Allan H. Young, Paul R. A. Stokes
Summary: This systematic review examined the relationship between sleep disturbance and cognitive impairment in mood disorders. The findings indicate a significant association between sleep disturbance and cognitive impairment in people with mood disorders after adjusting for demographic and clinical factors, while no such association was found in healthy participants. These results underscore the need for further research on sleep disturbances and cognitive impairment in people with mood disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Clinical
Hanne Lie Kjaerstad, Fillip Ferreira Eikeseth, Maj Vinberg, Lars Vedel Kessing, Kamilla Miskowiak
Summary: Recent research found that patients with bipolar disorder (BD) exhibit diverse neurocognitive impairments, which are associated with affective cognition deficits. This study replicated previous findings of neurocognitive subgroups in BD patients, and revealed a link between neurocognition patterns and impairments in affective cognition. Additionally, first-degree relatives of cognitively impaired patients showed signs of inherited risk for BD.
PSYCHOLOGICAL MEDICINE
(2021)
Review
Clinical Neurology
Jeffrey J. Rakofsky, Michael J. Lucido, Boadie W. Dunlop
Summary: This study aimed to determine if there were sufficient differences in the inclusion/exclusion criteria and baseline severity scores of clinical trials to justify their consideration in treatment guidelines. The results revealed significant differences among the studies, indicating that severity of the enrolled patient sample and treatment resistance should be considered when ranking medications in bipolar depression treatment guidelines.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Clinical Neurology
Kamilla Woznica Miskowiak, Johanna Mariegaard, Frida Simon Jahn, Hanne Lie Kjaerstad
Summary: Cognitive assessments are associated with recurrence in patients with bipolar disorder and illness onset in at-risk individuals, suggesting potential for personalized treatment strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Alessandro Cuomo, Giovanni Barilla, Matteo Cattolico, Pietro Carmellini, Alessandro Spiti, Andrea Pozza, Andrea Fagiolini
Summary: This retrospective study supports the use of intravenous valproic acid (IV-VPA) as a more efficacious treatment option for patients with Bipolar Disorder, particularly in acute settings where rapid symptom improvement is crucial. Both oral and IV-VPA were found to be safe and well-tolerated.
Article
Psychology, Clinical
Dimosthenis Tsapekos, Rebecca Strawbridge, Matteo Cella, Allan H. Young, Til Wykes
Summary: This study investigated the impact and transfer mechanisms of cognitive remediation (CR) on functional improvement in individuals with bipolar disorder. The results suggest that cognitive gains after CR contribute to functional changes, with psychosocial functioning partially mediating the effect. Cognitive performance after treatment also moderates the effect of CR on goal attainment at follow-up.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
David A. Cousins, Thomas R. E. Barnes, Allan H. Young, Oriana Delgado, Carol Paton
Summary: This service evaluation investigated the interchangeability of different brands of lithium carbonate from a pharmacokinetic perspective. Data analysis showed that switching from Priadel(R) tablets to Camcolit(R) controlled-release tablets at the same dose did not significantly affect plasma lithium levels, suggesting that the most common brands of lithium carbonate produce similar plasma lithium levels. This suggests that the guidance in the British National Formulary on switching lithium brands may be unnecessarily complex.
Article
Psychiatry
Cynthia H. Y. Fu, Guray Erus, Yong Fan, Mathilde Antoniades, Danilo Arnone, Stephen R. Arnott, Taolin Chen, Ki Sueng Choi, Cherise Chin Fatt, Benicio N. Frey, Vibe G. Frokjaer, Melanie Ganz, Jose Garcia, Beata R. Godlewska, Stefanie Hassel, Keith Ho, Andrew M. McIntosh, Kun Qin, Susan Rotzinger, Matthew D. Sacchet, Jonathan Savitz, Haochang Shou, Ashish Singh, Aleks Stolicyn, Irina Strigo, Stephen C. Strother, Duygu Tosun, Teresa A. Victor, Dongtao Wei, Toby Wise, Rachel D. Woodham, Roland Zahn, Ian M. Anderson, J. F. William Deakin, Boadie W. Dunlop, Rebecca Elliott, Qiyong Gong, Ian H. Gotlib, Catherine J. Harmer, Sidney H. Kennedy, Gitte M. Knudsen, Helen S. Mayberg, Martin P. Paulus, Jiang Qiu, Madhukar H. Trivedi, Heather C. Whalley, Chao-Gan Yan, Allan H. Young, Christos Davatzikos
Summary: In this study, a consortium called "COORDINATE-MDD" was established to define patterns of brain alteration in major depressive disorder (MDD) using neuroanatomical and neurofunctional heterogeneity as dimensions. By harmonizing imaging data and using machine learning methods, the project aims to predict treatment response at the individual level. International datasets from various MDD populations are being shared, and novel predictors of treatment response are being identified and validated externally.
