Progress in modelling of brain dynamics during anaesthesia and the role of sleep-wake circuitry

Explaining anaesthetic hysteresis with effect-site equilibration

(2020) Alex Proekt et al.   BRITISH JOURNAL OF ANAESTHESIA

Level of consciousness is dissociable from electroencephalographic measures of cortical connectivity, slow oscillations, and complexity

(2019) Dinesh Pal et al.   JOURNAL OF NEUROSCIENCE

Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep

(2019) Nina E. Fultz et al.   SCIENCE

How does general anaesthesia affect the circadian clock?

(2018) Raewyn C. Poulsen et al.   SLEEP MEDICINE REVIEWS

Key components of the delirium syndrome and mortality: greater impact of acute change and disorganised thinking in a prospective cohort study

(2018) R. A. Diwell et al.   BMC Geriatrics

NFTsim: Theory and Simulation of Multiscale Neural Field Dynamics

(2018) Paula Sanz-Leon et al.   PLoS Computational Biology

Mechanisms of hysteresis in human brain networks during transitions of consciousness and unconsciousness: Theoretical principles and empirical evidence

(2018) Hyoungkyu Kim et al.   PLoS Computational Biology

Multimodal General Anesthesia

(2018) Emery N. Brown et al.   ANESTHESIA AND ANALGESIA

Spiking patterns and synchronization of thalamic neurons along the sleep-wake cycle

(2018) Noah Holmgren Hopkins et al.   CHAOS

Activation of orexin system facilitates anesthesia emergence and pain control

(2018) Wei Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anesthetic action on the transmission delay between cortex and thalamus explains the beta-buzz observed under propofol anesthesia

(2017) Meysam Hashemi et al.   PLoS One

Bottom-Up and Top-Down Mechanisms of General Anesthetics Modulate Different Dimensions of Consciousness

(2017) George A. Mashour et al.   Frontiers in Neural Circuits

Molecular Mechanisms of Sleep Homeostasis in Flies and Mammals

(2017) Ravi Allada et al.   Cold Spring Harbor Perspectives in Biology

Effects of Anesthesia on the Response to Sleep Deprivation

(2017) Aaron B. Nelson et al.   SLEEP

Neural Correlates of Sevoflurane-induced Unconsciousness Identified by Simultaneous Functional Magnetic Resonance Imaging and Electroencephalography

(2016) Andreas Ranft et al.   ANESTHESIOLOGY

Resting-state Network-specific Breakdown of Functional Connectivity during Ketamine Alteration of Consciousness in Volunteers

(2016) Vincent Bonhomme et al.   ANESTHESIOLOGY

Electroencephalogram signatures of ketamine anesthesia-induced unconsciousness

(2016) Oluwaseun Akeju et al.   CLINICAL NEUROPHYSIOLOGY

Integrated information theory: from consciousness to its physical substrate

(2016) Giulio Tononi et al.   NATURE REVIEWS NEUROSCIENCE

Effects of Ketamine on Resting-State EEG Activity and Their Relationship to Perceptual/Dissociative Symptoms in Healthy Humans

(2016) Sara de la Salle et al.   Frontiers in Pharmacology

Understanding the Hysteresis Loop Conundrum in Pharmacokinetic / Pharmacodynamic Relationships

(2016) Christopher Louizos et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Resting-state Functional Magnetic Resonance Imaging Correlates of Sevoflurane-induced Unconsciousness

(2015) Ben Julian A. Palanca et al.   ANESTHESIOLOGY

Perioperative stroke: a question of timing?

