Drug discovery for polycystic kidney disease

Treatment Strategies and Clinical Trial Design in ADPKD

(2010) Vicente E. Torres   ADVANCES IN CHRONIC KIDNEY DISEASE

Rosiglitazone Inhibits Cell Proliferation by Inducing G1 Cell Cycle Arrest and Apoptosis in ADPKD Cyst-Lining Epithelia Cells

(2010) Yawei Liu et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

The HALT Polycystic Kidney Disease Trials: Design and Implementation

(2010) A. B. Chapman et al.   Clinical Journal of the American Society of Nephrology

Rosiglitazone attenuates development of polycystic kidney disease and prolongs survival in Han:SPRD rats

(2010) Bing Dai et al.   CLINICAL SCIENCE

Curcumin inhibits renal cyst formation and enlargement in vitro by regulating intracellular signaling pathways

(2010) Jinsheng Gao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The cell biology of polycystic kidney disease

(2010) Hannah C. Chapin et al.   JOURNAL OF CELL BIOLOGY

Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models

(2010) Thomas A Natoli et al.   NATURE MEDICINE

Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD

(2010) S. J. Leuenroth et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Everolimus in Patients with Autosomal Dominant Polycystic Kidney Disease

(2010) Gerd Walz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cyclic nucleotide signaling in polycystic kidney disease

(2009) Xiaofang Wang et al.   KIDNEY INTERNATIONAL

Polycystin-1 Regulates Extracellular Signal-Regulated Kinase-Dependent Phosphorylation of Tuberin To Control Cell Size through mTOR and Its Downstream Effectors S6K and 4EBP1

(2009) G. Distefano et al.   MOLECULAR AND CELLULAR BIOLOGY

Long-term rapamycin therapy in the Han:SPRD rat model of polycystic kidney disease (PKD)

(2009) I. Zafar et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Effect of pravastatin on kidney function and urinary protein excretion in autosomal dominant polycystic kidney disease

(2009) Robert G. Fassett et al.   SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1

(2008) Sekiya Shibazaki et al.   HUMAN MOLECULAR GENETICS

Small-Molecule CFTR Inhibitors Slow Cyst Growth in Polycystic Kidney Disease

(2008) B. Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Src Inhibition Ameliorates Polycystic Kidney Disease

(2008) W. E. Sweeney et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Triptolide Reduces Cystogenesis in a Model of ADPKD

(2008) S. J. Leuenroth et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A tumor necrosis factor-α–mediated pathway promoting autosomal dominant polycystic kidney disease

(2008) Xiaogang Li et al.   NATURE MEDICINE