Review
Clinical Neurology
Oliver Pearson, Nora Uglik-Marucha, Kamilla W. Miskowiak, Scott A. Cairney, Ivana Rosenzweig, Allan H. Young, Paul R. A. Stokes
Summary: This systematic review examined the relationship between sleep disturbance and cognitive impairment in mood disorders. The findings indicate a significant association between sleep disturbance and cognitive impairment in people with mood disorders after adjusting for demographic and clinical factors, while no such association was found in healthy participants. These results underscore the need for further research on sleep disturbances and cognitive impairment in people with mood disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Psychiatry
A. Ratheesh, D. Hett, J. Ramain, E. Wong, L. Berk, P. Conus, M. A. Fristad, T. Goldstein, M. Hillegers, S. Jauhar, L. Kessing, D. J. Miklowitz, G. Murray, J. Scott, M. Tohen, L. N. Yatham, A. H. Young, M. Berk, S. Marwaha
Summary: This systematic review examined the effectiveness of interventions in the early course of bipolar disorder (BD). The findings suggested that lithium use was associated with lower recurrence risk compared to other mood stabilizers, and mood stabilizers were associated with better global functioning compared to antipsychotics in the medium term. Psychological interventions, such as family-focused and cognitive-behavioral interventions, were associated with reduced recurrence risk or improved symptomatic outcomes. Pharmacological interventions were more efficacious when utilized in the earlier stages of illness.
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
(2023)
Review
Neurosciences
Rebecca Strawbridge, Nefize Yalin, Stelios Orfanos, Allan H. Young
Summary: This scoping review aimed to synthesize all available evidence on the potential effects of acetazolamide on symptoms related to bipolar disorder, acceptability and tolerability, and intervention characteristics. Based on the included studies, most patients responded well to acetazolamide treatment, but the evidence is limited and more clinical trials are needed to validate its efficacy.
Editorial Material
Biochemistry & Molecular Biology
Sameer Jauhar, Danilo Arnone, David S. Baldwin, Michael Bloomfield, Michael Browning, Anthony J. Cleare, Phillip Corlett, J. F. William Deakin, David Erritzoe, Cynthia Fu, Paolo Fusar-Poli, Guy M. Goodwin, Joseph Hayes, Robert Howard, Oliver D. Howes, Mario F. Juruena, Raymond W. Lam, Stephen M. Lawrie, Hamish McAllister-Williams, Steven Marwaha, David Matuskey, Robert A. McCutcheon, David J. Nutt, Carmine Pariante, Toby Pillinger, Rajiv Radhakrishnan, James Rucker, Sudhakar Selvaraj, Paul Stokes, Rachel Upthegrove, Nefize Yalin, Lakshmi Yatham, Allan H. Young, Roland Zahn, Philip J. Cowen
Summary: A recent umbrella review found no consistent evidence linking serotonin to the pathophysiology of depression. However, we argue that this conclusion is overstated due to methodological weaknesses, selective reporting of data, oversimplification, and errors in the interpretation of neuropsychopharmacological findings. We use the examples of tryptophan depletion and serotonergic molecular imaging, the two most relevant research areas, to support our argument.
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Jiayuan Xu, Nana Liu, Elli Polemiti, Liliana Garcia-Mondragon, Jie Tang, Xiaoxuan Liu, Tristram Lett, Le Yu, Markus M. Noethen, Jianfeng Feng, Chunshui Yu, Andre Marquand, Gunter Schumann
Summary: Analyses of data from the UK Biobank reveal that different urban living environments are associated with affective, anxiety, and emotional instability symptom groups in adults. These associations are mediated by distinct neurological and genetic pathways. Using data from 156,075 participants, researchers found that social deprivation, air pollution, street network, and urban land-use density were positively correlated with affective symptoms. On the other hand, greenness and generous destination accessibility were negatively correlated with anxiety symptoms. The study suggests that urban living environments may influence specific psychiatric symptom groups through different neurobiological pathways.