(2015) R.D. Sanders et al.   BRITISH JOURNAL OF ANAESTHESIA

The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia

(2015) P.L. Purdon et al.   BRITISH JOURNAL OF ANAESTHESIA

The thalamocortical network as a single slow wave-generating unit

(2015) Vincenzo Crunelli et al.   CURRENT OPINION IN NEUROBIOLOGY

Percolation Model of Sensory Transmission and Loss of Consciousness Under General Anesthesia

(2015) David W. Zhou et al.   PHYSICAL REVIEW LETTERS

Effects of Dexmedetomidine on Sleep Quality in Critically Ill Patients

(2014) Christina Alexopoulou et al.   ANESTHESIOLOGY

Effects of Sevoflurane and Propofol on Frontal Electroencephalogram Power and Coherence

(2014) Oluwaseun Akeju et al.   ANESTHESIOLOGY

GABAergic transmission in rat pontine reticular formation regulates the induction phase of anesthesia and modulates hyperalgesia caused by sleep deprivation

(2014) Giancarlo Vanini et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

α2-Adrenergic Stimulation of the Ventrolateral Preoptic Nucleus Destabilizes the Anesthetic State

(2014) Hilary S. McCarren et al.   JOURNAL OF NEUROSCIENCE

Physiologically-based modeling of sleep–wake regulatory networks

(2014) Victoria Booth et al.   MATHEMATICAL BIOSCIENCES

Characterization of the Relationship Between Intracranial Pressure and Electroencephalographic Monitoring in Burst-Suppressed Patients

(2014) Mark Connolly et al.   Neurocritical Care

Poor outcome prediction by burst suppression ratio in adults with post-anoxic coma without hypothermia

(2014) Qinglin Yang et al.   NEUROLOGICAL RESEARCH

A Physiologically Based Model of Orexinergic Stabilization of Sleep and Wake

(2014) Ben D. Fulcher et al.   PLoS One

Mathematical Models for Sleep-Wake Dynamics: Comparison of the Two-Process Model and a Mutual Inhibition Neuronal Model

(2014) Anne C. Skeldon et al.   PLoS One

Tracking the Sleep Onset Process: An Empirical Model of Behavioral and Physiological Dynamics

(2014) Michael J. Prerau et al.   PLoS Computational Biology

Essential Thalamic Contribution to Slow Waves of Natural Sleep

(2013) F. David et al.   JOURNAL OF NEUROSCIENCE

Differential Modulation of Spontaneous and Evoked Thalamocortical Network Activity by Acetylcholine Level In Vitro

(2013) J. C. Wester et al.   JOURNAL OF NEUROSCIENCE

Thalamocortical Mechanisms for the Anteriorization of Alpha Rhythms during Propofol-Induced Unconsciousness

(2013) S. Vijayan et al.   JOURNAL OF NEUROSCIENCE

Layer-specific excitatory circuits differentially control recurrent network dynamics in the neocortex

(2013) Riccardo Beltramo et al.   NATURE NEUROSCIENCE

Electroencephalogram signatures of loss and recovery of consciousness from propofol

(2013) P. L. Purdon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

A Theoretically Based Index of Consciousness Independent of Sensory Processing and Behavior

(2013) A. G. Casali et al.   Science Translational Medicine

Slow-Wave Activity Saturation and Thalamocortical Isolation During Propofol Anesthesia in Humans

(2013) R. Ni Mhuircheartaigh et al.   Science Translational Medicine

The Mesoscopic Modeling of Burst Suppression during Anesthesia

(2013) David T. J. Liley et al.   Frontiers in Computational Neuroscience

Ketamine, Propofol, and the EEG: A Neural Field Analysis of HCN1-Mediated Interactions

(2013) Ingo Bojak et al.   Frontiers in Computational Neuroscience

Orexin-A Facilitates Emergence from Propofol Anesthesia in the Rat

(2012) Li-Na Zhang et al.   ANESTHESIA AND ANALGESIA

Differential Effects of Deep Sedation with Propofol on the Specific and Nonspecific Thalamocortical Systems

(2012) Xiaolin Liu et al.   ANESTHESIOLOGY

Central and Peripheral Circadian Clocks in Mammals

(2012) Jennifer A. Mohawk et al.   Annual Review of Neuroscience

Direct Activation of Sleep-Promoting VLPO Neurons by Volatile Anesthetics Contributes to Anesthetic Hypnosis

(2012) Jason T. Moore et al.   CURRENT BIOLOGY

Thalamocortical interactions

(2012) S Murray Sherman   CURRENT OPINION IN NEUROBIOLOGY

Dexmedetomidine vs Midazolam or Propofol for Sedation During Prolonged Mechanical Ventilation

(2012) Stephan M. Jakob   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Meanfield modeling of propofol-induced changes in spontaneous EEG rhythms

(2012) Rikkert Hindriks et al.   NEUROIMAGE

Thalamo-cortical mechanisms underlying changes in amplitude and frequency of human alpha oscillations

(2012) Rikkert Hindriks et al.   NEUROIMAGE

Thalamic model of awake alpha oscillations and implications for stimulus processing

(2012) S. Vijayan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A neurophysiological-metabolic model for burst suppression

(2012) S. Ching et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Effect of Propofol Anesthesia on Rebound Spiking

(2012) Michelle M. McCarthy et al.   SIAM JOURNAL ON APPLIED DYNAMICAL SYSTEMS

State-specific Effects of Sevoflurane Anesthesia on Sleep Homeostasis

(2011) Dinesh Pal et al.   ANESTHESIOLOGY

Rapid Eye Movement Sleep Debt Accrues in Mice Exposed to Volatile Anesthetics

(2011) Jeremy Pick et al.   ANESTHESIOLOGY

General Anesthesia and Altered States of Arousal: A Systems Neuroscience Analysis

(2011) Emery N. Brown et al.   Annual Review of Neuroscience

Cortical Hypersynchrony Predicts Breakdown of Sensory Processing during Loss of Consciousness

(2011) Gernot G. Supp et al.   CURRENT BIOLOGY

Investigating paradoxical hysteresis effects in the mouse neocortical slice model

(2011) Logan J. Voss et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Management of refractory status epilepticus in adults: still more questions than answers

(2011) Andrea O Rossetti et al.   LANCET NEUROLOGY

Regional Slow Waves and Spindles in Human Sleep

(2011) Yuval Nir et al.   NEURON

The protective roles of mitochondrial ATP-sensitive potassium channels during hypoxia–ischemia–reperfusion in brain

(2011) Lin Wang et al.   NEUROSCIENCE LETTERS

Tracking brain states under general anesthesia by using global coherence analysis

(2011) A. Cimenser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disruption of the circadian system by environmental factors: Effects of hypoxia, magnetic fields and general anesthetics agents☆

(2010) Yvan Touitou et al.   ADVANCED DRUG DELIVERY REVIEWS

Isoflurane Anesthesia Does Not Satisfy the Homeostatic Need for Rapid Eye Movement Sleep

(2010) George A. Mashour et al.   ANESTHESIA AND ANALGESIA

Propofol Anesthesia Significantly Alters Plasma Blood Levels of Melatonin in Rats

(2010) Garance Dispersyn et al.   ANESTHESIOLOGY

Breakdown of within- and between-network Resting State Functional Magnetic Resonance Imaging Connectivity during Propofol-induced Loss of Consciousness

(2010) Pierre Boveroux et al.   ANESTHESIOLOGY

The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks

(2010) Charna Dibner et al.   Annual Review of Physiology

Study of the time course of the clinical effect of propofol compared with the time course of the predicted effect-site concentration: performance of three pharmacokinetic–dynamic models

(2010) M. Coppens et al.   BRITISH JOURNAL OF ANAESTHESIA

General Anesthesia, Sleep, and Coma

(2010) Emery N. Brown et al.   NEW ENGLAND JOURNAL OF MEDICINE

Physiology of Circadian Entrainment

(2010) Diego A. Golombek et al.   PHYSIOLOGICAL REVIEWS

A Conserved Behavioral State Barrier Impedes Transitions between Anesthetic-Induced Unconsciousness and Wakefulness: Evidence for Neural Inertia

(2010) Eliot B. Friedman et al.   PLoS One

Thalamocortical model for a propofol-induced  -rhythm associated with loss of consciousness

(2010) S. Ching et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breakdown in cortical effective connectivity during midazolam-induced loss of consciousness

(2010) F. Ferrarelli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular and chemical neuroscience of mammalian sleep

(2010) Subimal Datta   SLEEP MEDICINE

Practical Use of the Raw Electroencephalogram Waveform During General Anesthesia: The Art and Science

(2009) Cambell Bennett et al.   ANESTHESIA AND ANALGESIA

Involvement of the Basal Cholinergic Forebrain in the Mediation of General (Propofol) Anesthesia

(2009) Fatem-Zohra Laalou et al.   ANESTHESIOLOGY

Basal Forebrain Histaminergic Transmission Modulates Electroencephalographic Activity and Emergence from Isoflurane Anesthesia

(2009) Tao Luo et al.   ANESTHESIOLOGY

Circadian Disruption of Body Core Temperature and Rest–Activity Rhythms after General (Propofol) Anesthesia in Rats

(2009) Garance Dispersyn et al.   ANESTHESIOLOGY

Thalamic Microinfusion of Antibody to a Voltage-gated Potassium Channel Restores Consciousness during Anesthesia

(2009) Michael T. Alkire et al.   ANESTHESIOLOGY

No Association between Intraoperative Hypothermia or Supplemental Protective Drug and Neurologic Outcomes in Patients Undergoing Temporary Clipping during Cerebral Aneurysm Surgery

(2009) Bradley J. Hindman et al.   ANESTHESIOLOGY

Effects of the anesthetic agent propofol on neural populations

(2009) Axel Hutt et al.   Cognitive Neurodynamics

Anaesthetic mechanisms: update on the challenge of unravelling the mystery of anaesthesia

(2009) Andrea Kopp Lugli et al.   EUROPEAN JOURNAL OF ANAESTHESIOLOGY

Cerebral Activity during the Anesthesia-Like State Induced by Mesopontine Microinjection of Pentobarbital

(2009) R. Abulafia et al.   JOURNAL OF NEUROSCIENCE

Adenosine A1 and A2A Receptors in Mouse Prefrontal Cortex Modulate Acetylcholine Release and Behavioral Arousal

(2009) C. J. Van Dort et al.   JOURNAL OF NEUROSCIENCE

The Involvement of Hypothalamic Sleep Pathways in General Anesthesia: Testing the Hypothesis Using the GABAA Receptor  3N265M Knock-In Mouse

(2009) A. Y. Zecharia et al.   JOURNAL OF NEUROSCIENCE

Temporal Framing of Thalamic Relay-Mode Firing by Phasic Inhibition during the Alpha Rhythm

(2009) Magor L. Lőrincz et al.   NEURON

General Anesthetics Effects on Circadian Temporal Structure: An Update

(2008) Garance Dispersyn et al.   CHRONOBIOLOGY INTERNATIONAL

Desynchronization of Daily Rest–Activity Rhythm in the Days Following Light Propofol Anesthesia for Colonoscopy

(2008) G Dispersyn et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Role of endogenous sleep-wake and analgesic systems in anesthesia

(2008) Jun Lu et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Potential Network Mechanisms Mediating Electroencephalographic Beta Rhythm Changes during Propofol-Induced Paradoxical Excitation

(2008) M. M. McCarthy et al.   JOURNAL OF NEUROSCIENCE

General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal

(2008) Nicholas P. Franks   NATURE REVIEWS NEUROSCIENCE

Sleep as a fundamental property of neuronal assemblies

(2008) James M. Krueger et al.   NATURE REVIEWS NEUROSCIENCE

Anesthesia Awareness and the Bispectral Index

(2008) Michael S. Avidan et al.   NEW ENGLAND JOURNAL OF MEDICINE

An essential role for orexins in emergence from general anesthesia

(2008) M. B. Kelz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Consciousness and Anesthesia

(2008) M. T. Alkire et al.   SCIENCE

Automated characterization of multiple alpha peaks in multi-site electroencephalograms

(2007) A.K.I. Chiang et al.   JOURNAL OF NEUROSCIENCE METHODS