Article
Dentistry, Oral Surgery & Medicine
Ming-Yi Lu, Chih-Yuan Fang, Pei-Ling Hsieh, Yi-Wen Liao, Lo-Lin Tsai, Cheng-Chia Yu
Summary: The study identified that miR-509 expression is downregulated in oral cancer stem cells and upregulation of miR-509 can attenuate various characteristics of CSCs. A luciferase reporter assay confirmed the direct binding between miR-509 and plk1, suggesting the potential role of miR-509/plk1 axis in mediating cancer stemness in oral cancer and providing a potential therapeutic target.
JOURNAL OF DENTAL SCIENCES
(2022)
Article
Oncology
Chao Liu, Wenhui Gao, Yijun Shi, Lu Lv, Weifeng Tang
Summary: This study investigated the relationship between miRNA rs2910164, rs11614913, and rs3746444 polymorphisms and the susceptibility to esophageal squamous cell cancer (ESCC) in the Chinese Han nationality. The results suggest that the rs3746444 GG genotype is associated with an increased risk of ESCC, while rs11614913 and rs2910164 polymorphisms are not associated with ESCC.
Article
Oncology
Hossein Sendi, Mostafa Yazdimamaghani, Mengying Hu, Nikhila Sultanpuram, Jie Wang, Amber S. Moody, Ellie McCabe, Jiajie Zhang, Amanda Graboski, Liantao Li, Juan D. Rojas, Paul A. Dayton, Leaf Huang, Andrew Z. Wang
Summary: Efficient delivery of miR-122 to hepatocytes using a nanomedicine-based formulation has the potential to prevent and treat colorectal cancer liver metastasis. Mechanistically, it downregulates key genes involved in metastatic and cancer inflammation pathways, increases CD8(+)/CD4(+) T-cell ratio, and decreases immunosuppressive cell infiltration, making the liver more conducive to antitumor immune response.
Article
Oncology
Shuchang Ren, Xiaohui Tan, Melinda Z. Fu, Shuyang Ren, Xiaoling Wu, Tao Chen, Patricia S. Latham, Paul Lin, Yan-gao Man, Sidney W. Fu
Summary: In esophageal cancer, miR-375 is frequently downregulated and acts as a tumor suppressor by blocking the ERBB2/VEGFA pathway to inhibit cancer progression.
Review
Cell Biology
Boya Peng, Poh Ying Theng, Minh T. N. Le
Summary: miR-125b, a key miRNA in cancer pathogenesis, is deregulated in various types of cancer and plays important roles in tumourigenesis and cancer progression. Its potential as a diagnostic and prognostic biomarker, as well as a therapeutic tool against cancer, is supported by emerging evidence on its essential functions.
CELL PROLIFERATION
(2021)
Review
Biochemistry & Molecular Biology
Masoumeh Amirian, Amir Masoud Jafari-Nozad, Majid Darroudi, Tahereh Farkhondeh, Saeed Samarghandian
Summary: Accumulating evidence has shown the significant role of miR-29 in human malignancies, particularly breast cancer (BC). MiR-29 acts as a tumor suppressor by targeting multiple signaling pathways and transcripts, but it can also promote BC progression through gene and transcription factor targeting. The conflicting roles of miR-29 in BC may be attributed to its regulatory roles dependent on the environment and signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Cell Biology
Songjie Shen, Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yidong Zhou, Qiang Sun
Summary: The study identified miR-7641 as a key miRNA in cancer-derived exosomes promoting tumor progression and metastasis via intercellular communication. Exosomal miR-7641 may serve as a non-invasive diagnostic biomarker and potential therapeutic target in breast cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Oncology
Christos Miliotis, Frank J. Slack
Summary: In gastric cancer, miR-105-5p has been identified as a key regulator of PD-L1 expression, impacting T cell activation, and could serve as a potential biomarker and target for combination immunotherapy targeting PD-1/PD-L1 interactions.
Article
Medicine, Research & Experimental
Cagdas Aktan, Cag Cal, Burcin Kaymaz, Nur Selvi Gunel, Sezgi Kipcak, Buket Ozel, Cumhur Gunduz, Ali Sahin Kucukaslan, Duygu Ayguenes Jafari, Buket Kosova
Summary: In this study, differentially expressed miRNAs that target androgen receptors (ARs) were identified and investigated in castration resistant prostate cancer (CRPC) cells. The expression levels of miR-625-5p and miR-874-3p were significantly increased in CRPC cells compared with androgen dependent cells, and transfection of CRPC cells with anti-miRs suppressed their proliferation and AR protein levels.