Article
Development Studies
Benjamin Jones, Roberto Cardinale
Summary: Fossil fuel subsidy reforms are crucial for sustainable development goals, as fuel subsidies drain government funds and contribute to environmental degradation. However, progress in reducing these subsidies has been uneven due to weak political and social support for higher prices. The affordability of energy has gained significant attention recently, leading to social unrest in response to sustained energy and price inflation. This paper examines the factors that influence societal and political acceptability of fossil fuel subsidy reforms, drawing insights from a range of countries and emphasizing the need for tailored approaches to reform based on each country's unique context.
CLIMATE AND DEVELOPMENT
(2023)
Article
Psychiatry
Roger S. Mcintyre, Mohammad Alsuwaidan, Bernhard T. Baune, Michael Berk, Koen Demyttenaere, Joseph F. Goldberg, Philip Gorwood, Roger Ho, Siegfried Kasper, Sidney H. Kennedy, Josefina Ly-Uson, Rodrigo B. Mansur, R. Hamish McAllister-Williams, James W. Murrough, Charles B. Nemeroff, Andrew A. Nierenberg, Joshua D. Rosenblat, Gerard Sanacora, Alan F. Schatzberg, Richard Shelton, Stephen M. Stahl, Madhukar H. Trivedi, Eduard Vieta, Maj Vinberg, Nolan Williams, Allan H. Young, Mario Maj
Summary: Treatment-resistant depression is common and has serious public health implications. The lack of a consensus definition hampers accurate estimates of its prevalence and efforts to identify effective interventions, leading to heterogeneity in treatment decision-making and potentially compromising quality of care.
Article
Chemistry, Medicinal
Win Lee Edwin Wong, Chiara Fabbri, Benjamin Laplace, Danyang Li, Roos van Westrhenen, Cathryn M. Lewis, Gavin Stewart Dawe, Allan H. Young
Summary: This study suggests that CYP2C19 genotypes, and consequently metabolic phenotypes, may play a role in determining clinical responses to SSRIs, particularly escitalopram and citalopram. However, further investigation is needed to better understand this relationship.
Editorial Material
Psychiatry
Antje A. T. S. Reinders, Allan H. H. Young, Dick J. J. Veltman
Summary: This editorial summarizes and discusses papers from a themed series of BJPsych Open that aim to unravel the biological correlates of dissociative symptoms with the goal of improving treatment outcomes.
Review
Pharmacology & Pharmacy
Michail Kalfas, Rosie H. Taylor, Dimosthenis Tsapekos, Allan H. Young
Summary: Psychedelic therapy has the potential to revolutionize the treatment of treatment-resistant depression (TRD) by maximizing therapeutic benefits and minimizing risks. Psilocybin shows promise as a game-changer in TRD treatment, with initial evidence suggesting a rapid and sustained antidepressant effect. Further studies are needed to explore the mechanisms of action and long-term effects of psychedelics in TRD.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Psychiatry
Dimosthenis Tsapekos, Rebecca Strawbridge, Matteo Cella, Kimberley Goldsmith, Michail Kalfas, Rosie H. Taylor, Samuel Swidzinski, Steven Marwaha, Libby Grey, Elizabeth Newton, Julie Shackleton, Paul J. Harrison, Michael Browning, Catherine Harmer, Hannah Hartland, David Cousins, Stephen Barton, Til Wykes, Allan H. Young
Summary: Cognitive remediation (CR) has been shown to be beneficial for patients with bipolar disorder (BD). This study aims to evaluate the efficacy of CR in euthymic patients with BD and explore its mechanisms of action.
Article
Psychology, Clinical
Eshim S. Jami, Megan Pritchard, Hitesh Shetty, Robert Stewart, Allan H. Young, Margaret Heslin
Summary: This study investigates the use of antidepressant and antipsychotic treatment for Psychotic Major Depression (PMD) in clinical practice and examines how treatment profiles correlate with demographic and clinical symptoms. The results showed that combined antidepressant and antipsychotic pharmacotherapy is the most common treatment for PMD in clinical practice, in line with evidence from treatment research.
JOURNAL OF MENTAL HEALTH
(2023)
