The multiple universes of estrogen-related receptor α and γ in metabolic control and related diseases

Nuclear Receptors, RXR, and the Big Bang

(2014) Ronald M. Evans et al.   CELL

Tissue-Specific Differences in the Development of Insulin Resistance in a Mouse Model for Type 1 Diabetes

(2014) Tomas Jelenik et al.   DIABETES

Metformin Pharmacogenomics: Current Status and Future Directions

(2014) A. C. Pawlyk et al.   DIABETES

ERRαaugments HIF-1 signalling by directly interacting with HIF-1αin normoxic and hypoxic prostate cancer cells

(2014) Chang Zou et al.   JOURNAL OF PATHOLOGY

An overview of current and emerging SERMs

(2014) Barry S. Komm et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

De novo lipogenesis in health and disease

(2014) Fatima Ameer et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Ndrg2 is a PGC-1α/ERRα target gene that controls protein synthesis and expression of contractile-type genes in C2C12 myotubes

(2013) Victoria C. Foletta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Molecular and Genetic Crosstalks between mTOR and ERRα Are Key Determinants of Rapamycin-Induced Nonalcoholic Fatty Liver

(2013) Cédric Chaveroux et al.   Cell Metabolism

Inverse Agonist of Nuclear Receptor ERRγ Mediates Antidiabetic Effect Through Inhibition of Hepatic Gluconeogenesis

(2013) Don-Kyu Kim et al.   DIABETES

Estrogen-related receptor-α (ERRα) deficiency in skeletal muscle impairs regeneration in response to injury

(2013) Samuel LaBarge et al.   FASEB JOURNAL

Peroxisome Proliferator-activated Receptor γ Coactivator 1 (PGC-1)- and Estrogen-related Receptor (ERR)-induced Regulator in Muscle 1 (PERM1) Is a Tissue-specific Regulator of Oxidative Capacity in Skeletal Muscle Cells

(2013) Yoshitake Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potential applications for biguanides in oncology

(2013) Michael Pollak   JOURNAL OF CLINICAL INVESTIGATION

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

Liver adapts mitochondrial function to insulin resistant and diabetic states in mice

(2013) Andras Franko et al.   JOURNAL OF HEPATOLOGY

Estrogen-Related Receptor γ (ERRγ) Regulates Oxygen-Dependent Expression of Voltage-gated Potassium (K+) Channels and Tissue Kallikrein during Human Trophoblast Differentiation

(2013) Yanmin Luo et al.   MOLECULAR ENDOCRINOLOGY

Estrogen-Related Receptor Alpha Modulates Lactate Dehydrogenase Activity in Thyroid Tumors

(2013) Delphine Mirebeau-Prunier et al.   PLoS One

Loss of estrogen-related receptor   promotes hepatocarcinogenesis development via metabolic and inflammatory disturbances

(2013) E.-J. Hong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skeletal muscle PGC-1  controls whole-body lactate homeostasis through estrogen-related receptor  -dependent activation of LDH B and repression of LDH A

(2013) S. Summermatter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired myogenesis in estrogen-related receptor γ (ERRγ)-deficient skeletal myocytes due to oxidative stress

(2012) Jennifer Murray et al.   FASEB JOURNAL

Orphan Nuclear Receptor Estrogen-Related Receptor γ (ERRγ) Is Key Regulator of Hepatic Gluconeogenesis

(2012) Don-Kyu Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of glycolysis and the Warburg effect by estrogen-related receptors

(2012) Q Cai et al.   ONCOGENE

Estrogen-related receptor gamma modulates energy metabolism target genes in human trophoblast

(2012) D. Poidatz et al.   PLACENTA

Hypoxia Induces PDK4 Gene Expression through Induction of the Orphan Nuclear Receptor ERRγ

(2012) Ja Hee Lee et al.   PLoS One

AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

(2011) Ken Inoki et al.   Annual Review of Pharmacology and Toxicology

The Metabolic Regulator ERRα, a Downstream Target of HER2/IGF-1R, as a Therapeutic Target in Breast Cancer

(2011) Ching-yi Chang et al.   CANCER CELL

Exercise and PGC-1α-Independent Synchronization of Type I Muscle Metabolism and Vasculature by ERRγ

(2011) Vihang A. Narkar et al.   Cell Metabolism

Estrogen-related Receptor γ (ERRγ) Is a Novel Transcriptional Regulator of Phosphatidic Acid Phosphatase, LIPIN1, and Inhibits Hepatic Insulin Signaling

(2011) Don-Kyu Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Diaryl Ether-Based Ligands for Estrogen-Related Receptor α as Potential Antidiabetic Agents

(2011) Raymond J. Patch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metabolic syndrome: Is immunosuppression to blame?

