Article
Oncology
Anita Mamtani, Varadan Sevilimedu, Alain Vincent, Monica Morrow
Summary: Despite frequent postoperative complications and a 40% LRR rate after heroic mastectomy, the 3-year overall survival rate was 30%, suggesting limited benefit from surgery. Careful patient selection is advised when considering heroic mastectomy.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Heleen Bollen, Brigitte Decallonne, Sandra Nuyts
Summary: Parathyroid carcinoma (PC) is a rare malignancy characterized by difficult-to-control hypercalcemia, which is the main contributor to morbidity and mortality. In cases where surgical resection is not possible, radiation treatment can be considered to improve quality of life for symptomatic PC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Maria E. Rodriguez-Ruiz, Irantzu Serrano-Mendioroz, Eneko Garate-Soraluze, Paloma Sanchez-Mateos, Celia Barrio-Alonso, Inmaculada Rodriguez Lopez, Victor Diaz Pascual, Leire Arbea Moreno, Maite Alvarez, Miguel F. Sanmamed, Jose Luis Perez-Gracia, Helena Escuin-Ordinas, Marisol Quintero, Ignacio Melero
Summary: This study demonstrates that local BO-112 immunotherapy and focal irradiation can synergistically achieve local tumor control. Furthermore, irradiation plus BO-112 in one of the tumor lesions enhances the therapeutic effects on distant irradiated lesions that were not injected with BO-112.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Pharmacology & Pharmacy
Yingying Li, Kaiyuan Ni, Christina Chan, Nining Guo, Taokun Luo, Wenbo Han, August Culbert, Ralph R. Weichselbaum, Wenbin Lin
Summary: The combination of radiotherapy (RT) and immunotherapy, along with DMAMCL sensitization, significantly enhances anti-cancer efficacy by increasing tumor-infiltrating CD4 and CD8 T cells, and establishing immune memory.
ADVANCED THERAPEUTICS
(2022)
Review
Oncology
Filippo Gagliardi, Pierfrancesco De Domenico, Silvia Snider, Edoardo Pompeo, Francesca Roncelli, Lina Raffaella Barzaghi, Michele Bailo, Martina Piloni, Alfio Spina, Andrei Fodor, Giulia Berzero, Nadia Di Muzio, Massimo Filippi, Gaetano Finocchiaro, Pietro Mortini
Summary: The standard treatment for surgically inaccessible low-grade brainstem gliomas is external-beam radiotherapy, but Gamma Knife radiosurgery plays an increasingly important role in treatment. This meta-analysis compared different treatment methods for these tumors and evaluated their effects on patient survival, clinical outcomes, tumor control, and complications.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Letter
Oncology
Po-Lung Cheng, Ping-Hsiu Wu, We-Yu Kao, Yen-Ting Lai, Jason C. Hsu, Jeng-Fong Chiou, Meng-Huang Wu, Hsin-Lun Lee
Summary: Surgical intervention is the first-line treatment for hepatocellular carcinoma (HCC) patients, but only a few patients can undergo radical surgery. A systematic review and meta-analysis conducted on inoperable HCC patients evaluated the local control of four local ablative therapies: radiofrequency ablation therapy (RFA), microwave ablation therapy (MWA), stereotactic ablative radiotherapy (SABR), and particle radiotherapy. MWA and particle radiotherapy showed better local control rates compared to RFA, while SABR showed a non-significant trend. SABR and particle radiotherapy performed better than RFA for HCCs ≤30 mm in size. MWA, SABR, and particle radiotherapy were effective and safe for local control in HCC patients.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Review
Oncology
Tamara Ius, Giuseppe Lombardi, Cinzia Baiano, Jacopo Berardinelli, Andrea Romano, Nicola Montemurro, Luigi Maria Cavallo, Francesco Pasqualetti, Alberto Feletti
Summary: This review investigates the survival and functional outcomes in adult high-grade brainstem gliomas (BGSs) by comparing data from resective surgery and biopsy. The analysis shows that extensive resection surgery is associated with improved survival, but the higher complication rate makes it challenging to recommend surgery as the primary treatment for BSGs. Future research combining volumetric data and molecular profiles could provide important insights into the choice between resection and biopsy.