Article
Multidisciplinary Sciences
Yoona Seo, Yura Kang, Youngwook Ham, Mi-Hwa Kim, Seong-Jun Kim, Seung Kew Yoon, Sung Key Jang, Jong Bae Park, Sungchan Cho, Jong Heon Kim
Summary: This study identifies the regulatory role of PLK1-ELAVL1/HuR-miR-122 signaling in HCV proliferation and suggests that targeting this host cell signaling pathway could be a useful therapeutic approach for treating HCV and HCV-associated diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biotechnology & Applied Microbiology
Qiang Huang, Long Peng, Yuxiang Sun, Jiayu Huang, Tong Han, Yongjie Li, Hui Peng
Summary: miR-593-3p promotes proliferation, migration, and invasion in PCa cells by targeting ADIPOR1, involving the AMPK signaling pathway and EMT process.
ONCOTARGETS AND THERAPY
(2021)
Article
Urology & Nephrology
C. G. H. Ronnau, S. Fussek, F. P. Smit, T. W. Aalders, O. van Hooij, P. M. C. Pinto, M. Burchardt, J. A. Schalken, G. W. Verhaegh
Summary: This study identified several novel deregulated miRNAs in CRPC tissue, including two microRNAs potentially involved in tumor invasion. The data support the hypothesized involvement of miRNAs in PCa tumorigenesis and progression to CRPC. The applicability of these miRNAs as novel biomarkers for CRPC needs further investigation.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Oncology
Camila Meirelles S. Silva, Mateus C. Barros-Filho, Deysi Viviana T. Wong, Julia Bette H. Mello, Livia Maria S. Nobre, Carlos Wagner S. Wanderley, Larisse T. Lucetti, Heitor A. Muniz, Igor Kenned D. Paiva, Hellen Kuasne, Daniel Paula P. Ferreira, Maria Perpetuo S. S. Cunha, Carlos G. Hirth, Paulo Goberlanio B. Silva, Rosane O. Sant'Ana, Marcellus Henrique L. P. Souza, Josiane S. Quetz, Silvia R. Rogatto, Roberto Cesar P. Lima-Junior
Summary: By screening miRNAs in plasma, we identified four miRNAs as potential biomarkers for the early detection of colorectal cancer, presenting high performance and easy applicability in clinical practice.
Article
Oncology
Mauro Scaravilli, Sonja Koivukoski, Andrew Gillen, Aya Bouazza, Pekka Ruusuvuori, Tapio Visakorpi, Leena Latonen
Summary: The study demonstrates that miR-32 promotes MYC-induced prostate adenocarcinoma and identifies PDK4 as a PC-relevant metabolic target of miR-32-3p. Elevated expression of miR-32 influences prostate tumor growth and phenotype, and regulates the expression of prostate secretome and several PC-related target genes.
Article
Oncology
Yong Zhu, Yun Zhang, Xiaohua Li, Yuntao Su, Nina Wang, Minli Chen, Zhe Yang
Summary: MiR-106b-3p regulates the sensitivity of esophageal squamous cell carcinoma cells to cisplatin by targeting TGM3, and downregulation of miR-106b-3p may increase the sensitivity of cells to cisplatin.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Gastroenterology & Hepatology
Ling Li, Klaus Piontek, Masaharu Ishida, Michel Fausther, Jonathan A. Dranoff, Rongdang Fu, Esteban Mezey, Stephen J. Gould, Francis K. Fordjour, Stephen J. Meltzer, Alphonse E. Sirica, Florin M. Selaru
Article
Gastroenterology & Hepatology
Vivek Kumbhari, Ling Li, Klaus Piontek, Masaharu Ishida, Rongdang Fu, Bassem Khalil, Caroline M. Garrett, Eleni Liapi, Anthony N. Kalloo, Florin M. Selaru
GASTROINTESTINAL ENDOSCOPY
(2018)
Article
Gastroenterology & Hepatology
Adrian G. Murphy, Florin M. Selaru
Article
Gastroenterology & Hepatology
Fang Wang, Ling Li, Klaus Piontek, Masazumi Sakaguchi, Florin M. Selaru
Review
Gastroenterology & Hepatology
Alphonse E. Sirica, Gregory J. Gores, John D. Groopman, Florin M. Selaru, Mario Strazzabosco, Xin Wei Wang, Andrew X. Zhu
Article
Multidisciplinary Sciences
Takashi Hirosawa, Masaharu Ishida, Kentaro Ishii, Keigo Kanehara, Katsuyoshi Kudo, Shinobu Ohnuma, Takashi Kamei, Fuyuhiko Motoi, Takeshi Naitoh, Florin M. Selaru, Michiaki Unno
Article
Gastroenterology & Hepatology
Jiafei Cheng, Hong Shen, Reezwana Chowdhury, Tsion Abdi, Florin Selaru, Jiande D. Z. Chen
INFLAMMATORY BOWEL DISEASES
(2020)
Editorial Material
Gastroenterology & Hepatology
Jad Farha, Mohamad I. Itani, Yervant Ichkhanian, Mouen A. Khashab, Saowanee Ngamruengphong, Florin M. Selaru, Vivek Kumbhari
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Gastroenterology & Hepatology
Ling Li, Yicheng Zhang, Yang Zhou, Haijie Hu, Yizong Hu, Christos Georgiades, Hai-Quan Mao, Florin M. Selaru
Summary: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. Current therapies for Barcelona Clinic Liver Cancer (BCLC)-B patients have shown minimal improvement in clinical outcomes. This study identified bortezomib (BTZ) as a highly cytotoxic small molecule for HCC and designed sustained release BTZ nanoparticles (BTZ-NP) that showed a release of BTZ over 30 days. In vivo tests demonstrated that BTZ-NP effectively controlled tumor size and improved survival in three animal models, making it a promising localized treatment for HCC.
