Article
Biochemistry & Molecular Biology
Redona Hafizi, Faik Imeri, Roland H. Wenger, Andrea Huwiler
Summary: The research demonstrates that under normoxic conditions, S1P activates the S1P1 and S1P3 receptors in renal interstitial fibroblasts, promoting Epo production. This finding may have therapeutic implications for conditions like chronic kidney disease that result in anemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Angela Corvino, Ida Cerqua, Alessandra Lo Bianco, Giuseppe Caliendo, Ferdinando Fiorino, Francesco Frecentese, Elisa Magli, Elena Morelli, Elisa Perissutti, Vincenzo Santagada, Giuseppe Cirino, Elisabetta Granato, Fiorentina Roviezzo, Elisa Puliti, Caterina Bernacchioni, Antonio Lavecchia, Chiara Donati, Beatrice Severino
Summary: A new compound acting as an S1P(3) receptor antagonist has been identified, with derivatives synthesized to optimize its activity and selectivity. Further research has shown that compounds selective towards S1P(3) can inhibit skeletal muscle fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Xuehui Fan, Lili Liu, Yue Shi, Fanghan Guo, Xiao He, Xiuli Zhao, Di Zhong, Guozhong Li
Summary: Sphingosine 1-phosphate (S1P) is a sphingolipid metabolite found in various cells and body fluids, with five receptors, S1P1-S1P5, exhibiting tissue selectivity. Among these receptors, S1P3 plays a crucial role in processes related to inflammation, cell migration, tumor invasion and metastasis, and other pathophysiological processes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Chiara D'Aprile, Simona Prioni, Laura Mauri, Alessandro Prinetti, Sara Grassi
Summary: Lipid rafts are specialized membrane domains enriched in gangliosides, sphingomyelin, cholesterol, and proteins involved in signal transduction, modulating cell homeostasis. Sphingosine 1-phosphate participates in various signal transduction processes, with enzymes and receptors often localized in lipid rafts.
CELLULAR SIGNALLING
(2021)
Review
Pharmacology & Pharmacy
Gerhild van Echten-Deckert
Summary: Lipids are essential components of the CNS, and sphingolipids, a type of lipid, are highly concentrated in the brain. Sphingosine 1-phosphate (S1P), derived from membrane sphingolipids, has complex effects on the brain, which can be both beneficial and detrimental. However, the role of S1P in brain development and various brain pathologies is still controversial.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Celine Tolksdorf, Eileen Moritz, Robert Wolf, Ulrike Meyer, Sascha Marx, Sandra Bien-Moeller, Ulrike Garscha, Gabriele Jedlitschky, Bernhard H. Rauch
Summary: Sphingosine-1-phosphate (S1P) is a versatile signaling lipid that regulates various cellular processes. Platelets are an important source of S1P and can rapidly generate and release it to regulate cellular responses. Furthermore, platelet-generated and released S1P may also impact disease processes such as inflammation-driven vascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Bisera Stepanovska Tanturovska, Aleksandra Zivkovic, Faik Imeri, Thomas Homann, Burkhard Kleuser, Holger Stark, Andrea Huwiler
Summary: Sphingosine 1-phosphate (S1P) is a studied signaling molecule that contributes to various cellular functions. Drugs targeting S1P receptors show promise in treating autoimmune diseases. ST-2191 is a novel S1P(1) modulator with potential therapeutic effects.
Article
Medicine, Research & Experimental
Colin Niaudet, Bongnam Jung, Andrew Kuo, Steven Swendeman, Edward Bull, Takahiro Seno, Reed Crocker, Zhongjie Fu, Lois E. H. Smith, Timothy Hla
Summary: This study reveals the significance of S1P in vascular development. Activation of endothelial S1PR1 by circulating HDL-S1P can suppress neovascularization in retinopathy. These findings suggest that circulating HDL-S1P activation of endothelial S1PR1 serves as a protective mechanism against neovascular retinopathy.
EMBO MOLECULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Leiye Yu, Licong He, Bing Gan, Rujuan Ti, Qingjie Xiao, Hongli Hu, Lizhe Zhu, Sheng Wang, Ruobing Ren
Summary: This study reveals the activation and regulation mechanism of human S1PR1 receptor through cryo-electron microscopy analysis. The S1PR1 receptor plays an essential role in the immune and vascular systems, and understanding its function in depth contributes to the development of related therapeutic approaches.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Shah Alam, Sumaiya Yasmeen Afsar, Gerhild Van Echten-Deckert
Summary: In this study, the neural-targeted ablation of SGPL1 in a mouse model revealed that the accumulation of S1P due to SGPL1 deficiency led to increased expression of glycolytic enzymes, preferential entry of pyruvate into the TCA cycle, and elevated cellular ATP content. The high energy load activated mTOR, thus regulating astrocytic autophagy and potentially affecting neuronal viability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Michela Terlizzi, Chiara Colarusso, Giusy Ferraro, Anna Falanga, Maria Chiara Monti, Pasquale Somma, Ilaria De Rosa, Luigi Panico, Aldo Pinto, Rosalinda Sorrentino