(2011) Kymberly D. Watt   LIVER TRANSPLANTATION

Estrogen related receptors (ERRs): A new dawn in transcriptional control of mitochondrial gene networks

(2011) Lillian J. Eichner et al.   MITOCHONDRION

Estrogen related receptor α-induced adipogenesis is PGC-1β-dependent

(2011) Dapeng Ju et al.   MOLECULAR BIOLOGY REPORTS

Estrogen-related receptor-  is a metabolic regulator of effector T-cell activation and differentiation

(2011) R. D. Michalek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic Convergence among ERRα, PROX1, and BMAL1 in the Control of Metabolic Clock Outputs

(2011) Catherine R. Dufour et al.   PLoS Genetics

Functional and physiological genomics of estrogen-related receptors (ERRs) in health and disease

(2010) Geneviève Deblois et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Transcriptional Control of the ERBB2 Amplicon by ERR  and PGC-1  Promotes Mammary Gland Tumorigenesis

(2010) G. Deblois et al.   CANCER RESEARCH

miR-378 ∗ Mediates Metabolic Shift in Breast Cancer Cells via the PGC-1β/ERRγ Transcriptional Pathway

(2010) Lillian J. Eichner et al.   Cell Metabolism

Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlipidemia by Upregulating Hepatic Gluconeogenesis and Impairing Lipid Deposition in Adipose Tissue

(2010) V. P. Houde et al.   DIABETES

The homeobox protein Prox1 is a negative modulator of ERR /PGC-1  bioenergetic functions

(2010) A. Charest-Marcotte et al.   GENES & DEVELOPMENT

Estrogen-related Receptor γ Is a Key Regulator of Muscle Mitochondrial Activity and Oxidative Capacity

(2010) Shamina M. Rangwala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potent antifibrotic activity of mTOR inhibitors sirolimus and everolimus but not of cyclosporine A and tacrolimus in experimental liver fibrosis

(2010) Eleonora Patsenker et al.   JOURNAL OF HEPATOLOGY

The metabolic syndrome

(2010) Robert H Eckel et al.   LANCET

Genome-Wide Identification of Direct Target Genes Implicates Estrogen-Related Receptor   as a Determinant of Breast Cancer Heterogeneity

(2009) G. Deblois et al.   CANCER RESEARCH

Up-regulation of orphan nuclear estrogen-related receptor alpha expression during long-term caloric restriction in mice

(2009) Harmit S. Ranhotra   MOLECULAR AND CELLULAR BIOCHEMISTRY

Regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) gene expression by glucocorticoids and insulin

(2009) Sara Connaughton et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Physiological Genomics Identifies Estrogen-Related Receptor α as a Regulator of Renal Sodium and Potassium Homeostasis and the Renin-Angiotensin Pathway

(2009) Annie M. Tremblay et al.   MOLECULAR ENDOCRINOLOGY

An oestrogen-receptor-α-bound human chromatin interactome

(2009) Melissa J. Fullwood et al.   NATURE

Modulation of adipogenesis-related gene expression by estrogen-related receptor γ during adipocytic differentiation

(2008) Mayumi Kubo et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors

(2008) Vincent Giguère   ENDOCRINE REVIEWS

Suppressing the activity of ERRα in 3T3-L1 adipocytes reduces mitochondrial biogenesis but enhances glycolysis and basal glucose uptake

(2008) Yaohui Nie et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Involvement of estrogen-related receptors in transcriptional response to hypoxia and growth of solid tumors

(2008) A. Ao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERRα: a metabolic function for the oldest orphan

(2008) Josep A. Villena et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM