Article
Pediatrics
Poorva Deshpande, Amish Jain, Patrick J. McNamara
Summary: Phenobarbitone significantly suppresses cerebral electrical activity in infants with HIE undergoing TH, leading to worsening of background patterns on aEEG. Development of severe aEEG background patterns after phenobarbitone administration may be associated with MRI brain death or moderate-to-severe injury.
Article
Neurosciences
Bahar Saadatmehr, Mohammadreza Edalati, Laura Routier, Mahdi Mahmoudzadeh, Javad Safaie, Guy Kongolo, Ghida Ghostine, Fabrice Wallois, Sahar Moghimi
Summary: Temporal theta activity in coalescence with slow-wave (TTA-SW) is an early neurodevelopmental biomarker that can be measured through EEG. This study found that during neurodevelopment, there is a gradual enhancement of SW theta phase-amplitude coupling (PAC), primarily concentrated near the trough of the SW. The steepness of the SW's slope is related to the intensity of PAC, indicating a close relationship between PAC and neurodevelopment.
Article
Neurosciences
Xiangjun Cui, Bin Zhou, Jiebin Wu, Dong Yang, Xiao Liu, Yun Wang
Summary: The study revealed that brain injury induced by neonatal hyperbilirubinemia significantly affected the amplitude-integrated electroencephalography results, as well as increased levels of neuron-specific enolase and S100B. The combination of aEEG, NSE, and S100B showed good diagnostic value in diagnosing brain injury and predicting prognosis.
Article
Mathematical & Computational Biology
Saadullah Farooq Abbasi, Qammer Hussain Abbasi, Faisal Saeed, Norah Saleh Alghamdi
Summary: Sleep plays a crucial role in neonatal development, and accurately detecting and characterizing sleep stages is important for assessing early-stage development. In this study, a computationally efficient algorithm using a convolutional neural network (CNN) is proposed to automatically detect neonatal quiet sleep. The algorithm achieves impressive results and has the advantage of computational efficiency. This research opens up possibilities for real-time neonatal sleep stage classification and further investigations in early-stage development monitoring and neonatal health assessment.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2023)
Article
Pediatrics
Poorva Deshpande, Julia Dirks, Amish Jain, Patrick J. McNamara, Cecil Hahn, Prakesh S. Shah, Anne-Marie Guerguerian
Summary: The aim of this study was to investigate the patterns of aEEG cyclicity, background pattern, voltage margins, and maturation scores in ELGANs during the first 72 hours. The results showed that clinically stable ELGANs without neurological injury demonstrated increased cyclicity compared to those with a complicated course, and maturation score, high and low base voltage increased over time.
Article
Clinical Neurology
Jimmy J. Fraigne, Jeffrey Wang, Hanhee Lee, Russell Luke, Sara K. Pintwala, John H. Peever
Summary: Research on sleep-wake behaviors usually relies on manual inspection of EEG and EMG recordings to score sleep states, which is time-consuming and prone to errors. A four-state system provides more precision in behavioral analysis, but is more complex than the traditional three-state system. SleepEns, a novel machine learning ensemble, achieved high accuracy in automated classification and showed similar sleep-wake characteristics as human experts.
Article
Clinical Neurology
Fengzhen Hou, Lulu Zhang, Baokun Qin, Giulia Gaggioni, Xinyu Liu, Gilles Vandewalle
Summary: The study demonstrates that Multiscale Permutation Entropy (MSPE) significantly decreases before sleep onset and in the transition from wakefulness to sleep, effectively discriminating between different sleep stages and showing correlation with spectral measures of EEG related to sleep need.