Summary: Sex is a biological variable that can affect the activity of the lipid mediator S1P in lung conditions. This study found sex differences in circulating S1P levels among lung cancer patients, with ADK patients having lower levels compared to SCC patients. Additionally, the expression of S1P receptors and metabolic enzymes differed between male and female patients with different lung cancer types. These findings highlight the importance of considering sex differences when studying S1P as a prognostic mediator in lung cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Xuefeng Xu, Yi Han, Tianxin Zhu, Faxin Fan, Xin Wang, Yuqing Liu, Duosheng Luo
Summary: Osteoporosis is a common disease worldwide with significant economic burden. Understanding the role of SphK/S1P/S1PR signaling in regulating osteoblasts and osteoclasts is crucial for the treatment of osteoporosis. This review summarizes the effects of S1P on proliferation, differentiation, apoptosis, and functions, and focuses on S1P-based therapeutic approaches in bone metabolism.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Zafrul Hasan, Toan Q. Nguyen, Brenda Wan Shing Lam, Jovi Hui Xin Wong, Caleb Cheng Yi Wong, Clarissa Kai Hui Tan, Jiabo Yu, Chung Hwee Thiam, Yongliang Zhang, Veronique Angeli, Long N. Nguyen
Summary: The protein Spns2 is involved in regulating lymphocyte movement and has been shown to have potential as a drug target in autoimmune diseases. This study examined mice with a genetic deletion of Spns2 and found that it affected lymphocyte levels, S1P secretion, and lymph node vasculature. Additionally, these mice were resistant to multiple sclerosis, suggesting that targeting Spns2 could be a promising therapeutic approach for neuroinflammation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Pierre-Eric Juif, Markus S. Mueller, Hakim Charfi, Jasper Dingemanse
Summary: This study investigated the effect of Cenerimod on the pharmacokinetics of a combined oral contraceptive. The results showed that Cenerimod did not have a clinically relevant impact on the metabolism of the contraceptive drugs. Therefore, it is safe to use the combined oral contraceptive during and after Cenerimod therapy without the risk of interaction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Eileen M. McGowan, Yiguang Lin, Size Chen
Summary: Obesity is closely associated with inflammation and increased cancer risk in the digestive system. Saturated fat diets and being overweight can cause chronic inflammation. Bioactive sphingolipids, signaling molecules made from saturated fats, play essential roles in maintaining healthy gastrointestinal immunity. Excessive levels of these molecules can lead to chronic inflammation, but drugs that block their activity have the potential to reduce gastrointestinal cancer risk.
Article
Biochemistry & Molecular Biology
Euijung Jo, Barun Bhhatarai, Emanuela Repetto, Miguel Guerrero, Sean Riley, Steven J. Brown, Yasushi Kohno, Edward Roberts, Stephan C. Schuerer, Hugh Rosen
ACS CHEMICAL BIOLOGY
(2012)
Article
Multidisciplinary Sciences
Michael A. Hanson, Christopher B. Roth, Euijung Jo, Mark T. Griffith, Fiona L. Scott, Greg Reinhart, Hans Desale, Bryan Clemons, Stuart M. Cahalan, Stephan C. Schuerer, M. Germana Sanna, Gye Won Han, Peter Kuhn, Hugh Rosen, Raymond C. Stevens
Article
Multidisciplinary Sciences
M. C. Hansen, P. V. Potapov, R. Moore, M. Hancher, S. A. Turubanova, A. Tyukavina, D. Thau, S. V. Stehman, S. J. Goetz, T. R. Loveland, A. Kommareddy, A. Egorov, L. Chini, C. O. Justice, J. R. G. Townshend
Article
Pharmacology & Pharmacy
Yan-Rou Tsai, Dong Seok Kim, Shih-Chang Hsueh, Kai-Yun Chen, John Chung-Che Wu, Jia-Yi Wang, Yi-Syue Tsou, Inho Hwang, Yukyung Kim, Dayeon Gil, Eui Jung Jo, Baek-Soo Han, David Tweedie, Daniela Lecca, Michael T. Scerba, Warren R. Selman, Barry J. Hoffer, Nigel H. Greig, Yung-Hsiao Chiang
Summary: The immunomodulatory drug pomalidomide and its derivatives 3,6'-DP and 1,6'-DP have shown promising anti-inflammatory effects in a rat stroke model. These compounds may have the potential to be valuable therapies for stroke and should be further developed.
Article
Biochemistry & Molecular Biology
M. Germana Sanna, Sheng-Kai Wang, Pedro J. Gonzalez-Cabrera, Anthony Don, David Marsolais, Melanie P. Matheu, Sindy H. Wei, Ian Parker, Euijung Jo, Wei-Chieh Cheng, Michael D. Cahalan, Chi-Huey Wong, Hugh Rosen
NATURE CHEMICAL BIOLOGY
(2006)
Article
Immunology
SH Wei, H Rosen, MP Matheu, MG Sanna, SK Wang, EJ Jo, CH Wong, I Parker, MD Cahalan
Article
Biochemistry & Molecular Biology
EJ Jo, G Sanna, PJ Gonzalez-Cabrera, S Thangada, G Tigyi, DA Osborne, T Hla, AL Parrill, H Rosen
CHEMISTRY & BIOLOGY
(2005)
Article
Biochemistry & Molecular Biology
E Jo, AA Darabie, K Han, A Tandon, PE Fraser, J McLaurin
EUROPEAN JOURNAL OF BIOCHEMISTRY
(2004)
Article
Biochemistry & Molecular Biology
MG Sanna, JY Liao, EJ Jo, C Alfonso, MY Ahn, MS Peterson, B Webb, S Lefebvre, J Chun, N Gray, H Rosen
JOURNAL OF BIOLOGICAL CHEMISTRY
(2004)
Article
Biochemistry & Molecular Biology
EJ Jo, N Fuller, RP Rand, P St George-Hyslop, PE Fraser
JOURNAL OF MOLECULAR BIOLOGY
(2002)
Article
Biochemistry & Molecular Biology
EJ Jo, J McLaurin, CM Yip, P St George-Hyslop, PE Fraser
JOURNAL OF BIOLOGICAL CHEMISTRY
(2000)