Article
Oncology
Naoya Kemmotsu, Li Zhu, Joji Nagasaki, Yoshihiro Otani, Youki Ueda, Hiromichi Dansako, Yue Fang, Isao Date, Yosuke Togashi
Summary: Hydrogen peroxide (H2O2) combined with radiotherapy (RT) induces antitumor immunity and can be further enhanced by PD-1 blockade, promoting the development of H2O2/RT therapy combined with cancer immunotherapies.
Article
Medicine, General & Internal
Wei Zhang, Qing Xie, Bifa Zhu, Xiaokang Wang, Ling He, Yong Zhang
Summary: This retrospective study analyzed the data of 90 inoperable patients with locally advanced esophageal squamous cell carcinoma (ESCC) treated with intensity-modulated radiotherapy (IMRT), and found that a higher radiation dose (>60 Gy) was associated with better survival outcomes.
Article
Pharmacology & Pharmacy
Na Wang, Qin Gao, Juan Tang, YiQing Jiang, LiShi Yang, XiangXiang Shi, Yue Chen, Yan Zhang, ShaoZhi Fu, Sheng Lin
Summary: Endostatin-loaded hydrogel drug (ES/HA-Tyr) synthesized in this study showed sustained release, lower systemic toxicity, and better anti-tumor effects when administered locally. In combination with RT, ES/HA-Tyr exhibited enhanced anti-angiogenic effects and increased efficacy against tumor growth.
Article
Oncology
Indrawati Hadi, Daniel Reitz, Raphael Bodensohn, Olarn Roengvoraphoj, Stefanie Lietke, Maximilian Niyazi, Jorg-Christian Tonn, Claus Belka, Niklas Thon, Silke Birgit Nachbichler
Summary: The frequency and risk profile of radiation necrosis in patients with glioma undergoing different radiation therapies are mainly determined by treatment volume and irradiation time.
RADIATION ONCOLOGY
(2021)
Article
Engineering, Manufacturing
Seyed Mohammad Hosseini, Ehsan Amani
Summary: In this study, a combination of local and ruler ElectroMagnetic Brakes (EMBr) is proposed to reduce defects in thinslab steel continuous casting. Computational fluid dynamics is used to validate submodels and evaluate different EMBr design configurations. The results show that the combination of ruler and local EMBrs effectively resolves uneven solidified shell growth. However, using local EMBrs midway the SEN and meniscus can result in unstable flow structures. The best performance is achieved by combining a single-ruler EMBr below the SEN and a couple of local EMBrs near the center of the meniscus.
JOURNAL OF MANUFACTURING PROCESSES
(2023)
Article
Oncology
Qi Miao, Zhihao Wei, Chenchen Liu, Yuzhong Ye, Gong Cheng, Zhengshuai Song, Kailei Chen, Yunxuan Zhang, Jiawei Chen, Changjie Yue, Hailong Ruan, Xiaoping Zhang
Summary: Radical prostatectomy (RP) shows significant advantages over radiation therapy (RT) in improving overall survival (OS) and cancer-specific survival (CSS) for metastatic prostate cancer (mPCa).
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Norman Reppingen, Alexander Helm, Laura Doleschal, Marco Durante, Claudia Fournier
Summary: The combination of Cabozantinib and irradiation showed promising effects in vitro on triple-negative breast cancer cells, but did not increase tumor growth control or affect lung metastases in vivo. Additionally, treatment with Cabozantinib was found to decrease immune suppressive myeloid derived suppressor cells in mice livers.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Maria C. Thomas, Yu-Hui Chen, Elliot Fite, Andrew Pangilinan, Katerina Bubelo, Alexander Spektor, Tracy A. Balboni, Mai Anh Huynh