Review
Pediatrics
Poorva Deshpande, Patrick J. McNamara, Cecil Hahn, Prakesh S. Shah, Anne-Marie Guerguerian
Summary: This article reviews the literature on normal and abnormal aEEG patterns in preterm infants and proposes a stepwise clinical algorithm for aEEG assessment at the bedside.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Won Hyuk Lee, Seung Hyun Kim, Jae Yoon Na, Young-Hyo Lim, Seok Hyun Cho, Sung Ho Cho, Hyun-Kyung Park
Summary: This study investigated the possibility of quantitatively distinguishing and measuring sleep/wake states in neonates using IR-UWB radar technology and compared its accuracy with behavioral observation-based sleep/wake analyses. The results showed that the radar technology can provide considerable accuracy regarding sleep/wake decisions in neonates, demonstrating the feasibility of its use in the NICU for the first time. This unobtrusive, non-contact radar technology is a promising method for monitoring sleep/wake states with vital signs in neonates.
FRONTIERS IN PEDIATRICS
(2021)
Article
Engineering, Biomedical
Chen Chen, Yan Xu, Zeyu Wang, Chenglu Sun, Xian Zhao, Jiahao Fan, Hendrik Niemarkt, Peter Andriessen, Laishuan Wang, Wei Chen
Summary: This paper investigates the digital transformation procedure of deriving amplitude-integrated (a)EEG from raw EEG and evaluates the impact of different filters and envelope detection methods. The results demonstrate that the proposed approach achieved excellent performance in a clinical dataset, promoting the standardization of aEEG transformation procedure and exploration of automatic interpretation algorithms.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Review
Pharmacology & Pharmacy
Gratia Nguyen, Svetlana Postnova
Summary: General anaesthesia is widely used in surgery and interventional medical procedures, and computational modelling has provided valuable insights into the neural circuitry involved in generating unconsciousness from administering an anaesthetic drug. Current research focuses on the EEG features under GABAergic anaesthetic drugs in the brain activity, proposing theories for the origin of these features. Recent empirical findings suggest that anaesthetic drugs may act directly on the hypothalamic neural circuitry, which regulates sleep-wake states and circadian rhythms.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Clinical Neurology
Obertino Dilena, Federico Raviglione, Gaetano Cantalupo, Duccio M. Cordelli, Paola De Liso, Matteo Di Capua, Raffaele Falsaperla, Fabrizio Ferrari, Monica Fumagalli, Silvia Lori, Agnese Suppiej, Laura Tadini, Bernardo Dalla Bernardina, Massimo Mastrangelo, Francesco Pisani
Summary: This work aims to establish inclusive guidelines on electroencephalography (EEG) for all neonatal intensive care units (NICUs), while proposing shared recommendations for video EEG and amplitude-integrated EEG to promote collaboration between neonatal units of different complexity levels and provide suggestions for organizational restructuring and tele-neurophysiology implementation.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Ozge Ulgen, Hatice Ezgi Baris, Oyku Ozboru Askan, Selda Kucuk Akdere, Can Ilgin, Hulya Ozdemir, Nural Bekiroglu, Kivilcim Gucuyener, Eren Ozek, Perran Boran
Summary: The study found that actigraphy at a medium threshold can accurately depict the sleep of typically developing preterm infants in the NICU, and aEEG may be an alternative adjunctive method for evaluating sleep/wake states.
Article
Clinical Neurology
Joel S. Raymond, Nicholas A. Everett, Anand Gururajan, Michael T. Bowen
Summary: The study examined the effects of oxytocin on sleep-wake behavior and found that intraperitoneal administration of oxytocin promoted quiet wakefulness and suppressed active wakefulness, non-rapid eye movement (NREM) sleep, and rapid eye movement (REM) sleep. The sleep-wake effects of oxytocin were mediated by oxytocin receptor binding. In contrast, intranasal administration of oxytocin did not affect sleep-wake outcomes.
Article
Pediatrics
Gabriel F. T. Variane, Rafaela F. R. Pietrobom, Caroline Y. Noh, Krisa P. Van Meurs, Valerie Y. Chock
Summary: Continuous neuromonitoring in Neonatal Intensive Care Unit (NICU) allows for bedside assessment of oxygenation, perfusion, cerebral function and seizures. Near-infrared spectroscopy (NIRS) provides organ-specific assessment of perfusion, while amplitude-integrated electroencephalography (aEEG) evaluates cerebral function and identifies seizures. Multi-modality monitoring combines brain and vital sign monitoring, facilitating understanding of physiology.