Article
Chemistry, Multidisciplinary
Arijit Ghosh, Wangqu Liu, Ling Li, Gayatri J. Pahapale, Si Young Choi, Liyi Xu, Qi Huang, Ruili Zhang, Zijian Zhong, Florin M. Selaru, David H. Gracias
Summary: This study describes autonomous microinjectors that can efficiently deliver macromolecular drugs, such as insulin, to the systemic circulation via the gastrointestinal tract. In vitro studies showed that these microinjectors can penetrate the gastrointestinal mucosa and in vivo experiments in rats demonstrated successful release of insulin.
Article
Medicine, General & Internal
Evangelos Tsipotis, Ankith Maremanda, Laura Bowles Zeiser, Caoilfhionn Connolly, Sowmya Sharma, Sharon Dudley-Brown, Sarah Frey, Mark Lazarev, Joanna M. Melia, Alyssa M. Parian, Dorry L. Segev, Brindusa Truta, Huimin Yu, William A. Werbel, Florin M. Selaru
Summary: This study assessed the response to a third dose of mRNA vaccine against SARS-CoV-2 in inflammatory bowel disease (IBD) patients. The results showed that all patients had detectable antibodies at 3 months post-third dose, with 89% showing neutralizing antibodies. These findings support the recommendations for additional doses in immunocompromised individuals.
MEDICINA-LITHUANIA
(2023)
Review
Pharmacology & Pharmacy
Wangqu Liu, Soo Jin Choi, Derosh George, Ling Li, Zijian Zhong, Ruili Zhang, Si Young Choi, Florin M. Selaru, David H. Gracias
Summary: Recent studies show that the deployment of tether-free and shape-changing devices, especially at sub-mm scales, could greatly improve the diagnosis and treatment of GI diseases such as cancer, IBD, and IBS. These devices have the potential to enhance treatment efficacy, reduce costs, and increase medication compliance. The article discusses the challenges and possibilities associated with ensuring safe, reliable, and autonomous operation of these smart devices.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Review
Medicine, General & Internal
Rong Yan, Haiming Chen, Florin M. Selaru
Summary: This review provides a comprehensive overview of the role of extracellular vesicles (EVs) in hepatocellular carcinoma (HCC), focusing on their potential as diagnostic biomarkers and therapeutic agents. The article explores the utility of EVs as diagnostic biomarkers for HCC and discusses their potential as carriers for therapeutic payloads. Additionally, the emerging field of therapeutic EVs for modulating tumor immune responses is examined.
MEDICINA-LITHUANIA
(2023)
Article
Multidisciplinary Sciences
Arijit Ghosh, Ling Li, Liyi Xu, Ranjeet P. Dash, Neha Gupta, Jenny Lam, Qianru Jin, Venkata Akshintala, Gayatri Pahapale, Wangqu Liu, Anjishnu Sarkar, Rana Rais, David H. Gracias, Florin M. Selaru
Article
Medicine, Research & Experimental
Ling Li, Hildur Knutsdottir, Ken Hui, Matthew J. Weiss, Jin He, Benjamin Philosophe, Andrew M. Cameron, Christopher L. Wolfgang, Timothy M. Pawlik, Gabriel Ghiaur, Andrew J. Ewald, Esteban Mezey, Ljoel S. Bader, Florin M. Selaru
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)