Summary: Limited data exist to guide patient selection and treatment of bone metastases with curative intent using SBRT. This study analyzed the clinical characteristics of 434 patients treated with bone SBRT and identified factors associated with local control, progression-free survival, and overall survival. The study also found differences in outcomes based on the characteristics of the bone metastases and identified acute and late toxicities associated with the treatment.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Pediatrics
Petri Rahkonen, Aulikki Lano, Anu-Katriina Pesonen, Kati Heinonen, Katri Raikkonen, Sampsa Vanhatalo, Taina Autti, Leena Valanne, Sture Andersson, Marjo Metsaranta
Article
Radiology, Nuclear Medicine & Medical Imaging
Linda Kuusela, Sampsa Turunen, Leena Valanne, Outi Sipila
Article
Clinical Neurology
Padmini P. Polinati, Leena Valanne, Tiina Tyni
BRAIN & DEVELOPMENT
(2015)
Article
Clinical Neurology
Paivi Nevalainen, Petri Rahkonen, Elina Pihko, Aulikki Lano, Sampsa Vanhatalo, Sture Andersson, Taina Autti, Leena Valanne, Marjo Metsaranta, Leena Lauronen
CLINICAL NEUROPHYSIOLOGY
(2015)
Article
Clinical Neurology
Anna-Kaisa Anttonen, Taru Hilander, Tarja Linnankivi, Pirjo Isohanni, Rachel L. French, Yuchen Liu, Miljan Simonovic, Dieter Soell, Mirja Somer, Dorota Muth-Pawlak, Garry L. Corthals, Anni Laari, Emil Ylikallio, Marja Lahde, Leena Valanne, Tuula Lonnqvist, Helena Pihko, Anders Paetau, Anna-Elina Lehesjoki, Anu Suomalainen, Henna Tyynismaa
Article
Clinical Neurology
Liisa Metsaehonkala, Eija Gaily, Leena Valanne, Goeran Blomstedt
Article
Psychology, Clinical
Maarit Virta, Jyrki Launes, Leena Valanne, Laura Hokkanen
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2016)
Article
Medicine, General & Internal
Ruut Laitio, Marja Hynninen, Olli Arola, Sami Virtanen, Riitta Parkkola, Jani Saunavaara, Risto O. Roine, Juha Gronlund, Emmi Ylikoski, Johanna Wennervirta, Minna Backlund, Paivi Silvasti, Eija Nukarinen, Marjaana Tiainen, Antti Saraste, Mikko Pietila, Juhani Airaksinen, Leena Valanne, Juha Martola, Heli Silvennoinen, Harry Scheinin, Veli-Pekka Harjola, Jussi Niiranen, Kirsi Korpi, Marjut Varpula, Outi Inkinen, Klaus T. Olkkola, Mervyn Maze, Tero Vahlberg, Timo Laitio
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2016)
Article
Clinical Neurology
Jyrki P. Makela, Anne-Mari Vitikainen, Pantelis Lioumis, Ritva Paetau, Eero Ahtola, Linda Kuusela, Leena Valanne, Goran Blomstedt, Eija Gaily
Article
Clinical Neurology
Eija Gaily, Anna-Kaisa Anttonen, Leena Valanne, Elina Liukkonen, Ann-Liz Traskelin, Anne Polvi, Markus Lommi, Mikko Muona, Kai Eriksson, Anna-Elina Lehesjoki
Article
Neurosciences
Elina Pihko, Paivi Nevalainen, Selja Vaalto, Kristina Laaksonen, Helena Maenpaa, Leena Valanne, Leena Lauronen
HUMAN BRAIN MAPPING
(2014)
Article
Clinical Neurology
Suvi Maaria Koskinen, Lauri Soinne, Leena Valanne, Heli Silvennoinen
Article
Oncology
Mikaela Porkholm, Leena Valanne, Tuula Lonnqvist, Stefan Holm, Birgitta Lannering, Pekka Riikonen, Dorota Wojcik, Astrid Sehested, Niels Clausen, Arja Harila-Saari, Eckhard Schomerus, Halldora K. Thorarinsdottir, Paivi Lahteenmaki, Mikko Arola, Harald Thomassen, Ulla M. Saarinen-Pihkala, Sanna-Maria Kivivuori
PEDIATRIC BLOOD & CANCER
(2014)
Article
Pediatrics
Petri Rahkonen, Paivi Nevalainen, Leena Lauronen, Elina Pihko, Aulikki Lano, Sampsa Vanhatalo, Anu-Katriina Pesonen, Kati Heinonen, Katri Raikkonen, Leena Valanne, Taina Autti, Sture Andersson, Marjo Metsaranta
PEDIATRIC RESEARCH
(2013)
Article
Genetics & Heredity
Mikko Muona, Yuko Fukata, Anna-Kaisa Anttonen, Anni Laari, Aarno Palotie, Helena Pihko, Tuula Lonnqvist, Leena Valanne, Mirja Somer, Masaki Fukata, Anna-Elina Lehesjoki
NEUROLOGY-GENETICS
(2016)