FRONTIERS IN PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
Deanne K. Thompson, Lillian G. Matthews, Bonnie Alexander, Katherine J. Lee, Claire E. Kelly, Chris L. Adamson, Rod W. Hunt, Jeanie L. Y. Cheong, Megan Spencer-Smith, Jeffrey J. Neil, Marc L. Seal, Terrie E. Inder, Lex W. Doyle, Peter J. Anderson
NATURE COMMUNICATIONS
(2020)
Article
Neurosciences
Nathanael J. Yates, Kirk W. Feindel, Andrew Mehnert, Richard Beare, Sophia Quick, Dominique Blache, J. Jane Pillow, Rod W. Hunt
Article
Pediatrics
Alice C. Burnett, Julia K. Gunn-Charlton, Stephanie Malarbi, Esther Hutchinson, Tiong Yang Tan, Warwick J. Teague, Sebastian K. King, Rod W. Hunt
Summary: Children with OA showed varying cognitive, language, and executive functioning, with some displaying lower than expected intellectual development. At 5 years, they exhibited age-appropriate language and self-regulation, but reduced attention. By 8 years, the OA group had lower sustained attention, divided attention, and mathematics skills, but typical memory and literacy. Parents consistently reported increased working memory difficulties, and other executive functioning and behavioral symptoms were transiently observed. Findings did not consistently differ according to clinical characteristics.
JOURNAL OF PEDIATRIC SURGERY
(2021)
Article
Pediatrics
Sharman P. Tan Tanny, Sebastian K. King, Assia Comella, Alisa Hawley, Jo-Anne Brooks, Rod W. Hunt, Bryn Jones, Warwick J. Teague
Summary: Preoperative echocardiography is routinely used in neonates with esophageal atresia to identify those with congenital cardiac disease that may impact anesthesia and surgical decisions. Selective strategies can reduce the number of echocardiograms performed, improving timeliness of care and resource utilization without compromising patient safety.
PEDIATRIC SURGERY INTERNATIONAL
(2021)
Article
Environmental Sciences
Helen Shoemark, Marie Dahlstrom, Oscar Bedford, Lauren Stewart
Summary: This study examined the impact of the Time Together psycho-educational program on maternal self-efficacy, mother-infant bonding, and mood/anxiety for community-based mothers, showing promising results in improving early mother-infant interaction and maternal self-efficacy.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Clinical Neurology
Nicholas P. Ryan, Mardee Greenhom, Anne L. Gordon, Michael Ditchfield, Lee Coleman, Anna Cooper, Louise Crowe, Rod W. Hunt, Paul Monagle, Mark T. Mackay, Vicki Anderson
Summary: Childhood and adolescence coincide with rapid maturation of distributed brain networks supporting social cognition; however, little is known about the impact of early ischemic brain insult on the acquisition of these skills. This study aimed to examine the influence of arterial ischemic stroke (AIS) on facial emotion recognition and theory of mind (ToM) abilities of children and adolescents initially recruited to a single-center, prospective longitudinal study of recovery following AIS. The findings suggest that acute magnetic resonance imaging-based lesion characteristics may have predictive value for long-term social cognitive outcomes and may assist to identify children at elevated risk for social cognitive dysfunction.
Article
Clinical Neurology
Mardee Greenham, Anne L. Gordon, Anna Cooper, Stephen Hearps, Michael Ditchfield, Lee Coleman, Rod W. Hunt, Mark T. Mackay, Paul Monagle, Vicki Anderson
Summary: This study assessed the prevalence of fatigue symptoms in children 5 years after pediatric arterial ischemic stroke, finding that fatigue was associated with functional difficulties and the need for long-term monitoring. Factors such as age at stroke, lesion size, sex, and social risk were predictive of different types of fatigue symptoms.
Article
Pediatrics
Jolie Lawrence, Laure F. Pittet, Samar Hikmat, Eloise J. Silvester, Vanessa Clifford, Rodney Hunt, Amanda Gwee
Summary: This study aimed to determine the safety of early intravenous-to-oral antibiotic switch and identify risk factors for bacteraemia with UTIs. The results showed that for young infants with non-bacteraemic UTI, short-course intravenous antibiotics for <48 hours should be considered, provided meningitis has been excluded. Treatment failure and serious complications were rare in young infants with UTI.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Dentistry, Oral Surgery & Medicine
Stephanie Malarbi, Anita K. Chisholm, Julia K. Gunn-Charlton, Alice C. Burnett, Tiong Yang Tan, Shirley S. W. Cheng, Anastasia Pellicano, Jocelyn Shand, Andrew Heggie, Rod W. Hunt
Summary: This study describes the intelligence quotient (IQ) of children with Pierre Robin sequence (PRS). The results show that a significant proportion of PRS children have IQ scores below the average range, and there is a significant association between PRS subtype and IQ. Children with isolated PRS tend to have average or higher IQ, while those with syndromic PRS are more likely to have lower IQ, and the majority of PRS-plus children have low intellectual functioning.
CLEFT PALATE CRANIOFACIAL JOURNAL
(2022)
Article
Pediatrics
Abbey L. Eeles, Joy E. Olsen, Kate L. Cameron, Clare T. McKinnon, Kate L. Rawnsley, Melinda Cruz, Kylie Pussell, Kara Dubois, Rod W. Hunt, Jeanie L. Y. Cheong, Alicia J. Spittle
Summary: Parents of preterm or sick infants face mental health problems and financial stress. This study explores the use of Australian paid parental leave (PPL) and the financial impact on families with infants requiring neonatal care. Results indicate that having a preterm or sick infant has significant emotional and financial implications for families. The current Australian Government PPL scheme does not adequately support these parents, highlighting the need for urgent change to improve outcomes for this vulnerable population.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2022)
Editorial Material
Pediatrics
Simone Huntingford, Rod W. Hunt
PEDIATRIC RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Elys A. Green, Steven P. Garrick, Briana Peterson, Philip J. Berger, Robert Galinsky, Rod W. Hunt, Steven X. Cho, Jane E. Bourke, Marcel F. Nold, Claudia A. Nold-Petry
Summary: Preterm birth is a major cause of neonatal morbidity and mortality, with complications such as BPD, BPD-PH, WMI, ROP, NEC, and sepsis. Inflammation, particularly the imbalance of pro- and anti-inflammatory mediators, plays a key role in the pathophysiology of these diseases. This review focuses on the involvement of the IL-1 family in perinatal inflammation and its clinical implications, highlighting the potential of these cytokines as therapeutic targets for early life inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Angela X. Chen, Rod W. Hunt, Kirsten R. Palmer, Claudia F. Bull, Emily J. Callander
Summary: Conception via in vitro fertilisation (IVF) and ovulation induction (OI) is associated with an increased risk of breech presentation, according to a cohort study in Queensland, Australia. The study suggests that the increased risk is similar for both IVF and OI pregnancies, and low birthweight is the most significant mediating factor for breech presentation in these pregnancies.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Editorial Material
Pediatrics
Rod Hunt
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Psychology, Social
Elizabeth Harman, Helen Shoemark
Summary: The study aimed to examine patterns of toxic stress and trauma that develop throughout pediatric HSCT admissions, and to understand how music therapists can proactively intervene to mitigate the impact of traumatic experiences. The results identified patterns of toxic stress and trauma, as well as a responsive model of care for music therapy.
JOURNAL OF PSYCHOSOCIAL ONCOLOGY
(2023)
